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免疫疗法联合立体定向放疗治疗非小细胞肺癌脑转移:一项AIRO多中心回顾性研究

中国肺癌杂志 2022年第4期25卷 I0007-I0022页

作者： Silvia SCOCCIANTI emanuela olmetto Valentina PINZI Mattia Falchetto OSTI Rossella Di FRANCO Saverio CAINI Paola ANSELMO Paolo MATTEUCCI Davide FRANCESCHINI Cristina MANTOVANI Giancarlo BELTRAMO Francesco PASQUALETTI Alessio BRUNI Paolo TINI Emilia GIUDICE Patrizia CIAMMELLA Anna MERLOTTI Sara PEDRETTI Marianna TRIGNANI Marco KRENGLI NiccolòGIAJ-LEVRA Isacco DESIDERI Guido PECCHIOLI Paolo MUTO Ernesto MARANZANO Laura FARISELLI Pierina NAVARRIA Umberto RICARDI Vieri SCOTTI Lorenzo LIVI 王绿化(翻译/校对) Radiation Oncology Unit Ospedale Santa Maria AnnunziataDepartment of OncologyBagno a RipoliFlorenceItaly Radiation Oncology Unit Azienda Ospedaliero Universitaria CareggiDepartment of Experimental and Clinical Biomedical Sciences"Mario Serio"FlorenceItaly U.O Radioterapia Fondazione IRCCS Istituto Neurologico Carlo BestaDepartment of NeurosurgeryMilanItaly U.O.C Radioterapia A.O.U Sant'Andrea Facolta Medicina e Psicologia Universita SapienzaDepartment of MedicineSurgery and Translational MedicineRomeItaly Istituto Nazionale Tumori IRCCS Fondazione G.PascaleDepartment of RadiotherapyNaplesItaly Institute for Cancer Research Prevention and Clinical Network(ISPRO)Cancer Risk Factors and Life-Style Epidemiology UnitFlorenceItaly Radiotherapy Oncology Center S.Maria HospitalDepartment of OncologyTerniItaly Humanitas Research Hospital Radiotherapy and Radiosurgery DepartmentRozzanoItaly Radiotherapy Unit Department of OncologyTurinItaly Cyberknife Centro Diagnostico Italiano Department of RadiologyMilanItaly Radiation Oncology Azienda Ospedaliero Universitaria PisanaDepartment of Translational MedicinePisaItaly Radiotherapy Unit University Hospital of ModenaDepartment of Oncology and HematologyModenaItaly Radiotherapy Unit University of SienaDepartment of Radiotherapy and OncologySienaItaly UOC di Radioterapia Policlinico Universitario Tor VergataDepartment of Onco-HaematologyRomeItaly Radioterapia Oncologica"G.Prodi "AO-IRCCS Arcispedale S.Maria NuovaDepartment of Oncology and Advanced TechnologyReggio EmiliaItaly Radiation Oncology A.S.O.S.Croce e Carle Department of Radiation OncologyCuneoItaly U.O.Radioterapia Oncologica Department of Radiation OncologyASST Spedali Civili di Brescia e Universita degli studi di BresciaBresciaItaly U.O.C.Radioterapia Oncologica Ospedale Clinicizzato SS Annunziata-Universita Chieti G.D'AnnunzioDepartment of Radiation OncologyChietiItaly Radiation Oncology University Hospital Maggiore della CaritdDepartment of Translational Medicine

