检索结果-南通市图书馆

Nonlinear control of photonic higher-order topological bound states in the continuum

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2021年第9期10卷 1726-1735页

作者： Zhichan Hu Domenico Bongiovanni Dario Jukić ema.Jajtić Shiqi Xia Daohong Song Jingjun Xu Roberto Morandotti Hrvoje Buljan Zhigang Chen The MOE Key Laboratory of Weak-Light Nonlinear Photonics TEDA Applied Physics Institute and School of PhysicsNankai University300457TianjinChina INRS-EMT 1650 Boulevard Lionel-BouletVarennesQCJ3X 1S2Canada Faculty of Civil Engineering University of ZagrebA.Kačića Miošića 2610000ZagrebCroatia Department of Physics Faculty of ScienceUniversity of ZagrebBijenička c.3210000ZagrebCroatia Collaborative Innovation Center of Extreme Optics Shanxi University030006TaiyuanShanxiChina Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China610054ChengduSichuanChina Department of Physics and Astronomy San Francisco State UniversitySan FranciscoCA94132USA

Higher-order topological insulators(HOTIs)are recently discovered topological phases,possessing symmetry-protected corner states with fractional *** unexpected connection between these states and the seemingly unrelated phenomenon of bound states in the continuum(BICs)was recently *** nonlinearity is added to the HOTI system,a number of fundamentally important questions *** example,how does nonlinearity couple higher-order topological BICs with the rest of the system,including continuum states?In fact,thus far BICs in nonlinear HOTIs have rema.ned *** we unveil the interplay of nonlinearity,higher-order topology,and BICs in a photonic *** observe topological corner states that are also BICs in a laser-written second-order topological lattice and further demonstrate their nonlinear coupling with edge(but not bulk)modes under the proper action of both self-focusing and defocusing ***,we calculate the eigenvalue spectrum and analog of the Zak phase in the nonlinear regime,illustrating that a topological BIC can be actively tuned by nonlinearity in such a photonic *** studies are applicable to other nonlinear HOTI systems,with promising applications in emerging topology-driven devices.

关键词： topological nonlinearity nonlinear

Individual Differences in Blood Alcohol Concentrations after Moderate Drinking Are Mainly Regulated by Gastric Emptying Rate Together with Ethanol Distribution Volume

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food and Nutrition Sciences 2012年第6期3卷 732-737页

作者： Shunji Oshima Takeshi Haseba Chiaki Masuda ema.Kakimi Manabu Sami Tomomasa Kanda Youkichi Ohno Department of Legal Medicine Nippon Medical School Tokyo Japan. Research Laboratories for Fundamental Technology of Food Asahi Group Holdings Ltd. Ibaraki Japan

Blood alcohol concentration (BAC) differs greatly among individuals, even when people of the same sex and age drink alcohol under the same drinking conditions. In this study, we investigated the main factors involved in the internal reg-ulation of individual differences in BAC, focusing on the alcohol dehydrogenase 1B (ADH1B) genotype, blood acetal-dehyde concentration (BAcH), amount of habitual alcohol consumption, pharmacokinetic parameters of BAC, distribution volume of ethanol (Vd), and gastric emptying rate (GER) under the same drinking conditions. Twenty healthy Japanese males aged between 40 and 59 years old and having the aldehyde dehydrogenase 2 (ALDH2) genotype of ALDH 2*1/*2 were recruited for this study. The subjects were given 0.32 g ethanol/kg body weight in the form of commercially available beer (5%, v/v). The results showed that BAC-max differed greatly among individuals with a more than two-fold variation. When the BAC-time curve was compared among ADH1B genotypes (ADH1B*1/*1, *1/*2, and *2/*2), there were no differences in BAC among the genotypes. Although BAcH, monthly alcohol consumption, elimination rate of blood ethanol (β value) and ethanol disappearance rate from the body (EDR) can affect BAC, all of them had no correlations with BAC-max. However, Vd (liter/kg), ΔPlasma glucose concentration (ΔPGC = PGC30 min ? PGC0 min) and the serum concentration of gastric inhibitory polypeptide (GIP) did correlate with BAC-max. Model 2 in multiple linear regression analysis showed the optimal model for Vd and GIP with positive correlations with BAC-max. As GIP and ΔPGC are both reflected by gastric emptying rate (GER), we concluded that the individual differences in BAC after moderate drinking are mainly regulated by GER together with Vd. These findings demonstrate that together with body water content, the gastrointestinal tract plays an important role in the regulation of individual differences in BAC, involving first pass metabolism of ethanol.

