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Immunohistochemical measurement and expression of Mcl-1 in infertile testes

Frontiers of Medicine 2015年第3期9卷 361-367页

作者： Raafat Hegazy Abdelmonem Hegazy Mustafa Ammar emad Salem pathology Anatomy and Embryology Urology of Departments Faculty of Medicine Zagazig University Zagazig 44159 Egypt

The diagnosis of azoospermia represents a major challenge to andrologists as this condition may occur despite normal spermatogenesis and genital tracts. Myeloid cell leukemia-1 （Mcl-1） is a member of the Bcl-2 family of proteins involved in regulation of apoptosis in various cell types. This study aimed to investigate the immunohistochemical expression of McI-1 in testieular biopsies of subjects with azoospermia. Eighty-six cases with azoospermia were obtained from 509 infertile patients admitted to the Andrology Unit of the Zagazig University Hospitals from January 2010 to December 2011. Biopsies were diagnosed and classified using H＆E-stained slide sections. The specimens were subjected to immunohistochemical staining for Mcl-1 and examined through light microscopy. Forty-five cases of maturation arrest （25 at spermatids and 20 at the spermatocytes）, 31 cases of hypospermatogenesis （20 moderate and 11 severe）, 5 cases of Sertoli cell-only syndrome, 2 cases of basement membrane hyalinization, and 1 case of tubular and peritubular sclerosis were observed. Normal spermatogenesis was detected in 2 cases. A strong positive immunoreaction in Leydig cells was observed among all investigated specimens. A moderate reaction was detected in spermatocytes and spermatozoa in cases of normal spermatogenesis and hypospermatogenesis, but a negative reaction was detected in cases of maturation arrest and germ cell aplasia. Apoptosis was found to be associated with decreased rate of spermatogenesis. High apoptosis rates may result in azoospermia, which can occur despite normal spermatogenesis and absence of duct obstruction.

关键词： spermatogenesis testis Mcl-1 expression immunohistochemical study infertility

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The microsurgical treatment of glomus tumor at the nail bed of the finger

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The Chinese-German Journal of Clinical Oncology 2007年第1期6卷 85-86页

作者： emad Aburub Department of Orthopedics Zhongnan Hospital Wuhan University

Objective: To discuss the diagnosis and treatment of glomus tumor at the nail bed of the finger. Methods: The course and therapeutic outcome of 12 cases of glomus tumor which were resected and confirmed by histology examination were analyzed. Results: All cases were followed up for six months up to 2 years, no recurrences were observed, the shape of the nail was normal. Conclusion: Microsurgical treatment of glomus tumors of the nail bed is effective.

关键词：手指肿瘤甲床血管球瘤显微外科手术治疗

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Analytical Solution for Peristaltic Transport of Viscous Nanofluid in an Asymmetric Channel with Full Slip and Convective Conditions

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Communications in Theoretical Physics 2017年第7期67卷 96-102页

作者： Abdelhalim Ebaid emad H.Aly K.Vajravelu Department of Mathematics Faculty of Science University of Tabuk Department of Mathematics Faculty of Science University of Jeddah Department of Mathematics Faculty of Education Ain Shams University Department of Mathematics Department of Mechanical Materials and Aerospace Engineering University of Central Florida

The peristaltic flow of nanofluids is a relatively new area of research. Scientists are of the opinion that the no-slip conditions at the boundaries are no longer valid and consequently, the first and the second order slip conditions should be addressed. In this paper, the effects of slip conditions and the convective boundary conditions at the boundary walls on the peristaltic flow of a viscous nanofluid are investigated for. Also, the exact analytical solutions are obtained for the model. The obtained results are presented through graphs and discussed. The results reveal that the two slip parameters have strong effects on the temperature and the nanoparticles volume fraction profiles. Moreover, it has been seen that the temperature and nanoparticles volume fraction profiles attain certain values when the first slip condition exceeds a specified value. However, no limit value for the second slip parameter has been detected. Further, the effects of the various emerging parameters on the flow and heat transfer characteristics have been presented.

