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Small-bowel capsule endoscopy: A ten-point contemporary review

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World Journal of Gastroenterology 2013年第24期19卷 3726-3746页

作者： Anastasios Koulaouzidis emanuele Rondonotti Alexandros Karargyris Centre for Liver and Digestive Disorders the Royal Infirmary of EdinburghEdinburgh EH16 4SA Scotland United Kingdom Gastroenterology Unit Ospedale Valduce 22100 Como Italy National Library of Medicine National Institutes of HealthBethesda MD 20814 United States

The introduction of capsule endoscopy (CE) in clinical practice increased the interest for the study of the small-bowel. Consequently, in about 10 years, an impressive quantity of literature on indications, diagnostic yield (DY), safety profile and technical evolution of CE has been published as well as several reviews. At present time, there are 5 small-bowel capsule enteroscopy (SBCE) models in the worldwide market. Head-to-head trials have showed in the great majority of studies comparable results in terms of DY, image quality and completion rate. CE meta-analyses formed the basis of national/international guidelines; these guidelines place CE in a prime position for the diagnostic work-up of patients with obscure gastrointestinal bleeding, known and/or suspected Crohn's disease and possible small-bowel neoplasia. A 2-L polyethylene glycol-based purge, administered the day before the procedure,is the most widely practiced preparation regimen. Whether this regimen can be further improved (i.e. , by further decreasing its volume, changing the timing of administration, coupling it with prokinetics and/or other factors) or if it can really affect the DY, is still under discussion. Faecal calprotectin has been used in SBCE studies in two settings: in patients taking non-steroidal anti-inflammatory drugs, to evaluate the type and extent of mucosal damage and, more importantly from a clinical point of view, in patients with known or suspected Crohn's disease for assessment of inflam-mation activity. Although there is still a lot of debate around the exact reasons of SBCE poor performance in various small-bowel segments, it is worth to remember that the capsule progress is non-steerable, hence more rapid in the proximal than in lower segments of the small-bowel. Capsule aspiration, a relatively unexpected complication, has been reported with increasing frequency. This is probably related with the increase in the mean age of patients undergoing CE. CE video review is a ti

关键词： Capsule endoscopy Calprotectin Meta- analysis Review Preparation Reading software Complication Indications

Evaluation of 4 three-dimensional representation algorithms in capsule endoscopy images

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World Journal of Gastroenterology 2013年第44期19卷 8028-8033页

作者： Alexandros Karargyris emanuele Rondonotti Giovanna Mandelli Anastasios Koulaouzidis National Library of Medicine National Institutes of Health Bethesda MD 20892 United States Gastroenterology Unit Ospedale Valduce 22100 Como Italy Centre for Liver and Digestive Disorders The Royal Infirmary of Edinburgh Edinburgh EH16 4SAScotland United Kingdom

AIM:To evaluate the three-dimensional(3-D)representation performance of 4 publicly available Shapefrom-Shading(SfS)algorithms in small-bowel capsule endoscopy(SBCE).METHODS:SfS techniques recover the shape of objects using the gradual variation of *** are4 publicly available SfS *** the best of our knowledge,no comparative study with images obtained during clinical SBCE has been performed to *** experienced reviewers were asked to evaluate 54 twodimensional(2-D)images(categories:protrusion/inflammation/vascular)transformed to 3-D by the aforementioned SfS 3-D *** best algorithm was selected and inter-rater agreement was ***:Four publicly available SfS algorithms were ***’s SfS algorithm outperformed the rest(selected as best performing in 45/54 SBCE images),followed by Ciuti’s algorithm(best performing in 7/54images)and Torre o’s(in 1/54 images).In 26/54 images;Tsai’s algorithm was unanimously selected as the best performing 3-D representation SfS ***’s 3-D algorithm superiority was independent of lesion category(protrusion/inflammatory/vascular;P=0.678)and/or CE system used to obtain the 2-D images(MiroCam/PillCam;P=0.558).Lastly,the interobserver agreement was good(kappa=0.55).CONCLUSION:3-D representation software offers a plausible alternative for 3-D representation of conventional capsule endoscopy images(until optics technology matures enough to allow hardware enabled-"real"3-D reconstruction of the gastrointestinal tract).