关键词： Individual Differences Blood Ethanol Concentration Moderate Drinking Gastric Emptying Rate Distribution Volume

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

加拿大哥伦比亚大学新档案馆

设计 2017年第8期30卷 26-27页

作者： jacob ema.peter(图)

这是位于加拿大英属哥伦比亚大学的新档案馆，建筑出色展示了高度专业化的图书馆环境，它基于哈佛大学开发的模型，可以在典型图书馆环境中将图书馆印刷收藏品的寿命从30年延长到300年。在控制温度和湿度的条件下，图书馆藏品都被存储... 详细信息

这是位于加拿大英属哥伦比亚大学的新档案馆，建筑出色展示了高度专业化的图书馆环境，它基于哈佛大学开发的模型，可以在典型图书馆环境中将图书馆印刷收藏品的寿命从30年延长到300年。在控制温度和湿度的条件下，图书馆藏品都被存储在高密度的搁架单元中，通过使用该系统，档案馆成为北美最经济高效的存储设施。

关键词：哥伦比亚大学档案馆加拿大图书馆哈佛大学控制温度收藏品专业化

在线全文

学校读者我要写书评

暂无评论

心理学方法在竞技运动中的应用

应用心理学 1984年第2期 46-49页

作者： ema.Geron 叶平

历史的回顾体育运动的发展和人们对运动竞赛兴趣的日益浓厚,是现代社会的特点之一。由于运动是建立在人体活动基础之上的社会现象,因而它就成了心理学研究的对象。心理学要研究运动,而运动也需要心理学的帮助。尤其是在竞技运动中,竞赛... 详细信息

历史的回顾体育运动的发展和人们对运动竞赛兴趣的日益浓厚,是现代社会的特点之一。由于运动是建立在人体活动基础之上的社会现象,因而它就成了心理学研究的对象。心理学要研究运动,而运动也需要心理学的帮助。尤其是在竞技运动中,竞赛时的身体紧张和情绪情境都会引起心理问题,这时心理学的帮助就成为极为必要的了。人们在多年以前就已经

关键词：运动操作教练员竞技运动竞技体育运动员体育工作者心理学

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

英属哥伦毕业大学学生会大楼

设计 2016年第6期29卷 26-27页

作者： jacob ema.peter(图)

DIALOG与B＋H协作的英属哥伦比亚大学学生会大楼的设计方案旨在创造一个融入周边环境的模范社区，具有生态节能与可持续发展特色。方案将凭借灵动的建筑设计、广袤的空间以及鲜活的景观设计，为学生提供高质量的教学体验，并借此吸引来... 详细信息

DIALOG与B＋H协作的英属哥伦比亚大学学生会大楼的设计方案旨在创造一个融入周边环境的模范社区，具有生态节能与可持续发展特色。方案将凭借灵动的建筑设计、广袤的空间以及鲜活的景观设计，为学生提供高质量的教学体验，并借此吸引来自世界各地的优秀学生。新的学生会大楼将成为社交及生态可持续发展设计领域的全球标杆。

关键词：哥伦比亚大学学生大楼可持续发展设计毕业 DIALOG 生态节能建筑设计

Target specificity of selective bioactive compounds in blocking α-dystroglycan receptor to suppress Lassa virus infection: an in silico approach

在线全文

学校读者我要写书评

暂无评论

The Journal of Biomedical Research 2021年第6期35卷 459-473页

作者： Adittya Arefin Tanzila Ismail ema.Tamnia Islam MdSaddam Hossen Tariqul Islam Salauddin Al Azad MdNasir Uddin Badal MdAminul Islam Partha Biswas Nafee Ul Alam Enayetul Islam Maliha Anjum Afsana Masud MdShaikh Kamran Ahsab Rahman Parag Kumar Paul Wolfson Institute for Biomedical Research Division of MedicineUniversity College LondonLondon WC1E6AEUK Department of Biochemistry and Microbiology North South UniversityDhaka 1229Bangladesh Faculty of Life Sciences and Medicine Zhejiang Sci-Tech UniversityHangzhouZhejiang 310018China Faculty of Pharmacy International Islamic University MalaysiaKuantanPahang 25200Malaysia School of Biotechnology Jiangnan UniversityWuxiJiangsu 214122China Department of Biomedical Technology Tampere UniversityTampere 33014Finland Department of Genetic Engineering and Biotechnology Jashore University of Science and TechnologyJashore 7408Bangladesh Department of Genetic Engineering and Biotechnology University of ChittagongChittagong 4331Bangladesh Applied Statistics and Data Science Jahangirnagar UniversityDhaka 1342Bangladesh Department of Mathema.ics and Natural Sciences Brac UniversityDhaka 1212Bangladesh Department of Electrical and Electronic Engineering United International UniversityDhaka 1212Bangladesh.

