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Could JC virus provoke metastasis in colon cancer?

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World Journal of Gastroenterology 2014年第42期20卷 15745-15749页

作者： emanuele Sinagra Dario Raimondo Elena Gallo Mario Stella Mario Cottone Ambrogio orlando Francesca Rossi emanuele orlando Marco Messina Giovanni Tomasello Attilio Ignazio Lo Monte Ennio La Rocca Aroldo Gabriele Rizzo Gastroenterology and Endoscopy Unit Fondazione Istituto San Raffaele-G Giglio Contrada Pietra Pollastra Pisciotto course in Surgical Biotechnology and Regenerative Medicine University of Palermo Euro-Mediterranean Institute of Science and Technology (IEMEST) Unit of Pathology Ospedali Riuniti Villa Sofia - Cervello University of Palermo DIBIMIS Unit of Internal Medicine Ospedali Riuniti Villa Sofia - Cervello University of Palermo Oncology Unit Fondazione Istituto San Raffaele-G Giglio Contrada Pietra Pollastra Pisciotto Department of Surgical and Oncological Disciplines School of Medicine University of Palermo Unità Operativa di Medicina interna e trapiantologia Ospedale San Raffaele

AIM: To evaluate the prevalence of John Cunningham virus(JC virus) in a small cohort of patients with colon cancer and to assess its presence in hepatic ***: Nineteen consecutive patients with histologically diagnosed colon cancer were included in our study, together with ten subjects affected by histologically and serologically diagnosed hepatitis C virus infection. In the patients included in the colon cancer group, JC virus was searched for in the surgical specimen; in the control group, JC virus was searched for in the hepatic biopsy. The difference in the prevalence of JC virus in the hepatic biopsy between the two groups was assessed through the χ2 ***: Four out of 19 patients with colon cancer had a positive polymerase chain reaction(PCR) test for JC virus, and four had liver metastasis. Among the patients with liver metastasis, three out of four had a positive PCR test for JC virus in the surgical specimen and in the liver biopsy; the only patient with liver metastasis with a negative test for JC virus also presented a negative test for JC virus in the surgical specimen. In the control group of patients with hepatitis C infection, none of the ten patients presented JC virus infection in the hepatic biopsy. The difference between the two groups regarding JC virus infection was statistically significant(χ2 = 9.55, P = 0.002).CONCLUSION: JC virus may play a broader role than previously thought, and may be mechanistically involved in the late stages of these tumors.

关键词： John Cunningham virus Colon cancer Me-tastasis

Decline of Traditional Landscape in a Protected Area of the Southwestern Alps:the Fate of Enclosed Pasture Patches in the Land Mosaic Shift

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Journal of Mountain Science 2014年第2期11卷 544-554页

作者： Matteo GARBARINO emanuele SIBONA emanuele LINGUA Renzo MOTTA Department of Agricultural Food and Environmental Sciences (D3A) Università Politecnica delle MarcheVia delle Brecce BiancheI-60131 AnconaItaly Department of Agriculture Forest and Food Sciences (DISAFA) University of Torino Via L. da Vinci 44 I-10095 Grugliasco TO Italy Department of Land and Agro-Forestry Systems (TESAF) University of Padova Agripolis Viale dell'Università 16 I-35020 Legnaro PD Italy

