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BIOCelL 2022年第2期46卷 535-545页

作者： AMOURA M.ABOU-el-NAGA SHAKER A.MOUSA FAYEZ ALTHOBAITI eman FAYAD ENGY S.FAHIM Department of Zoology Faculty of ScienceMansoura UniversityMansouraEgypt The Pharmaceutical Research Institute Albany College of Pharmacy and Health SciencesRensselaerUSA Department of Biotechnology Faculty of SciencesTaif UniversityTaifSaudi Arabia

Testicular damage is one of the most hazardous effects as it’s associated with ***(Bu)is a highly toxic chemotherapeutic drug that affects *** male Swiss albino mice divided into six groups of 5 animals ***(oral 0.9%saline daily for 75 days);Mel(20 mg/kg/day orally for 30 days);ZnO NPs(5 mg/kg/day *** 30 days);BU(single *** of 40 mg/kg and then left for 45 days);BU+Mel(single 40 mg/kg dose of BU and left for 45 days followed by 20 mg/kg/day Mel for 30 days);BU+ZnO NPs(single dose of 40 mg/kg of BU and left for 45 days,then 5 mg/kg/day ZnO NPs for 30 days).Preparation and Characterization of ZnO *** from testis prepared for ultrastructural investigations using TEM after Masson’s trichrome and toluidine blue *** induced histological and ultrastructural damage of the ***,the present results could be concluded that Mel or ZnO NPs can protect the testicular tissue against ultrastructural alterations induced by BU by its antioxidant and anti-apoptotic effects.

关键词： Busulfan Melatonin Zinc oxide nanoparticles Ultrastructure Testis Mice

Mesenchymal stem cells are more effective than captopril in reverting cisplatin-induced nephropathy

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BIOCelL 2019年第2期43卷 73-79页

作者： ENTSAR A.SAAD REDA S.el-DEMERDASH eman M.abd EI-FATTAH Chemistry Department Faculty of ScienceDamietta UniversityDamiettaEgypt Urology&Nephrology Center Faculty of MedicineMansoura UniversityEgypt

Cisplatin is a powerful anticancer drug but its nephrotoxic effects limit its clinical *** aimed to evaluate the effect of mesenchymal stem cells(MSCs)injection or of captopril to counteract the cisplatin-induction of *** isolation,preparation and tracking,transforming growth factor-β(TGF-β)and interleukin-10(IL-10)expressions,kidney function tests,oxidative stress state,and histological examinations were ***-induced nephropathy was indicated biochemically and confirmed *** treatment showed normal kidney architecture and significantly decreased oxidative stress and TGF-β while increased IL-10 and improved kidney function *** treated with cisplatin+captopril showed noticeable kidney histopathological *** positive impact of MSCs in amelioration of cisplatin-induced nephropathy via their ability to motivate functional and structural renal repair is evidenced.

关键词： Histopathology IL-10 Minerals Nephropathy Oxidative stress PCR Repair TGF-β

Anti-inflammatory and antioxidant potential capacities of AD-MSCs and BM-MSCs in suppressing pancreaticβ-cells auto-immunity and apoptosis in rats with T1DM induced model

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BIOCelL 2022年第3期46卷 745-757页

作者： SHADY G.el-SAWAH FAYEZ ALTHOBAITI HANAN M.RASHWAN ADIL ALDHAHRANI MARWA A.abdel-DAYEM eman FAYAD REHAB M.AMEN el SHAIMAA SHABANA EHAB I.el-HALLOUS Zoology Department Faculty of ScienceArish UniversityNorth SinaiEgypt Biotechnology Department Faculty of ScienceTaif UniversityTaifSaudi Arabia Clinical Laboratory Science Department Turabah University CollegeTaif UniversityTaifSaudi Arabia Department of Pharmacology and Biochemistry Faculty of PharmacyHorus University-EgyptNew DamiettaEgypt Biology Department College of ScienceUniversity of BishaBishaSaudi Arabia Fellow of Biochemistry Genetic UnitChildren HospitalFaculty of MedicineMansoura UniversityDakahlia GovernorateEgypt Biology Department Faculty of ScienceTaif UniversityTaifSaudi Arabia

