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Safety and effectiveness of the SUPRACOR presbyopic LASIK algorithm on hyperopic patients

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Eye and Vision 2016年第1期3卷 253-262页

作者： Robert Edward T.Ang emerson m.cruz Alex U.Pisig maria Luisa Patricia C.Solis Rosalie mae m.Reyes Gerhard Youssefi Asian Eye Institute 8th Floor PHINMA PlazaRockwell CenterMakati City 1200Philippines Department of Ophthalmology Cardinal Santos Medical Center10 Wilson St.Greenhills WestSan Juan CityPhilippines TECHNOLAS PerfectVision GmbH A Bausch&Lomb CompanyMesserschmittstrasse 1-3Munich 80992Germany

Background:To evaluate the safety and effectiveness of the Supracor excimer laser algorithm to treat hyperopic presbyopic patients using laser in-situ keratomileusis(LASIK).methods:This is a retrospective case review of patients diagnosed with hyperopia(Sphere≥+0.0 D and presbyopia reading add≥1.0 D)who underwent Supracor excimer laser treatment on at least one eye for presbyopia correction from year may 2011 to may *** vision was further analyzed after patients were subdivided into three groups:Group A(n=22 eyes,11 patients)had Supracor on both eyes;Group B(n=18 eyes,18 patients)had Supracor in one eye and hyperopic LASIK on fellow eye;and Group C(n=29 eyes,29 patients)had Supracor in one eye and no treatment on the fellow ***:This study evaluated 58 patients wherein 69 eyes underwent Supracor presbyopic ***,mean manifest refraction spherical equivalent(mRSE)of all eyes that underwent Supracor was+1.37±0.72 D with mean uncorrected distance visual acuity(UDVA),uncorrected intermediate visual acuity(UIVA),and uncorrected near visual acuity(UNVA)of 20/50(0.35 logmAR),20/50(0.35 logmAR),and J9(0.61 logmAR),*** 6 months postoperatively,mean mRSE was−0.43±0.59 D with mean UDVA,UIVA and UNVA of 20/25(0.13 logmAR),20/20(0.01 logmAR),and J1(0.05 logmAR),*** of two lines of best-corrected distance visual acuity(BCDVA)was seen in 6%of *** corneal steepening of 1.0 D at the 3 mm zone and 0.7 D in the 5 mm zone was *** vertical coma increased from−0.02 to+0.10 while mean 4th order spherical aberration became more negative from 0.20 to−*** binocular UDVA,UIVA,and UNVA are 20/20,20/20 and J1,respectively,in all treatment groups at the 6 month postoperative *** significant differences in binocular UDVA(p≥0.36),UIVA(p≥0.19)and UNVA(p≥0.56)among groups were ***:Supracor excimer laser algorithm is safe and effective for the treatment of presbyopia in *** and bil

关键词： Presbyopia LASIK Supracor Hyperopia

morphological traits explain the individual position within resource-consumer networks of a Neotropical marsupial

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Current Zoology 2024年第4期70卷 453-464页

作者： Nicholas F.de Camargo Hernani F.m.de Oliveira Juliana F.Ribeiro Amabilio J.A.de Camargo emerson m.Vieira Laboratorio de Ecologia de Vertebrados Departamento de EcologiaInstituto de Ciencias BiologicasUniversidade de BrasiliaCP 04457BrasiliaDF70910-900Brazil Departamento de Zoologia Setor de Ciencias BiologicasUniversidade Federal do ParanaAvenida Coronel Francisco Heraclito dos Santos100CuritibaPR81531980Brazil Embrapa Cerrados Rodovia BR020km 18CP 08223PlanaltinaDE73310-970Brazil

Knowledge regarding the influence of individual traits on interaction patterns in nature can help understand the topological role of individuals within a network of intrapopulation *** tested hypotheses on the relationships between individuals'positions within networks(specialization and centrality)of 4 populations of the mouse opossum Gracilinanus agilis and their traits(i.e.,body length,body condition,tail length relative to body length,sex,reproductive condition,and botfly parasitism)and also seasonal effects in the Brazilian *** with lower body length,better body condition,and relatively shorter tail were more specialized(i.e.,less connected within the network).Individuals were also more specialized and less connected during the warm-wet *** relationship between individuals'position in the network and body traits,however,was independent of *** propose that specialization may arise not only as a result of preferred feed-ing strategies by more capable individuals(i.e.,those with better body condition and potentially prone to defend and access high-quality food resources)but alsobecause of morphological ***/younger individuals(consequently with less experience in foraging)and short-tailed individuals(less skilled to explore the vertical strata of the vegetation)would feed only on a subset of the available food resources and consequently become more ***,individuals are more specialized during the warm-wet season because of high competition(population-dense period)and higher ecological opportunities(resource-rich period).Therefore,our study reveals the relevance of individual traits inshaping interactionpatternsandspecialization inpopulations.

