检索结果-南通市图书馆

P-functionalized carbon nanotubes promote highly stable electrocatalysts based on Fe-phthalocyanines for oxygen reduction: Experimental and computational studies

引用

Journal of Energy Chemistry 2022年第9期31卷 276-290,I0008页

作者： Beatriz Martinez-Sanchez Diego Cazorla-Amors emilia morallon Departamento de Quimica Fisica and Instituto Universitario de Materiales de Alicante(IUMA)University of Alicante Ap.99.03080 AlicanteSpain Departamento de Quimica Inorganica and Instituto Universitario de Materiales de Alicante(IUMA) University of AlicanteAp.9903080 AlicanteSpain

Iron(Ⅱ) phthalocyanines(FePc) supported on functionalized nanostructured carbon materials have been studied as electrocatalysts for the oxygen reduction reaction(ORR) in an alkaline medium. Herein, two types of carbon nanotubes(CNTs) have been explored as support, Single-Walled Carbon Nanotubes and Herringbone Carbon Nanotubes(SWCNTs and h CNTs, respectively), both electrochemically modified with ortho-aminophenylphosphonic acid(2APPA), which provides phosphate axial coordinating ligands for the immobilization of FePc molecules. All the catalysts were prepared via a facile incipient wetness impregnation method. Comprehensive experimental analysis together with density functional theory(DFT) calculations has demonstrated both the importance of the five-coordinated Fe macrocycles that favor the interaction between the FePc and the carbon support, as well as the effect of the CNT structure in the ORR. FePc axial coordination provides a better dispersion, leading to higher stability and a favorable electron redistribution that also tunes the ORR performance by lowering the stability of the reaction intermediates. Interestingly, such improvement occurs with a very low content of metal(~1 wt% Fe),which is especially remarkable when h CNT support is employed. This work provides a novel strategy for the development of Fe-containing complexes as precious metal-free catalysts towards the ORR.

关键词： Carbon nanotubes Iron phthalocyanine Oxygen reduction Electrocatalysis Axial ligand

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Artificial intelligence as a tool in drug discovery and development

引用

World Journal of Experimental Medicine 2024年第3期14卷 11-19页

作者： Maria Kokudeva Mincho Vichev emilia Naseva Dimitrina Georgieva Miteva Tsvetelina Velikova Department of Pharmacology and Toxicology Faculty of PharmacyMedical University of SofiaSofia 1000Bulgaria Healthcare Solutions Sofia 1404Bulgaria Faculty of Public Health Medical University of SofiaSofia 1431Bulgaria Department of Genetics Faculty of BiologySofia University St.Kliment OhridskiSofia 1164Bulgaria Tsvetelina Velikova Medical FacultySofia University St.Kliment OhridskiSofia 1407Bulgaria

The rapidly advancing field of artificial intelligence(AI)has garnered substantial attention for its potential application in drug discovery and *** opinion review critically examined the feasibility and prospects of integrating AI as a transformative tool in the pharmaceutical ***,encompassing machine learning algorithms,deep learning,and data analytics,offers unprecedented opportunities to streamline and enhance various stages of drug *** opinion review delved into the current landscape of AI-driven approaches,discussing their utilization in target identification,lead optimization,and predictive modeling of pharmacokinetics and *** aimed to scrutinize the integration of large-scale omics data,electronic health records,and chemical informatics,highlighting the power of AI in uncovering novel therapeutic targets and accelerating drug repurposing *** the considerable potential of AI,the review also addressed inherent challenges,including data privacy concerns,interpretability of AI models,and the need for robust validation in realworld clinical ***,we explored ethical considerations surrounding AI-driven decision-making in drug *** opinion review provided a nuanced perspective on the transformative role of AI in drug discovery by discussing the existing literature and emerging trends,presenting critical insights and addressing potential *** conclusion,this study aimed to stimulate discourse within the scientific community and guide future endeavors to harness the full potential of AI in drug development.

