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Urinary polyomavirus infections in neurodevelopmental disorders

Open Journal of Psychiatry 2013年第2期3卷 18-25页

作者： Ivan Gentile Laura Altieri Carla Lintas Roberto Sacco Paolo Curatolo Arianna Benvenuto Filippo Muratori Elisa Santocchi Carmela Bravaccio Carlo Lenti Raffaella Faggioli Roberto Rigardetto Marina Gandione Giuseppe Portella emanuela Zappulo Guglielmo Borgia Antonio M. Persico Department of Child Neurology and Psychiatry I.R.C.C.S. “Stella Maris” University of Pisa Pisa Italy Department of Child Neuropsychiatry University “Tor Vergata” Rome Italy Department of Child Neuropsychiatry University of Milan Italy Department of Child Neuropsychiatry University of Turin Turin Italy Department of Clinical Medicine and Surgery University of Naples “Federico II” Naples Italy Department of Experimental Neurosciences I.R.C.C.S. “Fondazione Santa Lucia” Rome Italy Department of Translational Medical Science University “Federico II” Naples Italy Fondazione Teda per l’Autismo ONLUS Turin Italy Mafalda Luce Center for Pervasive Developmental Disorders Milan Italy Unit of Child and Adolescent Neuropsychiatry Laboratory of Molecular Psychiatry and Neurogenetics University “Campus Bio- Medico” Rome Italy

We have recently reported enhanced frequencies of polyomavirus infection in post-mortem brain tissue of autistic patients compared to controls. To further explore potential contributions to neurodevelopmental disorders by polyomaviruses, we have employed specie-specific TaqMan assays to assess the prevalence and titres of BKV, JCV and SV40 inthe urines of 87 patients with autism spectrum disorder, 84 controls matched by sex and age with the autistic sample, 15 subjects with Down syndrome and 13 fragile X individuals. Prevalence rates of urinary BKV infection were significantly greater in Down syndrome and fragile X patients compared to autistic and control individuals (P < 0.01). In a large majority of patients who showed the presence of urinary genomes, viral titres resulted significantly higher among Down syndrome patients (P < 0.01) compared to controls, autism spectrum disorder and fragile X individuals, who did not significantly differ from each other. Our results are consistent with previous evidence supporting hampered immunological surveillance and/or immune deficits in fragile X and especially in Down syndrome patients.

关键词： Autism BKV Down Syndrome Fragile X Syndrome JCV SV40

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Transcranial magnetic stimulation as a new tool to control pain perception

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World Journal of Anesthesiology 2016年第1期5卷 15-27页

作者： emanuela Onesti Maria Cristina Gori Vittorio Frasca Maurizio Inghilleri Department of Neurology and Psychiatry University of Rome "Sapienza"

Treatment for chronic pain is frequently unsuccessful or characterized by side-effects. The high-frequency repetitive transcranial magnetic stimulation(HF-rTMS) has been suggested in the management of refractory chronic pain. Various studies have shown that HF-rTMS sessions of long-duration applied at primary motor cortex induce pain relief through mechanisms of plastic changes. Efficacy of r TMS mostly depends on stimulation parameters, but this aspect requires better characterization. A rationale to target other cortical areas exists. Current data are promising, but a careful analysis of stimulation settings and maintenance treatment design are need.

关键词： Transcranial magnetic stimulation Repetitive transcranial magnetic stimulation Neuropathic pain Non-neuropathic pain Chronic pain Neuromodulation

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“海上丝绸之路”沿线国家插画艺术欣赏(67)

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青年博览 2021年第7期 F0002-F0002页

作者： [意大利]emanuela Cafferini 不详

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Public Initiatives Aiming at the Cycling System in a City in Southern Brazil

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Journal of Civil Engineering and Architecture 2021年第10期15卷 529-533页

作者： Marcela Juliana Cargnin Thaísa Leal da Silva emanuela Siqueira Alcindo Neckel Laércio Stolfo Maculan Lauro AndréRibeiro Postgraduate Program in Architecture and Urbanism(PPGARQ-IMED) Group of Studies and Research on Urban Mobility(NEPMOUR)Faculdade MeridionalIMEDPasso Fundo/RS 99070-220Brazil Group of Studies and Research on Urban Mobility(NEPMOUR) Faculdade MeridionalIMEDPasso Fundo/RS 99070-220Brazil

