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Feasibility study of computed vs measured high b-value(1400 s/mm2) diffusion-weighted MR images of the prostate

World Journal of Radiology 2014年第6期6卷 374-380页

作者： leonardo K Bittencourt Ulrike I Attenberger Daniel lima Ralph Strecker Andre de Oliveira Stefan O Schoenberg emerson l gasparetto Daniel Hausmann CDPI Ressonancia Magnética Avenida das Américas 4666 Barra da Tijuca RJ 22631-000 Brazil Institute of Clinical Radiology and Nuclear Medicine University of Heidelberg University Hospital Mannheim The-odor-Kutzer-Ufer 1-3 68167 Mannheim Germany Siemens Healthcare Brazil Avenida Mutinga 3800 Jardim Santo Elias SP 05110-902 Brazil Siemens AG Healthcare Sector Henkestrasse127 D-91052 Erlangen Germany

AIM: To evaluate the impact of computed b = 1400 s/mm2(C-b1400) vs measured b = 1400 s/mm2(M-b1400) diffusion-weighted images(DWI) on lesion detection rate, image quality and quality of lesion demarcation using a modern 3T-MR system based on a small-field-of-view sequence(sFOV). METHODS: Thirty patients(PSA: 9.5 ± 8.7 ng/ml; 68 ± 12 years) referred for magnetic resonance imaging(MRI) of the prostate were enrolled in this study. All measurements were performed on a 3T MR *** DWI, a single-shot EPI diffusion sequence(b = 0, 100, 400, 800 s/mm2) was utilized. C-b1400 was cal-culated voxelwise from the ADC and diffusion images. Additionally, M-b1400 was acquired for evaluation and comparison. lesion detection rate and maximum lesion diameters were obtained and compared. Image quality and quality of lesion demarcation were rated accord-ing to a 5-point likert-type scale. Ratios of lesion-to-bladder as well as prostate-to-bladder signal intensity(SI) were calculated to estimate the signal-to-noise-ratio(SNR). RESUlTS: Twenty-four lesions were detected on M-b1400 images and compared to C-b1400 images. C-b1400 detected three additional cancer suspicious lesions. Overall image quality was rated significantly better and SI ratios were significantly higher on C-b1400(2.3 ± 0.8 vs 3.1 ± 1.0, P lesion size showed no significant differences between C- and M-b1400(P = 0.22). CONClUSION: Combination of a high b-value extrap-olation and sFOV may contribute to increase diagnostic accuracy of DWI without an increase of acquisition time, which may be useful to guide targeted prostate biopsies and to improve quality of multiparametric MRI(mMRI) especially under economical aspects in a pri-vate practice setting.

关键词：前列腺癌症磁性的回声成像散开加权的成像超离频 b 值外推的 b 值

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Serum ferritin and the risk of early-onset colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3496-3506页

作者： Adam l Urback Kylee Martens Hannah Stowe McMurry emerson Y Chen Caitlin Citti Anil Sharma Adel Kardosh Joseph J Shatzel Division of Internal Medicine Oregon Health&Science UniversityPortlandOR 97239United States Division of Hematology and Medical Oncology Knight Cancer InstituteOregon Health&Science UniversityPortlandOR 97239United States Division of Gastroenterology&Hepatology Oregon Health&Science UniversityPortlandOR 97239United States

BACKGROUND The incidence of early-onset colorectal cancer(EO-CRC)is rising in the United States,and is often diagnosed at advanced *** serum ferritin is often incidentally discovered in young adults,however,the indication for endoscopy in EO-CRC is *** To compare serum ferritin between patients with EO-CRC and healthy controls(HCs),and examine the association of serum ferritin in EO-CRC with patient-and disease-specific *** A retrospective study of patientsly-diagnosed EO-CRC was conducted from 1/2013-12/*** were included if serum ferritin was measured within 2 years prior to 1 year following CRC histologic *** supplement the analysis,a cohort of HCs meeting similar inclusion and exclusion criteria were identified for comparison.A sensitivity analysis including only patients with serum ferritin obtained at or before diagnosis was separately performed to minimize risk of *** Among 85 patients identified with EO-CRC(48 females),the median serum ferritin level was 26 ng/ml(rangel).Compared to HCs(n=80211),there were a higher proportion of individuals with EO-CRC with serum ferritinl(female 65%,male 40%)versus HCs(female 32.1%,male 7.2%)age 29-39 years(P=0.002 and Ply).Stage IV disease was associated with significantly higher serum ferritin compared to less advanced stages(Plower than levels obtained after *** findings were confirmed in the sensitivity *** Severe iron deficiency may indicate an increased risk of EO-CRC,particularly at earlier *** studies defining the optimal serum ferritin threshold and routine incorporation of serum ferritin in screening algorithms is essential to develop more effective screening strategies for EO-CRC.

