检索结果-南通市图书馆

Confidence Intervals for Relative Intensity of Collaboration(RIC)Indicators

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Data and Information Science 2022年第4期7卷 5-15页

作者： Joel emanuel Fuchs Lawrence Smolinsky Ronald Rousseau University of Wuppertal Gaußstr.20D-42119 WuppertalGermany Louisiana State University Department of MathematicsBaton RougeLos AngelesUSA University of Antwerp Faculty of Social SciencesMiddelheimlaan 1B-2020 AntwerpBelgium KU Leuven Facultair Onderzoekscentrum ECOOMNaamsestraat 61B-3000 LeuvenBelgium

Purpose:We aim to extend our investigations related to the Relative Intensity of Collaboration(RIC)indicator,by constructing a confidence interval for the obtained ***/methodology/approach:We use Mantel-Haenszel statistics as applied recently by Smolinsky,Klingenberg,and ***:We obtain confidence intervals for the RIC indicatorResearch limitations:It is not obvious that data obtained from the Web of Science(or any other database)can be considered a random *** implications:We explain how to calculate confidence *** indicators are more often than not presented as precise values instead of an approximation depending on the database and the time of *** approach presents a suggestion to solve this ***/value:Our approach combines the statistics of binary categorical data and bibliometric studies of collaboration.

关键词： Contingency tables Confidence intervals Relative intensity of collaboration(RIC) Mantel-Haenszel statistics Science of science

Synthesis,photoluminescence properties and thermal investigation by TG-MS of RE（DAS）3·xH2O(RE=Eu3+,Tb3+)

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2019年第11期37卷 1164-1169页

作者： Rodrigo V.Rodrigues Lukasz Marciniak Latif U.Khan Antonio A.L.Marins Robert Tomala emanuel J.b.Muri Jivaldo R.Matos Wieslaw Strek Institute of Chemistry University of Sao PauloButanta 74826077 Sao PauloBrazil Institute of Low Temperature and Structure Research Polish Academy of SciencesOkolna 250-422 WroclawPoland brazilian Nanotechnology National Laboratory(LNNano-CNPEM) Campinas 13083-100Sao PauloBrazil Department of Chemistry Federal University of Espirito SantoVitoria 29220-000Brazil

Rare earth(Ⅲ)diphenyl-4-amine sulfonates(RE(DAS)3·xH2O,RE=Eu^3+,Tb^3+)phosphors were synthesized by precursor method from barium diphenyl-4-amine sulfonate and rare earth ***,TG/DSC coupled to mass spectrometry(TG/DSC/MS),X-ray powder diffraction(XPD),scanning electron microscopy(SEM)and photo luminesce nce(PL)spectroscopy were utilized to structurally and morphologically characterize the *** decomposition of Eu(DAS)3·7H2O and Tb(DAS)3·2H2O at 973 K under dynamic air atmosphere results in crystalline Eu2O2SO4 and Tb2O2SO4 materials,***,MS spectra reveal the liberation of thermal decomposition products of precursors,largely as CO2,NO2 and SO2 *** diphenyl-4-amine sulfonate(DAS)ligand demonstrats a good stabilizing property for Eu^3+and Tb^3+*** Eu(DAS)3·7H2O and Tb(DAS)3·2H2O compounds display efficient red and green emissions,under UV excitation,arising from the 5D0→7FJ(J=0-4)and 5D4→7FJ(J=0-6)transitions of the Eu^3+and Tb^3+ions,respectively.

关键词： Optical properties Rare earth oxysulfate Thermal decomposition Eu(DAS)3·7H2O Tb(DAS)3·2H2O Rare earths

Measurement of calprotectin in ascitic fluid to identify elevated polymorphonuclear cell count

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第13期19卷 2028-2036页

作者： emanuel burri Felix Schulte Jürgen Muser Rémy Meier Christoph beglinger Gastroenterology and Hepatology University Hospital Basel Gastroenterology Hepatology and Clinical NutritionCantonal Hospital Central Laboratories Cantonal Hospital