The discussion about the use of the bicycle as a means of transport has been gaining importance on a global scale,although countries like Brazil still have urban mobility difficulties caused by how urban densification occurs,the growing number of motor vehicles and the lack of space for the construction of cycle paths in *** general objective of this manuscript is to analyze the result of public policies aimed at the implementation of bicycle paths,with the“Passo Fundo Vai de Bici”Program created to investigate the variations in intensity in relation to the areas served by the current incentive for active cycling mobility in the city of Passo Fundo(South of Brazil).Methodologically,Google Earth Pro satellite images were used to map the existing bike paths in the ***,geographic coordinate points and altitudes of specific locations on the bike paths and bike sharing stations were collected,generating a database,transferred to the Qgis 3.10 software for the preparation of heat *** results showed the lack of integration between the cycling systems analyzed by the distance factor,needing to encourage discussions about its expansion and functionality,consolidating it as an urban public policy of local functionality to foster sustainable transport.

关键词： Urban sustainability medium city quality of life cycling mobility public policy.

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免疫疗法联合立体定向放疗治疗非小细胞肺癌脑转移:一项AIRO多中心回顾性研究

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中国肺癌杂志 2022年第4期25卷 I0007-I0022页

作者： Silvia SCOCCIANTI emanuela OLMETTO Valentina PINZI Mattia Falchetto OSTI Rossella Di FRANCO Saverio CAINI Paola ANSELMO Paolo MATTEUCCI Davide FRANCESCHINI Cristina MANTOVANI Giancarlo BELTRAMO Francesco PASQUALETTI Alessio BRUNI Paolo TINI Emilia GIUDICE Patrizia CIAMMELLA Anna MERLOTTI Sara PEDRETTI Marianna TRIGNANI Marco KRENGLI NiccolòGIAJ-LEVRA Isacco DESIDERI Guido PECCHIOLI Paolo MUTO Ernesto MARANZANO Laura FARISELLI Pierina NAVARRIA Umberto RICARDI Vieri SCOTTI Lorenzo LIVI 王绿化(翻译/校对) Radiation Oncology Unit Ospedale Santa Maria AnnunziataDepartment of OncologyBagno a RipoliFlorenceItaly Radiation Oncology Unit Azienda Ospedaliero Universitaria CareggiDepartment of Experimental and Clinical Biomedical Sciences"Mario Serio"FlorenceItaly U.O Radioterapia Fondazione IRCCS Istituto Neurologico Carlo BestaDepartment of NeurosurgeryMilanItaly U.O.C Radioterapia A.O.U Sant'Andrea Facolta Medicina e Psicologia Universita SapienzaDepartment of MedicineSurgery and Translational MedicineRomeItaly Istituto Nazionale Tumori IRCCS Fondazione G.PascaleDepartment of RadiotherapyNaplesItaly Institute for Cancer Research Prevention and Clinical Network(ISPRO)Cancer Risk Factors and Life-Style Epidemiology UnitFlorenceItaly Radiotherapy Oncology Center S.Maria HospitalDepartment of OncologyTerniItaly Humanitas Research Hospital Radiotherapy and Radiosurgery DepartmentRozzanoItaly Radiotherapy Unit Department of OncologyTurinItaly Cyberknife Centro Diagnostico Italiano Department of RadiologyMilanItaly Radiation Oncology Azienda Ospedaliero Universitaria PisanaDepartment of Translational MedicinePisaItaly Radiotherapy Unit University Hospital of ModenaDepartment of Oncology and HematologyModenaItaly Radiotherapy Unit University of SienaDepartment of Radiotherapy and OncologySienaItaly UOC di Radioterapia Policlinico Universitario Tor VergataDepartment of Onco-HaematologyRomeItaly Radioterapia Oncologica"G.Prodi "AO-IRCCS Arcispedale S.Maria NuovaDepartment of Oncology and Advanced TechnologyReggio EmiliaItaly Radiation Oncology A.S.O.S.Croce e Carle Department of Radiation OncologyCuneoItaly U.O.Radioterapia Oncologica Department of Radiation OncologyASST Spedali Civili di Brescia e Universita degli studi di BresciaBresciaItaly U.O.C.Radioterapia Oncologica Ospedale Clinicizzato SS Annunziata-Universita Chieti G.D'AnnunzioDepartment of Radiation OncologyChietiItaly Radiation Oncology University Hospital Maggiore della CaritdDepartment of Translational Medicine

