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Small for size syndrome difficult dilemma: Lessons from 10 years single centre experience in living donor liver transplantation

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World Journal of Hepatology 2017年第21期9卷 930-944页

作者： Hany Shoreem emad Hamdy Gad Hosam Soliman Osama Hegazy Sherif Saleh Hazem Zakaria Eslam Ayoub Yasmin Kamel Kalid Abouelella Tarek ibrahim ibrahim Marawan Hepatobiliary Surgery Department National Liver InstituteMenoufiya Univer-sity Anesthesia Department National Liver InstituteMenoufiya University

AIM To analyze the incidence, risk factors, prevention, treatment and outcome of small for size syndrome(SFSS) after living donor liver transplantation(LDLT). METHODS Through-out more than 10 years: During the period from April 2003 to the end of 2013, 174 adult-to-adults LDLT(A-ALDLT) had been performed at National Liver Institute, Menoufiya University, Shibin Elkoom, Egypt. We collected the data of those patients to do this cohort study that is a single-institution retrospective analysis of a prospectively collected database analyzing the incidence, risk factors, prevention, treatment and outcome of SFSS in a period started from the end of 2013 to the end of 2015. The median period of follow-up reached 40.50 m, range(0-144 m). RESULTS SFSS was diagnosed in 20(11.5%) of our recipients. While extra-small graft [small for size graft(SFSG)], portal hypertension, steatosis and left lobe graft were significant predictors of SFSS in univariate analysis(P = 0.00, 0.04, 0.03, and 0.00 respectively); graft size was the only independent predictor of SFSS on multivariate analysis(P = 0.03). On the other hand, there was lower incidence of SFSS in patients with SFSG who underwent splenectomy [4/10(40%) SFSS vs 3/7(42.9%) no SFSS] but without statistical significance, However, there was none significant lower incidence of the syndrome in patients with right lobe(RL) graft when drainage of the right anterior and/or posterior liver sectors by middle hepatic vein, V5, V8, and/or right inferior vein was done [4/10(28.6%) SFSS vs 52/152(34.2%) no SFSS]. The 6-mo, 1-, 3-, 5-, 7-and 10-year survival in patients with SFSS were 30%, 30%, 25%, 25%, 25% and 25% respectively, while, the 6-mo, 1-, 3-, 5-, 7-and 10-year survival in patients without SFSS were 70.1%, 65.6%, 61.7%, 61%, 59.7%, and 59.7% respectively, with statistical significant difference(P = 0.00). CONCLUSION SFSG is the independent and main factor for occurrence of SFSS after A-ALDLT leading to poor outcome. However, the mana

关键词： Living donor liver transplantation Outcome after living donor liver transplantation Small for size syndrome Small for size graft Portal inflow Venous outflow

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Optimization of Coronavirus Pandemic Model Through Artificial Intelligence

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Computers, Materials & Continua 2023年第3期74卷 6807-6822页

作者： Manal M.Alqarni Arooj Nasir Dumitru Baleanu Ali Raza Tahir Nawaz Cheema Nauman Ahmed Muhammad Rafiq Umbreen Fatima emad E.Mahmoud Department of Mathematics College of SciencesKing Khalid UniversityAbha61413Saudi Arabia Baqai Medical University Karachi75340Pakistan Shalamar Medical and Dental College Lahore54000Pakistan Department of Mathematics Cankaya UniversityBalgatAnkara06530Turkey Department of Medical Research China Medical UniversityTaichung40402TaiwanChina Institute of Space Sciences Magurele-Bucharest077125Romania Department of Mathematics Govt.Maulana Zafar Ali Khan Graduate College WazirabadPunjab Higher Education Department(PHED)Lahore54000Pakistan Department of Mathematics University of GujratGujrat52200Pakistan Department of Mathematics and Statistics The University of LahoreLahore54590Pakistan Department of Mathematics Faculty of Science and TechnologyUniversity of Central PunjabLahore54000Pakistan Department of Computer Science University of LahoreLahore54590Pakistan Department of Mathematics and Statistics College of ScienceTaif UniversityP.O.Box11099Taif21944Saudi Arabia

