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食品安全导刊 2010年第7期 36-38页

作者： Imma Ferrer E.Michael thurman Melissa Churley Harry Prest Phil Stremple Phil Wylie Jerry Zweigenbaum 科罗多拉大学环境质谱中心安捷伦科技公司

植物雌激素是来源于植物．分子结构和雌激素相似，在体肉有雌激素样作用的一组非类固醇多酚化合物．分为异黄酮．类黄酮类、木酚素类和coumestans，主要存在于大豆．三叶草、紫花苜蓿、黄豆，豌豆等豆科植物中。与合成激素不同，天然植... 详细信息

植物雌激素是来源于植物．分子结构和雌激素相似，在体肉有雌激素样作用的一组非类固醇多酚化合物．分为异黄酮．类黄酮类、木酚素类和coumestans，主要存在于大豆．三叶草、紫花苜蓿、黄豆，豌豆等豆科植物中。与合成激素不同，天然植物雌激素没有副作用。但是随着合成激素和动物雌激素在废水中的排放．植物雌激素也被认为会干扰鱼的内分泌。

关键词：植物雌激素 GC/MS/MS 豆奶多酚化合物激素样作用分子结构类黄酮类紫花苜蓿

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Evaluation of paracetamol toxicity in the cynomolgus monkey

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中国药理学与毒理学杂志 2013年第3期 544-544页

作者： YU Hong Nigel BARRASS Sonya GALES Eva LENZ Dan WESTON Ian WILSONB Tony PARRY Helen POWELL Dale thurman QIAO Jun-wen QIN Qiu-ping REN Jin Centre for Drug Safety Evaluation and Research Shanghai Institute of Materia Medica Global Safety Assessment AstraZeneca R&D BostonMAUSA and UK

Paracetamol(acetominophen,APAP) was administered orally in a rising dose protocol to 2 male and 2 female Cynomolgus monkeys to determine the Maximum Tolerated dose(MTD) for subsequent toxicology *** the subsequent repeat dose study involving 6 monkeys,no dose-limiting toxicity was seen at up to 900 mg·kg-1.d-1 APAP for 14 *** analysis showed that plasma exposure rose,albeit less than proportionally,with increasing *** were some fluctuations in clinical chemistry and haematology parameters,but these were not dose-related,and there were no compound-related findings observed *** monkeys at 900 mg·kg-1.d-1 had a 5 cm,gas filled segment in their large intestine that was considered *** profiling of the urine showed parent and glucuronidated APAP,but the cysteinyl conjugate which would be anticipated if the monkey has similar metabolism to rats and man was notably *** opens the possibility that metabolism in the cynomolgus monkey differs from that in the other species,and shows that the cynomolgus monkey is a poor model for investigating paracetamol-mediated toxicity in humans.

关键词： acetominophen toxicity

Evaluation of imipenem toxicity in cynomolgus macaques including assessment of biomarkers of renal damage

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Evaluation of imipenem toxicity in cynomolgus macaques inclu...

Evaluation of imipenem toxicity in cynomolgus macaques including assessment of biomarkers of renal damage

作者： YU Hong Sonya GALES ZHENG Wei-jun QIN Qiu-ping Dale thurman HU Li-ping QIAO Jun-wen REN Jin CHEN Ya-fei Russell BIALECKI Lew KINTER Nigel BARRASS Centre for Drug Safety Evaluation and Research Shanghai Institute of Materia Medica Global Safety Assessment AstraZeneca R&D Alderley Park

OBJECTIVE To assess the nephrotoxicity of imipenem and to correlate the pathogenesis of lesions in the kidney with changes in urinary biomarkers of kidney *** Study #1,11 monkeys(2 -3/sex/group) were given vehicle or imipenem(180 mg·kg~(-1),iv infusion once daily for 7 d) and urine was collected on days xxxxx for biomarker *** Study #2,24 monkeys(3/sex/group) were given of vehicle or imipenem(45,90 or 180 mg·kg~(-1),iv infusion once daily for 7 d).The following endpoints were assessed in both studies:clinical observations,body weight, food consumption,haematology,coagulation,blood chemistry,urine analysis,imipenem concentration/toxicokinetics (TK) and gross and microscopic *** Study #1:Imipenem causes minor body weight loss,increased urea and creatinine,and decreased phosphate in *** total protein and bilirubin were observed in the urine. These effects were progressive and most pronounced at days 7 and *** and relative kidney weights were increased in both *** histopathological findings were present in kidneys of the dosed monkeys,consisting of minimal to moderate tubular necrosis/degeneration/*** biomarkers(α-1 andβ-2 microglobulin,clusterin, Tamm-Horsfall protein and vascular endothelial growth factor) increased progressively and significantly from day 2 onward and preceded notable changes in urinalysis or plasma chemistry on day 7 or 8,*** #2:There were similar findings to Study #1 in the 180 mg·kg~(-1) imipenem treatment *** total bilirubin and decreased of phosphate in plasma and an increase of urinary urobilinogen/ketones were observed in a dose related *** to imipenem〔C_(max) and AUC_(0-3h)〕increased in proportion from 45 -90 mg·kg~(-1) but more than in proportion from 90-180 mg·kg~(-1). CONCLUSION The no observed adverse effect level(NOAEL) for the imipenem induced kidney injury was identified as 90 mg·kg~(-1).Early increases of five ur

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Evaluation of imipenem toxicity in cynomolgus macaques inclu...