背景与目的通过意大利放射治疗和临床肿瘤学学会(Italian Association of Radiotherapy and Clinical Oncology, AIRO)的一项多中心回顾性研究,明确免疫疗法(immunotherapy, IT)和立体定向放疗(stereotactic radiotherapy,SRT)包括放射外科治疗(radiosurgery, RS)或大分割立体定向放疗(hypofractionated stereotactic radiotherapy, HFSRT)治疗非小细胞肺癌(non-small cell lung cancer, NSCLC)脑转移的疗效和毒性。方法对来自19个意大利中心接受SRT+IT的NSCLC伴脑转移患者进行分析,并与单独接受SRT的对照组患者进行比较。结果共纳入SRT+IT组100例和单独SRT组50例。接受SRT+IT的患者有更长的颅内局部无进展生存期(intracranial local progression-free survival, i LPFS)(经倾向性评分调整后,P=0.007)。在诊断为脑转移时接受IT合并有颅外进展的患者中(n=24),接受SRT后再进行IT与较好的总生存期(overall survival, OS)相关(P=0.037)。多因素分析显示组织学类型为非腺癌、卡氏体能状态(Karnofsky performance status,KPS)评分=70分以及接受HFSRT与显著减少的生存期相关(P值分别为0.019、0.017和0.007)。与SRT和IT治疗间隔>7天(n=10)相比,治疗间隔≤7天(n=90)与更长的OS相关(经倾向性评分调整后,P=0.008)。联合治疗耐受性良好。在放射性坏死方面,接受SRT+IT的患者与单独SRT的患者无显著差异。SRT和IT的治疗间隔对毒性发生率无影响。结论 SRT+IT是一种安全的联合治疗方法,与单独SRT相比,具有更长的i LPFS。

关键词：立体定向放疗回顾性研究脑转移倾向性评分临床肿瘤学免疫疗法放射治疗

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Can cannabinoids be a potential therapeutic tool in amyotrophic lateral sclerosis？

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Neural Regeneration Research 2016年第12期11卷 1896-1899页

作者： Sabrina Giacoppo emanuela Mazzon IRCCS Centro Neurolesi"Bonino-Pulejo" Via Provinciale PalermoContrada CasazzaMessinaItaly

Amyotrophic lateral sclerosis（ALS） is the most common degenerative disease of the motor neuron system. Over the last years, a growing interest was aimed to discovery new innovative and safer therapeutic approaches in the ALS treatment. In this context, the bioactive compounds of Cannabis sativa have shown antioxidant, anti-inflammatory and neuroprotective effects in preclinical models of central nervous system disease. However, most of the studies proving the ability of cannabinoids in delay disease progression and prolong survival in ALS were performed in animal model, whereas the few clinical trials that investigated cannabinoids-based medicines were focused only on the alleviation of ALS-related symptoms, not on the control of disease progression. The aim of this report was to provide a short but important overview of evidences that are useful to better characterize the efficacy as well as the molecular pathways modulated by cannabinoids.

关键词： amyotrophic lateral sclerosis cannabinoids symptomatic ALS treatment experimental ALS model clinical trials mechanisms of neuroprotection

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Interactional behaviors of the parasitic beetle Paussus favieri with its ant host Pheidole pallidula:the mimetic role of the acoustical signals

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Insect Science 2021年第2期28卷 548-554页

作者： Simone Fattorini emanuela Maurizi Andrea Di Giulio Department of Life Health and Environmental SciencesUniversity of L'AquilaL'AquilaItaly Research Centre for Plant Protection and Certification Council for Agricultural Research and Economics(CREA-DC)FlorenceItaly Department of Science LIMERoma Tre UniversityRomeItaly

The social parasitic beetle Puussus favieri(Coleoptera,Carabidae,Paussini)performs different types of stridulations,which sclectively mimic those emitted by dif-ferent ant castes of its host Pheidole pallidula(Hymenoptera,Formicidae,Myrmicinae).However,the significance of this acoustical mimicry for the success of the parasitic strat-egy and the behaviors elicited in the host ants by stridulations was *** reared Paussus favieri in Pheidole pallidula colonies and filmed their interacting *** analyzed in slow motion the behavior of ants near a stridulating *** analyzed sep-arately trains of pulse(Pa+Pb,produced by repeated rubbings)and single pulse(Pc,produced by a single rubbing)of stridulations,clearly recognizable from the shaking up and down of the beetle hind *** associated them with differcent ant *** full repertoire of sounds produced by P:favieri elicited benevolent responses both in workers and *** found that different signals elicit different(sometimes multiplc)bchaviors in ants,with different frequency in the two ant ***,Pc(alone or in conjunction with other types of pulses)appears to be the type of acoustic signal mostly responsible for all recorded *** results indicate that the acoustic channel plays a pivotal role in the host-parasite *** that a parasite uses the acoustical channel so intensively,and in such a complicated way to trigger ant bchaviors,indicates that acoustic signals may be more important in ant societies than commonly recognized.