Artificial intelligence is demonstrated by machines,unlike the natural intelligence displayed by animals,including *** intelligence research has been defined as the field of study of intelligent agents,which refers to any system that perceives its environment and takes actions that maximize its chance of achieving its *** techniques of intelligent computing solve many applications of mathematical *** researchworkwas designed via a particularmethod of artificial neural networks to solve the mathematical model of *** representation of the mathematical model is made via systems of nonlinear ordinary differential *** differential equations are established by collecting the susceptible,the exposed,the symptomatic,super spreaders,infection with asymptomatic,hospitalized,recovery,and fatality *** generation of the coronavirus model’s dataset is exploited by the strength of the explicit Runge Kutta method for different countries like India,Pakistan,Italy,and many *** generated dataset is approximately used for training,validation,and testing processes for each cyclic update in Bayesian Regularization Backpropagation for the numerical treatment of the dynamics of the desired *** performance and effectiveness of the designed methodology are checked through mean squared error,error histograms,numerical solutions,absolute error,and regression analysis.

关键词： Coronavirus model artificial techniques analysis

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New Trends in the Modeling of Diseases Through Computational Techniques

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Computer Systems Science & Engineering 2023年第6期45卷 2935-2951页

作者： Nesreen Althobaiti Ali Raza Arooj Nasir Jan Awrejcewicz Muhammad Rafiq Nauman Ahmed Witold Pawłowski Muhammad Jawaz emad E.Mahmoud Department of Mathematics and Statistics College of ScienceTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Department of Mathematics Govt.Maulana Zafar Ali Khan Graduate College WazirabadPunjab Higher Education Department(PHED)Lahore54000Pakistan Baqai Medical University Karachi75340Pakistan Shalamar Medical and Dental College Lahore54000Pakistan Department of Automation Biomechanics and MechatronicsLodz University of Technology1/15 Stefanowskiego St.90-924LodzPoland Department of Mathematics Faculty of Sciences and TechnologyUniversity of Central PunjabLahore54000Pakistan Department of Mathematics and Statistics University of LahoreLahore54590Pakistan Institute of Machine Tools and Production Engineering Lodz University of Technology1/15 Stefanowskiego St.90-537LodzPoland

The computational techniques are a set of novel problem-solving methodologies that have attracted wider attention for their excellent *** handling strategies of real-world problems are artificial neural networks(ANN),evolutionary computing(EC),and many *** estimated fifty thousand to ninety thousand new leishmaniasis cases occur annually,with only 25%to 45%reported to the World Health Organization(WHO).It remains one of the top parasitic diseases with outbreak and mortality *** 2020,more than ninety percent of new cases reported to World Health Organization(WHO)occurred in ten countries:Brazil,China,Ethiopia,Eritrea,India,Kenya,Somalia,South Sudan,Sudan,and *** transmission of visceral leishmaniasis is studied dynamically and *** study included positivity,boundedness,equilibria,reproduction number,and local stability of the model in the dynamical *** detailed methods like Runge Kutta and Euler depend on time steps and violate the physical relevance of the *** produce negative and unbounded results,so in disease dynamics,such developments have no biological significance;in other words,these results are *** the implicit nonstandard finite difference method does not depend on time step,positive,bounded,dynamic and *** the computational techniques and their results were compared using computer simulations.

