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Malnutrition and non-compliance to nutritional recommendations in patients with cirrhosis are associated with a lower survival

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World Journal of Hepatology 2020年第10期12卷 829-840页

作者： Dana Crisan Bogdan Procopet Alexandra Epure Horia Stefanescu Alina Suciu Andreea Fodor emil mois Rares Craciun Nicolae Crisan Internal Medicine Department “Iuliu Hatieganu”University of Medicine and PharmacyCluj-Napoca 400126Romania 3rd Medical Clinic “Iuliu Hatieganu”University of Medicine and PharmacyCluj-Napoca 400126Romania Hepatology Unit “Prof.Dr.Octavian Fodor”Regional Institute of Gastroenterology and HepatologyCluj-Napoca 400162Romania Surgery Department “Prof.Dr.Octavian Fodor”Regional Institute of Gastroenterology and HepatologyCluj-Napoca 400126Romania Hepatology Unit “Prof.Dr.Octavian Fodor”Regional Institute of Gastroenterology and HepatologyCluj-Napoca 400126Romania

BACKGROUND Malnutrition is frequently encountered in patients with cirrhosis and appears to significantly impact their *** evaluating the burden of malnutrition in cirrhosis is gathering momentum,as suggested by multiple recently published reports,there is still a persistent scarcity of solid data in the field,especially with regards to the role of nutritional *** To assess the prevalence of malnutrition in patients with advanced cirrhosis and to evaluate its impact on *** One hundred and one consecutive patients with advanced cirrhosis were screened for malnutrition using the Subjective Global Assessment(SGA)criteria and the mid-arm circumference(MAC).Malnutrition was defined as SGA class B and C and MAC<10th *** patients were interviewed regarding their food intake using an adapted ***,total energy intake was calculated and further subdivided in main *** data were then compared to the available recommendations at the time of analysis to assess *** 54/79 patients(68.4%)in the decompensated group had malnutrition,while only 3/22 patients(13.6%)were malnourished in the compensated *** a median follow-up time of 27 mo(0-53),the overall mortality was 70%.Survival was significantly lower among patients with *** mortality rates were 50%at 1 year and 63%at 2 years for the patients with malnutrition,compared to 21%at 1 year and 30%at 2 years for patients without malnutrition(P=0.01).On multivariate analysis,the factors independently associated with mortality were age,creatinine level and adherence to the protein intake *** mortality was lower in patients with the appropriate protein intake:8%at 1 year and 28%at 2 years in the adherent group,compared to 47%at 1 year and 56%at 2 years in the non-adherent *** The prevalence of malnutrition is high among patients with advanced cirrhosis and might be related in part to a low adherenc

关键词： Malnutrition Decompensated cirrhosis Survival Subjective global assessment Protein intake

Surgical management of hydatid cyst disease of the liver: An improvement from our previous experience?

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World Journal of Gastrointestinal Surgery 2023年第5期15卷 847-858页

作者： Florin Zaharie Dan Valean Roxana Zaharie Calin Popa emil mois Diana Schlanger Alin Fetti Claudiu Zdrehus Andra Ciocan Nadim Al-Hajjar Department of Surgery “Octavian Fodor”Regional Institute of Gastroenterology and HepatologyCluj-Napoca 400636ClujRomania Department of Gastroenterology “Octavian Fodor”Regional Institute of Gastroenterology and HepatologyCluj-Napoca 400636ClujRomania Department of Gastroenterology “Iuliu Hatieganu”University of Medicine and PharmacyCluj-Napoca 400012ClujRomania Department of Anaesthesiology “Octavian Fodor”Regional Institute of Gastroenterology and HepatologyCluj-Napoca 400636ClujRomania

BACKGROUND Hydatid liver disease remains an important issue in endemic areas,which may require immediate *** laparoscopic surgery is on the rise,the presence of certain complications may require conversion to the open *** To compare the results of laparoscopic treatment and the open approach in the context of a 12-year single institution experience,and to perform a further comparison between results from the current study and those from a previous *** Between January 2009 and December 2020,247 patients underwent surgery for hydatic disease of the liver in our *** the 247 patients,70 underwent laparoscopic treatment.A retrospective analysis between the two groups was performed,as well as a comparison between current and previous laparoscopic experience(1999-2008).RESULTS There were statistically significant differences between the laparoscopic and open approaches regarding the cyst dimension,location,and presence of cystobiliary *** were no intraoperative complications in the laparoscopic *** cutoff value for the cyst size regarding the presence of cystobiliary fistula was 6.85 cm(P=0.001).CONCLUSION Laparoscopic surgery still plays an important role in the treatment of hydatid disease of the liver,with an increase in its usage over the course of years that has shown benefits regarding the postoperative recovery with a decreased rate of intraoperative *** experienced surgeons can perform laparoscopic surgery in the most difficult conditions,there are some selection criteria that need to be maintained for higher quality results.

