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Hepatocellular carcinoma and the risk of occupational exposure

World Journal of Hepatology 2016年第13期8卷 573-590页

作者： Venerando Rapisarda Carla Loreto Michele Malaguarnera Annalisa Ardiri Maria Proiti Giuseppe Rigano Evelise Frazzetto Maria Irene Ruggeri Giulia Malaguarnera Nicoletta bertino Mariano Malaguarnera Vito emanuele Catania Isidoro Di Carlo Adriana Toro emanuele bertino Dario Mangano Gaetano bertino Occupational Medi-cine Unit Department of Clinical and Experimental MedicineUniversity of Catania Department of Biomedical Sciences Human Anatomy and Histology Section University of Catania Department of Biomedical Sciences University of Catania Hepatology Unit Department of Clinical and Experimental Medicine University of Catania Internal Medicine Unit ARNAS Civic Hospital Research Centre "La Grande Senescenza" University of Catania Faculty of Pharmacy University of Catania Department of Surgical Sciences Organ Transplantation and Advanced TechnologiesUniversity of Catania

Hepatocellular carcinoma(HCC)is the most common type of liver *** main risk factors for HCC are alcoholism,hepatitis B virus,hepatitis C virus,nonalcoholic steatohepatitis,obesity,type 2 diabetes,cirrhosis,aflatoxin,hemochromatosis,Wilson’s disease and *** exposure to chemicals is another risk factor for *** the relationship between occupational risk and HCC is unclear and the reports are fragmented and *** review aims to summarize the current knowledge regarding the association of infective and non-infective occupational risk exposure and HCC in order to encourage further research and draw attention to this global occupational public health problem.

关键词： Hepatocellular carcinoma Autophagy Epigenetic events Hepatitis B virus Hepatitis C virus Occupational exposure Chemical agents Mitophagy Arsenic Cadmium

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Chronic hepatitis C:This and the new era of treatment

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World Journal of Hepatology 2016年第2期8卷 92-106页

作者： Gaetano bertino Annalisa Ardiri Maria Proiti Giuseppe Rigano Evelise Frazzetto Shirin Demma MariaIrene Ruggeri Laura Scuderi Giulia Malaguarnera Nicoletta bertino Venerando Rapisarda Isidoro Di Carlo Adriana Toro Federico Salomone Mariano Malaguarnera emanuele bertino Michele Malaguarnera Hepatology Unit-Department of Clinical and Experimental Medicine University of Catania95123 CataniaItaly Internal Medicine Unit ARNAS Civic Hospital90142 PalermoItaly Research Centre“La Grande Senesce” University of Catania95100 CataniaItaly Department of Biomedical Sciences University of Catania95100 CataniaItaly Faculty of Pharmacy University of Catania95123 CataniaItaly Occupational Medicine Unit Department of Clinical and Experimental MedicineUniversity of Catania95100 CataniaItaly Department of Surgical Sciences Organ Transplantation and Advanced TechnologiesUniversity of Catania95100 CataniaItaly Gastroenterology Unit Acireale Hospital95024 AcirealeCataniaItaly

Over the last years it has started a real revolution in the treatment of chronic hepatitis C. This occurred for the availability of direct-acting antiviral agents that allow to reach sustained virologic response in approximately 90% of cases. In the near future further progress will be achieved with the use of pan-genotypic drugs with high efficacy but without side effects.

关键词： Direct-acting antiviral agents Nucleosideinhibitors Boceprevir Sofosbuvir Telaprevir HepatitisC Simeprevir Daclatasvir Ledipasvir Faldaprevir Ritonavir Ombitasvir Dasabuvir

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Responsibility of hepatitis C virus in the development of hepatocellular carcinoma:From molecular alterations to possible solutions

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World Journal of Hepatology 2018年第6期10卷 448-451页

作者： Gaetano bertino Giulia Malaguarnera Evelise Frazzetto Alice Sciuto Gaetano Inserra Guido Nicola Zanghì Michele Malaguarnera Hepatology Unit Department of Clinical and Experimental MedicineUniversity of CataniaPoliclinico“G.Rodolico”Catania 95123Italy Research Center“the Great Senescence” University of CataniaCatania 95100Italy Department of Biomedical and Biotechnological Science University of CataniaCatania 95100Italy Department of Clinical and Experimental Medicine University of CataniaCatania 95123Italy Department of Surgery Policlinico Vittorio Emanuele University HospitalUniversity of CataniaCatania 95100Italy

There are several causes of hepatocellular carcinoma(HCC), but certainly the hepatitis C virus(HCV) is one of the most common. The HCV is able to contribute, both directly and indirectly, to the development of HCC. Determining early HCV clearance before an advanced liver disease develops, is absolutely necessary as this prevents the initiation of the cascade of events induced by HCV that may result in the development of HCC. The early treatment of the infection and the clearance of HCV represents today, in the age of the direct antiviral agents(DAAs), an extraordinary opportunity for true prevention of the development of HCV-related HCC.

关键词： Hepatitis C virus Hepatocellular carcinoma Inflammation Fibrosis Insulin-resistance Oxidative stress Direct acting antivirals

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