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Elucidation of the relationship of BNIP3 expression to gemcitabine chemosensitivity and prognosis

World Journal of Gastroenterology 2007年第34期13卷 4593-4597页

作者： Masaharu Ishida Makoto Sunamura Toru Furukawa Masanori Akada Hiroko Fujimura emiko shibuya Shinichi Egawa Michiaki Unno Akira Horii Departments of Molecular Pathology Tohoku University School of Medicine 2-1 Seiryo-machi Aoba-ku Sendai 980-8575 Japan Department of Gastroenterological Surgery Tohoku University School of Medicine 1-1 Seiryo-machi Aoba-ku Sendai 980-8574 Japan Department of Gastroenterological Surgery Tohoku University School of Medicine 1-1 Seiryo-machi Aoba-ku Sendai 980-8574 Japan Cancer Surgery Section Hammersmith Hospital Imperial College Du Cane Road London W12 0NN United Kingdom Departments of Molecular Pathology Tohoku University School of Medicine 2-1 Seiryo-machi Aoba-ku Sendai 980-8575 Japan Department of Gastroenterological Surgery Tohoku University School of Medicine 1-1 Seiryo-machi Aoba-ku Sendai 980-8574 Japan

AIM: To evaluate the significance of BNIP3 in the pathogenesis of pancreatic cancer, we analyzed the relationship between the expression of BNIP3 and survival rate of the patients with pancreatic cancer, or chemosensitivities in pancreatic cancer cell lines, particularly for gemcitabine, the first-line anti-tumor drug for pancreatic cancer. METHODS: To compare the expression level of BNIP3 with the resistance to gemcitabine, eight pancreatic cancer cell lines were subjected to gemcitabine treatment and the quantitative real-time RT-PCR method was used to evaluate BNIP3 expression. Immunohistochemical analysis was also performed using 22 pancreatic cancer specimens to study relationship between BNIP3 expression and survival rate. RESULTS: Although no significantly positive association between BNIP3 mRNA level and gemcitabine chemosensitivity was observed, pancreatic cancer cell lines that were sensitive to gemcitabine treatment tended to show high levels of BNIP3 expression. The converse, an absence of BNIP3 expression, was not correlated with gemcitabine resistance. We further compared the BNIP3 expression profiles of resected primary pancreaticcancer specimens with the prognosis of the patients, and found a tendency of favorable prognosis and low BNIP3 expression. CONCLUSION: High levels of BNIP3 expression cannot be used as one of the predicting factors for gemcitabine chemosensitivity, and some yet to be known factors will have to fill the gap for the accurate prediction of pancreatic cancer chemosensitivity to gemcitabine. However, BNIP3 expression may have an impact on prediction of prognosis of patients with pancreatic cancer.

关键词： BNIP3 Chemosensitivity Gemcitabine Pancreatic cancer Prognosis

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