关键词： Follow-up Cystobilliary communication Conversion Postoperative complications Imaging

A novel dual-core fiber-optic gyroscope with independent rotation rate measurements in different cores of a dual-core optical fiber

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Optoelectronics Letters 2024年第11期20卷 671-675页

作者： emil A.Milikov Viacheslav V.Zemlyakov Pavel S.Anisimov GAO Jiexing 2012 Labs Central Research Institute Huawei Technologies Co. Ltd.

We introduce an all-fiber stationary phase shifter for a fiber-optic gyroscope(FOG) which simultaneously provides phase shifts of opposite signs in different cores of the dual-core optical fiber. We propose a new dual-core fiber-optic gyroscope(DCFOG) in which different cores of the dual-core optical fiber provide independent rotation rate measurements.

关键词： A

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Anticancer therapeutic strategies for targeting mutant p53-Y220C

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Journal of Biomedical Research 2024年第3期38卷 222-232页

作者： Vitaly Chasov Damir Davletshin Elvina Gilyazova Regina Mirgayazova Anna Kudriaeva Raniya Khadiullina Youyong Yuan emil Bulatov Institute of Fundamental Medicine and Biology Kazan Federal UniversityKazan 420008Russia Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of SciencesMoscow 117997Russia Institute of Life Sciences School of MedicineSouth China University of TechnologyGuangzhouGuangdong 510006China

The tumor suppressor p53 is a transcription factor with a powerful antitumor activity that is controlled by its negative regulator murine double minute 2(MDM2,also termed HDM2 in humans)through a feedback *** the same time,TP53 is the most frequently mutated gene in human *** p53 proteins lose wild-type p53 tumor suppression functions but acquire new oncogenic properties,among which are deregulating cell proliferation,increasing chemoresistance,disrupting tissue architecture,and promoting migration,invasion and metastasis as well as several other pro-oncogenic *** oncogenic p53 mutation Y220C creates an extended surface crevice in the DNA-binding domain destabilizing p53 and causing its denaturation and *** cavity accommodates stabilizing small molecules that have therapeutic *** development of suitable small-molecule stabilizers is one of the therapeutic strategies for reactivating the Y220C mutant *** this review,we summarize approaches that target p53-Y220C,including reactivating this mutation with small molecules that bind Y220C to the hydrophobic pocket and developing immunotherapies as the goal for the near future,which target tumor cells that express the p53-Y220C neoantigen.

关键词： p53 Y220C mutation small molecule DNA-binding domain immunotherapy T cell receptor mimic antibody

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声波超材料中D类拓扑的观测

Science Bulletin 2024年第7期69卷 893-900页

作者：吴世巧程文婷刘啸宇吴柄权 emil Prodan Camelia Prodan 蒋建华 School of Physical Science and Technology&Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow UniversitySuzhou 215006China School of Physics and Optoelectronic Engineering Foshan UniversityFoshan 528000China Guangdong-Hong Kong-Macao Joint Laboratory for Intelligent Micro-Nano Optoelectronic Technology Foshan UniversityFoshan 528000China Department of Physics University of MichiganAnn Arbor MI 48109USA Department of Physics Yeshiva UniversityNew York NY 10033USA Department of Physics and Engineering Physics Fordham UniversityNew York NY 10023USA Suzhou Institute for Advanced Research University of Science and Technology of ChinaSuzhou 215123China

Topological materials and metamaterials opened new paradigms to create and manipulate phases of matter with unconventional *** D-class phases(TDPs)are archetypes of the ten-fold classification of topological phases with particle-hole *** two dimensions,TDPs support propagating topological edge modes that simulate the elusive Majorana elementary ***,a piercing ofπ-flux Dirac-solenoids in TDPs stabilizes localized Majorana excitations that can be braided for the purpose of topological quantum *** two-dimensional(2D)TDPs have been a focus in the research frontier,but their experimental realizations are still under ***,with a novel design scheme,we realize 2D TDPs in an acoustic crystal by synthesizing both the particle-hole and fermion-like time reversal symmetries for a wide range of *** design scheme leverages an enriched unit cell structure with real-valued couplings that emulate the targeted Hamiltonian of TDPs with complex hoppings:A technique that could unlock the realization of all topological classes with passive *** our experiments,we realize a pair of TDPs with opposite Chern numbers in two independent sectors that are connected by an intrinsic fermion-like timereversal symmetry built in the *** measure the acoustic Majorana-like helical edge modes and visualize their robust topological transport,thus revealing the unprecedented D and DIII class topologies with direct *** study opens up a new pathway for the experimental realization of two fundamental classes of topological phases and may offer new insights in fundamental physics,materials science,and phononic information processing.

