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Use of Basal Serum Testosterone Level as Predictor for Poor Ovarian Response in Women with Unexplained Infertility Undergoing <i>In Vitro</i>Fertilization Cycle: Prospective Study

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Open Journal of Obstetrics and Gynecology 2018年第14期8卷 1520-1531页

作者： Waleed m. khalaf Hayam Fathy Sarah Safwat Faculty of medicine Ain Shams University Cairo Egypt

Background: Delayed pregnancy in women and marked increase in the numbers of older women who fail to respond to ovarian stimulation had been a significant issue. This study aims to assess the value of basal serum testosterone level as a predictor of ovarian response for induction of ovulation in women with unexplained infertility undergoing IVF (in vitro fertilization) cycle. Patients and methods: A prospective study was conducted in Ain Shams University maternity hospital Infertility Center during a period of time from October 2016 to June 2017. This study recruited 89 women. On day 2 or 3 of a spontaneous menstrual cycle of the included women within 3 months before fresh IVF cycle, basal hormonal (FSH, LH, estradiol, total testosterone) concentrations, AFC (antral follicle count) were performed. Using the Long-protocol for induction of ovulation, serial monitoring of ovarian response was assessed by transvaginal ultrasound. When the expected ovarian response was reached (at least three oocytes ≥ 17 mm), we gave trigger dose of HCG. Ultrasound guided oocyte aspiration was performed 34 - 36 hours later. Two to three days after oocyte aspiration, we transferred the embryos according to the patient’s age and the condition of embryos available. Biochemical pregnancy was considered if serum B-hCG test was positive at day 14 from embryo transfer, where all the data were correlated with serum testosterone level and ovarian response as 1 ry outcome. Results: There were significant positive correlations between testosterone and LH, Prolactin, AFC, Number of oocytes & Number of Embryos (0.014, 0.032, 0.023, 0.004, 0.033, p 0.001 respectively). Poor responders versus good responders as regards testosterone level (0.81 ± 0.47 versus 1.08 ± 0.45) Fertilized & pregnant cases had significantly higher testosterone than non-fertilized & non pregnant had (1.20 ± 0.45, 0.92 ± 0.47 p value 0.035, 0.021 respectively). Yet, testosterone had significant low diagnostic performance in pred

关键词： Testosterone Induction Ovarian Reserve Pregnancy

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Radiological Doses and Risk Assessment of NORm Scrap metal by Using RESRAD-RECYCLE Computer Code

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Open Journal of modelling and Simulation 2014年第2期2卷 34-42页

作者： Amaal A. Tawfik eman m. Ahmed Radiation Protection Department Nuclear and Radiological Regulatory Authority Nasr City Cairo Egypt

In this work the radiological dose and risks resulting from recycling of radioactive contaminated NORm scrap metal that produced from one of oil and gas production companies in Egypt, were determined by using RESRAD-RECYCLE computer code. Two scenarios were used: the first was the workers’ scenario, while the second was end-use product scenario. Workers’ scenario was used in this study for evaluating the dose and risk to workers who process recycled materials. This scenario focused on the transport of radioactive NORm scrap metal from the place of origin to the smelter (scrap delivery step). Scenarios for six different workers were included under the scrap delivery step: two workers scrap cutter, two workers scrap loader, and two workers scrap truck driver. The values for each scenario were specified on the basis of processing 200 tons of NORm scrap metal. Because these operations occur before melting of the metal, mass and radionuclide partitioning factors were not applied in the scrap metal delivery step. The radionuclide concentration of the NORm scrap metal was used directly in the dose calculation. The maximum doses received from direct external exposure to all radio nuclides during cutter/sorter, scrap truck driver and unloading of scrap metals were 2.14E-04, 1.4E-06 and 1.86E-05 (mSv) respectively. The excess cancer risks for all radio nuclides during cutter/sorter of scrap metals reached 1.25E-07. Radiation exposures incurred by the scrap unloaders and scrap cutters/sorters were greater than those incurred by the other workers for their closer exposure distances and longer time.