背景与目的通过意大利放射治疗和临床肿瘤学学会(Italian Association of Radiotherapy and Clinical Oncology, AIRO)的一项多中心回顾性研究,明确免疫疗法(immunotherapy, IT)和立体定向放疗(stereotactic radiotherapy,SRT)包括放射外科治疗(radiosurgery, RS)或大分割立体定向放疗(hypofractionated stereotactic radiotherapy, HFSRT)治疗非小细胞肺癌(non-small cell lung cancer, NSCLC)脑转移的疗效和毒性。方法对来自19个意大利中心接受SRT+IT的NSCLC伴脑转移患者进行分析,并与单独接受SRT的对照组患者进行比较。结果共纳入SRT+IT组100例和单独SRT组50例。接受SRT+IT的患者有更长的颅内局部无进展生存期(intracranial local progression-free survival, i LPFS)(经倾向性评分调整后,P=0.007)。在诊断为脑转移时接受IT合并有颅外进展的患者中(n=24),接受SRT后再进行IT与较好的总生存期(overall survival, OS)相关(P=0.037)。多因素分析显示组织学类型为非腺癌、卡氏体能状态(Karnofsky performance status,KPS)评分=70分以及接受HFSRT与显著减少的生存期相关(P值分别为0.019、0.017和0.007)。与SRT和IT治疗间隔>7天(n=10)相比,治疗间隔≤7天(n=90)与更长的OS相关(经倾向性评分调整后,P=0.008)。联合治疗耐受性良好。在放射性坏死方面,接受SRT+IT的患者与单独SRT的患者无显著差异。SRT和IT的治疗间隔对毒性发生率无影响。结论 SRT+IT是一种安全的联合治疗方法,与单独SRT相比,具有更长的i LPFS。

关键词：立体定向放疗回顾性研究脑转移倾向性评分临床肿瘤学免疫疗法放射治疗

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‘Les liaisons dangereuses’: Hepatitis C, Rituximab and B-cell non-Hodgkin’s lymphomas

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2012年第2期3卷 21-28页

作者： Massimo Marignani Michela di Fonzo Paola Begini Elia Gigante Ilaria Deli Adriano M Pellicelli Sara Gallina emanuela de Santis Gianfranco Delle Fave M Christina Cox Department of Digestive and Liver Disease School of Medicine and Psychology University "Sapienza" Azienda Ospedaliera S. Andrea Via Grottarossa 1035-1039 00189 Rome Italy Liver Unit Azienda Ospedaliera San Camillo Forlanini 000149 Rome Italy Department of Haematology School of Medicine and Psychology University "Sapienza" Azienda Ospedaliera S. Andrea Via Grottarossa 1035-1039 00189 Rome Italy

Rituximab has provided a revolutionary contribution to the treatment of B-cell non-Hodgkin’s lymphomas (NHL). A high prevalence of hepatitis C virus (HCV) infection has been described in B-cell NHL patients. Cases of liver dysfunction in HCV-positive patients have been reported with Rituximab-containing regimens. In this paper we review the recent data regarding the effects of Rituximab in NHL patients with HCV infection. We also added a section devoted to improving communication between oncohaematologists and hepatologists. Furthermore, we propose a common methodological ground to study hepatic toxicity emerging during chemotherapy.