Since Type 1 diabetes(T1DM)occurs whenβ-cells mass is reduced to less than 20%of the normal level due to autoimmune destruction of cells resulting in the inability to secrete insulin,preservation or replenishment of the functionalβ-cells mass has become a major therapeutic focus for this diabetic type ***,this 4-week work plan was designed to determine which mesenchymal stem cells(MSCs)type is more appropriate to alleviate pancreatic hazards resulting from diabetes induction;via tracking a comparative study between MSCs derived from adipose tissue(AD-MSCs)and from bone marrow(BM-MSCs)in management of T1DM considering their immunomodulatory,anti-apoptotic and antioxidative *** were divided randomly into 4 groups;control,STZdiabetic(D),D+AD-MSCs,and D+BM-MSCs *** stem cells types in this study were ***,both oxidative stress and antioxidant markers were evaluated using colorimetric analysis,while inflammatory,immune and apoptotic markers were assessed through flow cytometric *** showed that diabetic rats treated with either AD-MSCs or BM-MSCs exhibited marked pancreatic antioxidant and anti-inflammatory activities that were able to initiate pancreatic immunomodulation and reducingβ-cells apoptotic death,thus,help to restore their normal insulin secretion and hypoglycemic ***,AD-MSCs injection was shown to be superior as a pancreatic regenerative tool in overcoming diabetes;owing to their marked antioxidant,anti-inflammatory,immunomodulatory,and anti-apoptotic characteristics over BM-MSCs treatment.

关键词： Antioxidants Apoptosis Diabetes Inflammation Stem cells

Deep Learning for Image Segmentation: A Focus on Medical Imaging

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计算机、材料和连续体（英文） 2023年第4期75卷 1995-2024页

作者： Ali F.Khalifa eman Badr Faculty of Computers and Artificial Intelligence Cairo UniversityGiza12613Egypt Zewail City of Science and Technology Giza12578Egypt

Image segmentation is crucial for various research areas. Manycomputer vision applications depend on segmenting images to understandthe scene, such as autonomous driving, surveillance systems, robotics, andmedical imaging. With the recent advances in deep learning (DL) and itsconfounding results in image segmentation, more attention has been drawnto its use in medical image segmentation. This article introduces a surveyof the state-of-the-art deep convolution neural network (CNN) models andmechanisms utilized in image segmentation. First, segmentation models arecategorized based on their model architecture and primary working ***, CNN categories are described, and various models are discussed withineach category. Compared with other existing surveys, several applicationswith multiple architectural adaptations are discussed within each category.A comparative summary is included to give the reader insights into utilizedarchitectures in different applications and datasets. This study focuses onmedical image segmentation applications, where the most widely used architecturesare illustrated, and other promising models are suggested that haveproven their success in different domains. Finally, the present work discussescurrent limitations and solutions along with future trends in the field.

关键词： Deep learning medical imaging convolution neural network image segmentation medical applications survey

Serum homocysteine,lipid profile and BMI as atherosclerotic risk factors in children with numerical chromosomal aberrations

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World Journal of Pediatrics 2022年第6期18卷 443-448页

作者： eman R.Youness Sherien Mel-Daly Hanaa Reyad abdallah Hala T.el-Bassyouni Hisham Megahed Azzah A.Khedr Marwa elhady Walaa Alsharany Abuelhamd Medical Biochemistry Department Medical Research DivisionNational Research CentreGizaEgypt Biological Anthropology Department Medical Research DivisionNational Research CentreGizaEgypt Clinical Genetics Department Human Genetics and Genome Research DivisionNational Research CentreEl-Tahrir StreetPO:12622GizaEgypt Human Cytogenetics Department Human Genetics and Genome Research DivisionNational Research CentreGizaEgypt Pediatric Department Faculty of Medicine for GirlsAl-Azhar UniversityCairoEgypt Department of Pediatrics Faculty of MedicineCairo UniversityCairoEgypt

Down syndrome,Turner syndrome,and Klinefelter syndrome are the most common chromosomal disorders *** syndrome is caused by an extra copy of the 21st chromosome and has an incidence of 1 in 800 to 1000 live *** syndrom... 详细信息

关键词： chromosomal Turner Serum

Pterostilbene induces cell apoptosis and inhibits lipogenesis in SKOV3 ovarian cancer cells by activation of AMPK-induced inhibition of Akt/mTOR signaling cascade

