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Annexin A2 as a biomarker for hepatocellular carcinoma in Egyptian patients

World Journal of Hepatology 2017年第9期9卷 469-476页

作者： Mohamed K Shaker Hanzada I abdel Fattah Ghada S Sabbour Iman F Montasser Sara M abdelhakam eman el Hadidy Rehab Yousry Ahmed K el Dorry Department of Tropical Medicine Faculty of MedicineAin Shams University Department of Clinical Pathology Faculty of MedicineAin Shams University Department of Radiodiagnosis and Inter-ventional Radiology Faculty of MedicineAin Shams University

AIM To investigate the clinical utility of serum annexin A2(ANXA2) as a diagnostic marker for early hepatocellular carcinoma(HCC).METHODS This study was performed in HCC Clinic of Ain Shams University Hospitals, Cairo, Egypt and included: Group 1: Fifty patients with early stage HCC(Barcelona Clinic Liver Cancer stage A); Group 2: Twenty five patients with chronic liver disease; and Control Group: Fifteen healthy, age-and sex-matched subjects who were seronegative for viral hepatitis markers. The followinglaboratory investigations were done: Viral hepatitis markers [hepatitis B surface antigen and hepatitis C virus(HCV) antibodies], HCV RNA in HCV antibody-positive patients, serum alpha fetoprotein(AFP), and serum ANXA2 *** In this study, 88% of HCC patients(n = 44) were HCVpositive, while HBV infection represented only 8% of all HCC patients(n = 4); and two patients were negative for both viral markers. A highly significant difference was found between patients with HCC and chronic liver disease as well as controls with regard to serum ANXA2 levels(130, IQR 15-240; 15, IQR 15-17; and 17, IQR 15-30 ng/m L, respectively). The area under the curve of ANXA2 was 0.865; the cut-off value was established to be 18 ng/mL with a diagnostic sensitivity of 74% and a specificity of 88%, while the sensitivity and specificity of AFP at the cut-off value of 200 ng/dL were 20% and 100%, *** Serum ANXA2 may serve as a biomarker for the early detection of HCC.

关键词： Hepatocellular carcinoma Hepatitis C virus Annexin A2 Alpha-fetoprotein Tumor markers

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Aqueous-Phase Sorption Behaviors of Cs+, Co2+, Sr2+and Cd2+ions on some Composite Ion Exchangers

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Advances in Chemical Engineering and Science 2012年第1期2卷 180-186页

作者： Ibrahim Mohammed el-Naggar Gehan Mohammed Ibrahim eman Ahmed el-Kady 不详

A two new hybrid “organic-inorganic” composite ion exchangers (SAM and FAM), was synthesized by the combination of inorganic ion exchanger tin (IV) silicate and tin (IV) antimonate respectively with organic polymer polyacrylamide (PAm). The sorption isotherms for Cs+, Co2+, Sr2+ and Cd2+ ions on composite ion exchanger were investigated in the range (0.0005 - 0.01M) at different reaction temperature (30℃, 45℃ and 60℃ ± 1℃). The sorption data were subjected to different sorption isotherms and the results verified that Langmuir isotherm is the best model to be applied, and the monolayer sorption capacity were calculated and was found to increase as the reaction temperature increases.

关键词： Organic-Inorganic Composite Polyacrylamide Tin (IV) Silicate Tin (IV) Antimonate Radioactive Waste Heavy Metals Sorption Isotherm Capacity

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Thermomechanical Testing of GGG 40 Spheroidal Graphite Cast Iron Alloy

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Materials Sciences and Applications 2017年第3期8卷 273-280页

作者： Marwan Faisal eman el-Shenawy Mohamed A. Taha Mechanical Design and Production Department Ain Shams University Cairo Egypt Department of Plastic Deformation Central Metallurgical R&D Institute Cairo Egypt

Spheroidal graphite cast iron GGG 40 was thermo-mechanically tested using thermo-mechanical simulator Gleeble-3500. Three deformation steps were successively applied on test-specimen at temperatures namely;900°C, 850°C and 750°C within the austenitic zone, at the same strain rate of 0.1 s-1. No cracks were observed, up to 50% deformation, after successive deformation steps. Stress-strain relationship obtained is correlated with previous work on SGCI with a different carbon equivalent. It was found that by decreasing the deformation temperature;for the same CE, young’s modulus, yield strength and strain hardening exponent increase. Microstructure of the deformed zone, for a specimen quenched after the final deformation step, reveals fine elongated ferrite and pearlite, as well as elongated graphite. While microstructure of the non-deformed zone subjected to the same treatment, includes coarser ferrite and pearlite with graphite spheres embedded in the matrix.