Evaluation of cisplatin-induced toxicity in cynomolgus macaques including assessment of potential biomarkers of renal toxicity

2013年（第三届）中国药物毒理学年会暨药物非临床安全性评价研究论坛

OBJECTIVE To assess the nephrotoxicity of imipenem and to correlate the pathogenesis of lesions in the kidney with changes in urinary biomarkers of kidney *** Study #1,11 monkeys(2 -3/sex/group) were given vehicle or imipenem(180 mg·kg,iv infusion once daily for 7 d) and urine was collected on days xxxxx for biomarker *** Study #2,24 monkeys(3/sex/group) were given of vehicle or imipenem(45,90 or 180 mg·kg,iv infusion once daily for 7 d).The following endpoints were assessed in both studies:clinical observations,body weight, food consumption,haematology,coagulation,blood chemistry,urine analysis,imipenem concentration/toxicokinetics (TK) and gross and microscopic *** Study #1:Imipenem causes minor body weight loss,increased urea and creatinine,and decreased phosphate in *** total protein and bilirubin were observed in the urine. These effects were progressive and most pronounced at days 7 and *** and relative kidney weights were increased in both *** histopathological findings were present in kidneys of the dosed monkeys,consisting of minimal to moderate tubular necrosis/degeneration/*** biomarkers(α-1 andβ-2 microglobulin,clusterin, Tamm-Horsfall protein and vascular endothelial growth factor) increased progressively and significantly from day 2 onward and preceded notable changes in urinalysis or plasma chemistry on day 7 or 8,*** #2:There were similar findings to Study #1 in the 180 mg·kg imipenem treatment *** total bilirubin and decreased of phosphate in plasma and an increase of urinary urobilinogen/ketones were observed in a dose related *** to imipenem [C and AUC(0-3h))) increased in proportion from 45 -90 mg-kg but more than in proportion from 90-180 mg·kg. CONCLUSION The no observed adverse effect level(NOAEL) for the imipenem induced kidney injury was identified as 90 mg·*** increases of five urinary biomarkers of kidney toxicit

关键词： imipenem toxicity biomarkers renal damage

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中国药理学与毒理学杂志 2013年第3期 466-466页

作者： YU Hong Sonya GALES ZHENG Wei-jun QIN Qiu-ping Dale thurman QIAO Jun-wen REN Jin CHEN Ya-fei Russell BIALECKI Lew KINTER Nigel BARRASS Centre for Drug Safety Evaduation and Research Shanghai Institute of Materia Medica AstraZeneca R&D Alderley Park MacclesfieldUK Global Safety Assessment AstraZeneca R&D BostonMAUSA

OBJECTIVE Cisplatin-induced nephrotoxicity has been characterized previously in animals and *** studies were conducted in cynomolgus macaques to assess the nephrotoxicity of cisplatin and to correlate the pathogenesis of lesions in the kidneys with expression of a panel of potential urinary biomarkers of kidney *** In study #1,6 monkeys(1 /sex /group) were given a single *** of cisplatin(1.25,2.5 and 5 mg·kg-1) and were terminated for necropsy on day 7 *** Study #2,36 monkeys(3 /sex /group) were given a single iv infusion of vehicle or cisplatin(2.5 mg·kg-1) and then they were terminated for necropsy on days 2,5,10 or 21,respectively,*** following endpoints were assessed in both studies: clinical observations,body weight,food consumption,haematology,coagulation,blood chemistry,urine analysis,cisplatin concentration /toxicokinetics(TK) and gross and microscopic *** of biomarkers for drug-induced kidney injury(DIKI) was confined to Study #*** Study #1: A single intravenous administration of cisplatin induced occasional vomiting,decreased motor activity,reduced food consumption and minor body weight loss at the highest dose(5 mg·kg-1).Urea and creatinine were markedly increased,plasma electrolytes showed dose-related alterations and blood and proteins were found in the *** high dose animals had reduced urine *** weights were increased following 2.5 and 5 mg·kg-1 and there were progressive renal histopathological *** to cisplatin〔Cmax and AUC(0-24) 〕increased slightly more than in proportion to the dose of cisplatin across the dose *** #2: One male dosed at 2.5 mg·kg-1 cisplatin was prematurely terminated on day *** other animals survived to their scheduled *** evaluation demonstrated that kidney lesions progressed with *** chemistry results indicated that 7 out of 24 animals treated with cisplatin had moderately to markedly inc