关键词： Real-world problem differential equations computational techniques analysis

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New Trends in Fuzzy Modeling Through Numerical Techniques

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Computers, Materials & Continua 2023年第3期74卷 6371-6388页

作者： M.M.Alqarni Muhammad Rafiq Fazal Dayan Jan Awrejcewicz Nauman Ahmed Ali Raza Muhammad Ozair Ahmad Witold Pawłowski emad E.Mahmoud Department of Mathematics College of SciencesKing Khalid UniversityAbha61413Saudi Arabia Department of Mathematics Faculty of Sciences and TechnologyUniversity of Central PunjabLahorePakistan Department of Mathematics School of ScienceUniversity of Management and TechnologyLahorePakistan Department of Automation Biomechanics and MechatronicsLodz University of Technology1/15 Stefanowskiego St.90-924LodzPoland Department of Mathematics and Statistics University of LahoreLahorePakistan Department of Mathematics Govt.Maulana Zafar Ali Khan Graduate College WazirabadPunjab Higher Education Department(PHED)Lahore54000Pakistan Institute of Machine Tools and Production Engineering Lodz University of TechnologyPoland Department of Mathematics College of ScienceTaif UniversityP.O.Box11099Taif21944Saudi Arabia

Amoebiasis is a parasitic intestinal infection caused by the highly pathogenic amoeba Entamoeba *** is spread through person-toperson contact or by eating or drinking food or water contaminated with *** transmission rate depends on the number of cysts present in the *** traditional models assumed a homogeneous and contradictory transmission with *** heterogeneity of its transmission rate is a significant factor when modeling disease *** heterogeneity of disease transmission can be described mathematically by introducing fuzzy *** this context,a fuzzy SEIR Amoebiasis disease model is considered in this *** equilibrium analysis and reproductive number are studied with *** numerical schemes forward Euler method and a nonstandard finite difference(NSFD)approach,are developed for the learned model,and the results of numerical simulations are *** numerical and simulation results reveal that the proposed NSFD method provides an adequate representation of the dynamics of the disease despite the uncertainty and ***,the obtained method generates plausible predictions that regulators can use to support decision-making to design and develop control strategies.

关键词： Epidemic model fuzzy parameters amoebiasis NSFD scheme convergence

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Prospects of effective microorganisms technology in wastes treatment in Egypt

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Asian Pacific Journal of Tropical Biomedicine 2011年第3期1卷 243-248页

作者： emad A Shalaby Biochemistry Department Faculty of AgricultureCairo University

Sludge dewatering and treatment may cost as much as the wastewater *** large proportion of the pollutants in wastewater is *** are attacked by saprophytic microorganisms,*** that feed upon dead organic *** of organisms causes decomposition of organic matter and destroys them,where the bacteria convert the organic matter or other constituents in the wastewater to new cells,water,gases and other *** activities,including renovation/remodeling works and complete or selective removal/demolishing of existing structures either by man-made processes or by natural disasters,create an extensive amount of *** demolition wastes are characterized as heterogeneous mixtures of building materials that are usually contaminated with chemicals and *** developing countries, it is estimated that demolition wastes comprise 20%to 30%of the total annual solid *** Egypt,the daily quantity of construction and demolition(C&D) waste has been estimated as 10 000 *** is equivalent to one third of the total daily municipal solid wastes generated per day in *** zabbaliin have since expanded their activities and now take the waste they collect back to their garbage villages where it is sorted into recyclable components:paper,plastics, rags,glass,metal and *** food waste is fed to pigs and the other items are sold to recycling *** paper summarizes the wastewater and solid wastes management in Egypt now and future.

关键词： Effective microorganisms Wastes treatment Egypt Sludge dewatering Wastewater Pollutant Organic matter Decomposition Bacteria Contamination

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中东地区高铁建设EPC项目风险管理研究

中东地区高铁建设EPC项目风险管理研究

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作者： emad SHIHAB 北京交通大学

学位级别：硕士

2013年,中国国家主席习近平提出了一项名为“一带一路”倡议的全球经济项目。同时,中国政府广泛推动“一带一路”倡议,并敦促中国企业向国际扩张。中国的高铁从学习阶段转入自主创新阶段后,获得了大量成功的经验。这些创新不仅有可能指... 详细信息