关键词： NORm Scrap metals Risk Assessment Dose Assessment RESRAD-RECYCLE Radioactive Waste

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An Automated System for Early Prediction of miscarriage in the First Trimester Using machine Learning

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Computers, materials & Continua 2023年第4期75卷 1291-1304页

作者： Sumayh S.Aljameel malak Aljabri Nida Aslam Dorieh m.Alomari Arwa Alyahya Shaykhah Alfaris maha Balharith Hiessa Abahussain Dana Boujlea eman S.Alsulmi Department of Computer Science College of Computer Science and Information TechnologyImam Abdulrahman Bin Faisal UniversityP.O.Box 1982Dammam31441Saudi Arabia Computer Science Department College of Computer and Information SystemsUmm Al-Qura UniversityMakkah21955Saudi Arabia Department of Computer Engineering College of Computer Science and Information TechnologyImam Abdulrahman Bin Faisal UniversityP.O.Box 1982Dammam31441Saudi Arabia Department of Obstetrics and Gynecology College of MedicineImam Abdulrahman Bin Faisal UniversityDammamSaudi Arabia

Currently, the risk factors of pregnancy loss are increasing andare considered a major challenge because they vary between cases. The earlyprediction of miscarriage can help pregnant ladies to take the needed careand avoid any danger. Therefore, an intelligent automated solution must bedeveloped to predict the risk factors for pregnancy loss at an early stage toassist with accurate and effective diagnosis. machine learning (mL)-baseddecision support systems are increasingly used in the healthcare sector andhave achieved notable performance and objectiveness in disease predictionand prognosis. Thus, we developed a model to help obstetricians predictthe probability of miscarriage using mL. And support their decisions andexpectations about pregnancy status by providing an easy, automated way topredict miscarriage at early stages using mL tools and techniques. Althoughmany published papers proposed similar models, none of them used Saudiclinical data. Our proposed solution used mL classification algorithms tobuild a miscarriage prediction model. Four classifiers were used in this study:decision tree (DT), random forest (RF), k-nearest neighbor (KNN), andgradient boosting (GB). Accuracy, Precision, Recall, F1-score, and receiveroperating characteristic area under the curve (ROC-AUC) were used to evaluatethe proposed model. The results showed that GB overperformed the otherclassifiers with an accuracy of 93.4% and ROC-AUC of 97%. This proposedmodel can assist in the early identification of at-risk pregnant women to avoidmiscarriage in the first trimester and will improve the healthcare sector inSaudi Arabia.

关键词： miscarriage pregnancy abortion machine learning gradient boosting

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Fatty Acids Composition and Biodiesel Characterization of <i>Dunaliella salina</i>

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Journal of Water Resource and Protection 2013年第9期5卷 894-899页

作者： eman m. Fakhry Dahlia m. El maghraby Department of Botany and microbiology Faculty of Science Alexandria University Alexandria Egypt

This study discusses the perspectives regarding the green alga Dunaliella salina Toed for biodiesel manufacturing purposes. The alga was cultivated under controlled lab conditions. Biomass concentration at early stationary grown microalga was 2.6 mg/L dry weight, while the algal oil was about 27.1% of the biomass. Algal oil was esterified and analyzed using GLC technique. Fourteen fatty acid methyl esters were identified. The amount of saturated and unsaturated fatty ester fractions was 35% and 65% respectively. The physicochemical properties of fatty acids comprising biodiesel were discussed. However, culture optimization coupled with genetic improvement will definitely represent contributions to bring about innovation in oil hyper-producing D. salina that will ultimately meet with success.

关键词： Biodiesel Characterization Biomass Dunaliella salina Fatty Acids

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Launching a paradigm for first and redo-surgery in primary congenital glaucoma: institutional experience

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International Journal of Ophthalmology(English edition) 2019年第2期12卷 226-234页

作者： Tharwat H.mokbel eman m.El Hefney Sherein m.Hagras Amani E.Badawi manal A.Kasem Ahmed A.Al Nagdy Sherief E.El Khouly Walid m.Gaafar mansoura Ophthalmic Center Faculty of Medicine Mansoura University