AIM: To evaluate the diagnostic capability of calprotectin in ascitic fluid for detecting a polymorphonuclear (PMN) cell count > 250/μL ascites. METHODS: In this prospective observational study, a total of 130 ascites samples were analysed from 71 consecutive patients referred for paracentesis. Total and differential leukocyte cell counts were determined manually with a Neubauer chamber and gentianviolet stain. Calprotectin was measured in 1 mL ascetic fluid by enzyme-linked immunosorbent assay (ELISA) and a point-of-care (POC) lateral flow assay with the Quantum blue Reader (bühlmann Laboratories). All measurements were carried out in a central laboratory by senior personnel blinded to patient history. A PMN count > 250/μL was the primary endpoint of the study. The diagnostic value of ascitic calprotectin measurement was assessed by comparing to the final diagnosis of each patient that had been adjudicated by investigators blinded to calprotectin values. RESULTS: The PMN count was > 250/μL in 19 samples (14.6%) from 15 patients (21.1%) and varied widely among the study population (range 10-19 800/mL and 1-17 820/mL, respectively). Spontaneous bacterial peritonitis (SbP) was the final diagnosis in four patients (5.6%). All patients with PMN ≤ 250/μL had negative bacterial culture. PMN count was elevated in five patients with peritoneal carcinomatosis, three with lymphoma, one with neuroendocrine carcinoma, and two with secondary peritonitis due to abdominal perforation. PMN cell counts correlated with ascitic calprotectin values (Spearman's rho; r = 0.457 for ELISA, r = 0.473 for POC). A considerable range of ascitic calprotectin concentrations was detected by ELISA [median 0.43 μg/mL, interquartile range (IQR) 0.23-1.23 (range 0.10-14.93)] and POC [median 0.38 μg/mL, IQR 0.38-0.56 (range 0.38-13.31)]. Ascitic calprotectin levels were higher in samples with PMN > 250/μL, by both ELISA [median (IQR) 2.48 μg/mL (1.61-3.65) vs 0.10 μg/mL (0.10-0.36), P < 0.001] and POC

关键词： Calprotectin Ascites Liver cirrhosis Spontaneous bacterial peritonitis Polymorphonuclear cells

Understanding bark thickness variations for Araucaria angustifolia in southern brazil

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Forestry Research 2021年第3期32卷 1077-1087页

作者： emanuel Arnoni Costa Veraldo Liesenberg César Augusto Guimaraes Finger AndréFelipe Hess Cristine Tagliapietra Schons Graduate Program in Forest Engineering Santa Catarina State University(UDESC)LagesSC 88520-000Brazil Department of Forest Engineering Federal University of Uberlandia(UFU)Monte CarmeloMG 38500-000Brazil Graduate Program in Forest Engineering Federal University of Santa Maria(UFSM)Santa MariaRS 97105-900Brazil Graduate Program in Agroecosystems Federal Technological University of Parana(UFTPR)Dois VizinhosPR 85660-000Brazil

This study aimed to understand bark thickness variations of Araucaria angustifolia(bertol.)Kuntze trees growing in natural forest remnants in southern brazil,and their relationship with quantitative and qualitative *** thickness must be accurately estimated in order to determine timber volume *** is an important variable for the sustainable management and conservation of araucaria *** spite of its importance and visibility,bark thickness variations have not been evaluated for this key species in southern brazil.A total of 104 trees were selected,and their qualitative and quantitative attributes such as diameter at breast height(D_(bH)),height(H),crown base height(C_(bH)),crown length(C_(L)),social position(S_(P)),stoniness(S_(T)),position on the relief(P_(R)),vitality(V_T)and branch arrangement(b_(A))were *** trees were categorized into two groups:red bark or gray *** analysis and artificial neural networks(ANN)were used for modelling bark *** results indicate that:(1)bark thickness showed good correlation to D_(bH),with 0.76 as coefficient of determination(RS_P),0.540 as Mean Absolute Error(M_(AE))and 22.4 root-meansquare error in percentage(R_(MSE%));(2)the trend changed according to bark colour,with significant differences for the intersection(_0–Pr>F:p=0.0124)and slope(β_(1)–Pr>F:p=0.0126)of bark thickness curves between groups;(3)the highest correlation of bark thickness was found with:D_(bH)(ρ=0.88),H(ρ=0.58),C_(bH)(ρ=0.46),S_(P)(ρ=-0.52),and b_(A)(ρ=-0.32);(4)modelling with ANN confirmed high adjustment(R^(2)=0.99)and accuracy(R_(MSE%)=3.0)of the *** is an efficient and robust technique for the modelling of various qualitative and quantitative attributes commonly used in forest *** effective use of ANN to estimate araucaria bark in natural forests reinforces its potential,besides the possibility of application for other forest species.

