检索结果-南通市图书馆

Systemic therapy without radiation may be appropriate as neoadjuvant therapy for localized pancreas cancer

Hepatobiliary Surgery and Nutrition 2020年第3期9卷 296-303页

作者： Scott Kizy Ariella M.Altman Keith M.Wirth Schelomo Marmor Jane Y.C.Hui Todd M.Tuttle emil lou Khalid Amin Jason W.Denbo Eric H.Jensen Division of Surgical Oncology Department of SurgeryUniversity of MinnesotaMinneapolisMNUSA Division of Hematology and Oncology Department of Internal MedicineUniversity of MinnesotaMinneapolisMNUSA Department of Laboratory Medicine and Pathology University of MinnesotaMinneapolisMNUSA

Background:The utility of neoadjuvant treatment for resectable pancreas cancer is yet to be determined,but has commonly included *** evaluated outcomes in patients with radiographically resectable pancreatic adenocarcinoma treated with neoadjuvant chemotherapy without ***:A retrospective review of patients in our institutional pancreatic cancer registry was performed,which identified 36 patients who received neoadjuvant chemotherapy alone for resectable pancreatic adenocarcinoma between 2012 and ***:Median age at diagnosis was 66.3 *** regimens included gemcitabine(n=17),gemcitabine/nab-paclitaxel(n=8),or 5-FU/leucovorin/irinotecan/oxaliplatin(FOLFIRINOX)(n=11).Surgical resection was performed in 69%of patients(n=25),with an R0 resection rate of 92%(n=23 patients).During chemotherapy,distant disease became apparent in 19%of patients(n=7),while no patients had evidence of local *** rates were similar between chemotherapy regimens(single agent=59%,multiple agent=79%).Median overall survival for all patients who received neoadjuvant chemotherapy was 30.3 and 34.4 months for those who underwent surgical *** was no difference in median survival for patients treated with gemcitabine(31.3 months)or multi-agent chemotherapy(29.7 months).Conclusions:A short course of neoadjuvant chemotherapy without chemoradiation may improve patient selection prior to surgical resection for pancreas ***,local disease progression did not limit surgical resection in this small series.

关键词： Pancreatic adenocarcinoma chemotherapy survival neoadjuvant chemotherapy resection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：