AIm: To evaluate the outcome of the initial and the redo-surgeries for primary congenital glaucoma(PCG) correlated to its degree of severity. mETHODS: A retrospective study involved patients with PCG presented between 2010 and 2018. medical records were reviewed to assess the degree of the preoperative severity according to the intraocular pressure(IOP), corneal diameter and corneal edema. Success and failure rates were calculated for both first and redo-surgeries at 6 and 12 mo respectively then correlated to the severity of the cases. RESULTS: Complete records were retrieved for 272 eyes(153 patients) with PCG: 43 eyes were mild, 136 moderate and 93 severe. Combined trabeculotomy and trabeculectomy(CTT) had the highest success rate in moderate(96.4%) and severe cases(59.3%) while trabeculotomy had the highest success rate in mild cases(96.3%). medical records of 88 eyes(63 patients) with recurrent PCG were analyzed, most with severe presentation(59 eyes). Ahmed glaucoma valve(AGV) was used in 67(76%) eyes and augmented trabeculectomy in 21(24%) eyes. At 12 mo, there was no statistically significant difference between both surgeries in total success rate(P=0.256). For mild cases, success rate was 100% for both surgeries. Severe cases had higher success rates following AGV(87%) than augmented trabeculectomy(20%). Preoperative severity of the disease was an independent factor affecting the failure rate in secondary trabeculectomy but not in AGV. Patients younger than 24 mo had higher probabilities of failure following both redo-surgeries with hazard ratio =1.325 and 0.37 for augmented trabeculectomy and AGV respectively. CONCLUSION: Preoperative assessment of the severity of eyes with PCG helps in the selecting the optimal primary and secondary surgery. For first surgery, trabeculotomy is more effective in mild cases whereas; CTT and augmented subscleral trabeculectomy(SST) are appropriate for moderate and severe cases. AGV proved to be superior to augmented SST in

关键词： Ahmed glaucoma valve augmented trabeculectomy Egypt primary congenital glaucoma

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Cardiac stem cells: Current knowledge and future prospects

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World Journal of Stem Cells 2022年第1期14卷 1-40页

作者： Radwa A mehanna marwa m Essawy mona A Barkat Ashraf K Awaad eman H Thabet Heba A Hamed Hagar Elkafrawy Nehal A Khalil Abeer Sallam marwa A Kholief Samar S Ibrahim Ghada m mourad medical Physiology Department/Center of Excellence for Research in Regenerative medicine and Applications Faculty of MedicineAlexandria UniversityAlexandria 21500Egypt Oral Pathology Department Faculty of Dentistry/Center of Excellence for Research in Regenerative Medicine and ApplicationsFaculty of MedicineAlexandria UniversityAlexandria 21500Egypt Human Anatomy and Embryology Department/Center of Excellence for Research in Regenerative medicine and Applications Faculty of MedicineAlexandria UniversityAlexandria 21500Egypt Center of Excellence for Research in Regenerative medicine and Applications Faculty of MedicineAlexandria UniversityAlexandria 21500Egypt Histology and Cell Biology Department/Center of Excellence for Research in Regenerative medicine and Applications Faculty of MedicineAlexandria UniversityAlexandria 21500Egypt medical Biochemistry Department/Center of Excellence for Research in Regenerative medicine and Applications Faculty of MedicineAlexandria UniversityAlexandria 21500Egypt Forensic medicine and Clinical toxicology Department/Center of Excellence for Research in Regenerative medicine and Applications Faculty of MedicineAlexandria UniversityAlexandria 21500Egypt

Regenerative medicine is the field concerned with the repair and restoration of the integrity of damaged human tissues as well as whole *** the inception of the field several decades ago,regenerative medicine therapies,namely stem cells,have received significant attention in preclinical studies and clinical *** from their known potential for differentiation into the various body cells,stem cells enhance the organ's intrinsic regenerative capacity by altering its environment,whether by exogenous injection or introducing their products that modulate endogenous stem cell function and fate for the sake of ***,research in cardiology has highlighted the evidence for the existence of cardiac stem and progenitor cells(CSCs/CPCs).The global burden of cardiovascular diseases’morbidity and mortality has demanded an in-depth understanding of the biology of CSCs/CPCs aiming at improving the outcome for an innovative therapeutic *** review will discuss the nature of each of the CSCs/CPCs,their environment,their interplay with other cells,and their *** addition,important issues are tackled concerning the potency of CSCs/CPCs in relation to their secretome for mediating the ability to influence other ***,the review will throw the light on the clinical trials and the preclinical studies using CSCs/CPCs and combined therapy for cardiac ***,the novel role of nanotechnology in cardiac regeneration will be explored.