关键词： Dendrometry attributes Crown characteristics Prediction models bark factor Parana-pine

Tissue-specific Gene Expression Changes Are Associated with Aging in Mice

在线全文

学校读者我要写书评

暂无评论

Genomics, Proteomics & bioinformatics 2020年第4期18卷 430-442页

作者： Akash Srivastava emanuel barth Maria A.Ermolaeva Madlen Guenther Christiane Frahm Manja Marz Otto W.Witte Hans-berger Department of Neurology University Hospital JenaFriedrich Schiller University Jena07747 JenaGermany bioinformatics/High Throughput Analysis Friedrich Schiller University Jena07743 JenaGermany FLI Leibniz Institute for Age Research 07745 JenaGermany

Aging is a complex process that can be characterized by functional and cognitive decline in an individual. Aging can be assessed based on the functional capacity of vital organs and their intricate interactions with one another. Thus, the nature of aging can be described by focusing on a specific organ and an individual itself. However, to fully understand the complexity of aging,one must investigate not only a single tissue or biological process but also its complex interplay and interdependencies with other biological processes. Here, using RNA-seq, we monitored changes in the transcriptome during aging in four tissues(including brain, blood, skin and liver) in mice at9 months, 15 months, and 24 months, with a final evaluation at the very old age of 30 *** identified several genes and processes that were differentially regulated during aging in both tissue-dependent and tissue-independent manners. Most importantly, we found that the electron transport chain(ETC) of mitochondria was similarly affected at the transcriptome level in the four tissues during the aging process. We also identified the liver as the tissue showing the largest variety of differentially expressed genes(DEGs) over time. Lcn2(Lipocalin-2) was found to be similarly regulated among all tissues, and its effect on longevity and survival was validated using its orthologue in Caenorhabditis elegans. Our study demonstrated that the molecular processes of aging are relatively subtle in their progress, and the aging process of every tissue depends on the tissue’s specialized function and environment. Hence, individual gene or process alone cannot be described as the key of aging in the whole organism.

关键词： Aging RNA-seq analysis Inflammaging Electron transport chain Tissue aging

Direct electrification of silicon microfluidics for electric field applications

在线全文

学校读者我要写书评

暂无评论

Microsystems & Nanoengineering 2023年第3期9卷 145-157页

作者： Diego Monserrat Lopez Philipp Rottmann Gabriel Puebla-Hellmann Ute Drechsler Marcel Mayor Sven Panke Martin Fussenegger emanuel Lörtscher IbM Research Europe-Zurich Säumerstrasse 4CH-8803 RüschlikonSwitzerland ETH Zürich Department of Biosystems Science and EngineeringMattenstrasse 264058 BaselSwitzerland University of basel Department of ChemistrySt.Johanns-Ring 19CH-4056 BaselSwitzerland Institute for Nanotechnology(INT) Karlsruhe Institute of Technology(KIT)P.O.Box 364076021 KarlsruheGermany University of basel Faculty of Life ScienceBaselSwitzerland

Microfluidic systems are widely used in fundamental research and industrial applications due to their unique behavior, enhanced control, and manipulation opportunities of liquids in constrained geometries. In micrometer-sized channels, electric fields are efficient mechanisms for manipulating liquids, leading to deflection, injection, poration or electrochemical modification of cells and droplets. While PDMS-based microfluidic devices are used due to their inexpensive fabrication, they are limited in terms of electrode integration. Using silicon as the channel material, microfabrication techniques can be used to create nearby electrodes. Despite the advantages that silicon provides, its opacity has prevented its usage in most important microfluidic applications that need optical access. To overcome this barrier, silicon-on-insulator technology in microfluidics is introduced to create optical viewports and channel-interfacing electrodes. More specifically, the microfluidic channel walls are directly electrified via selective, nanoscale etching to introduce insulation segments inside the silicon device layer, thereby achieving the most homogeneous electric field distributions and lowest operation voltages feasible across microfluidic channels. These ideal electrostatic conditions enable a drastic energy reduction, as effectively shown via picoinjection and fluorescence-activated droplet sorting applications at voltages below 6 and 15 V, respectively, facilitating low-voltage electric field applications in next-generation microfluidics.

关键词： injection walls overcome

In vitro 3D malignant melanoma model for the evaluation of hypericin-loaded oil-in-water microemulsion in photodynamic therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

bio-Design and Manufacturing 2022年第4期5卷 660-673页

作者： Hui LMa Wanlu Li Mian Wang Laudemir C.Varanda Janice R.Perussi Y.Shrike Zhang emanuel Carrilho Instituto de Química de São Carlos Universidade de São PauloUSPAv.Trabalhador São-carlenseSão CarlosSP 13566-590Brazil Instituto Nacional de Ciência e Tecnologia de bioanalítica INCTBioCampinasSP 13083-970Brazil Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMA 02139USA

