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Optoelectronics Letters 2024年第11期 671-675页

作者： emil a.milikov Viacheslav V.Zemlyakov Pavel S.Anisimov GAO Jiexing 2012 Labs Central Research Institute Huawei Technologies Co. Ltd.

We introduce an all-fiber stationary phase shifter for a fiber-optic gyroscope(FOG) which simultaneously provides phase shifts of opposite signs in different cores of the dual-core optical fiber. We propose a new dual-core fiber-optic gyroscope(DCFOG) in which different cores of the dual-core optical fiber provide independent rotation rate measurements.

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Anticancer therapeutic strategies for targeting mutant p53-Y220C

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Journal of Biomedical Research 2024年第3期38卷 222-232页

作者： Vitaly Chasov Damir Davletshin Elvina Gilyazova Regina Mirgayazova Anna Kudriaeva Raniya Khadiullina Youyong Yuan emil Bulatov Institute of Fundamental Medicine and Biology Kazan Federal UniversityKazan 420008Russia Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of SciencesMoscow 117997Russia Institute of Life Sciences School of MedicineSouth China University of TechnologyGuangzhouGuangdong 510006China

The tumor suppressor p53 is a transcription factor with a powerful antitumor activity that is controlled by its negative regulator murine double minute 2(MDM2,also termed HDM2 in humans)through a feedback *** the same time,TP53 is the most frequently mutated gene in human *** p53 proteins lose wild-type p53 tumor suppression functions but acquire new oncogenic properties,among which are deregulating cell proliferation,increasing chemoresistance,disrupting tissue architecture,and promoting migration,invasion and metastasis as well as several other pro-oncogenic *** oncogenic p53 mutation Y220C creates an extended surface crevice in the DNA-binding domain destabilizing p53 and causing its denaturation and *** cavity accommodates stabilizing small molecules that have therapeutic *** development of suitable small-molecule stabilizers is one of the therapeutic strategies for reactivating the Y220C mutant *** this review,we summarize approaches that target p53-Y220C,including reactivating this mutation with small molecules that bind Y220C to the hydrophobic pocket and developing immunotherapies as the goal for the near future,which target tumor cells that express the p53-Y220C neoantigen.

关键词： p53 Y220C mutation small molecule DNA-binding domain immunotherapy T cell receptor mimic antibody

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声波超材料中D类拓扑的观测

Science Bulletin 2024年第7期69卷 893-900页

作者：吴世巧程文婷刘啸宇吴柄权 emil Prodan Camelia Prodan 蒋建华 School of Physical Science and Technology&Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow UniversitySuzhou 215006China School of Physics and Optoelectronic Engineering Foshan UniversityFoshan 528000China Guangdong-Hong Kong-Macao Joint Laboratory for Intelligent Micro-Nano Optoelectronic Technology Foshan UniversityFoshan 528000China Department of Physics University of MichiganAnn Arbor MI 48109USA Department of Physics Yeshiva UniversityNew York NY 10033USA Department of Physics and Engineering Physics Fordham UniversityNew York NY 10023USA Suzhou Institute for Advanced Research University of Science and Technology of ChinaSuzhou 215123China

Topological materials and metamaterials opened new paradigms to create and manipulate phases of matter with unconventional *** D-class phases(TDPs)are archetypes of the ten-fold classification of topological phases with particle-hole *** two dimensions,TDPs support propagating topological edge modes that simulate the elusive Majorana elementary ***,a piercing ofπ-flux Dirac-solenoids in TDPs stabilizes localized Majorana excitations that can be braided for the purpose of topological quantum *** two-dimensional(2D)TDPs have been a focus in the research frontier,but their experimental realizations are still under ***,with a novel design scheme,we realize 2D TDPs in an acoustic crystal by synthesizing both the particle-hole and fermion-like time reversal symmetries for a wide range of *** design scheme leverages an enriched unit cell structure with real-valued couplings that emulate the targeted Hamiltonian of TDPs with complex hoppings:A technique that could unlock the realization of all topological classes with passive *** our experiments,we realize a pair of TDPs with opposite Chern numbers in two independent sectors that are connected by an intrinsic fermion-like timereversal symmetry built in the *** measure the acoustic Majorana-like helical edge modes and visualize their robust topological transport,thus revealing the unprecedented D and DIII class topologies with direct *** study opens up a new pathway for the experimental realization of two fundamental classes of topological phases and may offer new insights in fundamental physics,materials science,and phononic information processing.

