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Is GDNF to Parkinson’s disease what BDNF is to Huntington’s disease?

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Neural Regeneration Research 2024年第5期19卷 973-974页

作者： Francesca R.Fusco emanuela Paldino Laboratory of Neuroanatomy Fondazione Santa Lucia IRCCS HospitalRomeItaly

Neurotrophic factors,or neurotrophins,are a group of molecules supporting the growth,survival,and differentiation of developing and mature *** their role in the survival of neurons,and often of specific subsets of bra... 详细信息

关键词： Huntington supporting degenerative

Capital allocation for cash-subadditive risk measures:From BSDEs toBSVIEs

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Probability, Uncertainty and Quantitative Risk 2024年第3期9卷 339-370页

作者： emanuela Rosazza Gianin Marco Zullino Department of Statistics and Quantitative Methods University of Milano-Bicocca20126 MilanoItaly Department of Mathematics and Applications University of Milano-Bicocca20126 MilanoItaly

In the context of risk measures,the capital allocation problem is widely studied in the literature where different approaches have been developed,also in connection with cooperative game theory and systemic *** static capital allocation rules have been extensively studied in the recent years,only few works deal with dynamic capital allocations and its relation with ***,all those works only examine the case of an underneath risk measure satisfying cash-additivity and,moreover,a large part of them focuses on the specific case of the gradient allocation where Gateaux differentiability is *** main goal of this paper is,instead,to study general dynamic capital allocations associated to cash-subadditive risk measures,generalizing the approaches already existing in the literature and motivated by the presence of(ambiguity on)interest *** from an axiomatic approach,we then focus on the case where the underlying risk measures are induced by BSDEs whose drivers depend also on the *** this setting,we surprisingly find that the corresponding capital allocation rules solve special kinds of Backward Stochastic Volterra Integral Equations(BSVIEs).

关键词： Risk measures Capital allocation BSDE BSVIE Cash-subadditivity Subdifferential

Surgical management of tegmen defects of the temporal bone and meningoencephalic herniation: our experience

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Journal of Otology 2024年第1期19卷 30-34页

作者： Giuseppe De Donato emanuela Fuccillo Alberto Maria Saibene Elena Ferrari Giorgia Carlotta Pipolo Antonia Pisani Liliana Colletti Anastasia Urbanelli Luigi De Donato Giovanni Felisati Otorhinolaryngology Unit Head and Neck DepartmentASST Santi Paolo e Carlo HospitalVia Antonio di Rudinì820142MilanItaly Department of Health Sciences University of MilanVia Festa del Perdono720122MilanItaly Department of Biomedical Surgical and Dental SciencesUniversity of MilanVia Festa del Perdono720122MilanItaly ENT Unit Department of Surgical SciencesUniversity of TurinVia Verdi810124TurinItaly

1. Introduction The tegmental wall of the tympanic cavity is a thin plate of the temporal bone that separates the middle cranial fossa(MCF) from the ear. This anatomical region consists of two areas: an anterior one, comprised of the tegmen tympani(To′th et al., 2007), and a posterior one, formed by the tegmen antri and the tegmen mastoideum(Makki et al., 2011). In some patients, the tegmental region of the temporal bone can be interrupted, causing a tegmen defect(TD). A TD is sometimes associated with a meningoencephalic herniation(MEH), in which brain tissue herniates through a TD.

关键词： al. herniation bone

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深海环境海洋生态系统监测与修复新技术

Engineering 2024年第3期34卷 195-211页

作者： Jacopo Aguzzi Laurenz Thomsen Sascha Flögel Nathan J.Robinson Giacomo Picardi Damianos Chatzievangelou Nixon Bahamon Sergio Stefanni Jordi Grinyó emanuela Fanelli Cinzia Corinaldesi Joaquin Del Rio Fernandez Marcello Calisti Furu Mienis Elias Chatzidouros Corrado Costa Simona Violino Michael Tangherlini Roberto Danovaro Instituto de Ciencias del Mar(ICM-CSIC) Barcelona 08003Spain Stazione Zoologica Anton Dohrn Naples 80121Italy University of Gothenburg Göteborg 40530Sweden GEOMAR Helmholtz Centre for Ocean Research Kiel 24148Germany Fundación Oceanogràfic de la Comunitat Valenciana Valencia 46013Spain Royal Netherlands Institute for Sea Research(NIOZ) Den Burg Texel 1790 ABNetherlands Polytechnic University of Marche(UNIVPM) Ancona 60131Italy SARTI-MAR of the Universitat Politecnica de Catalunya(UPC) Vilanova i la Geltrú08800Spain Lincoln Institute for Agri-food Technology University of LincolnLincoln LN22LGUK Engitec Systems International Limited Limassol 3083Cyprus Consiglio per la Ricerca in Agricoltura e L’analisi Dell’economia Agraria(CREA) Centro di Ricerca Ingegneria e Trasformazioni AgroalimentariMonterotondo 00015Italy