关键词： D-class topology Chiral symmetry Time-reversal symmetry Particle-hole symmetry Gapless edge states

Assessment of Contamination Degree of Oil Residues on a Former Agricultural Site

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Journal of Agricultural Science and Technology(A) 2024年第2期14卷 67-82页

作者： Marinela Florica Bodog emil Catalin Schiopu Ghita Cristian Crainic Andra Nicoleta Lazar Department of Forestry and Forest Engineering University of OradeaBihor 418013Romania Department of Energy Environment and AgritourismFaculty of Engineering“Constantin Brancuși”UniversityTârgu Jiu 210185GorjRomania Department of Agriculture-Horticulture University of OradeaBihor 418013Romania

In this study,our goal is to identify the land surface that has been polluted/degraded by petroleum products or other identified causes through laboratory analysis,to assess the depth of current contamination and to identify the specific causes of *** level of contamination will be assessed by analyzing a total of 90 soil samples,both within the first 30 cm depth and within the 30-60 cm *** potential impact of the petroleum activities and their effects on the environment and agricultural development in the area will be evaluated by studying the distribution of the chemical elements analyzed,particularly total petroleum hydrocarbons(TPH).In addition,a thematic map was created using MapSys 10.0 software based on their distribution,indicating the polluted areas using color codes and *** analysis and mapping revealed that 7,473 square meters of the site were severely contaminated at 30 cm,representing approximately 25% of the site.

关键词： Degradation oil pollution residues soil surface thematic map

Gauge Inverse Monoids

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Algebra Colloquium 2020年第2期27卷 181-192页

作者： emil Daniel Schwab Department of Mathematical Sciences The University of Texas at El Paso El PasoTexas 79968USA

The paper introduces a class of inverse(sub)monoids which contains Jones-Lawson’s gauge inverse(sub)*** aim is to give examples and the basic properties of these ***-Lawson’s gauge inverse monoid,as an inverse submonoid of the polycyclic monoid,is the prototype in our development *** generalization leads also to Mea-kin-Sapir type results involving bijections between special congruences and special wide inverse submonoids.

关键词： inverse semigroup gauge inverse monoid polycyclic monoid

Region of Interest Imaging for a General Trajectory with the Rebinned BPF Algorithm

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Tsinghua Science and Technology 2010年第1期15卷 68-73页

作者： SIDKY emil Y Department of Radiology University of Chicago5841 S.Maryland AvenueChicagoIL 60637USA

The back-projection-filtration （BPF） algorithm has been applied to image reconstruction for cone-beam configurations with general source trajectories. The BPF algorithm can reconstruct 3-D region- of-interest （ROI） images from data containing truncations. However, like many other existing algorithms for cone-beam configurations, the BPF algorithm involves a back-projection with a spatially varying weighting factor, which can result in the non-uniform noise levels in reconstructed images and increased computation time. In this work, we propose a BPF algorithm to eliminate the spatially varying weighting factor by using a rebinned geometry for a general scanning trajectory. This proposed BPF algorithm has an improved noise property, while retaining the advantages of the original BPF algorithm such as minimum data requirement.

关键词： computed tomography region of interest general trajectory rebinned backprojection-filtration

Influence of Legislation in Toxicology

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Biomedical and Environmental Sciences 1989年第1期2卷 30-35页

作者： emil POULSEN Chief Advisor in Toxicology Ministry of Health 19 Moerkhoej Bygade DK-2860 Soeborg Denmark

The influence of toxicology on legislation is quite clear in countries where chemicals are regulated by the authorities. There is normally a toxicological evaluation—in addition to other considerations—behind sales and use permissions and the levels that are accepted in food, air, water, etc. How does legislation affect toxicology? If there is no legislation, then clinical and forensic toxicology will be the most used toxicological disciplines (accidents and other cases of poisoning). The more sophisticated and restrictive the legislation becomes, the more toxicology is used not only to permit the use of chemicals but also to ban them. In addition, legislation for the protection of experimental animals has a profound influence in toxicology and accelerates the use of in vitro and other alternative methods. This paper discusses whether countries in the 'developed' world are overdoing it, thereby maybe hampering the essential use of chemicals in the developing countries. 1989 Academic Press, Inc.

关键词： chemicals permit disciplines restrictive authorities poisoning sophisticated forensic worry maybe