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Current concepts in the management of non-cirrhotic non-malignant portal vein thrombosis

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World journal of Hepatology 2024年第5期16卷 751-765页

作者： Adam j Willington Dhiraj Tripathi Department of Hepatology University Hospitals Birmingham NHS Foundation TrustBirmingham B152GWUnited Kingdom Department of Hepatology University Hospitals BirminghamBirmingham B152THUnited Kingdom

Non-cirrhotic non-malignant portal vein thrombosis(NCPVT)is an uncommon condition characterised by thrombosis of the portal vein,with or without extension into other mesenteric veins,in the absence of cirrhosis or intra-abdominal *** can include intestinal infarction,variceal bleeding and portal *** this article,we address current concepts in the management of NCPVT including identification of risk factors,classification and treatment,and review the latest evidence on medical and interventional management options.

关键词： Non-cirrhotic portal vein thrombosis Portal vein Mesenteric veins Venous thrombosis Portal hypertension

A multi-shot target wheel assembly for high-repetition-rate, laser-driven proton acceleration

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High Power Laser Science and Engineering 2024年第2期12卷 87-94页

作者： j.Penas A.bembibre D.Cortina-Gil L.Martin A.Reija C.Ruiz M.Seimetz A.Alejo j.benlliure Instituto Galego de Fisica de Altas Enerxias Universidade de Santiago de CompostelaSantiago de CompostelaSpain Laboratorio Laser de Aceleracion y Aplicaciones RIAIDTUniversidade de Santiago de CompostelaSantiago de CompostelaSpain Instituto Universitario de Física Fundamental y Matematicas y Dpto.de Didactica de la Matematica y de las Ciencias Experimentales Universidad de SalamancaSalamancaSpain Instituto de Instrumentación para Imagen Molecular(I3M) CSIC-Universitat Politecnica de ValenciaValenciaSpain

A multi-shot target assembly and automatic alignment procedure for laser–plasma proton acceleration at high repetition rate are *** assembly is based on a multi-target rotating wheel capable of hosting more than 5000 targets,mounted on a 3D motorized stage to allow rapid replenishment and alignment of the target material between laser *** automatic alignment procedure consists of a detailed mapping of the impact positions at the target surface prior to the irradiation that ensures stable operation of the target,which alongside the purpose-built design of the target wheel,enables operation at rates up to 10 *** and continuous laser-driven proton acceleration at 10 Hz is demonstrated,with observed cut-off energy stability about 15%.

关键词： high repetition rate laser-plasma acceleration multi-shot operation proton source target assembly

共享社会经济路径（SSP1～5）中国及分省经济预估数据集v2

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气候变化研究进展 2024年第4期20卷 498-503页

作者：杨聿铭翟建青苏布达景丞姜彤郭欢欢南京信息工程大学地理科学学院/灾害风险管理研究院中国气象局国家气候中心南京信息工程大学气候与环境治理研究院中国科学院新疆生态与地理研究所荒漠与绿洲生态国家重点实验室江苏第二师范学院地理科学学院

随着全球经济快速增长，特别是基于传统工业化模式的增长，增加了化石燃料的使用，造成气候变暖和极端天气事件增加[1]。在追求短期经济利益的压力下，一些政府可能忽视或延迟实施必要的环境保护和气候治理措施。加之快速城市化和工业...

随着全球经济快速增长，特别是基于传统工业化模式的增长，增加了化石燃料的使用，造成气候变暖和极端天气事件增加[1]。在追求短期经济利益的压力下，一些政府可能忽视或延迟实施必要的环境保护和气候治理措施。加之快速城市化和工业化导致对煤炭、石油等化石能源的需求激增，温室气体大量排放，气候进一步恶化，气候治理的难度加大。

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Isochrone Fitting of Galactic Globular Clusters—Ⅵ.High-latitude Clusters NGC 5024 (M53),NGC 5053,NGC 5272 (M3),NGC 5466,and NGC7099 (M30)

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Research in Astronomy and Astrophysics 2024年第6期24卷 170-190页