关键词：对流边界条件精确解析解粘性流体非对称信道滑移蠕动颗粒体积分数运输

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Electroencephalogram (EEG) Brain Signals to Detect Alcoholism Based on Deep Learning

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Computers, Materials & Continua 2021年第6期67卷 3329-3348页

作者： emad-ul-Haq Qazi Muhammad Hussain Hatim A.AboAlsamh Visual Computing Lab Department of Computer ScienceCollege of Computer and Information SciencesKing Saud UniversityRiyadh11543Saudi Arabia

The detection of alcoholism is of great importance due to its effects on individuals and *** alcoholism detection system(AADS)based on electroencephalogram(EEG)signals is effective,but the design of a robust AADS is a challenging ***’current designs are based on conventional,hand-engineered methods and restricted *** by the excellent deep learning(DL)success in many recognition tasks,we implement an AAD system based on EEG signals using DL.A DL model requires huge number of learnable parameters and also needs a large dataset of EEG signals for training which is not easy to obtain for the AAD *** order to solve this problem,we propose a multi-channel Pyramidal neural convolutional(MP-CNN)network that requires a less number of learnable *** the deep CNN model,we build an AAD system to detect from EEG signal segments whether the subject is alcoholic or *** validate the robustness and effectiveness of proposed AADS using KDD,a benchmark dataset for alcoholism detection *** order to find the brain region that contributes significant role in AAD,we investigated the effects of selected 19 EEG channels(SC-19),those from the whole brain(ALL-61),and 05 brain regions,i.e.,TEMP,OCCIP,CENT,FRONT,and *** results show that SC-19 contributes significant role in AAD with the accuracy of 100%.The comparison reveals that the state-of-the-art systems are outperformed by the *** proposed AADS will be useful in medical diagnosis research and health care systems.

关键词： Electroencephalogram convolutional neural network deep learning alcoholism

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Prussian blue and its analogues as advanced supercapacitor electrodes

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Journal of Energy Chemistry 2020年第11期29卷 206-229页

作者： emad S.Goda Seungho Lee Muhammad Sohail Kuk Ro Yoon Organic Nanomarerials Lab Department of ChemistryHannam UniversityDaejeon 34054Republic of Korea Department of Chemistry Hannam UniversityDaejeon 34054Republic of Korea Fire Protection Laboratory National Institute of Standards136.Giza 12211Egypt Advanced Energy and System Engineering University of Science and TechnologyDaejeon 34113Republic of Korea

Remarkable attention has been directed to Prussian blue(PB) and its analogues(PBA) as one of the most widely used metal-organic frameworks(MOFs) especially in the field of energy storage devices due to their fabulous features such as 3D open framework, high surface area, controllable distribution of pores and the low cost. Nevertheless, their depressed conductivity causes some insulation when being used as an electrode for supercapacitors leading to be restricted in further applications particularly the electronics. To the best of our knowledge, our review aimed primarily to give a total picture of the research that was done on utilizing PB and PBA for fabricating the electrodes of supercapacitor, studying their synthesis approaches in addition to the hybridization with other materials such as graphene, CNTs and conducting polymer. It also addresses the transformation of PB or PBA into other interesting nanostructures such as oxides, sulfides, and bicomponent of graphitic carbon nitride/metal oxides, as well. Furthermore,It exhibits various avenues for overcoming their disadvantages of bad cycle life, retention rate and not achieving the desired values of energy/power densities opening the door for enlarging the number of researches on their application as supercapacitors.

关键词： Metal hexacyanoferrates Supercapacitors Electrolyte Energy density Cyclic stability

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Takotsubo cardiomyopathy in orthotopic liver transplant recipients: A cohort study using multi-center pooled electronic health record data

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World Journal of Hepatology 2022年第2期14卷 400-410页

作者： Mohammad Zmaili Jafar Alzubi Motasem Alkhayyat Joshua Cohen Saqer Alkharabsheh Mariam Rana Paulino A Alvarez emad Mansoor Bo Xu Robert and Suzanne Tomsich Department of Cardiovascular Medicine Sydell and Arnold Miller Family HeartVascular and Thoracic InstituteCleveland Clinic FoundationClevelandOH 44195United States Department of Medicine Division of CardiologyEinstein Medical CenterPhiladelphiaPA 19141United States Department of Gastroenterology Hepatology and NutritionDigestive Disease and Surgery InstituteCleveland Clinic FoundationClevelandOH 44195United States Department of Medicine University Hospitals Cleveland Medical CenterCase Western Reserve UniversityClevelandOH 44106United States Department of Gastroenterology University Hospitals Cleveland Medical CenterCase Western Reserve UniversityClevelandOH 44106United States