【Title】【Author】【Addresses】1Traditional landscape elements such as pasture patches enclosed in a forest matrix are progressively disappearing throughout the European Alps. We assessed the land mosaic shift of a protected area located in the western Italian Alps. In particular, the dynamics of pasture patches were studied at both landscape and stand level. Land-cover mapping through object-oriented analysis of historical aerial photographs was used to assess land-cover changes between 1954 and 2000. Spatial statistics were used to quantify landscape patterns, and field samplings within pasture patches were used to explore tree regeneration structure and composition. Our results showed a significant increase in the number of pasture patches caused by their fragmentation following forest expansion. The total surface area of pasture patches decreased by 43% and their core area decreased by 94%. The encroachment of trees on less accessible areas of the pasture patches caused a reduction of patch shape at landscape scale. The gap filling process started 40-50 years ago and began with an early invasion of light demanding species like sycamore maple （Acer pseudoplatanus L.） and common ash （Fraxinus excelsior L.）, followed by European beech （Fagus sylvatica L.） and secondarily silver fir （Abies alba Mill.）. Traditional land-use and population decline in the Pesio Valley led to a reduction in ecotone areas. A transition to a more homogeneous landscape is expected in the next decades. Given the cultural and productive nature of these mountain meadow-pasture communities, extensive livestock grazing systems could be used to manage their future conservation.

关键词： Landscape structure Secondary succession Historical ecology Pesio Valley Traditional land-use

Emerging and Innovative Materials for Hydropower Engineering Applications:Turbines,Bearings,Sealing,Dams and Waterways,and Ocean Power

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Engineering 2022年第1期8卷 148-158页

作者： emanuele Quaranta Peter Davies European Commission Joint Research Centre Ispra 21027Italy Marine Structures Laboratory IFREMER Centre BretagnePlouzané29280France

The hydropower sector is currently experiencing several technological *** technologies and practices are emerging to make hydropower more flexible and more *** materials have also been recently developed to increase performance,durability,and reliability;however,no systematic discussions can be found in the ***,in this paper,novel materials for hydropower applications are presented,and their performance,advantages,and limitations are *** example,composites can reduce the weight of steel equipment by 50%to 80%,polymers and superhydrophobic materials can reduce head losses by 4%to 20%,and novel bearing materials can reduce bearing wear by 6%.These improvements determine higher efficiencies,longer life span,waste reduction,and maintenance needs,although the initial cost of some materials is not yet competitive with respect to the costs of traditional *** novel materials are described here based on the following categories:novel materials for turbines,dams and waterways,bearings,seals,and ocean hydropower.

关键词： Bearing Composite Dam Hydropower Material Ocean Seal Turbine

Carbon sequestration in a bamboo plantation:a case study in a Mediterranean area

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Journal of Forestry Research 2024年第3期35卷 231-238页

作者： Tommaso Chiti emanuele Blasi Maria Vincenza Chiriaco Department for Innovation in Biological Agro-Food and Forest Systems(DIBAF)University of TusciaVia San C.De Lellis snc01100 ViterboItaly Foundation Euro-Mediterranean Center on Climate Change(CMCC) Division on Climate Change Impacts on AgricultureForests and Ecosystem Services(IAFES)Via Garbini5101100 ViterboItaly

In the Mediterranean region,despite bamboo being an alien species that can seriously alter plant and ani-mal biocoenosis,the area occupied by bamboo plantations continues to increase,especially for the purpose to seques-ter carbon(C).However,the C dynamics in the soil-plant system when bamboo is grown outside its native area are poorly *** we investigated the C mitigation potential of the fast-growing Moso bamboo(Phyllostachys edulis)introduced in Italy for climate-change *** analyzed aboveground(AGB)and belowground(as root/shoot ratio)biomass,litter and soil organic C(SOC)at O-15-and 15-30-cm depths in a 4-year-old bamboo plantation in comparison with the former annual cropland on which the bamboo was *** have an idea of the maximum C stored at an ecosystem level,a natural forest adjacent the two sites was also *** the plantation,C accumulation as AGB was stimulated,with 14.8±3.1 Mg C ha^(-1) stored in 3 years;because thinning was done to remove culms from the first year,the mean sequestration rate was 4.9 Mg C ha^(-1) a^(-1).The sequestration rates were high but comparable to other fast-growing tree species in Italy(e.g.,Pinus nigra).SOC was significantly higher in the bamboo plantation than in the cropland only at the 0-15 cm depth,but SOC stock did not *** 4 years were not enough time for a clear increase in SOC,or the high nutrient uptake by bamboos might have depleted the soil nutrients,thus inhibiting the soil organic matter formation by *** comparison,the natural forest had significantly higher C levels in all the *** C dynamics at an ecosystem level,the bamboo plantation on the former annual cropland led to substantial C removal from the atmosphere(about 12 Mg C ha^(-1) a^(-1)).However,despite the promising C sequestration rates by bamboo,its introduction should be carefully considered due to potential ecological problems caused by this species in overexploited environments such as the Med