The United Nations(UN)’s call for a decade of“ecosystem restoration”was prompted by the need to address the extensive impact of anthropogenic activities on natural *** ecosystem restoration is increasingly necessary due to increasing habitat degredation in deep waters(>200 m depth).At these depths,which are far beyond those accessible by divers,only established and emerging robotic platforms such as remotely operated vehicles(ROVs),autonomous underwater vehicles(AUVs),landers,and crawlers can operate through manipulators and multiparametric sensor arrays(e.g.,optoacoustic imaging,omics,and environmental probes).The use of advanced technologies for deep-sea ecosystem restoration can provide:①high-resolution three-dimensional(3D)imaging and acoustic mapping of substrates and key taxa,②physical manipulation of substrates and key taxa,③real-time supervision of remote operations and long-term ecological monitoring,and④the potential to work ***,we describe how robotic platforms with in situ manipulation capabilities and payloads of innovative sensors could autonomously conduct active restoration and monitoring across large spatial *** expect that these devices will be particularly useful in deep-sea habitats,such as①reef-building cold-water corals,②soft-bottom bamboo corals,and③soft-bottom fishery resources that have already been damaged by offshore industries(i.e.,fishing and oil/gas).

关键词： Ecosystem restoration Robotic manipulation Acoustic tracking Fishery resources Artificial reefs

Can cannabinoids be a potential therapeutic tool in amyotrophic lateral sclerosis？

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Neural Regeneration Research 2016年第12期11卷 1896-1899页

作者： Sabrina Giacoppo emanuela Mazzon IRCCS Centro Neurolesi"Bonino-Pulejo" Via Provinciale PalermoContrada CasazzaMessinaItaly

Amyotrophic lateral sclerosis（ALS） is the most common degenerative disease of the motor neuron system. Over the last years, a growing interest was aimed to discovery new innovative and safer therapeutic approaches in the ALS treatment. In this context, the bioactive compounds of Cannabis sativa have shown antioxidant, anti-inflammatory and neuroprotective effects in preclinical models of central nervous system disease. However, most of the studies proving the ability of cannabinoids in delay disease progression and prolong survival in ALS were performed in animal model, whereas the few clinical trials that investigated cannabinoids-based medicines were focused only on the alleviation of ALS-related symptoms, not on the control of disease progression. The aim of this report was to provide a short but important overview of evidences that are useful to better characterize the efficacy as well as the molecular pathways modulated by cannabinoids.

关键词： amyotrophic lateral sclerosis cannabinoids symptomatic ALS treatment experimental ALS model clinical trials mechanisms of neuroprotection

Interactional behaviors of the parasitic beetle Paussus favieri with its ant host Pheidole pallidula:the mimetic role of the acoustical signals

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Insect Science 2021年第2期28卷 548-554页

作者： Simone Fattorini emanuela Maurizi Andrea Di Giulio Department of Life Health and Environmental SciencesUniversity of L'AquilaL'AquilaItaly Research Centre for Plant Protection and Certification Council for Agricultural Research and Economics(CREA-DC)FlorenceItaly Department of Science LIMERoma Tre UniversityRomeItaly

The social parasitic beetle Puussus favieri(Coleoptera,Carabidae,Paussini)performs different types of stridulations,which sclectively mimic those emitted by dif-ferent ant castes of its host Pheidole pallidula(Hymenoptera,Formicidae,Myrmicinae).However,the significance of this acoustical mimicry for the success of the parasitic strat-egy and the behaviors elicited in the host ants by stridulations was *** reared Paussus favieri in Pheidole pallidula colonies and filmed their interacting *** analyzed in slow motion the behavior of ants near a stridulating *** analyzed sep-arately trains of pulse(Pa+Pb,produced by repeated rubbings)and single pulse(Pc,produced by a single rubbing)of stridulations,clearly recognizable from the shaking up and down of the beetle hind *** associated them with differcent ant *** full repertoire of sounds produced by P:favieri elicited benevolent responses both in workers and *** found that different signals elicit different(sometimes multiplc)bchaviors in ants,with different frequency in the two ant ***,Pc(alone or in conjunction with other types of pulses)appears to be the type of acoustic signal mostly responsible for all recorded *** results indicate that the acoustic channel plays a pivotal role in the host-parasite *** that a parasite uses the acoustical channel so intensively,and in such a complicated way to trigger ant bchaviors,indicates that acoustic signals may be more important in ant societies than commonly recognized.