关键词： D-class topology Chiral symmetry Time-reversal symmetry Particle-hole symmetry Gapless edge states

Assessment of Contamination Degree of Oil Residues on a Former Agricultural Site

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Journal of Agricultural Science and Technology(A) 2024年第2期14卷 67-82页

作者： Marinela Florica Bodog emil Catalin Schiopu Ghita Cristian Crainic Andra Nicoleta Lazar Department of Forestry and Forest Engineering University of OradeaBihor 418013Romania Department of Energy Environment and AgritourismFaculty of Engineering“Constantin Brancuși”UniversityTârgu Jiu 210185GorjRomania Department of Agriculture-Horticulture University of OradeaBihor 418013Romania

In this study,our goal is to identify the land surface that has been polluted/degraded by petroleum products or other identified causes through laboratory analysis,to assess the depth of current contamination and to identify the specific causes of *** level of contamination will be assessed by analyzing a total of 90 soil samples,both within the first 30 cm depth and within the 30-60 cm *** potential impact of the petroleum activities and their effects on the environment and agricultural development in the area will be evaluated by studying the distribution of the chemical elements analyzed,particularly total petroleum hydrocarbons(TPH).In addition,a thematic map was created using MapSys 10.0 software based on their distribution,indicating the polluted areas using color codes and *** analysis and mapping revealed that 7,473 square meters of the site were severely contaminated at 30 cm,representing approximately 25% of the site.

关键词： Degradation oil pollution residues soil surface thematic map

Gauge Inverse Monoids

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Algebra Colloquium 2020年第2期27卷 181-192页

作者： emil Daniel Schwab Department of Mathematical Sciences The University of Texas at El Paso El PasoTexas 79968USA

The paper introduces a class of inverse(sub)monoids which contains Jones-Lawson’s gauge inverse(sub)*** aim is to give examples and the basic properties of these ***-Lawson’s gauge inverse monoid,as an inverse submonoid of the polycyclic monoid,is the prototype in our development *** generalization leads also to Mea-kin-Sapir type results involving bijections between special congruences and special wide inverse submonoids.

关键词： inverse semigroup gauge inverse monoid polycyclic monoid

Region of Interest Imaging for a General Trajectory with the Rebinned BPF Algorithm

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Tsinghua Science and Technology 2010年第1期15卷 68-73页

作者： SIDKY emil Y Department of Radiology University of Chicago5841 S.Maryland AvenueChicagoIL 60637USA

The back-projection-filtration （BPF） algorithm has been applied to image reconstruction for cone-beam configurations with general source trajectories. The BPF algorithm can reconstruct 3-D region- of-interest （ROI） images from data containing truncations. However, like many other existing algorithms for cone-beam configurations, the BPF algorithm involves a back-projection with a spatially varying weighting factor, which can result in the non-uniform noise levels in reconstructed images and increased computation time. In this work, we propose a BPF algorithm to eliminate the spatially varying weighting factor by using a rebinned geometry for a general scanning trajectory. This proposed BPF algorithm has an improved noise property, while retaining the advantages of the original BPF algorithm such as minimum data requirement.

关键词： computed tomography region of interest general trajectory rebinned backprojection-filtration

Myocardial infarction patients' learning needs: Perceptions of patients, family members and nurses

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International Journal of Nursing Sciences 2019年第3期6卷 294-299页

作者： emil Huriani Faculty of Nursing Universitas Andalas Limau Manis Campuss Padang West Sumatera Indonesia

Purpose: This descriptive study aimed to identify and compare patient with myocardial infarction,their family member,and cardiac nurse perceptions on the learning needs of patients with myocardial infarction in the acute,sub-acute,and post-acute ***: A total of 288 patients with myocardial infarction,145 family members,and 40 cardiac unit nurses were enrolled in this *** were collected by survey method using the Cardiac Patient Learning Need Inventory (CPLNI).Data analysis was done using descriptive statistical analysis and analysis of ***: The results showed that the learning needs of patients with myocardial infarction were high according to the perceptions of patients,patients' family members,and *** were differences in the priority of learning that the patient need in relation to the disease and healing ***: Patients,family members,and nurses have different perceptions regarding the learning needs of patients with myocardial *** create adequate intervention to meet patient's learning needs,there should be an accurate *** results of this study support the importance of patient-centered,individualized education and attention to learning priorities.