关键词： Carbon sequestration Climate change mitigation Mediterranean area Moso bamboo Soil organic carbon

Unsupervised Electric Motor Fault Detection by Using Deep Autoencoders

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IEEE/CAA Journal of Automatica Sinica 2019年第2期6卷 441-451页

作者： emanuele Principi Damiano Rossetti Stefano Squartini Francesco Piazza the Department of Information Engineering Università Politecnica delle Marche Loccioni Group Angeli di Rosora IEEE

Fault diagnosis of electric motors is a fundamental task for production line testing, and it is usually performed by experienced human operators. In the recent years, several methods have been proposed in the literature for detecting faults automatically. Deep neural networks have been successfully employed for this task, but, up to the authors' knowledge, they have never been used in an unsupervised scenario. This paper proposes an unsupervised method for diagnosing faults of electric motors by using a novelty detection approach based on deep autoencoders. In the proposed method, vibration signals are acquired by using accelerometers and processed to extract LogMel coefficients as features. Autoencoders are trained by using normal data only, i.e., data that do not contain faults. Three different autoencoders architectures have been evaluated: the multilayer perceptron(MLP) autoencoder, the convolutional neural network autoencoder, and the recurrent autoencoder composed of long short-term memory(LSTM) units. The experiments have been conducted by using a dataset created by the authors, and the proposed approaches have been compared to the one-class support vector machine(OC-SVM) algorithm. The performance has been evaluated in terms area under curve(AUC) of the receiver operating characteristic curve, and the results showed that all the autoencoder-based approaches outperform the OCSVM algorithm. Moreover, the MLP autoencoder is the most performing architecture, achieving an AUC equal to 99.11 %.

关键词： Autoencoder convolutional neural networks electric motor fault detection long short-term memory neural networks novelty detection

Effect of stepover and torch tilting angle on a repair process using WAAM

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Advances in Manufacturing 2022年第4期10卷 541-555页

作者： Francesco Baffa Giuseppe Venturini Gianni Campatelli emanuele Galvanetto Department of Industrial Engineering University of FlorenceFlorenceItaly

To sustain the transition to a greener economy and greener manufacturing,it is necessary to develop new approaches and technologies to repair metal components;this will result in a drastic reduction in energy and material *** this study,wire arc additive manufacturing(WAAM)was used to deposit a layer of new material on an existing surface,with the objective of finding the optimal configuration that maximized the layer quality and material *** parameters considered are the stepover among the deposited beads and the inclination of the torch with respect to the repaired *** inclination angle is crucial when repairing complex surfaces,like those of a mold,owing to accessibility issues,the torch cannot be maintained orthogonal to the surfaces along the entire *** configurations were tested in order to assess the quality of the materials in terms of the presence of material voids,depth of penetration,and the heat affected zone(HAZ)and to understand the effects of these variables on the material efficiency and thickness of the repairing *** should be noted that by adopting deposition parameters set to have a low heat input,the use of a tilting angle has beneficial effects on the quality of the deposited layer and the process *** and geometrical measurements were carried out to assess the effect of these two variables depositing a layer of plain carbon steel.