2013年,中国国家主席习近平提出了一项名为“一带一路”倡议的全球经济项目。同时,中国政府广泛推动“一带一路”倡议,并敦促中国企业向国际扩张。中国的高铁从学习阶段转入自主创新阶段后,获得了大量成功的经验。这些创新不仅有可能指导中国高铁的未来发展,也会引起其他国家的兴趣。由于国际市场对高铁的需求不断增加,中国高铁“走出去”的机会越来越增加。中东地区具有发展较快的高铁建设和运输市场,尤其是中东地区对外开放以来,大量投资涌入中东地区高速铁路建设市场。海外高铁市场为中国国际承包商提供了机会,但这些项目在各地区面临独特的风险和挑战。因此,承包商必须对各地区的项目风险有一个全面的了解。纵观中国企业在中东地区完成的高铁项目,会发现中国企业在中东地区高铁建设时面临许多风险。在许多基础设施薄弱的国家,由于经济波动,为工程项目的资本预算提供资金可能是一个挑战。在这种情况下,公司必须找到解决融资问题的办法。为了解决资金问题,EPC+F模式为工程项目提供财政援助。近年来,EPC+F模式在中国和其他国家的工程企业中得到普及。因此,中国政府提供了大量政策和资金支持,以使中国工程企业能够通过EPC模式完成项目实际施工建设。本文探讨了在中东地区管理EPC项目风险的方式,并为希望“走出去”的企业提供了指导。为了获得理论意义和深入的研究成果,本文结合作者对中东地区局势的了解与文献研究,分析中国企业在海外项目包括中东地区的项目中面临的主要风险。为了确定初始风险清单是否与要评价的目的相一致,以及项目风险是否可以准确有效地表达出来,应该采用科学的方法。本论文中,用“内容有效度比”(缩写为“CVR”)与指标能否反应项目风险进行评价。其次,以调查问卷的方式,选取政治与社会风险、经济与法律风险、自然环境风险、管理风险、设计和施工风险五个方面的指标,建立中东地区高铁项目风险评价指标体系。并用层次分析AHP法,构建风险评价模型。最后,以埃及高铁项目为研究对象,通过专家打分法、层次分析法和模糊综合评价法对中东地区的风险进行定量分析,得出了中东地区在不同方面的风险指标。综上,本文旨在辅助中国企业分析中国高速铁路进入中东地区所面临的挑战和风险,评估这些风险,并提出相应的对策和建议。虽然面对诸多风险,但是在众多有利条件和关键因素下,中国未来在参与中东地区国家的高铁建设中具有巨大的发展潜力。因此,可预见,在不久的将来,中国的高铁将毫无疑问地在全球市场上占据主导地位。

关键词： “一带一路”倡议中东地区高铁建设风险管理

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Post-cholecystectomy iatrogenic bile duct injuries:Emerging role for endoscopic management

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World Journal of Gastrointestinal Surgery 2023年第12期15卷 2709-2718页

作者： Mohamed H Emara Mohammed Hussien Ahmed Mohamed I Radwan emad Hassan Emara Magdy Basheer Ahmed Ali Asem Ahmed Elfert Department of Hepatology Gastroenterology and Infectious DiseasesKafrelsheikh UniversityKafr-Elshikh 33516Egypt Department of Tropical Medicine Zagazig UniversityZagazig 44519Egypt Department of Diagnostic and Interventional Radiology Kafrelsheikh UniversityKafr-Elshikh 33516Egypt Department of Surgery Mansoura UniversityMansours 44176Egypt Department of Emergency Hargeisa Group HospitalHargeisa 1235Somalia Department of Tropical Medicine Tanta UniversityTanta 33120Egypt