关键词： Early-onset Young-onset Colorectal cancer Age Ferritin Iron deficiency

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健康行为改善常规的概念分析

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International Journal of Nursing Sciences 2023年第3期10卷 277-287页

作者： Sunny Y.Ruggeri Amanda emerson Cynthia l.Russell School of Nursing and Health Studies University of Missouri-Kansas CityMissouriUSA Dr.lillian R.Goodman Department of Nursing Worcester State UniversityMassachusettsUSA University of Kansas Medical Center University of Kansas School of NursingKansasUSA

目的慢性病患者常常有不健康的生活习惯,他们需要明确的指导,以建立和维持健康行为改善常规。本研究旨在根据文献中健康行为改善常规的应用情况,对其概念进行综合定义。方法于2022年1一5月,检索CINAHl、Medline、Scopus和谷歌学术中包... 详细信息

目的慢性病患者常常有不健康的生活习惯,他们需要明确的指导,以建立和维持健康行为改善常规。本研究旨在根据文献中健康行为改善常规的应用情况,对其概念进行综合定义。方法于2022年1一5月,检索CINAHl、Medline、Scopus和谷歌学术中包含健康行为改善情景下常规的定义的英文文献,未限定发表日期。采用系统分析方法和Rodgers演化概念分析法,描述健康行为改善常规的属性、前置因素和后续影响,形成该概念的定义。结果共纳人24篇文章。改善健康行为常规概念的属性为重复的模式、患者的可控制性、以目标为导向的健康及融入整个生活方式。前置因素为个体特征和环境因素。后续影响为个体和环境层面的心理、身体和社会健康。结论健康行为改善常规的明确定义可为未来研究提供启发,并为支持慢性病患者建立和保持健康生活习惯的临床护理干预提供依据,从而改善患者结局。

关键词：慢性病健康行为病人生活质量

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Assessment of the Anaerobic Speed Reserve during Specific High-Intensity Exercise in Judo Athletes

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Journal of Science in Sport and Exercise 2022年第3期4卷 266-274页

作者： emerson Franchini Rafael lima Kons Valéria leme Gonçalves Panissa Daniele Detanico Martial Arts and Combat Sports Research Group School of Physical Education and SportUniversity of São PauloSão PauloBrazil Biomechanics laboratory Center of SportsFederal University of Santa CatarinaFlorianópolisSC 88040-900Brazil

Purpose This study aimed to describe self-selected intensity and its relationship to performance during a high-intensity all-out judo protocol,and to verify whether athletes with different anaerobic speed reserve(ASR)perform differently during a high-intensity all-out interval uchi-komi(judo-specific skill).Methods We analyzed the performance of 28 judo athletes as a whole group and divided into groups,according to their *** performed several judo-specific protocols using a specific skill:maximal speed sprint(MSS)and maximal aerobic speed(MAS),and high-intensity intermittent uchi-komi protocol(12×20 s all-out:10 s passive recovery).Results The main results demonstrated a decrease in the number of repetitions and an increase in heart rate across the *** with greater ASR performed a higher number of repetitions,compared to the low ASR group,and they were able to exercise at a higher percentage of the MAS(low ASR=126%;SD=13%;high ASR=152%,SD=l9%)and at a lower percentage of MSS compared to the low ASR group(low ASR=84%,SD=7%;high ASR=76%,SD=11%).However,both groups exercised at a similar percentage of their own ASR during the protocol(low ASR=50%,SD=20%;high ASR=53%,SD=19%).Conclusions Athletes with different ASR seem to set their pace at around 50%of their ASR within an all-out uchi-komi ***,the ASR is useful for predicting performance during high-intensity judo-specific interval exercise intervals.