关键词： Artificial intelligence Drug discovery Drug development Decision-making AI-driven medicine Healthcare Public health

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Method“Monte Carlo”in healthcare

引用

World Journal of Methodology 2024年第3期14卷 40-47页

作者： Tsvetelina Velikova Niya Mileva emilia Naseva Medical Faculty Sofia University St.Kliment OhridskiSofia 1407Bulgaria Medical Faculty Medical University of SofiaSofia 1431Bulgaria Faculty of Public Health“Prof.Tsekomir Vodenicharov MDDsc”Medical University of SofiaSofia 1431Bulgaria

In public health,simulation modeling stands as an invaluable asset,enabling the evaluation of new systems without their physical implementation,experimentation with existing systems without operational adjustments,and testing system limits without real-world *** simulation modeling,the Monte Carlo method emerges as a powerful yet underutilized *** the Monte Carlo method has not yet gained widespread prominence in healthcare,its technological capabilities hold promise for substantial cost reduction and risk *** this review article,we aimed to explore the transformative potential of the Monte Carlo method in healthcare *** underscore the significance of experiential insights derived from simulated experimentation,especially in resource-constrained scenarios where time,financial constraints,and limited resources necessitate innovative and efficient *** public health faces increasing challenges,incorporating the Monte Carlo method presents an opportunity for enhanced system construction,analysis,and evaluation.

关键词： Monte Carlo Simulation Healthcare Modeling Decision analysis Stochastic methods Statistical techniques Health economics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phenotypic Characterization of Extended Spectrum Beta-Lactamase, Class C Cephalosporinase and Carbapenemase-Producing Klebsiella Species Isolated from Patients Consulted at Four Yaounde-Based Hospitals

引用

Open Journal of Medical Microbiology 2024年第2期14卷 105-119页

作者： emilia Enjema Lyonga Mbamyah Mangum Patience Kumcho Michel Toukam Dieudonné Sedena Florence Anjabie Enyeji Aime-Caesar Teukam Modestine Djuissi Martha Tongo Mesembe George Mondinde Ikomey Agnes Bedie Eyoh Hortense Kamga Gonsu Faculty of Medicine and Biomedical Sciences The University of Yaounde 1 Yaounde Cameroon Center for the Study and Control of Communicable Diseases Faculty of Medicine and Biomedical Sciences The University of Yaounde 1 Yaounde Cameroon Department of Microbiology School of Health Sciences Catholic University of Central Africa Yaounde Cameroon Faculty of Science University of Buea Buea Cameroon Bacteriology Unit Yaounde University Teaching Hospital Yaounde Cameroon

Background: Klebsiella spp. are bacteria of medical importance for their role in opportunistic infections which are often difficult to treat because of resistance to one or several antimicrobials. The aim of this study was to determine antimicrobial resistance due to Extended Spectrum Beta-lactamase (ESBL), Class C cephalosporinase (AmpC) and carbapenemase enzymes in Klebsiella spp. isolated from patients consulted at four hospitals. Methodology: The study was cross-sectional and descriptive. A total of 4190 non-repetitive patients specimens from 13 types of clinical specimens were analysed from February to November 2020. Two hundred and twenty-five (225) Klebsiella spp isolates were identified using API 20E and antimicrobial susceptibility testing done according to the Kirby Bauer disc diffusion method. ESBL and AmpC phenotypes were determined by the combination disc method and carbapenemases by double disc synergy method, referenced by EUCAST guidelines for the resistance testing. Results: The frequency of the species was Klebsiella pneumoniae (69%, 155/255), K. oxytoca (14%, 31/255), K. ozaenae (12%, 27/225) and K. rhinoscleromatis (5%, 11/225). Isolates were most resistant to sulphomethoxazole trimethoprim (84%, 189/225), cepaholosporins (80%, 180/225), and least resistant to carbapenems (10.7%, 24/225). Two K. oxytoca and one K. pneumoniae were resistant to all antibiotics tested. Klebsiella pneumoniae had the most multidrug resistant isolates (59.4%, 134/225). Most isolates (83.6%, 188/225) expressed at least one enzyme, while 63.6% (143/225) of the isolates expressed at least two enzymes. Some isolates were ESBL (71.6%, 161/225), carbapenemase (10.7%, 24/225) and AmpC (6.6%, 15/225) producers. Three carbapenemases (Klebsiella pneumoniae carbapenemase-KPC, Metallo-Beta Lactamase-MBL and OXA-48) were detected. Conclusion: These results revealed that resistance of Klebsiella spp. to cephalosporins is high and this may be exacerbated by co-expression of AmpC and

