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Pancreatic Cancer: Epidemiological, Clinical and Therapeutic Aspects in Abidjan (Ivory Coast)

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Open Journal of Gastroenterology 2017年第8期7卷 223-229页

作者： Amadou Ouattara Siaka Kone Dramane Soro Constant Assi emile allah-kouadio Rodrigue Irie Gohi Bi Fanoucoffi Denis Marie-Jeanne Lohoues-Kouacou Teaching Hospital Center of Cocody Abidjan C&ocirc te d’Ivoire

Aim: The aim was to study the epidemiological, clinical and therapeutic aspects of pancreatic cancers in Ivory Coast. Materials and methods: A retrospective multi-center and multidisciplinary study aimed at describing sixteen years and four months from January 1, 2000 to April 30, 2016 in several hospitals in the city of Abidjan taking charge of pancreatic cancers (hepato-gas troenterology services of the universities hospitals of Cocody and Yopougon), internal medicine departments of University Hospital of Treichville and Abidjan Military Hospital, the department of oncology of the university hospital center of Treichville, private clinics (DANGA, PISAM and GMP), the COBA center in Treichville. The diagnosis of cancer was based on either histological criteria or a set of clinical and paraclinical arguments. Patients whose files did not include imaging were excluded from this study. The following parameters were collected: age, sex, reason for consultation, physical signs, personal and family antecedents, tumor characteristics, delay in diagnosis and the nature of the treatment administered. Results: We have observed 150 cases of pancreatic cancer. The mean age of patients was 59.09 years with extremes ranging from 24 years to 88 years. Our study population consisted of 98 men and 52 women (sex ratio 1.88). Risk factors were dominated by diabetes 20.7%. Epigastralgia is the main reason for consultation (48%). The tumor was localized at the cephalic level in 84.67%. In 13 cases the diagnosis was histological and was dominated by adenocarcinoma (100%). The majority of our patients was seen at an advanced stage of the disease: stage IV (74.56%). The average time to diagnosis was 2.76 months. Fourteen of our patients (9.33%) had benefited surgery. This was curative surgery in 35.71% (n = 5) and palliative in 64.29% (n = 9). Among those who benefited from this curative surgery, three died two months after surgery and two lost to follow-up. The majority (90.67%) of our pa

关键词： Pancreas Cancer Epidemiological Ivory Coast

Screening for Hepatitis B and C in Occupational Settings: Cross-Sectional Study about 4268 Corporates Agents in Cote d’Ivoire

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Open Journal of Gastroenterology 2017年第3期7卷 89-95页

作者： Constant Assi Amadou Ouattara Siaka Kone Dramane Soro emile allah-kouadio Claude Ghislain Kouakou Nigué Luc Benoit-Mathieu Camara Marie-Jeanne Lohoues-Kouacou Teaching Hospital Center of Cocody Abidjan Cote d’Ivoire

Aim: To screen hepatitis B and C in occupational setting. Methods: Cross-sectional study multicenter in 16 enterprises (one occupational exposure;5602 agents). Screening was preceded by information, sensibilisation and informed consenting physician labor, labor union and agents. Hepatitis B surface antigen (HBsAg) and antibodies anti-hepatitis C (Elisa, third generation) were tested in all. For those with HBsAg positive, this test was completed by IgM and IgG, anti HBc, HBeAg, antibodies anti HBe, transaminases and HBB DNA;for those with positive anti-VHC antibodies, test was completed by transaminases and VHC’s RNA. Results: Rate of participation was 76.2% (4268/5602 labors). HBsAg or hepatitis C antibodies were positives in 425 (9.9%) of cases (HBsAg positive: 8.48%;Hepatitis C Antibodies positives: 1.50%;both: 0.05%). In HBsAg positive, viral replication and cytolysis were seen respectively in 2.5 % and 18.2%. According with transaminases, serologic markers and viral load, immunotolerance, inactive and immuno active phase were suspected in 0.56%, 80.9% and 1.6% of cases. In hepatitis C antibodies positives persons, any had viral replication but cytolysis was observed in 33.3% (n = 21). HBsAg was significantively (p < 0.00001) higher in exposed occupational enterprise versus non-occupational setting (14.4% vs 7.8%). They were no differences (p = 0.71) about hepatitis C antibodies in the two setting (1.8% vs 1.7%). Conclusion: Prevalence of HBsAg and hepatitis C antibodies was high in occupational setting in hepatitis endemic country. It’s important to screen all of person in these setting with no consideration with blood exposed or not exposed enterprise.