关键词： Combat sports Rating of perceived exertion Pace All-out exercise

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Spatio-temporal analysis of leprosy risks in a municipality in the state of Mato Grosso-Brazilian Amazon: results from the leprosy post-exposure prophylaxis program in Brazil

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Infectious Diseases of Poverty 2022年第1期11卷 98-98页

作者： lúbia Maieles Gomes Machado emerson Soares dos Santos Arielle Cavaliero Peter Steinmann Eliane Ignotti 不详 Swiss Tropical and Public Health Institute AllschwilSwitzerland

Background leprosy post-exposure prophylaxis(lPEP)with single dose rifampicin(SDR)can be integrated into different leprosy control program set-ups once contact tracing has been *** analyzed the spatio-temporal changes in the distribution of index cases(IC)and co-prevalent cases among contacts of leprosy patients(CP)over the course of the lPEP program in one of the four study areas in Brazil,namely the municipality of Alta Floresta,state of Mato Grosso,in the Brazilian Amazon *** leprosy cases were mapped,and socioeconomic indicators were evaluated to explain the leprosy distribution of all leprosy cases diagnosed in the period 2016–*** were obtained on new leprosy cases[Notifiable diseases information system(Sinan)],contacts traced by the lPEP program,and socioeconomic variables[Brazilian Institute of Geography and Statistics(IBGE)].Kernel,SCAN,factor analysis and spatial regression were applied to analyze *** Overall,the new case detection rate(NCDR)was 20/10000 inhabitants or 304 new cases,of which 55 were CP cases among the 2076 examined *** over time were observed in the geographic distribution of *** highest concentration of cases was observed in the northeast of the study area,including one significant cluster(Relative risk=2.24;population 27427,P-valuel regression(Coefficient 3.34,P-value=0.01).Conclusions The disease distribution was partly explained by poverty *** influences the spatial dynamic of the disease and results highlighted the relevance of systematic contact surveillance for leprosy elimination.

关键词： leprosy Epidemiological profile Contact tracing Spatial analysis Poverty Surveillance

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lack of support for Rensch＇s rule in an intraspecific test using red flour beetle （Tribo/ium castaneum） populations

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Insect Science 2017年第1期24卷 133-140页

作者： Oliver Y. Martin lukasz Michalczyk Anna l. Millard Brent C. emerson Matthew J. G. Gage School of Biological Sciences University of East Anglia Norwich Research Park Norwich NR4 7T J United Kingdom ETH Zurich Experimental Ecology Institute of Integrative Biology D-USYS Universitatsstrasse 16 CH-8092 Zurich Switzerland Department of Entomology Institute of Zoology Jagiellonian University Gronostajowa 9 30-387 Krakow Poland Island Ecology and Evolution Research Group (IPNA-CSIC) CIAstrofisico Francisco Sanchez 3 38206 La Laguna Tenerife Canary Islands Spain

Rensch＇s rule proposes a universal allometric scaling phenomenon across species where sexual size dimorphism （SSD） has evolved： in taxa with male-biased dimorphism, degree of SSD should increase with overall body size, and in taxa with female-biased dimorphism, degree of SSD should decrease with increasing average body size. Rensch＇s rule appears to hold widely across taxa where SSD is male-biased, but not consistently when SSD is female-biased. Furthermore, studies addressing this question within species are rare, so it remains unclear whether this rule applies at the intraspecific level. We assess body size and SSD within Tribolium castaneum （Herbst）, a species where females are larger than males, using 21 populations derived from separate locations across the world, and maintained in isolated laboratory culture for at least 20 years. Body size, and hence SSD patterns, are highly susceptible to variations in temperature, diet quality and other environmental factors. Crucially, here we nullify interference of such confounds as all populations were maintained under identical conditions （similar densities, standard diet and exposed to identical temperature, relative humidity and photoperiod）. We measured thirty beetles of each sex for all populations, and found body size variation across populations, and （as expected） female-biased SSD in all populations. We test whether Rensch＇s rule holds for our populations, but find isometry, i.e. no allometry for SSD. Our results thus show that Rensch＇s rule does not hold across populations within this species. Our intraspecific test matches previous interspecific studies showing that Rensch＇s rule fails in species with female-biased SSD.