关键词： Thermo-Mechanical Behavior Spheroidal Graphite Cast Iron Gleeble-3500

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On thermodynamic self-consistency of generic axiomatic-nonextensive statistics

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Chinese Physics C 2017年第5期41卷 73-90页

作者： abdel Nasser Tawfik Hayam Yassin eman R.Abo elyazeed Egyptian Center for Theoretical Physics (ECTP) Modern University for Technology and Information (MTI) 11571 Cairo Egypt World Laboratory for Cosmology and Particle Physics (WLCAPP) 11571 Cairo Egypt Physics Department Faculty of Women for Arts Science and Education Ain Shams University 11577 Cairo Egypt

Generic axiomatic-nonextensive statistics introduces two asymptotic properties,to each of which a scaling function is *** first and second scaling properties are characterized by the exponents c and d,*** the thermodynamic limit,a grand-canonical ensemble can be *** thermodynamic properties of a relativistic ideal gas of hadron resonances are studied,*** is found that this generic statistics satisfies the requirements of the equilibrium *** aspects of the thermodynamic self-consistency are *** expressions are proposed for the statistical fits of various transverse momentum distributions measured in most-central collisions at different collision energies and colliding *** for the freezeout temperature（T_（ch）） and the baryon chemical potential（μ_b） and the exponents c and d are *** earlier are found compatible with the parameters deduced from Boltzmann-Gibbs（BG） statistics（extensive）,while the latter refer to generic *** resulting equivalence class（c,d） is associated with stretched exponentials,where Lambert function reaches its asymptotic *** some measurements,the resulting nonextensive entropy is linearly composed on extensive *** from power-scaling,the particle ratios and yields are excellent quantities to highlighting whether the particle production takes place（non）*** particle ratios and yields measured by the STAR experiment in central collisions at 200,62.4 and 7.7 GeV are fitted with this novel *** found that both c and d 〈 1,*** to neither BG-nor Tsallis-type statistics,but to（c,d）-entropy,where Lambert functions exponentially *** freezeout temperature and baryon chemical potential are found comparable with the ones deduced from BG statistics（extensive）.We conclude that the particle production at STAR energies is likely a nonextensive process but not necessarily BG or Tsallis

关键词： thermodynamic consistency asymptotic relativistic momentum quantities exponentially collision entropy generic

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Exendin-4 inhibits the survival and invasiveness of two colorectal cancer cell lines via suppressing GS3Kβ/β-catenin/NF-κB axis through activating SIRT1

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BIOCelL 2021年第5期45卷 1337-1353页

作者： ATTALLA F.el-KOTT AYMAN E.el-KENAWY eman R.elBEALY ALI S.ALSHEHRI HEBA S.KHALIFA MASHAel MOHAMMED BIN-MEFERIJ EHAB E.MASSOUD AMIRA M.ALRAMLAWY Biology Department College of ScienceKing Khalid UniversityAbha61413Saudi Arabia Zoology Department College of ScienceDamanhour UniversityDamanhour22511Egypt Pathology Department College of MedicineTaif UniversityTaif11099Saudi Arabia Biology Department College of Science for GirlsKing Khalid UniversityAbha61413Saudi Arabia Biology Department College of SciencePrincess Nourah Bint Abdulrahman UniversityRiyadh84428Saudi Arabia Biology Department Faculty of Science and ArtsDahran AljnoubKing Khalid UniversityAbha61413Saudi Arabia Research Center for Advanced Materials Science King Khalid UniversityAbha61413Saudi Arabia Agriculture Research Centre SoilWater and Environment Research InstituteGiza12619Egypt Mansoura Research Centre for Cord Stem Cell(MARC-CSC) Stem Cells BankChildren’s HospitalMansoura UniversityMansoura35516Egypt

This study examined if the anti-tumorigenesis effect of Exendin-4 in HT29 and HCT116 colorectal cancer(CRC)involves modulation of SIRT1 and Akt/GSR3K/β-catenin/NF-κB ***29 and HCT116 cells were treated either with increasing levels of Exendin-4(0.0-200μM)or with Exendin-4(at its IC50)in the presence or absence of EX-527(10μM/a selective SIRT1 inhibitor)or Exendin-4(9-39)amide(E(9-39)A)(1μM/an Exendin-4 antagonist).In a dose-dependent manner,Exendin-4 inhibited cell survival,but enhanced levels of lactate dehydrogenase(LDH)and single-stranded DNA(ssDNA)in both HT29 and *** both cell lines and at it has an IC50(45μM for HT29 and 35μM for HCT1165),Exendin-4 also significantly reduced cell survival,migration,and invasion of both cell types,with no effect on the expression GLP-1 receptors(GLPRs)nor of the activity of *** these doses,Exendin-4 also increased the expression of SIRT1 but reduced the acetylation of NF-κB and the expression of Bax and cleaved caspase-3 and in both cell ***,protein levels of p-GS3Kβ(Ser9),total and acetylatedβ-catenin,and Anix2 were significantly decreased,but levels of p-GS3Kβ(Ser9)and p-β-catenin(Ser33/37/Thr41)were significantly increased in both HT29 and HCT116-exendin-4 treated *** the effects exerted by Exendin-4 were completely prevented by Ex527 or E(9-39)*** conclusion,Exendin-4 suppresses the tumorigenesis of HT29 and HCT116 CRC cell activation of GS3Kβ-induced inhibition ofβ-catenin and NF-κβin a SIRT1-dependent mechanism.