关键词： Acute coronary syndrome Health education Learning Needs assessment

Influence of Legislation in Toxicology

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Biomedical and Environmental Sciences 1989年第1期2卷 30-35页

作者： emil POULSEN Chief Advisor in Toxicology Ministry of Health 19 Moerkhoej Bygade DK-2860 Soeborg Denmark

The influence of toxicology on legislation is quite clear in countries where chemicals are regulated by the authorities. There is normally a toxicological evaluation—in addition to other considerations—behind sales and use permissions and the levels that are accepted in food, air, water, etc. How does legislation affect toxicology? If there is no legislation, then clinical and forensic toxicology will be the most used toxicological disciplines (accidents and other cases of poisoning). The more sophisticated and restrictive the legislation becomes, the more toxicology is used not only to permit the use of chemicals but also to ban them. In addition, legislation for the protection of experimental animals has a profound influence in toxicology and accelerates the use of in vitro and other alternative methods. This paper discusses whether countries in the 'developed' world are overdoing it, thereby maybe hampering the essential use of chemicals in the developing countries. 1989 Academic Press, Inc.

关键词： chemicals permit disciplines restrictive authorities poisoning sophisticated forensic worry maybe

An analysis of silver candlesticks from a casting point of view:originals,copies,forgeries

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China Foundry 2010年第1期7卷 68-75页

作者： Jaromir Audy emil Evin Faculty of Regional Professional Studies School of Enterprise and TechnologyEdith Cowan UniversitySouth West Campus BunburyAustralia 6230 Department Technologies and Materials Faculty of Mechanical EngineeringTechnical University KosiceM-siarska 74Ko-iceSlovakia 04001

Collecting silver artefacts has traditionally been a very popular *** is addictive,therefore the number of potential collectors and investors appears to grow each ***,increases in the interest and buying potentials resulted in a number of forgeries manufactured and introduced to the open antique *** items such as early silver candlesticks dictate a very high price,for many high quality fakes show very good appearances and matching similarities with *** copies are traditionally manufactured by casting using the original items as *** details and variances in design features,position and shape of hallmarks,including the final surface quality are usual features to distinguish the fakes from the *** paper presents results of a study conducted on several silver candlesticks,including two artefacts bearing features of those produced in the mid 18th century,one original Italian candelabrum from Fascist era,and small candlesticks made in the early 20th ***,the paper presents some interesting contemporary coins-replicas of many those produced in different *** coins were offered for sale by unscrupulous dealers via auctions and *** the main results and findings from this study are discussed from a manufacturing point of view,such as fabrication technology,surface quality and hallmarks,which will help the collectors,dealers and investors to detect and avoid forgeries.

关键词： candlesticks candelabra originals copies forgeries silver manufacturing technology hallmarks

Recent behavior and possible future evolution of the glacieret in the cirque Golemiya Kazan in the Pirin Mountains under conditions of climate warming

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Journal of Mountain Science 2019年第1期16卷 16-29页

作者： Peter NOJAROV emil GACHEV Karsten GRUNEWALD National Institute of Geophysics Geodesy and Geography Bulgarian Academy of Sciences South-West University "Neofit Rilski" Leibniz Institute of Ecological Urban and Regional Development

This research reveals relationships between climate variables and inter-annual dynamics in the area of the glacieret located in the cirque Golemiya Kazan in the Pirin Mountains. The study period is 1993–2017. The correlations are identified using statistical methods. Also, a statistical model is constructed, including some climate variables as predictors. Despite the evident decrease of the glacieret's size in the period from the 1950 s onwards, the long-term trends for the last decades have been insignificant. The main climatic factors influencing the inter-annual dynamics in the area of the glacieret are air temperature, precipitation, zonal and meridional winds and relative humidity. With respect to the dynamics in the area of the glacieret, the important trends in the different climate variables are those of the warm period air temperatures and zonal(u) wind. They also determine to a great extent its future development by acting in two opposite directions – rising temperatures in the warm period will lead to a rapid decrease of its area by the end of the melting season, while the change of wind directionfrom west to east in the warm period will increase its area. The influence of the zonal wind in the warm period is explained mainly by the location of the glacieret in the cirque. Generally, the glacieret is tilted downwards from west to east. Thus, westerly winds facilitate blowing away the snow from the surface of the glacieret, assisting its melting in the warm period. Easterly winds do not have such an effect. The combination of the opposite effects of these two most important climate variables leads to the most likely scenario for the future development of the glacieret, according to which by the middle of this century it is expected to turn into a semi-permanent snow patch, which disappears after some summers, and by the end of the century to completely melt every year before the end of the melting season.

关键词： Climate warming Glacieret Pirin Mountains Statistical modeling Glacieret area Projection