Post-cholecystectomy iatrogenic bile duct injuries(IBDIs),are not uncommon and although the frequency of IBDIs vary across the literature,the rates following the procedure of laparoscopic cholecystectomy are much higher than open *** injuries caries a great burden on the patients,physicians and the health care systems and sometime are *** are associated with different manifestations that are not limited to abdominal pain,bile leaks from the surgical drains,peritonitis with fever and sometimes *** injuries if not witnessed during the surgery,can be diagnosed by combining clinical manifestations,biochemical tests and imaging *** such techniques abdominal US is usually the first choice while Magnetic Resonance Cholangio-Pancreatography seems the most *** approach was the ideal approach for such cases,however the introduction of Endoscopic Retrograde Cholangio-Pancreatography(ERCP)was a paradigm shift in the management of such injuries due to accepted success rates,lower cost and lower rates of associated morbidity and ***,the literature lacks consensus for the optimal timing of ERCP intervention in the management of *** management of IBDIs can be tailored according to the nature of the underlying *** the subgroup of patients with complete bile duct ligation and lost ductal continuity,transfer to surgery is indicated without *** patients will not benefit from endoscopy and hence should not do unnecessary *** low–flow leaks *** bed leaks,conservative management for 1-2 wk prior to ERCP is advised,in contrary to high-flow leaks *** duct leaks and stricture lesions in whom early ERCP is *** plus stenting is the ideal management line for cases of *** radiologic techniques are promising options especially for cases of failed endoscopic repair and also for cases with altered *** studies will

关键词： Iatrogenic bile duct injuries Cholecystectomy Surgical repair Endoscopic Retrograde Cholangio-Pancreatography Interventional radiology

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Impedance spectroscopy and DFT/TD-DFT studies of diyttrium trioxide for optoelectronic fields

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Journal of Rare Earths 2023年第4期41卷 605-612页

作者： Ali A.Alkathiri A.A.Atta Moamen S.Refat Sonam Shakya A.M.Hassanien Saud A.Algarni emad M.A.Ahmed Sultan E.Alomariy Mohammed Alsawat Norah Algethami Department of Physics College of ScienceTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Department of Chemistry College of ScienceTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Department of Chemistry Aligarh Muslim UniversityAligarh202002India Department of Physics Faculty of Science and Humanity Studies at Al-QuwayiyahShaqra UniversityAl-Quwayiyah11971Saudi Arabia

Yttrium(Ⅲ)oxide or so-called diyttrium trioxide(Y_2O_3)is an excellent candidate ceramic material for optoelectronic ***,electrical conductivity,and dielectric relaxation properties of bulk yttrium(Ⅲ)oxide were studied.X-ray diffraction(XRD)results indicate that the yttrium(Ⅲ)oxide compound has a crystalline cubic *** transform infrared(FTIR)technique was used to ascertain the chemical structure of the yttrium(Ⅲ)oxide *** spectroscopy was used to analyze frequency-dependent electrical properties as a function of temperature in the range of 303-423 K and frequency range of 0.1 Hz-2 *** spectroscopy parameters such as dielectric constant,dielectric loss,loss factor,electric modulus,and complex impedance of the yttrium(Ⅲ)oxide compound were *** Nyquist plot describes the complex impedance of the yttrium(Ⅲ)oxide for different *** universal Jonscher's power law was used for the analysis of the complex electrical conductivity of the yttrium(Ⅲ)oxide *** is found that the real(σ')and imaginary(σ")parts of the complex conductivity increase with increasing *** exponent frequency(s)equals unity,which confirms that the predominant conduction mechanism is a nearly constant loss(NCL)***/TD-DFT studies using B3LYP/LanL2DZ level of theory were used to provide comparable theoretical data and electronic energy gap of HOMO→LUMO.