关键词： acoustical channel ant castes beetle-ant interactions behavioral repertoire social parasites stridulation

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Experience with intraoperative radiotherapy for breast cancer: the Geneva University Hospital's experience

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Chinese Journal of Cancer Research 2016年第4期28卷 463-466页

作者： emanuela Esposito Michael Douek Division of Cancer Studies King's College London Department of Breast Surgery Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione Giovanni Pascale"–IRCCS

Background Breast conserving surgery along with adjuvant radiotherapy is effective in terms of local control and survival for early- stage breast cancer （1）. External beam radiotherapy （EBRT） following breast conserving surgery has been shown to improve survival by preventing local recurrence, in the Early Breast Cancer Trialists＇ Collaborative Group meta-analysis （2）. Standard radiotherapy typically requires numerous fractions over a 3-5 week period and is performed weeks or months after surgery or chemotherapy.

关键词： IORT Experience with intraoperative radiotherapy for breast cancer the Geneva University Hospital’s experience

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Climate policy and cross-border lending:evidence from the syndicated loan market

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Economic and Political Studies 2021年第4期9卷 463-476页

作者： emanuela Benincasa Department of Banking and Finance University of ZurichZurichSwitzerland Swiss Finance Institute ZurichSwitzerland

Do cross-country differences in climate policy influence bank lending?This paper focusses on the period 2007–2017 and uses syndicated loan-level data to examine if the stringency of homecountry climate policies increases cross-border bank *** fixed effects allow us to disentangle loan demand from supply and to control for unobserved and observed loan and firm characteristics.I find evidence that a strict home-country climate policy is associated with an increase in banks’cross-border loan *** suggests that the transition to a low-carbon economy might be threatened if global coordination between governments is not enforced.

关键词： Cross-border lending climate policy syndicated loans

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An Implicit Scheme for Moving Walls and Multi-Material Interfaces in Weakly Compressible Materials

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Communications in Computational Physics 2020年第1期27卷 116-144页

作者： emanuela Abbate Angelo Iollo Gabriella Puppo Universit`a degli Studi dell’Insubria via ValleggioComo 22100Italy Universit́e Bordeaux IMBUMR 5251F-33400 TalenceFrance Equipe-projet Memphis Inria Bordeaux-Sud OuestF-33400 TalenceFrance La Sapienza Universit`a di Roma Piazzale Aldo Moro00185 RomaItaly

We propose a numerical method for the simulation of flows from weakly compressible to low Mach regimes in domains with moving ***-miscible weakly compressible materials separated by an interface are included as *** scheme is fully implicit and it exploits the relaxation all-speed scheme introduced in[1].We consider media with significantly different physical properties and constitutive laws,as fluids and hyperelastic *** proposed numerical scheme is fully Eulerian and it is the same for all *** present numerical validations by simulating weakly compressible fluid/fluid,solid/solid and solid/fluid interactions.

关键词： Multi-material interfaces moving boundaries low Mach regime Eulerian elasticity

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Is GDNF to Parkinson’s disease what BDNF is to Huntington’s disease?

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Neural Regeneration Research 2024年第5期19卷 973-974页

作者： Francesca R.Fusco emanuela Paldino Laboratory of Neuroanatomy Fondazione Santa Lucia IRCCS HospitalRomeItaly

Neurotrophic factors,or neurotrophins,are a group of molecules supporting the growth,survival,and differentiation of developing and mature *** their role in the survival of neurons,and often of specific subsets of bra... 详细信息

关键词： Huntington supporting degenerative

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Subcellular localization of alpha-synuclein aggregates and their interaction with membranes

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Neural Regeneration Research 2018年第7期13卷 1136-1144页

作者： Fabiana Miraglia Alessio Ricci Lucia Rota emanuela Colla BioSNS Laboratory Scuola Normale Superiore Department of Pharmacy University of Pisa