关键词： Klebsiella Spp. Multidrug Resistance ESBL AmpC Carbapenemase

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The use of mineral interfaces in sand-sized volcanic rock fragments to infer mechanical durability

引用

Journal of Palaeogeography 2020年第3期9卷 288-313页

作者： emilia Le Pera Consuele Morrone Dipartimento di Biologia Ecologia e Scienze della Terra(DiBEST)Universita

The use of mineral interfaces, in sand-sized rock fragments, to infer the influence exerted by mechanical durability on the generation of siliciclastic sediments, has been determined for plutoniclastic sand. Conversely, for volcaniclastic sand, it has received much less attention, and, to our knowledge, this is the first attempt to make use of the volcaniclastic interfacial modal mineralogy of epiclastic sandy fragments, to infer mechanical durability control at a modern beach environment. Volcaniclastic sand was collected along five beaches developed on five islands, of the southern Tyrrhenian Sea(Alicudi, Filicudi, Salina, Panarea and Stromboli) from the Aeolian Archipelago, and one sample was collected near the Stromboli Island volcanic crater. Each sample was sieved and thin sectioned for petrographic analysis. The modal mineralogy of the very coarse, coarse and medium sand fractions was determined by point-counting of the interfacial boundaries discriminating 36 types of interfaces categories, both no-isomineralic and/or no iso-structural(e.g., phenocrystal/glassy groundmass or phenocrystal/microlitic groundmass boundaries) and iso-mineralic interfaces, inside volcanic lithic grains with lathwork and porphyric textures. A total of 47,386 interfacial boundaries have been counted and, the most representative series of interfaces, from the highest to the lowest preservation, can be grouped as: a) ultrastable interfaces, categorized as Pl(Plagioclase)/Glgr(Glassy groundmass) > > Px(Pyroxene)/Glgr > > Ol(Olivine)/Glgr > > Op(Opaque)/Glgr > > Hbl(Hornblende)/Glgr> > Bt(Biotite)/Glgr > > Idd(Iddingsite)/Glgr > > Rt(Rutile)/Glgr;b) stable interfaces, categorized as Pl/Migr(Microlitic groundmass) > > Op/Migr > > Px/Migr > > Ol/Migr;c) moderately stable interfaces, categorized as Op/Px > > Op/Hbl > > Px/P > > Ol/Pl> > Bt/Op;and d) unstable interfaces, categorized as Pl/Pl > > Px/Px > > Ol/Ol > >Op/Op > > Hbl/Hbl > > Bt/Bt. Grains, eroded from the volcanic bedrock, if aff

关键词： Volcaniclastic sand Mineral interfaces Volcanic beach environment Mechanical durability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Emissions of fluorides from welding processes

引用

Journal of Environmental Sciences 2015年第11期27卷 179-183页

作者： Malgorzata Szewczynska emilia Pagowska Krystyna Pyrzynska Department of Chemical and Aerosol Hazards Central Institute for Labour Protection-National Research Institute Faculty of Chemistry University of Warsaw