关键词： Colorectal cancer Exendin-4 SIRT1 GS3Kβ β-catenin NF-κB

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An ellipsoidal Set-Membership Approach to Distributed Joint State and Sensor Fault Estimation of Autonomous Ground Vehicles

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IEEE/CAA Journal of Automatica Sinica 2021年第6期8卷 1107-1118页

作者： eman Mousavinejad Xiaohua Ge Senior Member Qing-Long Han Teng Joon Lim Ljubo Vlacic School of electrical and Information Engineering The University of SydneySydneyNSW 2006Australia School of Engineering and Built Environment Griffith UniversityGold CoastQLD 4222Australia chool of Software and electrical Engineering Swinburne University of TechnologyMelbourneVIC 3122Australia

This paper is concerned with the problem of distributed joint state and sensor fault estimation for autonomous ground vehicles subject to unknown-but-bounded(UBB)external disturbance and measurement *** order to improve the estimation reliability and performance in cases of poor data collection and potential communication interruption,a multisensor network configuration is presented to cooperatively measure the vehicular yaw rate,and further compute local state and fault *** this aim,an augmented descriptor vehicle model is first established,where the unknown sensor fault is modeled as an auxiliary state of the system ***,a new distributed ellipsoidal set-membership estimation approach is developed so as to construct an optimized bounding ellipsoidal set which guarantees to contain the vehicle’s true state and the sensor fault at each time step despite the existence of UBB disturbance and measurement ***,a convex optimization algorithm is put forward such that the gain matrix of each distributed estimator can be recursively ***,simulation results are provided to validate the effectiveness of the proposed approach.

关键词： Autonomous ground vehicle(AGV) distributed setmembership estimation fault estimation sensor networks vehicle lateral dynamics

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The Need for Cardiac Pacing after Isolated Coronary Artery Bypass Graft Surgery

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Open Journal of Thoracic Surgery 2022年第2期12卷 21-32页

作者： Montaser elsawy abd elaziz eman Gomaa Saleh Mohamed Gaber elsayed Bassem A. Hafez Cardiothoracic Surgery Department Faculty of Medicine Menoufia University Menoufia Egypt Faculty of Medicine Jazan University Jazan Saudi Arabia Neuropsychiatry Department Faculty of Medicine Menoufia University Menoufia Egypt

Background: The aim of this study is to assess the necessity of temporary cardiac pacing and identify the predictors of pacing after coronary artery bypass graft (CABG). Methods: This was a retrospective observational study of 150 patients who had isolated CABG between November 2013 and December 2021. Patients were classified into two groups: group A, (n = 135) who did not need to be paced and group B, (n = 15) who needed temporary epicardial pacing. Only 10% (15/150) of patients in the study needed pacing. The primary outcome variable was assessment of the need for postoperative temporary cardiac pacing (TCP) (patients were paced during chest closure or at any time during hospital admission). The incidence of pacing during the postoperative period was observed. Univariate and multivariate predictors for postoperative pacing were determined and specicific predictors for cardiac pacing were found. Results: In both univariate and multivariate analysis, Old age > 65 years, diabetes mellitus, pacing to come off cardiopulmonary bypass (CPB), CPB time > 100 min, cardioversion to leave OR, antiarrhythmics to leave OR and new onset of atrial fibrillation (AF), were found to be significant predictors for the need to cardiac pacing. Conclusion: After coronary artery bypass surgery, a small percentage of patients require TCP. We emphasize unique predictors for postoperative pacing in this study.