For more than a decade numerous evidence has been reported on the mechanisms of toxicity of α-synuclein（αS） oligomers and aggregates in α-*** species were thought to form freely in the cytoplasm but recent reports of αS multimer conformations when bound to synaptic vesicles in physiological conditions,have raised the question about where αS aggregation *** this review we focus on recent literature regarding the impact on membrane binding and subcellular localization of αS toxic species to understand how regular cellular function of αS contributes to *** αS has been reported to mainly associate with specific membranes in neurons such as those of synaptic vesicles,ER/Golgi and the mitochondria,while toxic species of αS have been shown to inhibit,among others,neurotransmission,protein trafficking and mitochondrial *** interfering with αS membrane binding have shown to improve αS-driven toxicity in worms and in ***,a selective membrane binding that would result in a specific subcellular localization could be the key to understand how aggregation and pathology evolves,pointing out to αS functions that are primarily affected before onset of irreversible damage.

关键词： alpha-synuclein oligomers aggregates subcellular localization membranes binding Parkinson's disease neurodegeneration alpha-synucleinopathies

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Compositional Features of Fine Sediments Involved in the Montescaglioso Landslide(Southern Italy)

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Journal of Earth Science 2022年第6期33卷 1513-1525页

作者： Vito Summa Rosa Sinisi Eleonora Paris Agnese emanuela Bonomo National Research Council Institute of Methodologies for Environmental AnalysisC/da S.Loja 85050Tito ScaloItaly School of Science and Technology Geology DivisionUniversity of Camerino62032CamerinoItaly

This paper presents the multidisciplinary study of the southern Italy Plio-Pleistocene sediments involved in the large Montescaglioso *** principal aim of the work is to assess the compositional characters(i.e.,grain-size,mineralogy,petrography and geochemistry)and some rheological features(Atterberg’s limits,plasticity index and activity)of these sediments to enrich our knowledge about the Montescaglioso fine sediments and correlation among the lithological properties *** types of sediments,from a deep geognostic borehole and from the surrounding landslide area,were collected and *** significant compositional differences have been found between the core and landslide area ***,some changes have been detected in sediments along the ***,the-15 to-20 m lithostratigraphic level hosts the highest percentages of phyllosilicates and clay fraction(CF),commonly considered as possible hazard factors for the landslide *** more,in the studied core sediments,the CF contents correlate with the Atterberg’s liquid and plastic limits and a CF value of about 38%was suggested as threshold value for the changing of index properties of *** factors,such as the weathering degree and clay mineral type,do not show significant correlations with the rheological properties of sediments here studied.

关键词： grain-size mineralogy geochemistry index properties Plio-Pleistocene sediments

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Searching for Chinese Medicinal Plants in Greek Classical Medicine: A First Approach

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Chinese Medicine and Culture 2018年第1期1卷 40-45页

作者： Alain Touwaide emanuela Appetiti The Huntington San MarinoCA Institute for the Preservation of Medical Traditions WashingtonDCUSA

This article examines the presence and uses of plants attested in the Chinese medical tradition in the materia medica literature of classical *** is based on the consultation of the major ancient compilations on materia medica of Chinese medicine and classical antiquity,specifically Bencao Gangmu by Li Shizhen(16th cent.)and De materia medica by Dioscorides(1st cent.A.D.).The article is divided in three major parts:the identification of plants used in the Chinese medical tradition in the medicine of the Mediterranean World in Antiquity;the analysis of the knowledge of these plants and their origin in classical antiquity;a comparison of the uses of these plants in the Bencao Gangmu and De materia *** traces the presence of plants of the Chinese medical tradition in Classical *** their exact origin was not known,they were reputed at that time to be native to either India or the Black Sea,two areas that correspond to the ending points of the Silk *** for their uses in both traditions,they correspond for some plants,whereas they do not for others because either the uses attested in the Chinese tradition were not preserved on the Mediterranean or different uses appeared in the Mediterranean *** differentiated uses hint at both continuities and ruptures,with the latter resulting from the long journey of the plants from the Chinese World to the Mediterranean and,at the same time,attempts aimed to diversify and optimize the applications of non-native medicinal substances.

关键词： Apricot Bencao Gangmu Black Sea Caper spurge Cassia Classical antiquity Cucumber Dioscorides India Japanese rose Li Shizhen materia medica Mediterranean World rhubarb silk road spikenard Sweetflag

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