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BIOCelL 2021年第1期45卷 89-101页

作者： ATTALLA el-KOTT eman elBEALY FAHMY elSAID HAITHAM el-MEKKAWY abd-el-KARIM abd-LATEIF abdULALI TAWEel HEBA KHALIFA AHMAD KANDEel KAREEM MORSY ESSAM IBRAHIM MASHAel MOHAMMED BIN-MEFERIJ Biology Department College of ScienceKing Khalid UniversityAbha61413Saudi Arabia Zoology Department College of ScienceDamanhour UniversityDamanhour22511Egypt Biology Department College of Science for GirlsKing Khalid UniversityAbha61413Saudi Arabia Zoology Department College of ScienceMansoura UniversityMansoura35511Egypt Zoology Department College of ScienceFayoum UniversityFayoum63511Egypt Zoology Department Faculty of ScienceAl-Zawia UniversityAl-ZawiaLibya Biology Department Faculty of ScienceCairo UniversityCairo12611Egypt Research Center for Advanced Materials Science(RCAMS) King Khalid UniversityAbha61413Saudi Arabia Blood Products Quality Control and Research Department National Organization for Research and Control of BiologicalsCairo12611Egypt Biology Department College of SciencePrincess Nourah bint Abdulrahman UniversityRiyadhSaudi Arabia

This study investigates if the anti-tumor effect of Pterostilbene in the SKOV3 ovarian cancer(OC)cell line involves inhibition of cell metabolism and tested in this effect involves modulating AMPK and Akt-induced regulation of ***,SKOV3 cells were cultured in the humidified conditions in DMEM media for 24 h with or without increasing concentration of ***,the cells were incubated with Pterostilbene(IC_(50)=50μM)under similar conditions with or without pre-incubation with Dorsomorphin,an AMPK *** a dose-dependent manner,Pterostilbene inhibited SKOV3 cell survival and increased their lysate levels of lactate dehydrogenase(LDH)and single-stranded DNA(ssDNA).When SKOV3 cells were treated with 50μM Pterostilbene,Pterostilbene significantly suppressed cell migration and invasion,reduced lysate levels of lactic acid and the optical density of Oil Red O staining,and increased lysate glucose *** also increased levels of malondialdehyde(MDA),reactive oxygen species(ROS),and induced intrinsic cell apoptosis by upregulating protein levels of Bax and cleaved caspase-3 and reducing protein levels of ***,Pterostilbene reduced mRNA levels of sterol regulatory element-binding protein 1(SREBP-1),fatty acid synthase(FAS),acetyl CoA carboxylase-1(ACC-1),and AMP-activated protein kinase(AMPK).Furthermore,Pterostilbene increased the protein levels of p-AMPK,p-p53,p-raptor,p-TSC-2,but significantly decreased protein levels of p-Akt,p-TSC-2,p-mTOR,p-S6K1,and *** with Dorsomorphin(CC)abolished all the anti-tumorigenesis effects afforded by Pterostilbene and prevented Pterostilbene-induced phosphorylation of Akt,p53,and *** conclusion,the tumorsuppressive effect of Pterostilbene in SKOV3 cells involves the induction of ROS and inhibition of dysregulation cell metabolism mainly due to AMPK-induced Akt-dependent or independent suppression of mTOR.

关键词： Pterostilbene Ovarian cancer Lipogenesis Apoptosis AMPK

Assessment of auditory and vestibular functions in vitiligo patients

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Journal of Otology 2017年第3期12卷 143-149页

作者： eman abd elmohsin Dawoud elshahat Ibrahem Ismail Soheir abdel-Gaber eltoukhy Ayman el-Saeed el-Sharabasy Kafr el Sheikh General Hospital Egypt ENT Department Faculty of MedicineMansoura UniversityEgypt Dermatology Department Faculty of MedicineMansoura UniversityEgypt

