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Carnosine and crocin ameliorate oxidative stress in rats with rhabdomyolysis-induced acute kidney injury through upregulating HO-1 gene expression

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Food Bioscience 2022年第5期49卷 904-914页

作者： Nahla E.El-Ashmawy eman g.khedr Ahmed S.Doghish Mohammed S.Elballal Department of Biochemistry Faculty of PharmacyTanta UniversityTantaEgypt Department of Biochemistry Faculty of PharmacyBadr University in Cairo(BUC)Badr CityCairo11829Egypt Department of Biochemistry and Molecular Biology Faculty of Pharmacy(Boys)Al-Azhar UniversityNasr CityCairo11651Egypt

We aimed to investigate whether carnosine(a natural dipeptide found in humans)and crocin(a natural product extracted from saffron and gardenia)can prevent the harmful effects of acute kidney injury(AKI)caused by glycerol-induced rhabdomyolysis with a focus on the role of the nuclear factor E2-related factor-2/heme oxygenase-1(Nrf2/HO-1)signaling ***-six male Wistar rats were divided into 6 groups:3 of them received saline,carnosine,and crocin IP for 7 days and the other 3 groups received the same treatment in addition to a single IM injection of 50%glycerol(10 ml/kg,divided between the two limb muscles)on 8th *** animals were sacrificed after 24 h of the IM *** samples,muscles,and kidneys were collected for further *** was evidenced by the histopathological alterations in muscle sections and increased levels of myoglobin in kidney tissue homogenate *** injury was characterized by increased creatinine,kidney injury molecule-1,malondialdehyde,nitric oxide,and decreased catalase *** injury also increased inflammatory markers and histopathological alterations in kidney *** these effects were corrected by pretreatment with carnosine and *** agents could also elevate HO-1 gene ***,both agents failed to restore the declined Nrf2 expression in glycerol-treated *** and crocin can effectively prevent rhabdomyolysis-induced AKI in rats through augmenting gene expression of HO-1 and antioxidant system and suppressing the generation of reactive oxygen species,lipid peroxidation,and inflammatory response.

关键词： Carnosine Crocin Acute kidney injury Rhabdomyolysis Antioxidant

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Synthesis, Structural Characterization, and Antimicrobial Activities of Mn（II）, Co（II）, Ni（II）, Cu（ll） and Zn（II） Complexes of Triazole-based Azodyes

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Chinese Journal of Chemistry 2011年第6期29卷 1124-1132页

作者： khedr, Abdalla M. gaber, Mohamed Abd EI-Zaher, eman H. Chemistry Department Faculty of Science Tanta University Tanta Egypt Botany Department Faculty of Science Tanta University Tanta Egypt

The synthesis and characterization of new transition metal complexes of Mn（ll）, Co（II）, Ni（II）, Cu（II） and Zn（II） with 3-（2-hydroxynaph-l-ylazo）-1,2,4-triazole （HL1） and 3-（2-hydroxy-3-carboxynaph-l-ylazo）-1,2,4-triazole （HL2） have been carried out. Their structures were confirmed by elemental analyses, thermal analyses, spectral and magnetic data. The IR and 1H NMR spectra indicated that HL1 and HL2 coordinated to the metal ions as bidentate monobasic ligands via the hydroxyl O and azo N atoms. The UV-Vis, ESR spectra and magnetic moment data revealed the formation of octahedral complexes [MnL1（AcO）（H2O）3] （1）, [CoL1（AcO）（HzO）3]·H2O （2）, [MnL2- （AcO）（H20）3] （6） and [CoL2（AcO）（H2O）3] （7）, [NiL1（AcO）（H2O）] （3）,[ZnLI（AcO）（HzO）]·H2O （5）, [NiL2- （AcO）（H2O）] （8）, [ZnL2（AcO）（H2O）]·H2O （10） have tetrahedral geometry, whereas [CuLI（AcO）（H2O）2] （4） and [CuL2（AcO）（H2O）2]·5H2O （9） have square pyramidal geometry.. The mass spectra of the complexes under EI-con- ditions showed the highest peaks corresponding to their molecular weights, based on the atomic weights of 55Mn, 59Co, 58Ni, 63Cu and 64Zn isotopes; besides, other peaks containing other isotopes distribution of the metal. Kinetic and thermodynamic parameters of the thermal decomposition stages were computed from the thermal data using Coats-Redfern method. HL2 and complexes 6--10 were found to have moderate antimicrobial activities against Staphylococcus＇ aureus （gram positive）, Escherichia coli （gram negative） and Salmonella sp bacteria, and antifungal activity against Fusarium oxysporum, Aspergillus niger and Candida albicans. Also, in most cases, metallation increased the activity compared with the free ligand.

关键词： analytical and inorganic chemistry triazole azodyes metal(II) chelates antimicrobial activities

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Serum homocysteine,lipid profile and BMI as atherosclerotic risk factors in children with numerical chromosomal aberrations

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World Journal of Pediatrics 2022年第6期18卷 443-448页

作者： eman R.Youness Sherien MEl-Daly Hanaa Reyad Abdallah Hala T.El-Bassyouni Hisham Megahed Azzah A.khedr Marwa Elhady Walaa Alsharany Abuelhamd Medical Biochemistry Department Medical Research DivisionNational Research CentreGizaEgypt Biological Anthropology Department Medical Research DivisionNational Research CentreGizaEgypt Clinical genetics Department Human Genetics and Genome Research DivisionNational Research CentreEl-Tahrir StreetPO:12622GizaEgypt Human Cytogenetics Department Human Genetics and Genome Research DivisionNational Research CentreGizaEgypt Pediatric Department Faculty of Medicine for GirlsAl-Azhar UniversityCairoEgypt Department of Pediatrics Faculty of MedicineCairo UniversityCairoEgypt

Down syndrome,Turner syndrome,and Klinefelter syndrome are the most common chromosomal disorders *** syndrome is caused by an extra copy of the 21st chromosome and has an incidence of 1 in 800 to 1000 live *** syndrom... 详细信息

关键词： chromosomal Turner Serum

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