关键词： Rituximab B-cell non-Hodgkin’s lymphoma Hepatitis C virus Immunochemotherapy Methodology

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Geoctenologies Applied to Evolution in Urban Design in a City in Southern Brazil

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Journal of Civil Engineering and Architecture 2021年第10期15卷 541-545页

作者： Michele Bianchini Alcindo Neckel Maria Eduarda Cargnin Bade Laura Pasa Cambrussi emanuela Brandelero Siqueira Julian Grub Luana Pasquetti Paloma Toscan Henrique Aniceto Kujawa Isadora Cezar Caino Postgraduate Program in Architecture and Urbanism(PPGArq-IMED) Group of Studies and Research on Urban Mobility(NEPMOUR)Passo Fundo/RS 99070-220Brazil Postgraduate Program in Architecture and Urbanism(PPG Arq e Urb-UNISINOS) São Leopoldo/RS 93022-750Brazil University of Perugia Piazza Università1Perugia 06123Italy

The evolution process of urban design is the result of transformations due to population increase along the expansion of cities on a global *** applied to forms of mapping make it possible to understand the changes that have occurred in urban spaces in relation to temporal *** general objective of this study is to analyze the change that occurred from the year 2010 to 2021,in the evolution of urban design,in the city of Marau(southern Brazil).The identification of urban evolution in the years 2010 and 2021 was carried *** data were modeled using the QGIS software,in the SIRGAS(Geocentric Reference System for the Americas)database,related to the evolution of urban design in *** results demonstrate the need to apply geotechnologies not only in the city of Marau,but in other cities worldwide,because city halls need precision maps,avoiding the fragmentation of the urban fabric,a result of population expansion not projected in the built environment.

关键词： Urban evolution urban grid remote sensing urban design

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Negative association between trunk fat, insulin resistance and skeleton in obese women

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World Journal of Diabetes 2013年第2期4卷 31-39页

作者： emanuela A Greco Davide Francomano Rachele Fornari Chiara Marocco Carla Lubrano Vincenza Papa Francesca Wannenes Luigi Di Luigi Lorenzo M Donini Andrea Lenzi Antonio Aversa Silvia Migliaccio Department of Experimental Medicine Section of Medical Pathophysiology Endocrinology and Nutrition University "Sapienza"of Rome Department of Experimental Medicine Section of Medical Pathophysiology Endocrinology and Nutrition University "Sapienza" of Rome Unit of Endocrinology Department of Health Sciences University "Foro Italico" of Rome

AIM: To evaluate the potential interference of trunk fat (TF) mass on metabolic and skeletal metabolism. METHODS: In this cross-sectional study, 340 obese women (mean age: 44.8 ± 14 years; body mass index: 36.0 ± 5.9 kg/m 2 ) were included. Patients were evaluated for serum vitamin D, osteocalcin (OSCA), inflammatory markers, lipids, glucose and insulin (homeostasis model assessment of insulin resistance, HOMA-IR) levels, and hormones profile. Moreover, all patients underwent measurements of bone mineral density (BMD;at lumbar and hip site) and body composition (lean mass, total and trunk fat mass) by dual-energy X-ray absorptiometry. RESULTS: Data showed that: (1) high TF mass was inversely correlated with low BMD both at lumbar (P < 0.001) and hip (P < 0.01) sites and with serum vitamin D (P < 0.0005), OSCA (P < 0.0001) and insulin-like growth factor-1 (IGF-1; P < 0.0001) levels; (2) a positive correlation was found between TF and HOMA-IR (P < 0.01), fibrinogen (P < 0.0001) and erythrocyte sedimentation rate (P < 0.0001); (3) vitamin D levels were directly correlated with IGF-1 (P < 0.0005), lumbar (P < 0.006) and hip (P < 0.01) BMD; and (4) inversely with HOMA-IR (P < 0.001) and fibrinogen (P < 0.0005). Multivariate analysis demonstrated that only vitamin D was independent of TF variable. CONCLUSION: In obese women, TF negatively correlates with BMD independently from vitamin D levels. Reduced IGF-1 and increased inflammatory markers might be some important determinants that account for this relationship.