关键词： Hepatitis B and C Screening Occupational Setting Blood Exposed Enterprise

Hydrogeochemical Characterization of Groundwater from Fissured Aquifers in the Angovia Mine Operating Permit Area (Central-West Côte d’Ivoire)

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Journal of Water Resource and Protection 2024年第1期16卷 83-101页

作者： kouadio Michel Yao Tanina Drissa Soro Tanoh Jean Jacques Koua Akaie Jean Fabrice Tchakray Yao emile Desmond Konan Brou Dibi Laboratory of Sciences and Technologies of Environment University Jean Lorougnon Guede Daloa C&ocircte d’Ivoire

The main objective of this study is to determine the hydrogeochemical specificities of the groundwater of the Angovia mine operating permit, located in the Yaouré mountains in the center-west of Côte d’Ivoire. To do so, descriptive and multivariate statistical analysis methods with the SOM (Self Organizing Maps) algorithm were applied to the physicochemical parameters of 17 boreholes using the calcite (ISC) and dolomite (ISD) saturation indices. The results obtained have shown that the groundwater in the Angovia mine operating permit area has an average temperature of 27.52°C (long rainy season) and 27.87°C (long dry season) and has an average pH of 7.09 ± 0.35 during the main rainy season and 7.32 ± 0.35 during the main dry season. They are mineralized with an average electrical conductivity of 505.98 ± 302.85 μS/cm during the long rainy season and with 450.33 ± 233.74 μS/cm as average during the long dry season. The main phenomena at the origin of groundwater mineralization are water residence time, oxidation-reduction and surface inflow. The study of the relative age of the water shows that the groundwater in the Angovia mine operating permit area is mainly undersaturated with respect to calcite and dolomite. They are therefore very old in the aquifer with a slow circulation speed during the long rainy season and the long dry season.

关键词： Hydrogeochemistry Mineralization Fissure Aquifers Operating Permits The Angovia Mine

Appropriateness of colonoscopy in Cocody teaching hospital center in 2010: A prospective study using criteria established by the European panel on the appropriateness of gastrointestinal endoscopy (EPAGE)

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Open Journal of Gastroenterology 2012年第4期2卷 193-199页

作者： Constant Assi Marie Jeanne Lohouès-Kouacou emile allah-kouadio Christian Jomo Njossu Anassi Jean-Baptiste Okon Stanislas Doffou Siaka Koné Ganda Soumaré Amadou Koné Amadou Ouattara Dramane Soro Mamadou Diakité Benoit-Mathieu Camara Department of Gastroenterology Faculty of Medical Sciences Cocody Teaching Hospital Center AbidjanCote d’Ivoire

Aims: 1) To assess the feasibility of EPAGE criteria in clinical practice;2) To assess appropriateness colonoscopy using EPAGE criteria;3) To compare colonoscopy appropriateness and endoscopic lesions. Method: Hundred thirtynine consecutive patients explored by colonoscopy were included. The appropriateness of colonoscopy was evaluated by EPAGE criteria. Results: EPAGE criteria were applicable among 127 patients (91% of the cases). Colonoscopies were appropriate, uncertain and inappropriate in respectively 40%;27% and 24% of the cases. Rate of abnormal colonoscopies was significantly different between the 3 groups (p = 0.03). Cancers were diagnosed exclusively in the groups with appropriate and uncertain colonoscopies (11% and 5%). Colonic adenomas were observed in the three groups (appropriate (7%), uncertain (5%) and inappropriate (6%)). Subjects with uncertain indication were older (58.25 years;p = 0.035). Conclusion: EPAGE criteria are feasible in clinical practice in Cocody’s teaching hospital center. Colonoscopies are generally appropriate in our hospital. However, within sight of the significant number of normal colonoscopies and discovered lesions in uncertain indication, colonoscopy cannot concern exclusively calculation of a score of appropriateness.