Advances in biomimetic three-dimensional(3D) melanoma models have brought new prospects of drug screening and disease modeling, since their physiological relevancy for recapitulating in vivo tumor architectures is more accurate than traditional two-dimensional(2D) cell culture. Gelatin methacryloyl(GelMA) is widely used as a tissue-engineered scaffold hydrogel for 3D cell culture. In the present study, an in vitro 3D malignant melanoma model based on Gel MA was fabricated to evaluate the efficiency of hypericin(Hy)-loaded microemulsion(ME) in photodynamic therapy against melanoma. The ME was produced by the spontaneous emulsification method to enhance the bioavailability of Hy at tumor sites. Hy-loaded MEs were applied to a 3D malignant melanoma model made using 6% Gel MA and the co-culture of b16F10 and balb/c 3T3 cells,followed by crosslinking using violet light(403 nm). The observation revealed excellent cell viability and the presence of F-actin cytoskeleton network. Hy-loaded MEs exhibited higher phototoxicity and cell accumulation(about threefold) than free Hy, and the cells cultured in the 3D system displayed lower susceptibility(about 2.5-fold) than those in 2D *** findings indicate that the developed MEs are potential delivery carriers for Hy;furthermore, Gel MA hydrogel-based modeling in polydimethylsiloxane(PDMS) molds is a user-friendly and cost-effective in vitro platform to investigate drug penetration and provide a basis for evaluating nanocarrier efficiency for skin cancer and other skin-related diseases.

关键词： Malignant melanoma 3D cell culture Hypericin Microemulsion Photodynamic therapy

Promising drug targets and associated therapeutic interventions in Parkinson's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2021年第9期16卷 1730-1739页

作者： Sachchida Nand Rai Payal Singh Ritu Varshney Vivek K.Chaturvedi emanuel Vamanu M.P.Singh brijesh Kumar Singh Centre of biotechnology University of AllahabadPrayagrajIndia Department of Zoology Institute of ScienceBanaras Hindu UniversityVaranasiIndia Department of bioengineering and Chemistry Indian Institute of Technology GandhinagarPalajGujaratIndia Faculty of biotechnology University of Agronomic Science and Veterinary MedicineBucharestRomania Department of Pathology and Cell biology Columbia University Medical CenterNew YorkNYUSA

Parkinson's disease(PD) is one of the most debilitating brain diseases. Despite the availability of symptomatic treatments, response towards the health of PD patients remains scarce. To fulfil the medical needs of the PD patients, an efficacious and etiological treatment is required. In this review, we have compiled the information covering limitations of current therapeutic options in PD, novel drug targets for PD, and finally, the role of some critical beneficial natural products to control the progression of PD.

关键词： dopamine epigenetics gene therapies glutamate receptor levodopa molecular chaperones monoamine oxidase b mucuna alpha-synuclein Parkinson's disease striatum substantia nigra

Urbanization effects on the river systems in the bucharest City region(Romania)

在线全文

学校读者我要写书评

暂无评论

Ecosystem Health and Sustainability 2016年第11期2卷 20-38页

作者： Liliana Zaharia Gabriela Ioana-Toroimac Octavian Cocoş Florin Adrian Ghiţă emanuel Mailat Faculty of Geography University of Bucharest1 Nicolae BălcescuSector 1Bucharest010041Romania Water Management System Ilfov-bucureşti Argeş-Vedea Water BranchNational Administration“Romanian Waters”294 Splaiul IndependenţeiSector 6Bucharest060031Romania Argeş-Vedea Water branch National Administration“Romanian Waters”6-8 Calea CâmpulungPiteştiArgeşCounty110147Romania

This article identifies and analyzes the effects of human pressures on the river systems,landscape,flow regime,and water quality in the bucharest region,the largest urbanized area in *** analyses focused on four streams crossing the bucharest region,namely the Dâmboviţa,Colentina,Argeş,and Sabar *** approach relied especially on three types of information:(1)spatial data;(2)hydrological data sets;and(3)water quality *** made a diachronic analysis of the available maps and ran classic statistical analysis of the data sets,as well as trend *** the same time,we compared the flows in natural(reconstituted)and modified(current)*** results showed that the stream system and its associated landscapes have considerably changed due to several engineering works(reservoirs,dams,channelization works,diversion canals,water intakes,etc.).Under these circumstances,the flow regime suffered changes that differed among the ***,the multiannual discharges of the Argeşand Dâmboviţa rivers did not exhibit significant changes,but only mitigated the monthly discharge *** the case of Sabar and Colentina,a significant increase of the annual and monthly discharges was identified,due to the water transferred from the neighboring *** quality worsened,especially on the lower courses of the Dâmboviţa and Argeşrivers,degrading the states and health of the aquatic ecosystems in the study region.

关键词： aquatic ecosystems bucharest region ecological state ecosystem health engineering works flow regime river system Romania urbanization water quality