Objectives: To evaluate audiological and vestibular functions via basic audiological evaluation. otoacoustic emissions and videonystagmography(VNG) in vitiligo *** and methods: 30 vitiligo patients(8 acrofacial and 22 mixed types) as the study group and 30 normal healthy adults as the control group were included in the study. All participants were submitted to basic audiological evaluation. transient and distortion product otoacoustic emmisions(TEOAEs and DPOAEs), vestibular assessment including history taking, office tests and videonystagmography(VNG) and dermatological assessment to determine type, percent of body surface area involvement and duration of ***: This study showed statistically significant difference between control and study groups in pure tone audiometry(PTA) and otoacoustic emissions results. Fitfty percent of vitiligo patients had peripheral vestibular disorders(10 vestibulhar neuritis and 5 posterior canal benign paroxysmal positional ***: The results in this study showed that 50% of vitiligo patients suffered from peripheral vestibular disorders in addition to auditory affection. Vitiligo patients require routine monitoring for auditory and vestibular functions for early identification and monitoring of changes as the disease progress.

关键词： Otoacoustic emissions Videonystagmography

Agmatine induces gastric protection against ischemic injury by reducing vascular permeability in rats

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World Journal of Gastroenterology 2012年第18期18卷 2188-2196页

作者： Abeer A Al Masri eman el Eter Department of Physiology College of Medicine and King Khalid University HospitalKing Saud UniversityRiyadh 11461Saudi Arabia

AIM:To investigate the effect of administration of agmatine(AGM) on gastric protection against ischemia reperfusion(I/R) ***:Three groups of rats(6/group);sham,gastric I/R injury,and gastric I/R + AGM(100 mg/kg,*** 15 min prior to gastric ischemia) were *** injury was conducted by ligating celiac artery for 30 min and reperfusion for another 30 *** tissues were histologically studied and immunostained with angiopoietin 1(Ang-1) and *** endothelial growth factor(VEGF) and monocyte chemoattractant protein-1(MCP-1) were measured in gastric tissue *** assess whether AKt/phosphatidyl inositol-3-kinase(PI3K) mediated the effect of AGM,an additional group was pretreated with Wortmannin(WM)(inhibitor of Akt/PI3K,15 μg/kg,i.p.),prior to ischemic injury and AGM treatment,and examined histologically and *** set of experiments was run to study vascular permeability of the stomach using Evan's blue ***:AGM markedly reduced Evan's blue dye extravasation(3.58 ± 0.975 μg/stomach vs 1.175 ± 0.374 μg/stomach,P el(29.5 ± 7 pg/100 mg protein vs 41.17 ± 10.4 pg/100 mg protein,P < 0.01).It preserved gastric histology and reduced ***-1 and Ang-2 immunostaining were reduced in stomach sections of AGM-treated *** administration of WM abolished the protective effects of AGM and extensive hemorrhage and ulcerations were ***:AGM protects the stomach against I/R injury by reducing vascular permeability and *** protection is possibly mediated by Akt/PI3K.

关键词：再灌注损伤缺血再灌注血管通透性保护管理胍丁胺单核细胞趋化蛋白-1 胃癌大鼠

Predictors of anti-SARS-CoV-2 seropositivity:An Egyptian population-based study

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Infectious Medicine 2022年第2期1卷 113-123页

作者： Engy Mohamed el-Ghitany Ayat Ashour Azza Galal Farghaly Mona H.Hashish eman A.Omran Department of Tropical Health High Institute of Public HealthAlexandria UniversityAlexandriaEgypt Department of Family Health High Institute of Public HealthAlexandria UniversityAlexandriaEgypt Department of Microbiology High Institute of Public HealthAlexandria UniversityAlexandriaEgypt