关键词： cisplatin renal toxicity biomarkers

中低收入国家癫痫过早死亡:国际抗癫痫联盟死亡率专业组系统评价

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癫痫杂志 2019年第1期5卷 47-56页

作者： Levira F thurman DJ Sander JW Hauser WA Hesdorffer DC Masanja H OdermattP Logroscino G Newton CR 陆璐童馨慕洁

为了确定中低收入国家(Low-and middle-income countries,LMICs)癫痫相关的危险因素大小与过早死亡原因,专业组对来自LMICs(世界银行定义)的死亡率及癫痫相关文献报道进行系统检索,根据代表性,病例、诊断和死亡率的确证度对研究进行评估... 详细信息

为了确定中低收入国家(Low-and middle-income countries,LMICs)癫痫相关的危险因素大小与过早死亡原因,专业组对来自LMICs(世界银行定义)的死亡率及癫痫相关文献报道进行系统检索,根据代表性,病例、诊断和死亡率的确证度对研究进行评估,并提取癫痫患者中的标准化死亡比(Standardized mortality ratios,SMR)和死亡率数据。研究调查了死亡的危险因素和原因。据估计,在高质量的群体研究中,癫痫患者年死亡率为19.8/1 000(9.7/1 000～45.1/1 000),加权中位SMR为2.6(1.3～7.2)。而临床队列研究显示的死亡率为7.1/1 000(1.6/1 000～25.1/1 000),加权中位SMR在男性中为5.0,女性中为4.5。在儿童和青少年、症状性癫痫或治疗依从性低的患者中发现了相对较高的SMR。群体研究显示,LMICs癫痫患者死亡的主要原因中直接归因于癫痫的平均比例死亡比(Proportional mortality ratio,PMR)为27.3%(5.0%～73.5%)。这些直接原因包括癫痫持续状态(报道的PMR为5.0%～56.5%)和癫痫猝死(Sudden unexpected death in epilepsy,SUDEP)(报道的PMR为1.0%～18.9%),与癫痫相关的间接死亡原因包括溺水、头部创伤和烧伤。LMICs癫痫患者的早亡率明显高于高收入国家。在LMICs,死亡率过高可能与患者难以获得医疗资源有关,例如发生癫痫持续状态时,以及包括溺水、头外伤和烧伤在内的可预防死因。这类过高的早亡率可以通过进行关于死亡风险的教育,提高治疗,包括抗癫痫药物治疗的可得性而大大降低。

关键词：痫性发作强直死亡病死发展中国家资源贫乏国家早亡

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SARS-COV-2急性感染后小气道病变的定量胸部CT评价

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国际医学放射学杂志 2022年第5期 604-604页

作者： J.L.Cho R.Villacreses P.Nagpal J.F.Guo A.A.Pezzulo A.L.thurman 李琪

摘要 SARS-COV-2感染对肺结构和功能的长期影响仍不完全明确。目的检测SARS-COV-2感染是否会导致症状持续的小气道疾病。资料与方法在一所大学教学医院进行

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抹布

考试与评价（英语中考专刊） 2018年第10期 1-1页

作者：朱迪斯·思厄曼

夜风将一片云撕成抹布，然后，把十月的月亮擦呀，擦直到擦得像铜把手一样发光。

关键词：中学英语课外阅读阅读材料

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镰刀样细胞特征孕妇与菌尿

世界核心医学期刊文摘（妇产科学分册） 2006年第9期2卷 23-23页

作者： thurman A. R. Steed L. L. Hulsey T. Soper D. E. 柳蕴(译) 韩瑾(校) Departments of Obstetrics and Gynecology 不详

Objective: The purpose of this study was to compare the following outcome variables in pregnant patients with sickle cell trait and matched pregnant control patients: asymptomatic bacteriuria,acute cystitis, urinary pathogens that were present, and pyelonephritis. Study design: This was a retrospective cohort study that was conducted at a university clinic. Pregnant patients with sickle cell trait (n = 455) were matched with control patients (n = 448) for race, age, gestational age at entry into prenatal care, and number of prenatal visits. Results: Women with sickle cell trait received urine testing significantly more often. There was no difference in the incidence of positive urine cultures, urinary pathogens, or asymptomatic bacteriuria among the comparison groups. Sickle cell trait carriers had significantly higher rates of pyelonephritis, but many affected patients had risk factors, such as previous pyelonephritis or noncompliance with therapy. Conclusion: Sickle cell trait carriers were no more susceptible to acute cystitis and asymptomatic bacteriuria than were the control patients. On the basis of these data, we outline recommendations for urinary screening and pyelonephritis prevention in pregnant patients with sickle celltrait.

关键词：无症状菌尿正常孕妇细胞特征回顾性队列研究急性膀胱炎肾盂肾炎尿培养阳性显著性差异

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