关键词： bodytraits centrality Cerrado Gracilinanus agilis seasonality specialization.

Star power: harnessing the reactive astrocyte response to promote remyelination in multiple sclerosis

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Neural Regeneration Research 2024年第3期19卷 578-582页

作者： markley Silva Oliveira Junior Laura Reiche emerson Daniele Ines Kortebi maryam Faiz Patrick Küry Department of Neurology Neuroregeneration laboratoryMedical FacultyHeinrich-Heine-UniversityDüsseldorfGermany Institute of medical Science University of TorontoTorontoCanada Division of Anatomy Department of SurgeryUniversity of TorontoTorontoCanada

Astrocytes are indispensable for central nervous system development and *** response to injury and disease,astrocytes are integral to the immunological-and the,albeit limited,repair *** this review,we will examine some of the functions reactive astrocytes play in the context of multiple sclerosis and related animal *** will consider the heterogeneity or plasticity of astrocytes and the mechanisms by which they promote or mitigate ***,we will discuss a set of biomedical strategies that can stimulate astrocytes in their promyelinating response.

关键词： astrocytes demyelination drug-based therapies myelin repair oligodendrocyte precursor cells reactive astrogliosis

Serum ferritin and the risk of early-onset colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3496-3506页

作者： Adam L Urback Kylee martens Hannah Stowe mcmurry emerson Y Chen Caitlin Citti Anil Sharma Adel Kardosh Joseph J Shatzel Division of Internal medicine Oregon Health&Science UniversityPortlandOR 97239United States Division of Hematology and medical Oncology Knight Cancer InstituteOregon Health&Science UniversityPortlandOR 97239United States Division of Gastroenterology&Hepatology Oregon Health&Science UniversityPortlandOR 97239United States

BACKGROUND The incidence of early-onset colorectal cancer(EO-CRC)is rising in the United States,and is often diagnosed at advanced *** serum ferritin is often incidentally discovered in young adults,however,the indication for endoscopy in EO-CRC is *** To compare serum ferritin between patients with EO-CRC and healthy controls(HCs),and examine the association of serum ferritin in EO-CRC with patient-and disease-specific *** A retrospective study of patientsm 1/2013-12/*** were included if serum ferritin was measured within 2 years prior to 1 year following CRC histologic *** supplement the analysis,a cohort of HCs meeting similar inclusion and exclusion criteria were identified for comparison.A sensitivity analysis including only patients with serum ferritin obtained at or before diagnosis was separately performed to minimize risk of *** Among 85 patients identified with EO-CRC(48 females),the median serum ferritin level was 26 ng/mL(rangemL).Compared to HCs(n=80211),there were a higher proportion of individuals with EO-CRC with serum ferritinmL(female 65%,male 40%)versus HCs(female 32.1%,male 7.2%)age 29-39 years(P=0.002 and Pm ferritin compared to less advanced stages(Pm ferritin obtained before or at the time of diagnosis was lower than levels obtained after *** findings were confirmed in the sensitivity *** Severe iron deficiency may indicate an increased risk of EO-CRC,particularly at earlier *** studies defining the optimal serum ferritin threshold and routine incorporation of serum ferritin in screening algorithms is essential to develop more effective screening strategies for EO-CRC.

关键词： Early-onset Young-onset Colorectal cancer Age Ferritin Iron deficiency

Biodiversity Assessment of Avifauna in the Forest Reservation of Aurora State College of Technology (ASCOT), Philippines

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Open Journal of Ecology 2024年第4期14卷 292-308页

作者： Afed S. Daiwey Heherson B. Ong emerson V. Barcellano Edmundo C. Gumpal michelle Ann m. Calubaquib Rafael J. Padre School of Forestry and Environmental Sciences Aurora State College of Technology Baler Philippines College of Forestry and Environmental Science Isabela State University Cabagan Philippines College of Agriculture Isabela State University Cabagan Philippines College of Engineering Isabela State University Echague Philippines

The research study was conducted to assess and quantify the current status of avifauna biodiversity assets of Aurora State College of Technology’s Forest Reservation in Baler, Aurora, Philippines. Assessment of avifaunal diversity was undertaken by traversing the four established circular plots having a radius of 125 meters or 250 meters diameters each as permanent monitoring stations. Study revealed a total number of 151 Individual species, classified into 23 genera and 21 families. Eighteen of these species are endemic while the remaining five were fully migrated birds. All birds observed were classified as Least Concern (LC) species according to the International Union for Conservation of Nature’s Red List of Threatened Species and the updated list of the Birds of the World online. Its abundance, richness and diversity index were calculated using Shannon Diversity Index (H') while Pielou’s evenness (J') for distribution of species. Forest reservation of ASCOT has more even (0.756 J') and moderate diversity (2.812 H') observation on avifauna in general. However, this avian population evaluation was threatened into a verge of extinction due to natural and anthropological threats that causes forest deforestation. Such deforestation of habitat causes dwindling of wildlife territory leading to the scarcity of bird’s population. Thus, the assessment was conducted to aid ASCOT administration find significant plans to ensure sustainable conservation and protection of the remaining avifauna species in the reservation area.