Background:Population-based studies on the determinants of COVID-19 seroprevalence constitute a cornerstone in guiding appropriate preventive *** studies are scarce in Egypt,thus we conducted this study to explore risk factors for SARS-CoV-2 ***:This survey included 2919 participants from 10 Egyptian *** were tested for SARS-CoV-2 spike(S)and nucleocapsid(N)*** and multivariate analyses were performed to identify associated factors and predictors of seropositivity regarding sociodemographic factors,clinical data,and personal practices of participants.A subgroup analysis was performed to investigate the occupational risks of ***:Seropositivity was recorded in 1564 participants(53.6%).Independent predictors of seropositivity in-cluded non-smokers(aOR=1.817;95%CI:1.407-2.346,p=0.000),having blood group A(aOR=1.231;95%CI:1.016-1.493,p=0.034),a history of COVID-19 infection(aOR=2.997;95%CI:2.176-4.127,p=0.000),COVID-19 vaccination(aOR=4.349;95%CI:2.798-6.759,p=0.000),higher crowding index(aOR=1.229;95%CI:1.041-1.451,p=0.015),anosmia and/or ageusia(aOR=3.453;95%CI:2.661-4.481,p=0.000)and history of fever(aOR=1.269;95%CI:1.033-1.560,p=0.023).Healthcare worker and Obesity/overweight were additional significant predictors of seropositivity among the working participants(aOR=1.760;95%CI:1.301-2.381,p=0.000 and aOR=1.384;95%CI:1.059-1.808,p=0.019,respectively).Additional factors showing association with seropositivity in the univariate analysis were:female gender,age group(15-39 years),higher educational level(preparatory and above),lack of environmental disinfection and having roommates at the *** was a positive correlation between the titers of both *** was weakly corre-lated with anti-S titer,while anti-N was significantly correlated with the number of protective measures applied by the *** antibodies were significantly correlated with adult BMI,while both we

关键词： COVID-19 Predictors Seroprevalence Anti-spike Anti-nucleocapsid

Diffusion-weighted magnetic resonance imaging and micro-RNA in the diagnosis of hepatic fibrosis in chronic hepatitis C virus

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World Journal of Gastroenterology 2019年第11期25卷 1366-1377页

作者： Tarek Besheer Hatem elalfy Mohamed abd el-Maksoud Ahmed abd el-Razek Saher Taman Khaled Zalata Wagdy elkashef Hossam Zaghloul Heba elshahawy Doaa Raafat Wafaa elemshaty eman elsayed abdel-Hady el-Gilany Mahmoud el-Bendary Department of Tropical Medicine and Hepatology Mansoura Faculty of Medicine-Mansoura University Department of Diagnostic Radiology Mansoura Faculty of Medicine-Mansoura University Department of Pathology Mansoura Faculty of Medicine-Mansoura University Department of Clinical Pathology Mansoura Faculty of Medicine-Mansoura University Department of Public Health and Preventive Medicine Mansoura Faculty of Medicine-Mansoura University

BACKGROUND Diffusion-weighted magnetic resonance imaging has shown promise in the detection and quantification of hepatic fibrosis. In addition, the liver has numerous endogenous micro-RNAs(miRs) that play important roles in the regulation of biological processes such as cell proliferation and hepatic *** To assess diffusion-weighted magnetic resonance imaging and miRs in diagnosing and staging hepatic fibrosis in patients with chronic hepatitis *** This prospective study included 208 patients and 82 age-and sex-matched controls who underwent diffusion-weighted magnetic resonance imaging of the abdomen, miR profiling, and liver biopsy. Pathological scoring was classified according to the METAVIR scoring system. The apparent diffusion coefficient (ADC) and miR were calculated and correlated with pathological *** The ADC value decreased significantly with the progression of fibrosis, from controls(F0) to patients with early fibrosis(F1 and F2) to those with late fibrosis(F3 and F4)(median 1.92, 1.53, and 1.25 × 10^(-3) mm^2/s, respectively)(P = 0.001).The cut-off ADC value used to differentiate patients from controls was 1.83 × 10^(-3) mm^2/s with an area under the curve(AUC) of 0.992. Combining ADC and miR-200 b revealed the highest AUC(0.995) for differentiating patients from controls with an accuracy of 96.9%. The cut-off ADC used to differentiate early fibrosis from late fibrosis was 1.54 × 10^(-3) mm^2/s with an AUC of 0.866. The combination of ADC and miR-200 b revealed the best AUC(0.925) for differentiating early fibrosis from late fibrosis with an accuracy of 80.2%. The ADC correlated with miR-200 b(r =-0.61, P = 0.001), miR-21(r =-0.62, P = 0.001), and miR-29(r = 0.52,P = 0.001).CONCLUSION Combining ADC and miRs offers an alternative surrogate non-invasive diagnostic tool for diagnosing and staging hepatic fibrosis in patients with chronic hepatitis C.

关键词： Diffusion Magnetic resonance imaging Fibrosis Liver Hepatitis C virus Micro-RNA