关键词： allometry body size Coleoptera sexual selection sexual size dimorphism Tenebrionidae

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Direct Electrochemical Determination of Glyphosate Herbicide Using a Screen-Printed Carbon Electrode Modified with Carbon Black and Niobium Nanoparticles

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Journal of Analysis and Testing 2023年第4期7卷 425-434页

作者： Julia Oliveira Fernandes Cassiano Augusto Rolim Bernardino Juliana dos Santos Fernandes Claudio Fernando Mahler Bernardo Ferreira Braz luiz Henrique Carpenter dos Santos Rodrigo JoséCorrêa Ricardo Erthal Santelli Braulio Soares Archanjo emerson Schwingel Ribeiro Fernando Henrique Cincotto Departament of Analytical Chemistry Institute of ChemistryFederal University of Rio de JaneiroRio de Janeiro 21941-909Brazil Departament of Civil Engineering COPPEFederal University of Rio de JaneiroRio de Janeiro 21941-598Brazil National Institute of Science&Technology of Bioanalytics(INCTBio) CampinasSão Paulo 13083-862Brazil Departament of Inorganic Chemistry Institute of ChemistryFederal University of Rio de JaneiroRio de Janeiro 21941-909Brazil Unesp National Institute of Alternative Technologies for DetectionToxicological Assessment and Removal of Micropollutants and Radioactives(INCT-DATREM)AraraquaraSão Paulo 14800-060Brazil National Institute of Metrology Quality and TechnologyInmetroAv.Nossa Senhora das Graças50XerémDuque de Caxias 25250-020Brazil

Glyphosate is a herbicide that has been widely used worldwide and is used in agricultural areas to control weeds and unwanted *** sensors developed from different nanomaterials have high efficiency,excellent cost-benefit,and fast analysis time for detecting traces of environmental *** study aimed to produce an electrochemical sensor with disposable screen-printed electrodes based on carbon black modified with niobium nanoparticles to determine glyphosate in aqueous *** morphology,structure and electrochemical performance of the sensor were characterized by scanning electron microscopy,energy-dispersive X-ray spectroscopy,X-ray diffraction and cyclic *** pulse voltammetry in BR buffer solution at pH 5.0 allowed the generation of a method to quantify glyphosate concentration in a linear range of 5.90-172.30μmol/l(1.00-29.13μg/ml),with a limit of detection calculated at 3.07μmol/l(0.52μg/ml).The method efficiently quantified glyphosate in real water samples and showed no interference from K^(+),Na^(+),Ca^(2+),Mg^(2+)ions or thiamethoxam,imidacloprid and carbendazim pesticides.

关键词： Glyphosate Electrochemical sensor Carbon black Niobium nanoparticles

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Polymer Nanocomposites Used as Scaffolds for Bone Tissue Regeneration

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Materials Sciences and Applications 2018年第8期9卷 679-697页

作者： Raquel Couto de Azevedo Goncalves Mota emerson Oliveira da Silva lívia Rodrigues de Menezes Instituto de Macromoléculas Professora Eloisa Mano Universidade Federal do Rio de JaneiroRio de JaneiroBrazil

Scaffolds are three-dimensional biocompatible structures that can mimic the properties of the extracellular matrix (ECM) of a given tissue, like mechanical support and bioactivity, which provides a platform for cellular adherence, proliferation and differentiation. Consequently, scaffolds are frequently used in tissue engineering with the intention of assisting the regeneration of a damaged tissue, and a major application in bone regeneration. An ideal scaffold needs to be biodegradable, biocompatible, and needs to match the biomechanical properties of bone. Polymers are widely used in this field because they fulfil the first two requirements. However, no polymeric material can achieve mechanical properties similar to the bone. For that reason, polymeric nanocomposites, which consist of ceramic/metallic nanoparticles dispersed in a polymer matrix, are being considered for bone scaffold fabrication in order to overcome this problem, since nanoparticles are known to improve composite mechanical strength, and enhance other properties.