关键词： Biodiversity Avifauna Abundance Species Richness Species Diversity

Temporal niche overlap among insectivorous small mammals

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Integrative Zoology 2011年第4期6卷 375-386页

作者： emerson m.VIEIRA Gabriela PAISE Laboratory of Ecology of mammals ZoologyUniversity of Vale do Rio dos SinosSão LeopoldoBrazil Graduate Program of Ecology University of CampinasCampinasBrazil

Being active in the same environment at different times exposes animals to the effects of very different environmental factors,both biotic and *** the present study,we used live traps equipped with timing devices to evaluate the potential role of biotic factors(competition and food abundance)on overall overlap in the temporal niche axis of 4 insectivorous small mammals in high-elevation grassland fields(‘campos de altitude’)of southern *** on resources availability(invertebrates),data on animal captures were pooled in 2 seasons:‘scarcity’(June 2001−September 2001)and‘abundance’(November 2001-may 2002)*** tested for non-random structure in temporal niche overlap among the species in each *** species were the rodents Oxymycterus nasutus(Waterhouse,1837),Deltamys sp.,Akodon azarae(Fischer,1829),and the marsupial monodelphis brevicaudis Olfers,*** studied community was mainly diurnal with crepuscular *** using the Pianka index of niche overlap indicated that the empirical assemblage-wide overlap was not significantly different from randomly generated patterns in the abundance season but significantly greater than expected by chance alone in the scarcity *** the species showed an increase in temporal niche breadth during the abundance season,which appears to be related to longer daylength and high nocturnal *** on both temporal niche overlap and temporal niche breadth were the opposite to those that we were expecting in the case of diel activity patterns determined by competition for dietary ***,we conclude that competition did not seem to be preponderant for determining patterns of temporal niche overlap by the studied community.

关键词： activity patterns Brazil chronoecology community structure competition niche partitioning

Comparison of clinical outcomes between femtosecond laser-assisted versus conventional phacoemulsification

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Eye and Vision 2018年第1期5卷 78-90页

作者： Robert Edward Ty Ang michelle marie Salcedo Quinto emerson marquez cruz mark Christian Reyes Rivera Gladness Henna Austria martinez Asian Eye Institute Rockwell CenterMakati City 1200Philippines Cardinal Santos medical Center 10 Wilson St.San Juan City 1502Philippines

Background:To compare femtosecond laser-assisted versus conventional phacoemulsification in terms of visual and refractive outcomes,cumulative dissipated energy,anterior chamber inflammation and endothelial cell ***:In this retrospective cohort study,records of eyes that underwent femtosecond laser-assisted cataract surgery(FLACS)or conventional phacoemulsification(CP)were *** Victus femtosecond laser(Bausch and Lomb,Germany)was used to carry out corneal incisions,anterior capsulotomy,and lens fragmentation in FLACS *** refraction spherical equivalence(mRSE),uncorrected distance visual acuity(UDVA),corrected distance visual acuity(CDVA),cumulative dissipated energy(CDE),postoperative cells and flare and endothelial cell count data were *** analysis of the visual acuity tests was performed based on the type of intraocular lens implanted(monofocal,monofocal toric,multifocal,multifocal toric,accommodating).Results:A total of 735 eyes were included in the study(296 eyes for the FLACS group and 439 eyes for the CP group).At one year follow-up,120 eyes comprised the FLACS group and 265 eyes for the CP *** in the FLACS group was−0.16±0.58 D and−0.20±0.52 D in the CP group(P=0.50).UDVA in the FLACS group was 20/25(mean logmAR 0.12±0.13)and 20/25(mean logmAR 0.11±0.13)in the CP group(P=0.48).CDVA was 20/20(mean logmAR 0.03±0.07)in the FLACS group and 20/20(mean logmAR 0.02±0.06)in the CP group(P=0.15).No statistically significant trend was seen for FLACS versus CP by intraocular type for visual *** for the different cataract grades ranged from 6.97±5.74 to 29.02±16.07 in the FLACS group and 7.59±6.42 to 35.69±18.30 in the CP *** FLACS group was significantly lower for post-operative central corneal edema(P=0.05),cells and flare(P=0.01),and endothelial cell loss(P=0.04).Conclusions:Femtosecond laser-assisted cataract surgery and conventional phacoemulsification had similar refractive and visual ***