关键词： Capsule endoscopy Small-bowel Threedimensional Software Algorithm Reconstruction Technology Advance

Heavy cigarette smoking and alcohol consumption are associated with impaired sperm parameters in primary infertile men

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Asian Journal of Andrology 2019年第5期21卷 478-485页

作者： Luca Boeri Paolo Capogrosso Eugenio Ventimiglia Filippo Pederzoli Walter Cazzaniga Francesco Chierigo Federico Deho emanuele Montanari Francesco Montorsi Andrea Salonia Division of Experimental Oncology/Unit of Urology URIIRCCS San Raffaele HospitalMilan 20132Italy Department of Urology Foundation IRCCS Ca'Granda Maggiore Policlinico HospitalUniversity of MilanMilan 20122Italy University Vita-Salute San Raffaele Milan 20132Italy

We assessed the concomitant impact of cigarette smoking and alcohol con sumption in men presenting for primary couple's *** from 189 in fertile men were an a *** analysis,serum hormones,and sperm DNA fragmentation(SDF)were *** status was categorized as follows:current nonsmoker(-S),moderate smoker(+MS),and heavy smoker(+HS).Alcohol consumption was categorized as follows:abstainer(-D),moderate drinker(+md),and heavy drinker(+HD).Descriptive statistics and logistic regression models were *** all the participants,132(69.8%),30(15.9%),and 27(14.3%)patients were-S,+MS,and+HS,*** addition,67(35.4%),77(40.7%)and 45(23.8%)men were-D,+md and+HD,*** concomitant habits,52(27.5%)patients were nonsmokers and abstainers(-S/-D:Group 1),91(48.1%)had at least one recreational habit(-S/+D or+S/-D:Group 2),and 46(24.3%)were both smokers and drinkers(+S/+D:Group 3).Sperm concentration and progressive motility were lower in+HS and+HD,compared with-S and-D(all P<0.05),***,both parameters were significantly lower in Group 3 than Groups 1 and 2(all P<0.05).SDF values were higher in Group 3 than Groups 1 and 2(both P<0.05).In multivariate analysis,follicle-stimulating hormone(FSH)levels and concomitant+S/+D status were independent predictors of impaired sperm concentration and progressive motility(all P<0.05).Heavy smoking and heavy drinking were associated with worse seminal parameters than moderate smoking/drinking and nonsmoking/*** concomitant,+S/+D status has an even greater detrimental effect on semen parameters.

关键词： alcohol con sumption cigarette smoki ng in fertility risk factors seme n an alysis

Wireless endoscopy in 2020:Will it still be a capsule?

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World Journal of Gastroenterology 2015年第17期21卷 5119-5130页

作者： Anastasios Koulaouzidis Dimitris K Iakovidis Alexandros Karargyris emanuele Rondonotti The Royal Infirmary of Edinburgh Endoscopy UnitEH16 4SA EdinburghScotlandUnited Kingdom Department of Computer Engineering Technological Educational Institute of Central Greece35100 LamiaGreece The National Institute of Health BethesdaMD 20810United States Gastroenterology Department Ospedale Valduce22100 ComoItaly

Currently,the major problem of all existing commercial capsule devices is the lack of control of *** the future,with an interface application,the clinician will be able to stop and direct the device into points of interest for detailed inspection/diagnosis,and therapy *** editorial presents current commerciallyavailable new designs,European projects and delivery capsule and gives an overview of the progress required and progress that will be achieved-according to the opinion of the authors- in the next 5 year leading to 2020.

关键词： Capsule endoscopy Hardware Future Development

Use of biological meshes for abdominal wall reconstruction in highly contaminated fields

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World Journal of Gastroenterology 2010年第15期16卷 1928-1933页

作者： Andrea Cavallaro emanuele Lo Menzo Maria Di Vita Antonio Zanghì Vincenzo Cavallaro Pier Francesco Veroux Alessandro Cappellani General Surgery and Senology Department of Surgery "Policlinico - Vittorio Emanuele" Hospital University of Catania Medical School Via S. Sofi a 78 95123 Catania Italy Department of Surgery University of Maryland School of Medicine Baltimore MD 21201 United States Department of Surgical Sciences Organs Trasplants Advanced Technologies Medical University of Catania "Policlinico - Vittorio Emanue-le" Hospital Via S. Sofi a 78 95123 Catania Italy

Abdominal wall defects and incisional hernias represent a challenging problem. In particular, when a synthetic mesh is applied to contaminated wounds, its removal is required in 50%-90% of cases. Biosynthetic meshes are the newest tool available to surgeons and they could have a role in ventral hernia repair in a potential-ly contaminated field. We describe the use of a sheet of bovine pericardium graft in the reconstruction of abdominal wall defect in two patients. Bovine pericardium graft was placed in the retrorectus space and secured to the anterior abdominal wall using polypropylene sutures in a tension-free manner. We experienced no evidence of recurrence at 4 and 5 years follow-up.