关键词： Yttrium(Ⅲ)oxidel Impedance spectroscopy DFT/TD-DFT Rare earths

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Membrane Fouling in Microfiltration of Sanitary Landfill Leachate for Removals of Colourand Solids

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应用与环境生物学报 2013年第1期19卷 184-188页

作者： emad S.M.Ameen Water Research Alliance Institute of Environmental and Water Resource ManagementFaculty of Civil EngineeringUniversiti Teknologi Malaysia

In this research,the treatability of solids from sanitary landfill leachate by microfiltration membrane was investigated and the fouling of the membrane was carefully *** microfiltration process was carried out for 21 h in experimental system involved coagulation with Moringa oleifera followed by filtration using submerged hollow fibre microfiltration membrane (MFM).Coagulation with ***,air diffusers and back flush technique were used for preventing or alleviating fouling of the *** hollow fibre MFM showed high removals of 98%,91% and 99% for turbidity,colour and total suspended solids *** was obtained at the beginning of the ***,quality of the filtrate rapidly declined during the filtration *** was found to proceed according to the classical cake filtration *** with *** as well as the back-flush technique could not fully restore the deterioration occurred to the membrane.

关键词： RAPD ISSR AFLP 环境生物学

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Uncoupling tumor necrosis factor-αand interleukin-10 at tumor immune microenvironment of breast cancer through miR-17-5p/MALAT-1/H19 circuit

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BIOCELL 2022年第3期46卷 769-783页

作者： RAGHDA A.SOLIMAN RANA A.YOUNESS TAMER M.MANIE emad KHALLAF MOHAMED EL-SHAZLY MONA ABDELMOHSEN HEBA HANDOUSSA MOHAMED Z.GAD Pharmaceutical Biology Department Faculty of Pharmacy and BiotechnologyGerman University in CairoCairo11835Egypt School of Life and Medical Sciences University of Hertfordshire Hosted by Global Academic FoundationNew Administrative Capital11578Egypt Breast Surgery Department National Cancer InstituteCairo UniversityCairoEgypt General Surgery Department Faculty of MedicineCairo UniversityCairoEgypt Department of Phytochemistry National Research CentreGiza12622Egypt Biochemistry Department Faculty of Pharmacy and BiotechnologyGerman University in CairoCairo11835Egypt

Triple Negative Breast Cancer(TNBC)immunotherapy has recently shown promising ***,some TNBC patients presented with *** of the reasons was attributed to the excessive release of cytokines at the tumor microenvironment(TME)such as Tumor necrosis factor alpha(TNF-α)and Interleukin-10(IL-10).Fine regulation of these cytokines’levels via non-coding RNAs(ncRNAs)might alleviate the immune quiescent nature of TME at TNBC ***,the extrapolation of ncRNAs as therapeutic tools is highly ***,disentanglement the nature for the isolation of natural compounds that could modulate the ncRNAs and their respective targets is an applicable translational therapeutic ***,this study aimed to targeting the chief immune suppressive cytokines at the TME(TNF-αand IL-10)via ncRNAs and to examine the effects of Rosemary aerial parts extract on the expression levels of these ncRNAs in *** revealed miR-17-5p as a dual regulator of TNF-αand ***,an intricate interaction has been shown between miR-17-5p and the oncogenic lncRNAs:MALAT1 and *** down of MALAT1 and/or H19 caused an induction in miR-17-5p and reduction in TNF-αand IL-10 expression ***-17-5p was found to be down-regulated,while TNF-α,IL-10,MALAT1 and H19 were up-regulated in BC *** expression of miR-17-5p in MDA-MB-231 cells reduced TNF-α,IL-10,MALAT1 and H19 expression levels,as well as several BC *** a translational approach,ursolic acid(UA)isolated from rosemary induced the expression of miR-17-5p,MALAT1 and decreased H19 expression *** conclusion,this study suggests miR-17-5p as a tumor suppressor and an immune-activator miRNA in BC through tuning up the immunological targets TNF-α,IL-10 at the TME and the oncological mediators MALAT1 and H19 lncRNAs.

关键词： Breast cancer Tumor microenvironment Cytokines TNF-α IL-10 miR-17-5p MALAT1 H19 lncRNAs miRNA Ursolic acid

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