关键词： Femtosecond laser Phacoemulsification Cataract Cumulative dissipated energy Endothelial cell loss Flare

metabolic pathways as possible therapeutic targets for progressive multiple sclerosis

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Neural Regeneration Research 2017年第8期12卷 1262-1267页

作者： Rebecca m.Heidker mitchell R.emerson Steven m.Le Vine Department of molecular and Integrative Physiology University of Kansas Medical Center Department of Pharmaceutical Sciences College of Pharmacy-Glendale Midwestern University

Unlike relapsing remitting multiple sclerosis, there are very few therapeutic options for patients with progressive forms of multiple sclerosis. While immune mechanisms are key participants in the pathogenesis of relapsing remitting multiple sclerosis, the mechanisms underlying the development of progressive multiple sclerosis are less well understood. Putative mechanisms behind progressive multiple sclerosis have been put forth： insufficient energy production via mitochondrial dysfunction, activated microglia, iron accumulation, oxidative stress, activated astrocytes, Wallerian degeneration, apoptosis, etc. Furthermore, repair processes such as remyelination are incomplete. Experimental therapies that strive to improve metabolism within neurons and glia, e.g., oligodendrocytes, could act to counter inadequate energy supplies and/or support remyelination. most experimental approaches have been examined as standalone interventions; however, it is apparent that the biochemical steps being targeted are part of larger pathways, which are further intertwined with other metabolic pathways. Thus, the potential benefits of a tested intervention, or of an established therapy, e.g., ocrelizumab, could be undermined by constraints on upstream and/or downstream steps. If correct, then this argues for a more comprehensive, multifaceted approach to therapy. Here we review experimental approaches to support neuronal and glial metabolism, and/or promote remyelination, which may have potential to lessen or delay progressive multiple sclerosis.

关键词： acetyl-coenzyme A carboxylase biotin estrogen iron Kynurenine pathway mitochondria thyroidhormone remyelination stem cells vitamin D

An acute naproxen dose does not affect core temperature or Interleukin-6 during cycling in a hot environment

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Sports medicine and Health Science 2021年第4期3卷 243-251页

作者： Dawn m.emerson Stephen CL.Chen Toni m.Torres-mcGehee Craig E.Pfeifer Charles C.emerson J.mark Davis Department of Physical Therapy Rehabilitation Scienceand Athletic TrainingSchool of Health ProfessionsUniversity of Kansas Medical Center3901 Rainbow BlvdMS 2002Kansas CityKansas66160USA. Division of Exercise and Sport Science Bob Jones University1700 Wade Hampton BlvdGreenvilleSouth Carolina29614USA. Department of Exercise Science Arnold School of Public HealthUniversity of South Carolina921 Assembly StreetColumbiaSC29208USA Applied Sport and Exercise Sciences The ParkUniversity of GloucestershireCheltenham GL502RHUnited Kingdom. Department of Athletics 5100 Rockhill Rd SRC 201University of Missouri-Kansas CityKansas CityMissouri64110USA.

Non-steroidal anti-inflammatory drugs’anti-pyretic and anti-inflammatory effects has led some individuals to theorize these medications may blunt core body temperature(Tc)increases during *** utilized a double-blind,randomized,and counterbalanced cross-over design to examine the effects of a 24-h naproxen dose(3–220 mg naproxen pills)and placebo(0 mg naproxen)on Tc and plasma interleukin-6(IL-6)concentrations during cycling in a hot or ambient ***(n=11;6 male,5 female;age=27.8±6.5 years,weight=79.1±17.9 kg,height=177±9.5 cm)completed 4 conditions:1)placebo and ambient(Control);2)placebo and heat(Heat);3)naproxen and ambient(Npx);and 4)naproxen and heat(NpxHeat).Dependent measures were taken before,during,and immediately after 90 min of cycling and then 3 h after ***,Tc significantly increased pre-(37.1±0.4℃)to post-cycling(38.2±0.3℃,F_(1.7,67.3)=150.5,pmaximum Tc were not significantly different between ***-6 increased pre-(0.54±0.06 pg/ml)to post-exercise(2.46±0.28 pg/ml,pmained significantly higher than pre-at 3 h post-(1.17±0.14 pg/ml,95%CI=-1.01 to-0.23,p=0.001).No significant IL-6 differences occurred between conditions.A 24-h,over-the-counter naproxen dose did not significantly affect Tc or IL-6 among males and females cycling in hot or ambient environments.

关键词： Cytokine Exertional heat illness NSAIDs Thermoregulation Exercise