关键词： Temporary Epicardial Pacing Coronary Artery Bypass Arrhythmias

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Diagnosis of Autism Spectrum Disorder by Imperialistic Competitive Algorithm and Logistic Regression Classifier

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Computers, Materials & Continua 2023年第11期77卷 1515-1534页

作者： Shabana R.Ziyad Liyakathunisa eman Aljohani I.A.Saeed Department of Computer Science College of Computer Engineering and SciencesPrince Sattam bin Abdulaziz UniversityAl Kharj16274Saudi Arabia Department of Computer Science College of Computer Science and EngineeringTaibah UniversityMadinah41411Saudi Arabia Department of Information Systems College of Computer Engineering and SciencesPrince Sattam bin Abdulaziz UniversityAl Kharj16274Saudi Arabia

Autism spectrum disorder(ASD),classified as a developmental disability,is now more common in children than ever.A drastic increase in the rate of autism spectrum disorder in children worldwide demands early detection of autism in *** can seek professional help for a better prognosis of the child’s therapy when ASD is diagnosed under five *** research study aims to develop an automated tool for diagnosing autism in *** computer-aided diagnosis tool for ASD detection is designed and developed by a novel methodology that includes data acquisition,feature selection,and classification *** most deterministic features are selected from the self-acquired dataset by novel feature selection methods before *** Imperialistic competitive algorithm(ICA)based on empires conquering colonies performs feature selection in this *** performance of Logistic Regression(LR),Decision tree,K-Nearest Neighbor(KNN),and Random Forest(RF)classifiers are experimentally studied in this research *** experimental results prove that the Logistic regression classifier exhibits the highest accuracy for the self-acquired *** ASD detection is evaluated experimentally with the Least Absolute Shrinkage and Selection Operator(LASSO)feature selection method and different *** Exploratory Data Analysis(EDA)phase has uncovered crucial facts about the data,like the correlation of the features in the dataset with the class variable.

关键词： Autism spectrum disorder feature selection imperialist competitive algorithm LASSO logistic regression random forest

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Seasonal Effect on Biomarkers of Exposure to Petroleum Hydrocarbons in the Coasts of North Western Suez Gulf,Egypt

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Journal of Environmental & Earth Sciences 2019年第1期1卷 38-48页

作者： Omayma E.Ahmed Mustafa M.Emara Nazik A.Farid1 Enas A.el-Sabagh eman M.Kamal Egyptian Petroleum Research Institute Egypt Chemistry Department Faculty of Science(boys)Al-Azhar UniversityEgypt Faculty of Science(girls)Al-Azhar University CairoEgypt

Petroleum hydrocarbons of surface water were collected from eight loca-tions of from the coasts of north western Suez Gulf,*** extracted petroleum hydrocarbons were determined by gas chromatography-flame ionization detector and quantified by integrating the areas of both the resolved and unresolved *** results confirm that the con-centration is relatively higher than the recommended in the regulations of the Egyptian low of Environment of No.4/1994 of petroleum *** various *** dissolved petroleum hydrocarbons ranged from 5.639 to 74.8 and 1.868 to 65.698 mg/ml for summer and winter sea-sons,*** indicates that chronic oil pollution,in addition to hydrocarbon concentrations,the diagnostic indices used shows that the hydrocarbons in the area were comes from biogenic,petrogenic and anthropogenic ***-IR spectrometric analysis confirms die petro-genic nature of pollutants.

关键词： Egypt Oil hydrocarbon Physicochemical Diagnostic Gas chromatography Suez canal

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Deep Reinforcement Learning-Based Job Shop Scheduling of Smart Manufacturing

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Computers, Materials & Continua 2022年第12期73卷 5103-5120页

作者： eman K.elsayed Asmaa K.elsayed Kamal A.eldahshan School of Computers Science Canadian International College(CIC).Department of MathematicsFaculty of Science(Girls)AL-Azhar UniversityCairo11511Egypt Department of Mathematics Faculty of Science(Girls)AL-Azhar UniversityCairo11511Egypt Department of Mathematics Faculty of ScienceAL-Azhar UniversityCairo11511Egypt

Industry 4.0 production environments and smart manufacturing systems integrate both the physical and decision-making aspects of manufacturing operations into autonomous and decentralized *** of the key aspects of these systems is a production planning,specifically,Scheduling operations on the *** cope with this problem,this paper proposed a Deep Reinforcement Learning with an Actor-Critic algorithm(DRLAC).We model the Job-Shop Scheduling Problem(JSSP)as a Markov Decision Process(MDP),represent the state of a JSSP as simple Graph Isomorphism Networks(GIN)to extract nodes features during scheduling,and derive the policy of optimal scheduling which guides the included node features to the best next action of *** addition,we adopt the Actor-Critic(AC)network’s training algorithm-based reinforcement learning for achieving the optimal policy of the *** prove the proposed model’s effectiveness,first,we will present a case study that illustrated a conflict between two job scheduling,secondly,we will apply the proposed model to a known benchmark dataset and compare the results with the traditional scheduling methods and trending *** numerical results indicate that the proposed model can be adaptive with real-time production scheduling,where the average percentage deviation(APD)of our model achieved values between 0.009 and 0.21 comparedwith heuristic methods and values between 0.014 and 0.18 compared with other trending approaches.

关键词： Reinforcement learning job shop scheduling graphical isomorphism network actor-critic networks

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