关键词： Colonoscopy Appropriateness EPAGE Score Colorectal Cancer Cote d’Ivoire

Prevalence of HBs Ag among blood donors in Transfusion Center, Abidjan (Ivory Coast)

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Open Journal of Gastroenterology 2013年第3期3卷 165-169页

作者： N’guessan N’dri Amani Sroboua Thot’o Anassi Jean-Baptiste Okon Constant Assi emile allah-kouadio Dramane Soro Mamadou Diakité Amadou Koné Siaka Koné Marie Jeanne Lohouès-Kouacou Benoit-Mathieu Camara Department of Gastroenterology Faculty of Medical Sciences Cocody Teaching Hospital Center Abidjan Cote d’Ivoire

Aim: To study the prevalence of HBsAg among persons without risk factors for hepatitis B. Patients and Methods: Cross-sectional study (28 January to 31 December 2010) about 4310 new volunteers blood donors consecutively recruited. Among all, a risk factor for hepatitis B was investigated (standardized questionnaire and clinical examination). Blood of all blood donors without risk factors of hepatitis B (n = 3823) were systematically collected for HBsAg, hepatitis C antibody, syphilis serology and human immunodeficiency virus serology. The blood was analyzed with a third generation ELISA (Abbott Murex). Results: HBsAg was positive in 179 persons (4.68% [95% CI 4% - 5%]). It was associated with hepatitis C antibodies (0.28% (n = 11)), syphilis antibodies (0.68% (n = 26)) or anti-human immunodeficiency virus antibodies (0.2% (n = 8)). In multivariate analysis, age 30 to 39 years (1.545 [95% CI 1.074 to 2.222]), male sex (2.426 [95% CI 1.550 to 3.799]) and positive syphilis serology (14.344 [95% CI 5.161 to 39.865]) were associated with presence of HBsAg. Conclusion: The prevalence of HBsAg among adult without risk factors for hepatitis B was not negligible. Also, it is essential to maintain routine screening before any vaccination against hepatitis B in adult. Our study is not for an immunization against hepatitis B only targeting risk populations in adult.

关键词： HBsAg Prevalence Risk Factor Adult Abidjan

Prevalence of Heartburn in Abidjan, a Black African Country, and Associated Factors

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Open Journal of Gastroenterology 2014年第4期4卷 175-180页

作者： Constant Assi Siaka Koné Antonin W. Ndam Ndjitoyap Amadou Ouattara Laté Mawuli Lawson-Ananissoh Diallo Djenabou Stanislas Doffou Jean-Kalpy Coulibaly Christian Ebela Dramane Soro emile allah-kouadio Marie-Jeanne Lohouès-Kouacou Beno?t-Mathieu Camara Division of Gastroenterology University Hospital of Cocody Abidjan Cote d’Ivoire

Aims: To determine the prevalence and risk factors of heartburn in Abidjan, a black African city. Patients and Methods: cross-sectional study from June 15 to September 30, 2003. One thousand nine hundred forty (1940) persons from five health zones of the city Abidjan were included after their informed consent. Socio demographic and clinical parameters were collected using a questionnaire in an interview format. Heartburn was defined as a discomfort or burning sensation extending from the sternal manubrium to the base of the neck. Factors related to the complaint were asked such as predisposing factors, habits (tobacco, alcohol and coffee intake) and body mass index. Stepwise multiple logistic regression analyses were used to examine associations between these factors and heartburn. Results: Among 1940 respondents (mean age 28 ± 9 years;sex ratio (M:F) 0.86), heartburn occurred in 433 persons (once a week in 9.2% of case (178 persons)). Five factors were statistically associated with heartburn: male sex (p = 0.025, OR = 0.555 [CI95% 0.331 - 0.930]), heartburn in a family member (p = 0.010, OR = 1.765 [95%CI 1.143 - 2.725]), constipation (p = 0.011, OR = 2.182 [95%CI 11,953,983]), right lateral decubitus (p = 0.001, OR = 6.247 [95%CI 2.079 - 18.775]) and after a meal (p = 0.000, OR = 2.643 [95%CI 1.594 4.383]). Conclusion: Heartburn is common in this black African population. Male sex appears to be less associated. Constipation, right lateral decubitus and after a meal are trigger factors for heartburn. Heartburn in a family member is a risk factor.