关键词： Obesity Skeleton Vitamin D Osteocalcin Insulin resistance Trunk fat Inflammation

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Right ventricular septal pacing: Safety and efficacy in a long term follow up

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World Journal of Cardiology 2015年第8期7卷 490-498页

作者： Eraldo Occhetta Gianluca Quirino Lara Baduena Rosaria Nappo Chiara Cavallino emanuela Facchini Paolo Pistelli Andrea Magnani Miriam Bortnik Gabriella Francalacci Gabriele Dell’Era Laura Plebani Paolo Marino Cardiology Department AOU Maggiore della Carità 28100 Novara Italy Cardiology Division P.O. SS. Annunziata 87100 Cosenza Italy Cardiology Division Ospedale SS. Trinità 28021 Borgomanero Italy Cardiology Division Ospedale S. Andrea 13100 Vercelli Italy Cardiology Division Ospedale Civile 10015 Ivrea Italy Cardiology Department AOU Maggiore della Carità 28100 Novara Italy

AIM: To evaluate the safety and efficacy of the permanent high interventricular septal pacing in a long term follow up, as alternative to right ventricular apical pacing. METHODS: We retrospectively evaluated:(1) 244 patients(74 ± 8 years; 169 men, 75 women) implanted with a single(132 pts) or dual chamber(112 pts) pacemaker(PM) with ventricular screw-in lead placed at the right ventricular high septal parahisian site(SEPTAL pacing);(2) 22 patients with permanent pacemaker and low percentage of pacing( 80%) right ventricular apical pacing(RVA). All patients had a narrow spontaneous QRS(101 ± 14 ms). We evaluated New York Heart Association(NYHA) class, quality of life(Qo L), 6 min walking test(6MWT) and left ventricular function(end-diastolic volume, LV-EDV; end-systolic volume, LVESV; ejection fraction, LV-EF) with 2D-echocardiography. RESULTS: Pacing parameters were stable duringfollow up(21 mo/patient). In SEPTAL pacing group we observed an improvement in NYHA class, Qo L score and 6MWT. While LV-EDV didn't significantly increase(104 ± 40 m L vs 100 ± 37 m L; P = 0.35), LV-ESV slightly increased(55 ± 31 m L vs 49 ± 27 m L; P = 0.05) and LV-EF slightly decreased(49% ± 11% vs 53% ± 11%; P = 0.001) but never falling < 45%. In the RVA pacing control group we observed a worsening of NYHA class and an important reduction of LV-EF(from 56% ± 6% to 43% ± 9%, P < 0.0001).CONCLUSION: Right ventricular permanent high septal pacing is safe and effective in a long term follow up evaluation; it could be a good alternative to the conventional RVA pacing in order to avoid its deleterious effects.

关键词： Right ventricular septal pacing Parahisian pacing Resynchronization therapy Left ventricular cardiac function Permanent cardiac pacing

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Migraine attack restores the response of vascular smooth muscle cells to nitric oxide but not to norepinephrine

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World Journal of Cardiology 2013年第10期5卷 375-381页

作者： Raffaele Napoli Vincenzo Guardasole emanuela Zarra An-tonietta De Sena Francesco Saccà Antonio Ruvolo Simona Grassi Speranza Giugliano Giovanna De Michele Antonio Cittadini Pietro Biagio Carrieri Luigi Saccà Department of Translational Medical Sciences Federico Ⅱ University School of Medicine Department of Neurology Federico Ⅱ University School of Medicine

AIM:To clarify whether the vasoconstrictory response is impaired and to study vascular function in patients with migraine during the headache ***:We studied vascular reactivity in the resistance arteries by using the forearm perfusion technique associated with *** measuredforearm blood flow by strain-gauge plethysmography during intra-brachial infusion of acetylcholine,sodium nitroprusside or norepinephrine in 11 controls and 13patients with migraine,11 of them(M) in the interval between the migraine attacks and 4 during a headache attack(MH).Written informed consent was obtained from patients and healthy controls,and the study was approved by the Ethics Committee of the University Federico Ⅱ.RESULTS:Compared to healthy control subjects,in patients with migraine studied during the interictal period,the vasodilating effect of acetylcholine,that acts through the stimulation of endothelial cells and the release of nitric oxide,was markedly reduced,but became normal during the headache attack(P0.05).CONCLUSION:In migrainers,the impaired relaxation of VSMCs is restored during the headache *** vasoconstrictory response is impaired and remains unchanged during the migraine attack.

关键词： Migraine Nitric oxide Endothelium Vascular smooth muscle cells

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