关键词： acoustical channel ant castes beetle-ant interactions behavioral repertoire social parasites stridulation

Hyperkalemia in Patients on Peritoneal Dialysis: Clinical Use Experience with New Potassium-Binders

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Open Journal of Nephrology 2024年第3期14卷 324-333页

作者： Gennaro Argentino Mario Iorio Alessandra Antonia Mele Andrea Camocardi Enrica emanuela Cascone Maria Elena Liberti Adelia Sagliocca Andrea Pota Luigi Russo Maria Luisa Sirico Germano Terzini Michele Cavasso Chiara Mennillo Francesca Nettuno Raffaele Genualdo Giuseppe Surfaro Lucia Di Micco UOC Nefrologia e Dialisi Ospedale del Mare Naples Italy UOC Chirurgia Generale Ospedale del Mare Naples Italy

Background: Patients with end-stage kidney disease (ESKD) on maintenance dialysis have a high risk of developing hyperkalemia. In addition to traditional approaches, a new option for the management of patients on dialysis includes the use of a potassium binder, sodium zirconium cyclosilicate (SZC). We evaluated the effect and safety of SZC in patients with chronic PD. Objective: To present a case series that illustrates the real-world use of new potassium-binders in hyperkalemic patients on peritoneal dialysis. Methods: This case series collected 9 patients on PD with baseline potassium values > 5.5 mmol/l and who were treated with SZC 5 g once a day. Data were collected at baseline and at 1, 2, and 3 months after initiation of treatment. Results: The median age of patients was 64.5 years and the median duration of observation was 90 ± 5 days. It was observed that median serum potassium decreased (5.8 mmol/l at baseline with a range of 5.8 mmol/L - 6.8 mmol/L versus 4.5 in the third month with a range of 3.6 mmol/L - 5.3 mmol/L) after SZC treatment. Adverse events were observed in 2 (22.2%). The unique adverse event was constipation and presented in 2 patients (22.2%). Constipation was mild and transient during the observation period. No adverse events of special interest were reported. Conclusion: Normokalemia was established and maintained in this series of patients treated with SZC. No episodes of hyper- or hypo-kalemia were observed. SCZ had a good safety profile and was well tolerated over 3 months.

关键词： SZC Sodium Zirconium Cyclosilicate Hyperkalaemia Peritoneal Dialysis

Experience with intraoperative radiotherapy for breast cancer: the Geneva University Hospital's experience

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Chinese Journal of Cancer Research 2016年第4期28卷 463-466页

作者： emanuela Esposito Michael Douek Division of Cancer Studies King's College London Department of Breast Surgery Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione Giovanni Pascale"–IRCCS

Background Breast conserving surgery along with adjuvant radiotherapy is effective in terms of local control and survival for early- stage breast cancer （1）. External beam radiotherapy （EBRT） following breast conserving surgery has been shown to improve survival by preventing local recurrence, in the Early Breast Cancer Trialists＇ Collaborative Group meta-analysis （2）. Standard radiotherapy typically requires numerous fractions over a 3-5 week period and is performed weeks or months after surgery or chemotherapy.

关键词： IORT Experience with intraoperative radiotherapy for breast cancer the Geneva University Hospital’s experience

Climate policy and cross-border lending:evidence from the syndicated loan market

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Economic and Political Studies 2021年第4期9卷 463-476页

作者： emanuela Benincasa Department of Banking and Finance University of ZurichZurichSwitzerland Swiss Finance Institute ZurichSwitzerland

Do cross-country differences in climate policy influence bank lending?This paper focusses on the period 2007–2017 and uses syndicated loan-level data to examine if the stringency of homecountry climate policies increases cross-border bank *** fixed effects allow us to disentangle loan demand from supply and to control for unobserved and observed loan and firm characteristics.I find evidence that a strict home-country climate policy is associated with an increase in banks’cross-border loan *** suggests that the transition to a low-carbon economy might be threatened if global coordination between governments is not enforced.

关键词： Cross-border lending climate policy syndicated loans