关键词： Wire arc additive manufacturing(WAAM) Repairing·Torch inclination Stepover Remanufacturing

Capsule endoscopy in neoplastic diseases

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World Journal of Gastroenterology 2008年第34期14卷 5245-5253页

作者： Marco Pennazio emanuele Rondonotti Roberto de Franchis Division of Gastroenterology 2 Department of Gastroenterology and Clinical Nutrition S. Giovanni A.S. Hospital University of Milan IRCCS Policlinico MangiagalliRegina Elena Foundation Gastroenterology and Gastrointestinal Endoscopy Unit University of Milan IRCCS Policlinico MangiagalliRegina Elena Foundation Gastroenterology and Gastrointestinal Endoscopy Unit

Until recently, diagnosis and management of small-bowel tumors were delayed by the diffi culty of access to the small bowel and the poor diagnostic capabilities of the available diagnostic techniques. An array of new methods has recently been developed, increasing the possibility of detecting these tumors at an earlier stage. Capsule endoscopy (CE) appears to be an ideal tool to recognize the presence of neoplastic lesions along this organ, since it is non-invasive and enables the entire small bowel to be visualized. High- quality images of the small-bowel mucosa may be captured and small and ? at lesions recognized, without exposure to radiation. Recent studies on a large population of patients undergoing CE have reported small-bowel tumor frequency only slightly above that reported in previous surgical series (range, 1.6%-2.4%) and have also confirmed that the main clinical indication to CE in patients with small-bowel tumors is obscure gastrointestinal (GI) bleeding. The majority of tumors identified by CE are malignant; many were unsuspected and not found by other methods. However, it remains difficult to identify pathology and tumor type based on the lesion’s endoscopic appearance. Despite its limitations, CE provides crucial information leading in most cases to changes in subsequent patient management. Whether the use of CE in combination with other new diagnostic (MRI or multidetector CT enterography) and therapeutic (Push- and-pull enteroscopy) techniques will lead to earlier diagnosis and treatment of these neoplasms, ultimately resulting in a survival advantage and in cost savings,remains to be determined through carefully-designed studies.

关键词： Capsule endoscopy Enteroscopy Obscure gastrointestinal bleeding Small-bowel tumors Polyposis syndromes

Injectable versus oral first-line multiple sclerosis therapies:knows and unknowns from observational studies

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Neural Regeneration Research 2022年第3期17卷 567-568页

作者： emanuele D’Amico Aurora Zanghì Carlo Avolio Department“G.F.Ingrassia” MS CenterUniversity of CataniaCataniaItaly Department of Medical and Surgical Sciences University of Foggia Multiple Sclerosis Center Department of NeurosciencesPoliclinico Riuniti HospitalFoggiaItaly

The approval of oral disease modifying therapies(DMTs) for relapsing-remitting multiple sclerosis(RRMS) has changed considerably the therapeutic scenario and they often represent the first therapeutic choice for patie... 详细信息

关键词： al. therapies sclerosis

Comparison of smart panels for tonal and broadband vibration and sound transmission active control

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International Journal of Smart and Nano Materials 2020年第4期11卷 431-484页

作者： Paolo Gardonio emanuele Turco Loris Dal Bo Dipartimento Politecnico Di Ingegneria E Architettura UniversitàDegli Studi Di UdineUdineItaly

This paper presents a comprehensive overview of the principal features of smart panels equipped with feed-forward and feedback systems for the control of the flexural response and sound transmission due respectively to tonal and to stochastic broadband *** smart panels are equipped with two types of actuators:first,distributed piezoelectric actuators formed either by small piezoelectric patches or large piezoelectric films bonded on the panels and second,point actuators formed by proof-mass electromagnetic ***,the panels encompass three types of sensors:first,small capacitive microphone sensors placed in front of the panels;second,distributed piezoelectric sensors formed by large piezoelectric films bonded on the panels and third point sensors formed by miniaturized *** proposed systems implement both single-channel and multi-channel feed-forward and feedback control *** study shows that,the vibration and sound radiation control performance of both feed-forward and feedback systems critically depends on the sensor-actuator configurations.

关键词： Active structural acoustic control active vibration control feed-forward control feedback control piezoelectric transducers proof-mass electromagnetic actuators