关键词： Gastro-Esophageal Reflux Disease Heartburn Regurgitation Abidjan Epidemiology Clinical

Effect of Herbicides Used in Horticulture (2,4-D, Glyphosate and Nicosulfuron) on Snails <i>Achatina fulica</i>(Bowdich, 1720)

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Journal of Agricultural Chemistry and Environment 2021年第4期10卷 402-414页

作者： Aya Elichama Désirée Phaceli Mama Koné Ardjouma Dembele Jean Florent Haba emile kouadio Yao Laboratoire de physiologie de pharmacologie et de pharmacopée UFR des Sciences de la Nature Université Nangui Abrogoua Abidjan C&ocirc te d’Ivoire Laboratoire National d’Appui au Développement Agricole (LANADA) Abidjan C&ocirc te d’Ivoire Laboratoire de biodiversité et de gestion durable des écosystèmes UFR des Sciences de la Nature Université Nangui Abrogoua Abidjan C&ocirc te d’Ivoire

2,4-Dichlorophenoxyacetic (2,4-D), glyphosate, and nicosulfuron, because of their modes of action and selectivity, are the most widely used herbicides in Ivorian horticulture. Fuels toxicity was the reason of many debates in the world because of their massive and uncontrolled use. They are frequently blamed for the reduction of soil fertility and terrestrial biodiversity observed in agricultural areas. In view of the debates raised by their toxicities, the use of these herbicides requires the greatest caution and clear information on the real risk incurred by the edaphic fauna by conducting ecotoxicity studies. The present study aims to evaluate the effect of 2,4-D, glyphosate and nicosulfuron herbicides on the growth and reproduction of Achatina fulica snails in microcosm. To do this, we treated each plot on which snail microcosms were placed with 2,4-D, glyphosate or nicosulfuron herbicides according to the manufacturer’s recommendations. The results showed for all the herbicides used, that after 28 days of exposure, the growth of juvenile snails was slowed down. The number of eggs laid per pair was reduced in adult snails. The egg hatchability test revealed a reduction in egg hatchability. In addition, each effect was dependent on the herbicide used. Thus, toxicity was found to be greater according to the following order: nicosulfuron ? glyphosate ? 2,4-D. From the results obtained, we concluded that 2,4-D, glyphosate, and nicosulfuron treatments under field conditions are a potential threat to the sustainability of snail species and therefore to soil life. The intensity of the effect depends on the toxicity of the herbicides used.

关键词： Herbicide Effect Growth Reproduction Achatina fulica Microcosm

Duodenal Metastases of Malignant Melanoma: One Case Report

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Open Journal of Gastroenterology 2015年第8期5卷 111-114页

作者： Soro Dramane Ouattara Amadou Okon Anassi Jean Baptiste Koné Siaka Assi Constant allah-kouadio emile N’dah K. Justin Ndjitoyap Ndam Antonin Wilson Diallo Djeinabou Lohoues-Kouacou Marie Jeanne d’Arc Camara Benoit Mathieu Service d’Hépato-Gastroentérologie CHU Cocody Abidjan Cote d’Ivoire Service d’Hépato-Gastroentérologie CHU Bouaké Bouaké Cote d’Ivoire Service d’Anatomie Pathologique CHU Cocody Abidjan Cote d’Ivoire