关键词： Biological meshes Bovine Pericardium Infection Hernia

Incidental gallbladder cancer during laparoscopic cholecystectomy:Managing an unexpected finding

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World Journal of Gastroenterology 2012年第30期18卷 4019-4027页

作者： Andrea Cavallaro Gaetano Piccolo Vincenzo Panebianco emanuele Lo Menzo Massimiliano Berretta Antonio Zanghì Maria Di Vita Alessandro Cappellani Department of Surgery General Surgery and Breast UnitUniversity of CataniaVia S.Sofia 7895123 CataniaItaly Department of Surgery General Surgery Unit of Taormina Hospital "San Vincenzo"98039 MessinaItaly Division of Laparoscopic and Bariatric Surgery University of MarylandBaltimoreMD 21201United States Department of Medical Oncology National Cancer Institute-IRCCS33081 AvianoItaly

AIM:To evaluate the impact of incidental gallbladder cancer on surgical ***:Between 1998 and 2008 all cases of cholecystectomy at two divisions of general surgery,one university based and one at a public hospital,were retrospectively *** pathology was diagnosed by history,physical examination,and laboratory and imaging studies [ultrasonography and computed tomography(CT)].Patients with gallbladder cancer(GBC) were further analyzed for demographic data,and type of operation,surgical morbidity and mortality,histopathological classification,and *** GBC was compared with suspected or preoperatively diagnosed *** primary endpoint was diseasefree survival(DFS).The secondary endpoint was the difference in DFS between patients previously treated with laparoscopic cholecystectomy and those who had oncological resection as first ***:Nineteen patients(11 women and eight men) were found to have *** male to female ratio was 1:1.4 and the mean age was 68 years(range:45-82 years).Preoperative diagnosis was made in 10 cases,and eight were diagnosed *** was suspected intraoperatively and confirmed by frozen *** ratio between incidental and nonincidental cases was 9/*** tumor node metastasis stage was:pTis(1),pT1a(2),pT1b(4),pT2(6),pT3(4),pT4(2);five cases with stageⅠa(T1 a-b);two with stageⅠb(T2 N0);one with stage Ⅱa(T3 N0);six with stage Ⅱb(T1-T3 N1);two with stage Ⅲ(T4 Nx Nx);and one with stage Ⅳ(Tx Nx Mx).Eighty-eight percent of the incidental cases were discovered at an early stage(≤Ⅱ).Preoperative diagnosis of the 19 patients with GBC was:GBC with liver invasion diagnosed by preoperative CT(nine cases),gallbladder abscess perforated into hepatic parenchyma and involving the transversal mesocolon and hepatic hilum(one case),porcelain gallbladder(one case),gallbladder adenoma(one case),and chronic cholelithiasis(eight cases).Every case,except one,with a T1b or more advanced invasi

关键词： Incidental gallbladder cancer Laparoscopic cholecystectomy Lymph nodes Hepatic resection Management Outcome

Relevance of Spike/Estrogen Receptor-αinteraction for endothelial-based coagulopathy induced by SARS-CoV-2

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Signal Transduction and Targeted Therapy 2023年第6期8卷 2459-2462页

作者： Silvia Stella Barbieri Franca Cattani Leonardo Sandrini Magda Maria Grillo Alessandra Amendola Carmen Valente Carmine Talarico Daniela Iaconis Gabriele Turacchio Miriam Lucariello Lucia Lione Erika Salvatori Patrizia Amadio Gloria Garoffolo Mariano Maffei Francesca Galli Andrea Rosario Beccari Giuseppe Sberna emanuele Marra Marica Zoppi Michael Michaelides Giuseppe Roscilli Luigi Aurisicchio Riccardo Bertini Marcello Allegretti Maurizio Pesce Centro Cardiologico Monzino IRCCSMilanoItaly Dompéfarmaceutici S.p.A. L’AquilaItaly Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani RomaItaly Institute of Experimental Endocrinology and Oncology“G.Salvatore”(IEOS) National Research CouncilNaplesItaly EXSCALATE DompéFarmaceutici S.p.ANapoliItaly Takis S.r.l. RomeItaly National Institute on Drug Abuse Intramural Research Program Baltimore21224MDUSA Johns Hopkins School of Medicine BaltimoreMDUSA Atreius S.a.s. L’AquilaItaly

Dear Editor,The severe coagulation syndrome in numerous organs is the major life-threatening conditions characterizing the acute infection by *** inflammation/dysfunction,platelet hyper-reactivity,generation of neutro... 详细信息

关键词： organs infection acute