作者： G.A.Gontcharov S.S.Savchenko A.A.Marchuk C.j.bonatto O.S.Ryutina M.Yu.Khovritchev V.b.Il'in A.V.Mosenkov D.M.Poliakov A.A.Smirnov Central(Pulkovo)Astronomical Observatory Russian Academy of SciencesPulkovskoye chaussee 65/1St.Petersburg 196140Russia Saint Petersburg State University Universitetskij pr.28St.Petersburg 198504Russia Special Astrophysical Observatory Russian Academy of Sciences369167 Nizhnij ArkhyzRussia Departamento de Astronomia Instituto de FísicaUFRGSAv.Bento Gonçalves9500Porto AlegreRSBrazil Saint Petersburg University of Aerospace Instrumentation Bol.Morskaya ul.67ASt.Petersburg 190000Russia Department of Physics and Astronomy Brigham Young UniversityN283 ESCProvoUT 84602USA

We fit various color–magnitude diagrams(CMDs) of the high-latitude Galactic globular clusters NGC 5024(M53),NGC 5053,NGC 5272(M3),NGC 5466,and NGC 7099(M30) by isochrones from the Dartmouth Stellar Evolution Database and bag of Stellar Tracks and Isochrones for α–enrichment [α/Fe] = +*** the CMDs,we use data sets from Hubble Space Telescope,Gaia,and other sources utilizing,at least,25 photometric filters for each *** obtain the following characteristics with their statistical uncertainties for NGC 5024,NGC 5053,NGC 5272,NGC 5466,and NGC 7099,respectively:metallicities [Fe/H] =-1.93 ± 0.02,-2.08 ± 0.03,-1.60 ± 0.02,-1.95 ± 0.02,and-2.07 ± 0.04 dex with their systematic uncertainty 0.1 dex;ages 13.00 ± 0.11,12.70 ± 0.11,11.63 ± 0.07,12.15 ± 0.11,and 12.80 ± 0.17 Gyr with their systematic uncertainty 0.8 Gyr;distances(systematic uncertainty added) 18.22 ± 0.06 ± 0.60,16.99 ± 0.06 ± 0.56,10.08 ± 0.04 ± 0.33,15.59 ±0.03 ± 0.51,and 8.29 ± 0.03 ± 0.27 kpc;reddenings E(b-V) = 0.023 ± 0.004,0.017 ± 0.004,0.023 ± 0.004,0.023 ± 0.003,and 0.045 ± 0.002 mag with their systematic uncertainty 0.01 mag;extinctions AV= 0.08 ± 0.01,0.06 ± 0.01,0.08 ± 0.01,0.08 ± 0.01,and 0.16 ± 0.01 mag with their systematic uncertainty 0.03 mag,which suggest the total Galactic extinction AV= 0.08 across the whole Galactic dust to extragalactic objects at the North Galactic *** horizontal branch morphology difference of these clusters is explained by their different metallicity,age,mass-loss efficiency,and loss of low-mass members in the evolution of the core-collapse cluster NGC 7099 and loose clusters NGC 5053 and NGC 5466.

关键词： (stars:)Hertzsprung Russell and C-M diagrams (ISM:)dust extinction (Galaxy:)globular clusters:general (Galaxy:)globular clusters:individual(NGC 5024,NGC 5053,NGC 5272,NGC 5466,NGC7099)

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SARS-CoV-2 variants are associated with different clinical courses in children with MIS-C

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World journal of Pediatrics 2024年第2期20卷 143-152页

作者： Andres F.Moreno Rojas Emelia bainto Helen Harvey Adriana H.Tremoulet jane C.burns Kirsten b.Dummer Department of Pediatrics Division of Pediatric CardiologyUniversity of California San Diegoand Rady Children’s Hospital3020 Children’s Way MC 5004San DiegoCA 92123USA Kawasaki Disease Research Center La JollaCAUSA Department of Pediatrics Division of Pediatric Critical CareUniversity of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA Department of Pediatrics University of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA

