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Endotics system vs colonoscopy for the detection of polyps

World Journal of Gastroenterology 2010年第43期16卷 5452-5456页

作者： emanuele tumino Rodolfo Sacco Marco Bertini Michele Bertoni Giuseppe Parisi Alfonso Capria Operative Unit of Gastroenterology and Metabolic Diseases Department of Gastroenterology Pisa University Hospital Institute of Internal Medicine University of Foggia

AIM: To compare the endotics system (ES), a set of new medical equipment for diagnostic colonoscopy, with video-colonoscopy in the detection of polyps. METHODS: Patients with clinical or familial risk of colonic polyps/carcinomas were eligible for this study. After a standard colonic cleaning, detection of polyps by the ES and by video-colonoscopy was performed in each patient on the same day. In each single patient, the assessment of the presence of polyps was performed by two independent endoscopists, who were randomly assigned to evaluate, in a blind fashion, the presence of polyps either by ES or by standard colonoscopy. The frequency of successful procedures (i.e. reaching to the cecum), the time for endoscopy, and the need for sedation were recorded. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the ES were also calculated. RESULTS: A total of 71 patients (40 men, mean age51.9 ± 12.0 years) were enrolled. The cecum was reached in 81.6% of ES examinations and in 94.3% of colonoscopies (P = 0.03). The average time of endoscopy was 45.1 ± 18.5 and 23.7 ± 7.2 min for the ES and traditional colonoscopy, respectively (P < 0.0001). No patient required sedation during ES examination, compared with 19.7% of patients undergoing colonoscopy (P < 0.0001). The sensitivity and specificity of ES for detecting polyps were 93.3% (95% CI: 68-98) and 100% (95% CI: 76.8-100), respectively. PPV was 100% (95% CI: 76.8-100) and NPV was 97.7% (95% CI: 88-99.9). CONCLUSION: The ES allows the visualization of the entire colonic mucosa in most patients, with good sensitivity/specificity for the detection of lesions and without requiring sedation.

关键词： Colonoscopy Diagnosis Endotics system Polyps Sedation

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Clinical impact of selective transarterial chemoembolization on hepatocellular carcinoma:A cohort study

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World Journal of Gastroenterology 2009年第15期15卷 1843-1848页

作者： Rodolfo Sacco Marco Bertini Pasquale Petruzzi Michele Bertoni Irene Bargellini Giampaolo Bresci Graziana Federici Luigi Gambardella Salvatore Metrangolo Giuseppe Parisi Antonio Romano Antonio Scaramuzzino emanuele tumino Alessandro Silvestri emanuele Altomare Claudio Vignali Alfonso Capria Gastroenterology Department Pisa University Hospital Institute of Interna Medicine University of Foggia Department of Diagnostic and Interventional Radiology Pisa University Hospital

AIM:To prospectively evaluate the short and long term clinical impact of selective transarterial chemoembolization (TACE) on liver function in patients with hepatocellular carcinoma (HCC).To assess side effects in relation to treatments.To analyze the overall survival and HCC progression free survival probability. METHODS:One hundred and seventeen cirrhotic patients with HCC were enrolled.Baseline liver function included Child-Pugh score and serum levels of alanineaminotransferase (ALT),prothrombin time(PT)and bilirubin.According to Cancer Liver Italian Program (CLIP) and Barcelona Clinic Liver Cancer (BCLC) staging systems,71 patients were eligible for TACE; 32 had previously received treatment for HCC.No significant differences in liver function were observed between previously treated and not treated patients. TACE was performed by selective catheterization of the arteries nourishing the lesions.While hospitalized, patient sunder went clinical,hematologicand ultrasonographic assessments.One month after TACE a CT scan was performed to assess tumor response. A second TACE was performed"on demand".Liver function tests were checked in all patients every four months.RESULTS:After first TACE,the mean Child-Pugh score increased from a mean baseline 5.62±1.12 to 6.11±1.57 at discharge time (P<0.0001),decreasing after four months to 5.81±0.73 (not significant).ALT,PT and bilirubin significantly (P<0.0001)increased 24 h after TACE and progressively decreased until discharge. After the second TACE,variations in Child-Pugh score,ALT,PT and bilirubin were comparable to that described after the first TACE.No major complications were observed.The mean follow-up was 14.7±6.3 mo (median:16 mo).Only one patient died.No other patient experienced important long term worsening of clinical status.The overall survival probability at twenty-four months was 98.18%with a correspondent HCC progression free survival probability of 69%. CONCLUSION:Selectiv TAC Emayproduce significant,but transitory increases in ALT values, with no major i

关键词：肝动脉化疗栓塞术肝癌患者临床表现队列研究血清丙氨酸转氨酶肝动脉栓塞化疗肝功能试验肝硬化患者

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Assessment of clinical and radiological response to sorafenib in hepatocellular carcinoma patients

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World Journal of Hepatology 2015年第1期7卷 33-39页