关键词： Cardiac stem and progenitor cells Cardiac stem cells’secretome Cardiac stem cells’niche and metabolism Nanotechnology Clinical trials Combined therapy

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multisystem inflammatory syndrome in pediatric COVID-19 patients:a meta-analysis

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World Journal of Pediatrics 2021年第2期17卷 141-151页

作者： eman A.Toraih mohammad H.Hussein Rami m.Elshazli Adam Kline Ruhul munshi Nasrin Sultana Sharven Taghavi mary Killackey Juan Duchesne manal S.Fawzy Emad Kandil Department of Surgery Tulane UniversitySchool of MedicineNew OrleansLAUSA Genetics Unit Department of Histology and Cell BiologyFaculty of MedicineSuez Canal UniversityIsmailiaEgypt Department of Biochemistry and molecular Genetics Faculty of Physical TherapyHorus University-EgyptNew Damietta 34517Egypt Tulane University School of MedicineNew OrleansLAUSA Division of Endocrine and Oncologic Surgery Department of SurgerySchool of MedicineTulane UniversityNew OrleansLA 70112USA Department of medicine Larkin Community HospitalFlorida.MiamiUSA Trauma/Acute Care and Critical Care Department of SurgeryTulane UniversitySchool of MedicineNew OrleansLAUSA Department of medical Biochemistry and molecular Biology Faculty of MedicineSuez Canal UniversityIsmailiaEgypt Department of Biochemistry College of MedicineNorthern Border UniversityArarKingdom of Saudi Arabia

Background We aimed to systematically review the clinical and laboratory features of patients with the multisystem inflam-matory syndrome in pediatrics diagnosed during the COVID-19 *** sources A literature search in Web of Science,Pubmed,Scopus,and Science Direct was made up to June 29,*** Analysis of 15 articles(318 COVID-19 patients)revealed that although many patients presented with the typical multisystem inflammatory syndrome in pediatrics,Kawasaki-like features as fever(82.4%),polymorphous maculopapular exanthema(63.7%),oral mucosal changes(58.1%),conjunctival injections(56.0%),edematous extremities(40.7%),and cervical lymphadenopathy(28.5%),atypical gastrointestinal(79.4%)and neurocognitive symptoms(31.8%)were also *** had elevated serum lactic acid dehydrogenase,D-dimer,C-reactive protein,procalcitonin,interleukin-6,troponin I levels,and *** 77.0%developed hypotension,and 68.1%went into shock,while 41.1%had acute kidney *** care was needed in 73.7%of cases;13.2%were intubated,and 37.9%required mechanical *** immunoglobulins and steroids were given in 87.7%and 56.9%of the patients,respectively,and anticoagulants were utilized in 67.0%.Pediatric patients were discharged after a hospital stay of 6.77 days on average(95%CI 4.93-8.6).Conclusions Recognizing the typical and atypical presentation of the multisystem inflammatory syndrome in pediatric COVID-19 patients has important implications in identifying children at *** cardiac and renal decompensation and early interventions in patients with multisystem inflammatory syndrome is critical to prevent further morbidity.

关键词： COVID-19 Kawasaki-like syndrome multisystem inflammatory syndrome in pediatrics SARS-CoV-2

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Fractional Order Generalized Thermoelastic Infinite medium with Cylindrical Cavity Subjected to Harmonically Varying Heat

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Engineering（科研） 2011年第1期3卷 32-37页

作者： Hamdy m. Youssef eman A. Al-Lehaibi 不详

In this work, a mathematical model of an elastic material with cylindrical cavity will be constructed. The governing equations will be taken into the context of the fractional order generalized thermoelasticity theory (Youssef 2010). Laplace transform and direct approach will be used to obtain the solution when the boundary of the cavity is exposed to harmonically heat with constant angular frequency of thermal vibration. The inverse of Laplace transforms will be computed numerically using a method based on Fourier expansion techniques. Some comparisons have been shown in figures to present the effect of the fractional order parameter and the angular frequency of thermal vibration on all the studied felids.