background Recent infection with SARS‑CoV-2 in children has been associated with multisystem inflammatory syndrome in children(MIS-C).SARS‑CoV-2 has undergone different *** publications exist about specific variants and their correlation with the severity of *** This was a single-center,retrospective study including all patients admitted with MIS-C at Rady Children’s Hospital-San Diego between May 2020 and March *** epidemiologic data,including viral genomic information,were obtained from public ***,clinical presentation,laboratory values,and outcomes were obtained from electronic medical *** The analysis included 104 pediatric *** MIS-C waves were *** variants in San Diego during the first wave included clades 20A to *** the second wave,there were variants from clades 20A to C,20G,21C(Epsilon),20I(Alpha),and 20j(Gamma).The third wave had Delta strains(clades 21A,21I,and 21j),and the fourth had Omicron variants(clades 21K,21L,and 22C).MIS-C presented with similar symptoms and laboratory findings across all *** patients were admitted to the pediatric intensive care unit(PICU)(74%)and required inotropic support(63%)during the second *** of the patients required mechanical circulatory support,and only two required invasive ventilatory *** was no *** The various strains of SARS-CoV-2 triggered MIS-C with differing severities,with the second wave having a more severe clinical *** the differences in disease severity across variants were due to changes in the virus or other factors remains unknown.

关键词： Complications COVID-19 MIS-C SARS-CoV-2 variants

Interleukin-10 suppresses lipid metabolism-mediated intestinal inflammation

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Life Metabolism 2024年第3期3卷 3-5页

作者： Tristram A.j.Ryan Ivan Zanoni Division of Immunology and Division of Gastroenterology Boston Children’s Hospital and Harvard Medical SchoolBostonMA 02115United States

In a recent paper published in Nature,York et *** that the anti-inflammatory cytokine interleukin(IL)-10 regulates sphingolipid metabolism to limit NF-κb-mediated *** of Il10 in mice,or genetic mutation of IL10 in humans,predisposes to inflammatory bowel disease,which may be overcome by restoring homeostatic sphingolipid metabolism.

关键词： metabolism inflammation al.

Further investigation on the fusion of ^(6)Li with ^(209)bi target at near-barrier energies

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Chinese Physics C 2024年第7期48卷 106-117页

作者：张高龙焦振威张广鑫 M.R.Cortes 胡世鹏钱建强 D.Mengoni 屈卫卫李聪博郑云张焕乔孙慧斌王楠张春雷 j.j.Valiente-Dobón D.Testov M.Mazzocco A.Gozzelino C.Parascandolo D.Pierroutsakou M.La Commara A.Goasduff D.bazzacco D.R.Napoli F.Galtarossa F.Recchia A.Illana S.bakes I.Zanon S.Aydin G.de Angelis M.Siciliano R.Menegazzo S.M.Lenzi j.L.Ferreira j.Rangel Serkan Akkoyun L.F.Canto j.Lubian School of Physics Beihang UniversityBeijing 100191China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China Instituto de Física Universidade Federal Fluminense24210-340NiteróiRio de JaneiroBrazil Institute for Advanced Study in Nuclear Energy&Safety Shenzhen UniversityShenzhen 518060China Shenzhen Key Laboratory of Research and Manufacture of High Purity Germanium Materials and Fetectors Shenzhen UniversityShenzhen 518060China INFN Sezione di PadovaPadovaItaly Dipartimento di fisica Astronomia dell'Universita di padova PadovaItaly State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionSoochow UniversitySuzhou 215123China China Institute of Atomic Energy Beijing 102413China The Key Laboratory of beam Technology and Material Modification of Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China INFN Laboratori Nazionali di LegnaroI-35020 LegnaroItaly INFN Sezione di NapoliI-80126 NapoliItaly Dipartimento di Farmacia Universitàdi Napoli"Federico II"I-80131 NapoliItaly Department of Natural and Mathematical Sciences Faculty of EngineeringTarsus University33480 MersinTurkiye Physics Division Argonne National LaboratoryLemont-ILUSA Departamento de Matemaética Física e Computaç˜ao Universidade do Estado do Rio de JaneiroFaculdade de Tecnologia27537-000ResendeRio de JaneiroBrazil Department of Physics Sivas Cumhuriyet UniversitySivasTurkey Instituto de Física Universidade Federal do Rio de JaneiroCP 6852821941-972Rio de JaneiroBrazil

The complete and incomplete fusion cross sections for ^(6)Li+^(209)bi were measured using the in-beamγ-ray method around the Coulomb *** cross sections of(deuteron captured)incomplete fusion(ICF)products were re-quantified experimentally for this reaction *** results reveal that the ICF cross section is equivalent to that of complete fusion(CF)above the Coulomb barrier and dominant near or below the Coulomb barrier.A theoretical calculation based on the continuum discretized coupled channel(CDCC)method was performed for the aforementioned CF and ICF cross sections;the result is consistent with the *** universal fusion function(UFF)was also compared with the measured CF cross section for different barrier parameters,demonstrating that the CF suppression factor is significantly influenced by the choice of potential,which can reflect both dynamic and static effects of breakup on the fusion process.