The levels of fluoride airborne particulates emitted from welding processes were investigated. They were sampled with the patented IOM Sampler, developed by J. H Vincent and D. Mark at the Institute of Occupational Medicine（IOM）, personal inhalable sampler for simultaneous collection of the inhalable and respirable size fractions. Ion chromatography with conductometric detection was used for quantitative analysis. The efficiency of fluoride extraction from the cellulose filter of the IOM sampler was examined using the standard sample of urban air particle matter SRM-1648 a. The best results for extraction were obtained when water and the anionic surfactant N-Cetyl-N-N-Ntrimethylammonium bromide（CTAB） were used in an ultrasonic bath. The limits of detection and quantification for the whole procedure were 8 μg/L and 24 μg/L, respectively The linear range of calibration was 0.01–10 mg/L, which corresponds to 0.0001–0.1 mg of fluorides per m3 in collection of a 20 L air sample. The concentration of fluorides in the respirable fraction of collected air samples was in the range of 0.20–1.82 mg/m3, while the inhalable fraction contained 0.23–1.96 mg/m3 of fluorides during an eight-hour working day in the welding room.

关键词： Fluorides Particle size distribution Welding processes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Petrography of Middle Jurassic to Early Cretaceous sandstones in the Kutch Basin,western India:Implications on provenance and basin evolution

引用

Journal of Palaeogeography 2018年第3期7卷 239-252页

作者： Angana Chaudhuri Santanu Banerjee emilia Le Pera Department of Earth Sciences Indian Institute of Technology Bombay Dipartimento di Biologia Ecologia e Scienze della Terra University della

This paper investigates the provenance of Middle Jurassic to Early Cretaceous sediments in the Kutch Basin, western India, on the basis of mineralogical investigations of sandstones composition （Quartz-Feldspar-Lithic （QFL） fragment）, Zircon-Tourmaline-Rutile （ZTR） index, and mineral chemistry of heavy detrital minerals of the framework. The study also examines the compositional variation of the sandstone in relation to the evolution of the Kutch Basin, which originated as a rift basin during the Late Triassic and evolved into a passive margin basin by the end Cretaceous. This study analyzes sandstone samples of Jhumara, Jhuran and Bhuj Formations of Middle Jurassic, Upper Jurassic and Lower Cretaceous, respectively, in the Kutch Mainland. Sandstones record a compositional evolution from arkosic to subarkosic as the feldspar content decreases from 68% in the Jhumara Formation to 27% in the Bhuj Formation with intermediate values in the Jhuran Formation. The QFL modal composition indicates basement uplifted and transitional continental settings at source. Heavy mineral content of these sandstones reveals the occurrence of zircon, tourmaline, rutile, garnet, apatite, monazite and opaque minerals. Sub-rounded to well-rounded zircon grains indicate a polycyclic origin. ZTR indices for samples in Jhumara, Jhuran and Bhuj Formations are 25%, 30% and 50% respectively. Chemistry of opaque minerals reveals the occurrence of detrital varieties such as ilmenite, rutile, hematite/magnetite and pyrite, in a decreasing order of abundances. Chemistry of ilmenites in the Jhumara Formation reveals its derivation from dual felsic igneous and metabasic source, while those in Jhuran and Bhuj Formations indicate a metabasic derivation. Chemistry of garnet reveals predominantly Fe-rich （almandine） variety of metabasic origin. X-ray microscopic study provides the percentage of heavy minerals ranging from 3% to 5.260. QFL detrital modes reflect the evolution of the basin from an active rif

关键词： Siliciclastic provenance Tectonic setting Heavy minerals Mineral chemistry X-ray microscopy Mesozoic,Kutch Basin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hegel after Nancy:Sensibility,Singularity,and the Problem of the Phenomenology of Spift

引用

Frontiers of Philosophy in China 2018年第4期13卷 535-553页

作者： emilia Angelova Department of Philosophy The Chinese University of Hong KongHong KongChina

This article takes up two models of punishment in Hegel, one that is underdeveloped in the Phenomenology of Spirit and one more fully developed in the Elements of the Philosophy of Right. Both models focus on the notions of law and the legality of personhood. I argue that beyond this, they share a common concept of singularity as an excess over and above the ethical-political order. This concept opens up to what Jean-Luc Nancy calls the “event” of freedom in Hegel. This point about excess lets me deploy Lacan and then Nancy to underscore how, for Hegel, problems concerning the question “what is law?” might be a clue as to how the bad infinite is opposed to the good or “actual” infinite. I take this up in the context of Hegel’s theory of “value,” including the value of the “good.” Altogether this analysis reveals that Hegel’s method allows for a more complex humanism than is typically understood, since his points about law and punishment lead to a more radicalized notion of intentionality and forgiveness than usually derived from the logic of recognition.