关键词： Thermoelasticity Generalized Thermoelasticity Fractional Order Cylindrical Cavity Harmonically Heat

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Anti-inflammatory and antioxidant potential capacities of AD-mSCs and Bm-mSCs in suppressing pancreaticβ-cells auto-immunity and apoptosis in rats with T1Dm induced model

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BIOCELL 2022年第3期46卷 745-757页

作者： SHADY G.EL-SAWAH FAYEZ ALTHOBAITI HANAN m.RASHWAN ADIL ALDHAHRANI mARWA A.ABDEL-DAYEm eman FAYAD REHAB m.AmEN EL SHAImAA SHABANA EHAB I.EL-HALLOUS Zoology Department Faculty of ScienceArish UniversityNorth SinaiEgypt Biotechnology Department Faculty of ScienceTaif UniversityTaifSaudi Arabia Clinical Laboratory Science Department Turabah University CollegeTaif UniversityTaifSaudi Arabia Department of Pharmacology and Biochemistry Faculty of PharmacyHorus University-EgyptNew DamiettaEgypt Biology Department College of ScienceUniversity of BishaBishaSaudi Arabia Fellow of Biochemistry Genetic UnitChildren HospitalFaculty of MedicineMansoura UniversityDakahlia GovernorateEgypt Biology Department Faculty of ScienceTaif UniversityTaifSaudi Arabia

Since Type 1 diabetes(T1Dm)occurs whenβ-cells mass is reduced to less than 20%of the normal level due to autoimmune destruction of cells resulting in the inability to secrete insulin,preservation or replenishment of the functionalβ-cells mass has become a major therapeutic focus for this diabetic type ***,this 4-week work plan was designed to determine which mesenchymal stem cells(mSCs)type is more appropriate to alleviate pancreatic hazards resulting from diabetes induction;via tracking a comparative study between mSCs derived from adipose tissue(AD-mSCs)and from bone marrow(Bm-mSCs)in management of T1Dm considering their immunomodulatory,anti-apoptotic and antioxidative *** were divided randomly into 4 groups;control,STZdiabetic(D),D+AD-mSCs,and D+Bm-mSCs *** stem cells types in this study were ***,both oxidative stress and antioxidant markers were evaluated using colorimetric analysis,while inflammatory,immune and apoptotic markers were assessed through flow cytometric *** showed that diabetic rats treated with either AD-mSCs or Bm-mSCs exhibited marked pancreatic antioxidant and anti-inflammatory activities that were able to initiate pancreatic immunomodulation and reducingβ-cells apoptotic death,thus,help to restore their normal insulin secretion and hypoglycemic ***,AD-mSCs injection was shown to be superior as a pancreatic regenerative tool in overcoming diabetes;owing to their marked antioxidant,anti-inflammatory,immunomodulatory,and anti-apoptotic characteristics over Bm-mSCs treatment.

关键词： Antioxidants Apoptosis Diabetes Inflammation Stem cells

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minimizing the Loss Probability in m/m/2/1 Queueing System with Ordered Entry

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American Journal of Operations Research 2018年第1期8卷 33-41页

作者： eman Ahmed Kamel Department of mathematic Faculty of Science EL-Minia University EL-Minia City Egypt

This study analyzed the m/m/2/1 queueing model with queue of length one (waiting room of capacity just one), heterogeneous servers and ordered entry using the method of semi-markov process. The customers who arrive in the system enter the free server;if the two servers are free, the customers enter the first server. If the two servers are busy, just one customer can wait at the waiting room. If the two servers are busy and the waiting room has a customer, the following customers will leave the system without receiving any service. Such a customer is called LOST COSTOmER. The probability of lost customers in the queueing system under examination was computed. Furthermore, by using inequality obtained from Jensen’s inequality, it was shown that the loss probability was minimum when inter-arrival times fit deterministic distribution [1] [2].

关键词： Loss Probability Heterogeneous Servers Semi-markov Process Laplace-Stieltjes Transform

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