关键词： Scaffolds Polymer Nanocomposites Nanoparticles Bone Tissue Engineering

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Effect of the Addiction of Metal Oxide Nanoparticles on the Physical, Chemical and Thermal Properties of PVA Based Nanocomposites

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Materials Sciences and Applications 2018年第5期9卷 473-488页

作者： Raquel Couto de Azevedo Gon&ccedil alves Mota emerson Oliveira da Silva lí via Rodrigues de Menezes Instituto de Macromolé culas Professora Eloisa Mano Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil

In this study, poly(vinyl alcohol) (PVA)-based nanocomposites consisting of metallic oxide nanoparticles (TiO2, ZnO, ZrO2) were obtained from an aqueous solution of 7% PVA, in order to compare the microstructural, and physical properties of bionanocomposite films reinforced with various loading contents (0.1%, 0.2% and 0.3% w/w). They were evaluated regarding their molecular toughness through Nuclear Magnetic Resonance (NMR), regarding their chemical structural through Fourier Transform Infrared Spectroscopy (FTIR), regarding their crystallinity throught X-ray Diffraction (XRD), and regarding termal properties through Thermogravimetric Analysis (TGA) and Differential Scanning Calorimetry (DSC). The NMR results showed that the smallest concentrations of these oxides have a tendency to disperse better in the polymeric matrix, improving the structural toughness. Besides, changes in the termal resistance of the material were found with the use of TGA and DSC.

关键词： Poly(vinyl alcohol) Nanocomposites Metallic Oxides Titanium Oxide Zirconium Oxide Zinc Oxide

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Association between Helicobacterpylori, Epstein-Barr virus, human papillomavirus and gastric adenocarcinomas

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World Journal of Gastroenterology 2018年第43期24卷 4928-4938页

作者： Carolina Rosal Teixeira de Souza Marcelli Carolini Alves Almeida Andre Salim Khayat emerson lucena da Silva Paulo Cardoso Soares luiz Claudio Chaves Rommel Mario Rodriguez Burbano laboratory of Human Cytogenetics Institute of Biological Sciences Federal University of Para Belem Para 66075-110 Brazil Oncology Research Center Federal University of Para Joao deBarros Barreto University Hospital Belem Para 66073-000Brazil Ophir loyola Hospital Belem Para 66060-281 Brazil

AIM To correlate Helicobacter pylori(H. pylori), Epstein-Barr virus(EBV) and human papillomavirus(HPV) with gastric cancer(GC) cases in Pará State, *** Tissue samples were obtained from 302 gastric adenocarcinomas. A rapid urease test was used to detect the presence of H. pylori, and the presence of the cagA gene in the HP-positive samples was confirmed by PCR. An RNA in situ hybridization test designed to complement Eber1 RNA was used to detect the presence of EBV in the samples, and the l1 region of HPV was detected using nested PCR. Positive HPV samples were genotyped and analyzed for E6 and E7 viral gene expression. Infections were also correlated with the clinical and pathological characteristics of the *** The majority of the 302 samples analyzed were obtained from men(65%) aged 55 years or older(67%) and were classified as the intestinal subtype(55%). All three pathogens were found in the samples analyzed in the present study(H. pylori : 87%, EBV: 20%, HPV: 3%). Overall, 78% of the H. pylori-positive(H. pylori+) samples were cag A +(H. pylori-cag A+), and there was an association between the cytotoxic product of this gene and EBV. Coinfections of H. pylori-cagA+ and EBV were correlated with the most advanced tumor stages. Although only 20% of the tumors were positive for EBV, infection with this virus was associated with distant metastasis. Only the HPV 16 and 18 strains were found in the samples, although no expression of the E6 and E7 oncoproteins was detected. The fundus of the stomach was the region least affected by the *** HPV was not involved in gastric tumorigenesis. Prophylactic and therapeutic measures against H. pylori and EBV may prevent the development of GC, especially the more aggressive forms.

关键词：乳头状瘤病毒协会腺癌胃区域检测测试设计 HPV EBV

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