关键词： cross section incomplete fusion suppression factor weakly bound nuclei

Mucopolysaccharidosis typeⅢb:a current review and exploration of the AAV therapy landscape

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Neural Regeneration Research 2024年第2期19卷 355-359页

作者： Courtney j.Rouse Victoria N.jensen Coy D.Heldermon Lacerta Therapeutics AlachuaFLUSA University of Florida College of Medicine GainesvilleFLUSA

Mucopolysaccharidoses typeⅢb is a rare genetic disorder caused by mutations in the gene that encodes for *** results in the aggregation of heparan sulfate polysaccharides within cell lysosomes that leads to progressive and severe debilitating neurological *** treatment options are expensive,limited,and presently there are no approved cures for mucopolysaccharidoses typeⅢ***-associated virus gene therapy has significantly advanced the field forward,allowing researchers to successfully design,enhance,and improve potential *** group recently published an effective treatment using a codon-optimized triple mutant adeno-associated virus 8 vector that restores N-acetyl-alpha-glucosaminidase levels,auditory function,and lifespan in the murine model for mucopolysaccharidoses typeⅢb to that seen in healthy ***,we review the current state of the field in relation to the capsid landscape,adeno-associated virus gene therapy and its successes and challenges in the clinic,and how novel adenoassociated virus capsid designs have evolved research in the mucopolysaccharidoses typeⅢb field.

关键词： adeno-associated virus central nervous system gene therapy heparan sulfate immune response mucopolysaccharidoses type IIIb N-acetyl-alpha-glucosaminidase newborn screening

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Low-carbon Development Path of Ordos based on LEAP Model

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Huanjing Kexue/Environmental Science 2024年第9期45卷 5097-5105页

作者： Yu Y.-W.-Q. Liu b. Zhu X.-H. Zhang j.-Y. Wang b.-H. Wang M.-P. Yang j.-G. bai Y. Yang F.-Y. School of Vehicle and Mobility Tsinghua University Beijing 100084 China Ordos Carbon Neutral Research and Application Co.，Ltd. Ordos 017004 China

To determine the low-carbon development path of Ordos，three scenarios（baseline scenario，low carbon scenario，and enhanced low carbon scenario）were constructed based on the LEAP model to forecast the energy demand and carbon emission in Ordos from 2020 to 2050 and to analyze the contribution of various policy initiatives to reduce carbon emission. The results showed that under the enhanced low carbon scenario，the energy demand in Ordos peaked at 52 million tons of standard coal equivalent in 2025 and decreased to 40 million tons of standard coal equivalent in 2050，and carbon emissions peaked at 163 million tons in 2025 and decreased to 16 million tons in 2050，which was 88% lower than that in 2020. Regarding emission reduction contribution，comparing the baseline scenario and the enhanced low-carbon scenario，the increase in renewable energy power generation installation，the reduction in energy consumption of terminal energy use，and the increase in terminal electrification rate contributed to the emission reductions of 43%，25%，and 24%，respectively. The Ordos should vigorously develop renewable energy and make full use of the rich endowment of wind and light resources；at the same time，it should promote economic transformation and gradually increase the proportion of high-value-added and low-energy-consuming industries in the industrial structure. For the power sector，the power generation structure should be adjusted. Traditional thermal power generation should be replaced by zero-carbon and low-carbon power generation technologies. For the industrial and transportation sectors，the terminal electrification rate should be increased，and the energy intensity should be reduced. © 2024 Science Press. All rights reserved.

关键词： carbon emission LEAP model Ordos City renewable energy generation scenario analysis