The duodenal metastases of a malignant melanoma are rare. We report a case at a 86-year-old, hypertense patient, without tumoral history, who was hospitalized in our department for a change of the general state and an anaemia ferriprive without found home (foyer) of display. In the clinical examination, we had found anemia syndrome, nodules under cutaneous about 2 cm in diameter at the level of the thorax, of the belly, the members and of the lower lip partners in a painless left adenopathy axillary about 3 cm in diameter and an absence of méléna in the rectal touch. The gastroscopy had highlighted polypoides ulcéro-bourgeonnantes hurts with a blackish pigmentation by places at the level of the bulb and of the second duodenum. In the histology of biopsie fragments, we noted a fuso-cellular proliferation and epithelioid with deposits of melanin. The positivity of antibodies anti-protein S100 and anti HMB45 in the immunohistochemical study allowed confirming the diagnosis. The gastroduodenal hurts, persons suffering from a liver complaint and lungworts in the scanner testify of a terminal metastatic scattering. The death arose two months later, in a picture of circulatory collapse further to a high digestive bleeding of big abundance.

关键词： Duodenal Metastases Malignant Melanoma

Acute Intestinal Invagination of the Child at the Teaching Hospital of Bouaké: Ultrasound Diagnosis and Clinical-Echo-Surgical Correlation

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Open Journal of Medical Imaging 2021年第1期11卷 18-28页

作者： Bouassa Davy Melaine Kouakou Konaté Issa Kouamé Paul Bonfils Kouassi Adoubs Cé lestin Bé nié Tsri Akoli Baudouin Bravo Kesse emile Tanoh Allou Florent kouadio Brou Lambert Yao Achie Jean-Ré gis Akobe Sara Carole Sanogo Malick Soro kouadio N’Dri Medical Imaging and Radiodiagnostic Departement of the Teaching Hospital of Bouaké Bouak&#233 Ivory Coast Training and Research Unit Medical Sciences Alassane Ouattara University Bouak&#233 Ivory Coast Pediatric Surgery Unit of the Teaching hospital of Bouaké Bouak&#233 Ivory Coast

Background: Acute intestinal invagination or intussusception is the most common abdominal surgical emergency in infants, but it can occur at any age. Performing an ultrasound scan at the slightest clinical suspicion contributes to early diagnosis and therapeutic management. Objective: To show the relevance of ultrasound in the therapeutic management of the child’s intussusception through a correlation between the ultrasound diagnosis and the clinical and/or per operative diagnosis. Patients and Methods: It was a retrospective study of 24 cases from July 2017 to September 2020 (30 months) in the Medical Imaging and Paediatric Surgery departments of Teaching Hospital of Bouaké. We included only patients from 0 to 15 years old who had digestive symptoms, an abdominal ultrasound scan. These patients were eligible for surgery. Data analysis was performed with Epi info 7 software. Results: Median age was 17.2 months [02 - 120]. Male gender predominated (83.3%). Clinico-biological data were dominated by abdominal pain (79.2%), vomiting (75%) and rectorragies (33.3%), with Ombredanne’s triad in 33.3% and hyperleukocytosis (70.8%). Ultrasonography showed invaginated coves (95.8%) sitting in the right angl iliac fossa, peri-umbilical and right flank in 73.9%. Cockade image coupled with the sandwich image accounted for 95.6%. Superficial adenopathies (45.8%) and peri-lesional fluid effusion (20.8%) were associated with it. An occlusive syndrome complicating intussusception was observed in 41.67% associated with intra-peritoneal effusion of fluid (25%). There was a significant diagnostic agreement between the clinic, ultrasound and surgery according to the Fisher’s exact test (p = 0.002). That between ultrasound and surgery was calculated at 95.4%. Conclusion: This study allowed us to show a good clinical-echo-surgical concordance. Ultrasound is therefore an undeniable diagnostic, prognostic an

关键词： Ultrasound Acute Intestinal Invagination Child