BACKGROUND Takotsubo cardiomyopathy(TCM),or stress-induced cardiomyopathy,is associated with adverse *** data suggest that TCM occurring in orthotopic liver transplant(OLT)recipients is associated with elevated perioperative *** To characterize the predictors of TCM in OLT recipients,using a large,multicenter pooled electronic health *** A multi-institutional database(Explorys Inc,Cleveland,OH,USA),an aggregate of de-identified electronic health record data from 26 United States healthcare systems was surveyed.A cohort of patients with a Systematized Nomenclature of Medicine-Clinical Terms of“liver transplant”between 09/2015 and 09/2020 was ***,individuals who developed a new diagnosis of TCM following OLT were ***,the risk associations with TCM among this patient population were characterized using linear *** Between 09/2015 and 09/2020,of 37718540 patients in the database,38740(0.10%)had a history of OLT(60.6%had an age between 18-65 years,58.1%female).A new diagnosis of TCM was identified in 0.3%of OLT recipients(45.5%had an age between 18-65 years,72.7%female),compared to 0.04%in non-OLT patients[odds ratio(OR):7.98,95%confidence intervals:6.62-9.63,(P<0.0001)].OLT recipients who developed TCM,compared to those who did not,were more likely to be greater than 65 years of age,Caucasian,and female(P<0.05).There was also a significant association with cardiac arrhythmias,especially ventricular arrhythmias(P<0.0001).CONCLUSION TCM was significantly more likely to occur in LT recipients vs *** age,Caucasian ethnicity,female gender,and presence of arrhythmias were significantly associated with TCM in LT recipients.

关键词： Takotsubo cardiomyopathy Orthotopic liver transplant Stress-induced cardiomyopathy Clinical outcomes

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Prevention of wing rock motion for lightly damped aircraft in lateral-directional dynamics

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Journal of Harbin Institute of Technology(New Series) 2008年第5期15卷 613-619页

作者： emad N.Abdulwahab 陈红全 College of Aerospace Engineering Nanjing University of Aeronautics and Astronautics

Based on the Ricatti technique, the methodology for preventing the limit cycle accomplished by adding a control function to the original equation of wing rock motion is presented in this paper. To analyze the state variables of the system, the complete set of nonlinear equations of motion including an effective linear control function was solved for A-4D and Mig-21 Aircraft. The roll angle responding to the linear control function for both models was estimated when the systems were tested under different damping ratios. The numerical results show that a linear control function including both the roll attitude and the roll rate is sufficient to suppress the wing rock motion with an acceptable error in desired time. A good agreement between the numerical results and the published work is obtained for the limit cycle oscillation existence at different damping ratios.

关键词：机翼振动非线性动态方程周期运动控制航空技术

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Mild haemoglobin drop and clinical outcomes in acute coronary syndrome patients:finding from the BleeMACS registry

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Journal of Geriatric Cardiology 2022年第12期19卷 981-989,1016页

作者： Ze-Kun ZHANG Yan YAN Si-Yi LI Sergio Raposeiras-Roubín emad Abu-Assi JoséPHenriques Fabrizio D’Ascenzo Jorge Saucedo Wei GONG Shao-Ping NIE on behalf of the BleeMACS registry investigators Center for Coronary Artery Disease Division of CardiologyBeijing Anzhen HospitalCapital Medical UniversityBeijingChina National Clinical Research Center for Cardiovascular Diseases BeijingChina Beijing Institute of Heart Lungand Blood Vessel DiseasesBeijingChina Department of Cardiology Álvaro Cunqueiro University HospitalVigoSpain Department of Cardiology Amsterdam University Medical CenterAmsterdamthe Netherlands Division of Cardiology Department of Medical ScienceUniversity of TurinTurinItaly Division of Cardiovascular Medicine Medical College of WisconsinWisconsinUSA 不详