关键词： Sensibility subjectivity Phenomenology Hegel Nancy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Self-healing effect of ceria electrodeposited thin films on stainless steel in aggressive 0.5 mol/L NaCl aqueous solution

引用

Journal of Rare Earths 2015年第11期33卷 1212-1227页

作者： Desislava Guergova emilia Stoyanova Dimitar Stoychev Ivalina Avramova Plamen Stefanov "Rostislaw Kaischew" Institute of Physical Chemistry Bulgarian Academy of Sciences Institute of General and Inorganic Chemistry Bulgarian Academy of Sciences

The self-healing effect of electrochemically deposited CeO2-Ce2O3 films on stainless steel OC404（SS） in 0.5 mol/L NaCl solution was studied. It was established that the corrosion potential of the steel, after covering it with CeO2-Ce2O3 layer and thermal treatment（i.e. potential of the system CeO2-Ce2O3/SSt.t.）, was shifted sharply to a considerably more positive value, while the corrosion current was reduced noticeably. The X-ray photoelectron spectroscopy（XPS）, energy dispersive spectroscopy（EDS） and scanning electron microscopy（SEM） analyses on the observed scratched surface area of the system CeO2-Ce2O3/SSt.t., after exposure of investigated specimens to 0.5 mol/L NaCl corrosion media, showed partial accumulation of ceria, as well as remarkable increase in the concentrations of oxides of Al, Cr and Fe, on the mechanically revealed steel surface. On the basis of the obtained results one could conclude that the secondary passive oxide/hydroxide films, formed after a definite time interval of exposure to corrosion media, acted as barriers, hindering the corrosion processes in active zones. A hypothesis was put forward about the mechanism of self-repairing oxide layers on the steel surface and their corrosion protection effect respectively.

关键词： stainless steel ceria films corrosion self-healing effect rare earths

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Genotoxicity of gold nanoparticles functionalized with indolicidin towards Saccharomyces cerevisiae

引用

Journal of Environmental Sciences 2018年第4期30卷 138-145页

作者： Elisabetta de Alteriis Annarita Falanga Stefania Galdiero Marco Ouida Valeria Maselli emilia Galdiero Department of Biology University of Naples "Federico II" 80100 Naples Italy Department of Pharmacy University of Naples "Federico II" 80134 Naples Italy

The toxic effects of gold nanoparticles surface-functionalized with the antimicrobial peptide indolicidin（Au NPs-indolicidin） towards the yeast Saccharomyces cerevisiae, one of the major eukaryotic model organisms, have been evaluated. Growth and survival,genotoxicity, as measured by comet assay, and expression of the YCA1, an apoptosis indicating gene, following 72 hr exposure of yeast to Au NPs-indolicidin, and to Au NPs and indolicidin alone have been examined. The gold nanoparticles exerted toxicity with DNA damage, accompanied by reactive oxygen species production（ROS）, but they do not inhibit yeast growth and viability. Genotoxicity was less pronounced for surface-functionalized nanoparticles, showing that S. cerevisiae is quite resistant to the complex Au NPs-indolicidin.A progressive reduction of the genotoxic effect was observed along 72 hr exposure,presumably due to the activation of DNA repair mechanisms. These findings suggest the occurrence of a physiological protective response of S. cerevisiae towards nanoparticles,thereby providing useful information to the assessment of the environmental impact of metal nanoparticles.

关键词： Ecotoxicity Antimicrobial peptide Comet assay Yeast Nanoparticles Oxidative stress

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：