作者： Rodolfo Sacco Valeria Mismas Antonio Romano Marco Bertini Michele Bertoni Graziana Federici Salvatore Metrangolo Giuseppe Parisi emanuele tumino Giampaolo Bresci Luca Giacomelli Sara Marceglia Irene Bargellini Dipartimento di Gastroenterologia-UO Gastroenterologia e Malattie del Ricambio Azienda Ospedaliero Universitaria Pisana56124 PisaItaly Dipartimento di Elettronica Informazione e BioingegneriaPolitecnico di Milano20100 MilanItaly Dipartimento di Radiologia-Azienda Ospedaliero Universitaria Pisana 56124 PisaItaly

Sorafenib is an effective anti-angiogenic treatment forhepatocellular carcinoma(HCC). The assessment of tumor progression in patients treated with sorafenib is crucial to help identify potentially-resistant patients,avoiding unnecessary toxicities. Traditional methods to assess tumor progression are based on variations in tumor size and provide unreliable results in patients treated with sorafenib. New methods to assess tumor progression such as the modified Response Evaluation Criteria in Solid Tumors or European Association for the Study of Liver criteria are based on imaging to measure the vascularization and tumor volume(viable or necrotic). These however fail especially when the tumor response results in irregular development of necrotic tissue. Newer assessment techniques focus on the evaluation of tumor volume,density or perfusion. Perfusion computed tomography and Dynamic ContrastEnhanced-UltraS ound can measure the vascularization of HCC lesions and help predict tumor response to antiangiogenic therapies. Mean Transit Time is a possible predictive biomarker to measure tumor response. Volumetric techniques are reliable,reproducible and time-efficient and can help measure minimal changes in viable tumor or necrotic tissue,allowing the prompt identification of non-responders. Volume ratio may be a reproducible biomarker for tumor response. Larger trials are needed to confirm the use of these techniques in the prediction of response to sorafenib.

关键词： Hepatocellular carcinoma Sorafenib ResponseEvaluation Criteria in Solid Tumors Perfusioncomputed tomography Dynamic Contrast-Enhanced-UltraSound Volumetric assessment

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Transarterial radioembolization for hepatocellular carcinoma:An update and perspectives

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World Journal of Gastroenterology 2015年第21期21卷 6518-6525页

作者： Rodolfo Sacco Valeria Mismas Sara Marceglia Antonio Romano Luca Giacomelli Marco Bertini Graziana Federici Salvatore Metrangolo Giuseppe Parisi emanuele tumino Giampaolo Bresci Ambra Corti Manuel Tredici Michele Piccinno Luigi Giorgi Carlo Bartolozzi Irene Bargellini Department of Gastroenterology Pisa University Hospital Department of Electronics Information technology and BioengineeringEngineering School of Milan Department of Nuclear Medicine Pisa University Hospital Division of Health Physics Pisa University Hospital Department of Radiology Pisa University Hospital

In the last decade trans-arterial radioembolization has given promising results in the treatment of patients with intermediate or advanced stage hepatocellular carcinoma(HCC),both in terms of disease control and tolerability profile.This technique consists of the selective intra-arterial administration of microspheres loaded with a radioactive compound(usually Yttrium90),and exerts its therapeutic effect through the radiation carried by these microspheres.A careful and meticulous selection of patients is crucial before performing the radioembolization to correctly perform the procedure and reduce the incidence of complications.Radioembolization is a technically complex and expensive technique,which has only recently entered clinical practice and is supported by scant results from phase Ⅲ clinical trials.Nevertheless,it may represent a valid alternative to transarterial chemoembolization(TACE) in the treatment of intermediate-stage HCC patients,as shown by a comparative retrospective assessment that reported a longer time to progression,but not of overall survival,and a more favorable safety profile for radioembolization.In addition,this treatment has reported a higher percentage of tumor shrinkage,if compared to TACE,for pre-transplant downsizing and it represents a promising therapeutic option in patients with large extent of disease and insufficient residual liver volume who are not immediately eligible for surgery.Radioembolization might also be a suitable companion to sorafenib in advanced HCC or it can be used as a potential alternative to this treatment in patients who are not responding or do not tolerate sorafenib.

关键词： Hepatocellular carcinoma Radioembolization Transarterial chemoembolization Sorafenib Staging RECIST, Modified RECIST Downsizing Clinical trial

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微波技术对ECR离子源性能的影响(英文)

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Chinese Physics C 2007年第S1期31卷 147-151页

作者： L.Celona F.Consoli S.Barbarino G.Ciavola S.Gammino F.Maimone D.Mascali L.tumino Istituto Nazionale di Fisica Nucleate-Laboratori Nazionali del Sud Via S.Sofia 6295123 CataniaItaly Istituto Nazionale di Fisica Nucleate-Laboratori Nazionali del Sud Via S.Sofia 6295123 CataniaItaly Università degli Studi di CataniaDipartirnento di Fisica e AstronomiaVia S.Sofia 6495123 CataniaItaly Università degli Studi di Catania Dipartimento di Ingegneria Informatica e delle TelecomunicazioniViale A.Doria 695123 CataniaItaly