BACKGROUND Haemoglobin drop is common in acute coronary syndrome(ACS)patients and correlates with poor ***,the association between mild haemoglobin drop and adverse clinical outcome remains insufficiently *** study aimed to examine the association between in-hospital haemoglobin drop and risk for adverse clinical outcomes in ACS patients,especially those with mild *** Included patients from the BleeMACS(Bleeding complications in a Multicenter registry of patients discharged after an Acute Coronary Syndrome)registry were categorized into three groups by the presence and amount of in-hospital haemoglobin drop(non-drop,mild drop and severe drop).The cut-off point between mild drop and severe drop is≥3 g/*** Cox regression was used to assess the association between haemoglobin drop and major adverse cardiac endpoints(MACE).Patients taking potent P2Y_(12) inhibitors were selected for the additional *** score matching was used to avoid selective bias in the additional *** Of 6911 patients,4949 patients(71.6%)experienced in-hospital haemoglobin *** with non-drop group,patients with haemoglobin drop had higher risk of MACE[adjusted hazard ratio(HR)=1.36,95%CI:1.03–1.80 for mild drop group;adjusted HR=1.70,95%CI:1.07–2.68 for severe drop group].Patients in mild drop group were less likely to receive potent P2Y_(12) inhibitors at discharge(mild drop group *** drop group ***-drop group:10.9%vs.10.7%vs.23.8%).After propensity score matching adjustment among patients with potent P2Y_(12) inhibitors,patients in mild drop group were not associated with an increased risk of MACE than those in non-drop group(adjusted HR=1.52,95%CI:0.49–4.72).CONCLUSIONS In-hospital haemoglobin drop was common in ACS patients and associated with a higher risk for adverse *** prescription for potent P2Y_(12) inhibitors may be responsible for poor prognoses among patients with mild haemoglobin dro

关键词： patients clinical coronary

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linear and nonlinear fractional differential equation modified Riemann–Liouville derivatives exact solutions fractional auxiliary sub-equation expansion method Mittag–Leffler function method

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Communications in Theoretical Physics 2016年第2期65卷 127-135页

作者： emad A-B.Abdel-Salam Gamal F.Hassan Department of Mathematics Faculty of Science Assiut University New Valley Branch E1-Kharja 72511 Egypt

In this paper, the fractional auxiliary sub-equation expansion method is proposed to solve nonlinear fractional differential equations. To illustrate the effectiveness of the method, we discuss the space-time fractional KdV equation, the space-time fractional RLW equation, the space-time fractional Boussinesq equation, and the (3+1)-space-time fractional ZK equation. The solutions are expressed in terms of fractional hyperbolic and fractional trigonometric functions. These solutions are useful to understand the mechanisms of the complicated nonlinear physical phenomena and fractional differential equations. Among these solutions, some are found for the first time. The analytical solution of homogenous linear FDEs with constant coefficients are obtained by using the series and the Mittag–Leffler function methods. The obtained results recover the well-know solutions when α = 1.

关键词：非线性微分方程组分数阶微分方程 Liouville 辅助方程展开法生物改性 Boussinesq方程精确解

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Analysis of the effect of passive measures on the energy consumption and zero-energy prospects of residential buildings in Pakistan

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Building Simulation 2021年第4期14卷 1325-1342页

作者： Muhammad Wasim Anwar Zaib Ali Abdullah Javed emad Ud Din Muhammad Sajid School of Mechanical and Manufacturing Engineering National University of Sciences and TechnologyIslamabadPakistan

Climate change can adversely impact the thermal comfort and energy efficiency of the buildings stock. The South Asian countries are particularly vulnerable to the adverse impacts of climate change specially in the form of rising temperatures and increasing frequency of heat waves. The passive building design measures can be useful in mitigating and adapting to the climate change by increasing energy efficiency and reducing greenhouse gas (GHG) emissions. In this study various passive climate change adaptation measures (PCAMs) have been used individually and in form of combinations in order to analyze their impact on the energy efficacy of residential buildings in Pakistan. It has been found that the natural ventilation and front green wall are the most efficient options for reducing the overall energy consumption. By implementation of these PCAMs, cooling demand can be decreased by 27.75% while heating demand can be reduced by 35%. Secondly, the prospect of net zero-energy building and reduced CO2 emissions are also studied. It has been shown that building can achieve net-zero energy on an annual basis at every orientation and it can attain the status of nearly zero-energy building on a monthly basis. Moreover, emitted CO2 can be reduced by 31% by using the renewable energy.

关键词： building energy simulations net zero-energy passive climate adaptation measures climate change energy consumption Pakistan

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