The coupling between microwave generators and ECR ion sources(ECRIS)is a key point for the design of the new generation ECRIS as well as for the optimization of the existing ones.The electromagnetic characterization of the plasma chamber where the ionization phenomena take place is a fundamental starting point to understand and model such process.In such effort the complex structures of the injection and extraction flanges together with the large dimensions of the chamber and the high frequencies that are typically used make impossible an analytical solution and also create great difficulties in the modelling even with state-of- art electromagnetic simulators(CST,HFSS),In the following paper the results of some numerical calculations for the optimum plasma chamber excitation will be presented along with the experimental measurements carried out with the SERSE ion source at INFN-LNS.A campaign of measurements is also planned to further investigate the microwave coupling and the mode excitation,which determines the efficiency of the ECR plasma heating.

关键词： plasma ion sources ECR heating

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特洛伊木马方法中一种新的准自由反应事件挑选方法

特洛伊木马方法中一种新的准自由反应事件挑选方法

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第十四届全国核物理大会暨第十届会员代表大会

作者：文群刚李成波周书华孟秋英 Claudio Spitaleri Aurora tumino Rosario Gianluca Pizzone 中国科学技术大学近代物理系中国原子能科学研究院北京市辐射中心 Laboratori Nazionalidel Sud-INFN

特洛伊木马方法是一种间接测量方法,特别适用于间接测量带电粒子两体反应在低能区的裸核截面。该方法是建立在准自由反应机制基础上,在适当的运动学条件下,选取一个与两体反应密切相关的三体反应,其反应在库仑位垒之上发生,从而避免了... 详细信息

特洛伊木马方法是一种间接测量方法,特别适用于间接测量带电粒子两体反应在低能区的裸核截面。该方法是建立在准自由反应机制基础上,在适当的运动学条件下,选取一个与两体反应密切相关的三体反应,其反应在库仑位垒之上发生,从而避免了库仑位垒对截面的

关键词：特洛伊木马方法准自由条件中间破裂过程

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9Be(p,α)6Li低能区裸核反应S(E)因子的间接测量

9Be(p,α)6Li低能区裸核反应S(E)因子的间接测量

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“创新——核科学技术发展的不竭源泉”——中国核学会20...

作者：李成波文群刚周书华孟秋英李笑梅周静付元勇胡守扬 C.Spitaleri R.G.Pizzone A.tumino L.Lamia 中国原子能科学研究院 INFN-LNS CataniaItaly 北京市辐射中心

Be丰度是检验宇宙大爆炸模型的一个关键参数,在天体能区Be(p,α)Li裸核反应截面的精确测量将加深对Be原始丰度及其天体演化过程的认识。利用特洛伊木马方法间接测量Be(p,α)Li在天体物理相关低能区的裸核反应截面和S(E)因子,克服了直接... 详细信息

Be丰度是检验宇宙大爆炸模型的一个关键参数,在天体能区Be(p,α)Li裸核反应截面的精确测量将加深对Be原始丰度及其天体演化过程的认识。利用特洛伊木马方法间接测量Be(p,α)Li在天体物理相关低能区的裸核反应截面和S(E)因子,克服了直接测量中因受库仑抑制而导致截面甚低的困难并排除电子屏蔽效应的影响,而且避免了S(E)外推法的不确定性。实验采用原子能院HI-13串列加速器提供的22.35MeV Be束流轰击氘靶(CD),利用两套位置灵敏探测器(PSD)对出射粒子α和Li做符合测量,以同时获取精确的能量和角度信息。利用特洛伊木马方法的基本关系式,通过三体反应Be+d→α+Li+n的截面测量,提取出了感兴趣的两体反应Be+p→α+Li在300 keV以下能区的裸核反应截面和S(E)因子,在此基础上进一步研究了电子屏蔽效应。

关键词：特洛伊木马方法准自由反应裸核天体能区 S（E）因子电子屏蔽势

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Measurement of^(25)Al+p Resonant Scattering

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IMP & HIRFL Annual Report 2019年第1期 54-55页

作者： Hu Jun H.Yamaguchi Xu Shiwei Zhang Ningtao Ma Shaobo Ru Longhui Liu Enqiang Liu Tong S.Hayakawa Yang Lei H.Shimizu D.Kahl C.B.Hamill A.Murphy Su Jun Fang Xiao K.Chae M.Kwag S.Cha N.N.Duy N.K.Uyen D.Kim R.G.Pizzone M.La Cognata S.Cherubini S.Romano A.tumino J.Liang A.Psaltis M.Sferrazza D.Kim S.Kubono 不详

Type I X-ray bursts are the most frequently observed thermonuclear explosions in nature[1].They take place on the surface of accreting neutron star in low-mass X-ray binary systems.

关键词： Scattering systems.

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