Lassa hemorrhagic fever,caused by Lassa mammarenavirus(LASV)infection,accumulates up to 5000 deaths every ***,there is no vaccine available to combat this *** this study,a library of 200 bioactive compounds was virtually screened to study their drug-likeness with the capacity to block theα-dystroglycan(α-DG)receptor and prevent LASV *** rigorous absorption,distribution,metabolism,and excretion(ADME)and quantitative structure-activity relationship(QSAR)profiling,molecular docking was conducted with the top ligands against theα-DG *** compounds chrysin,reticuline,and 3-caffeoylshikimic acid emerged as the top three ligands in terms of binding ***-docking analysis revealed that interactions with Arg76,Asn224,Ser259,and Lys302 amino acid residues of the receptor protein were important for the optimum binding affinity of *** dynamics simulation was performed comprehensively to study the stability of the protein-ligand ***-depth assessment of root-mean-square deviation(RMSD),root mean square fluctuation(RMSF),polar surface area(PSA),B-Factor,radius of gyration(Rg),solvent accessible surface area(SASA),and molecular surface area(MolSA)values of the protein-ligand complexes affirmed that the candidates with the best binding affinity formed the most stable protein-ligand *** authenticate the potentialities of the ligands as target-specific drugs,an in vivo study is underway in real time as the continuation of the research.

关键词： LASV infection α-dystroglycan receptor bioactive compounds target specificity molecular docking molecular dynamic simulations

ANTIVIRAL EFFECTS OF BACTERIOCIN AGAINST ANIMAL-TO-HUMAN TRANSMITTABLE MUTATED SARS-COV-2:A SYSTema.IC REVIEW

在线全文

学校读者我要写书评

暂无评论

Frontiers of Agricultural Science and Engineering 2021年第4期8卷 603-622页

作者： Dipta DEY Tanzila Ismail ema.Partha BISWAS Sharmin AKTAR Shoeba ISLAM Urmi Rahman RINIK Mahmudul FIROZ Shahlaa Zernaz AHMED Salauddin AL AZAD Ahsab RAHMAN Sadia AFRIN Rezwan Ahmed MAHEDI MdNasir Uddin BADAL Department of Biochemistry and Molecular Biology Bangabandhu Sheikh Mujibur Rahman Science&Technology UniversityGopalganj 8100Bangladesh Department of Microbiology and Biochemistry North South UniversityDhaka 1229Bangladesh Department of Genetic Engineering and Biotechnology Jashore University of Science and TechnologyJashore 7408Bangladesh Department of Microbiology University of DhakaDhaka 1000Bangladesh Department of Naval Architecture and Marine Engineering Bangladesh University of Engineering and TechnologyDhaka 1205Bangladesh Biotechnology and Genetic Engineering Discipline Khulna UniversityKhulna 9208Bangladesh Department of Mechanical and Production Engineering Islamic University of TechnologyGazipur 1704Bangladesh School of Biotechnology Jiangnan UniversityWuxi 214122China Department of Mathema.ics and Natural Sciences Brae UniversityDhaka 1212Bangladesh Department of Pharmacy Comilla UniversityComilla 3506Bangladesh Department of Biomedical Technology Tampere UniversityTampere 33100Finland

The COVID-19 caused by SARS-CoV-2 has resulted in millions of people being infected and thousands of deaths globally since November *** date,no unique therapeutic agent has been developed to slow the progression of this *** possessing antiviral traits the potential of bacteriocins to combat SARS-CoV-2 infection has not been fully *** review summarizes the mechanisms by which bacteriocins can be manipulated and implemented as effective virus entry blockers with infection suppression potential properties to highly transmissible viruses through comprehensive immune modulations that are potentially effective against *** antimicrobial peptides have been suggested as effective antiviral therapeutics and therapeutic supplements to prevent rapid virus *** review also provides a new insight into the cellular and molecular alterations which have made SARS-CoV-2 self-modified with diversified infection *** addition,the possible applications of antimicrobial peptides through both natural and induced mechanisms in infection prevention perspectives on changeable virulence cases are comprehensively *** attention is given to the antiviral mechanisms of the molecules along with their integrative use with synthetic biology and nanosensor technology for rapid *** bacteriocin based therapeutics with cutting-edge technologies might be potential substitutes for existing time-consuming and expensive approaches to fight this newly emerged global threat.

关键词： antimicrobial proteins antiviral profiling of bacteriocins antiviral therapeutics immunomodulation nanosensor technology mutated SARS-CoV-2

p18^(INK4C)缺失通过激活LMO2加快Notch-1诱导的急性T淋巴细胞白血病进展

在线全文

学校读者我要写书评

暂无评论

中国科学：生命科学 2017年第12期47卷 1386-1396页

作者：董芳拜海涛王晓芳张森张珊珊马士卉 Hideo ema.程涛郝莎中国医学科学院&北京协和医学院血液病医院(血液学研究所) 实验血液学国家重点实验室天津300020 中国医学科学院干细胞医学中心天津300020 北京协和医学院干细胞与再生医学系天津300020

p18^(INK4C)(CDKN2C)属于细胞周期蛋白激酶抑制剂家族成员,通过阻断细胞周期蛋白激酶4/6使细胞周期处于G1早期.研究提示,p18缺失影响T细胞的正常发育并可能参与急性T淋巴细胞白血病(T-ALL)的发生,但p18缺失导致T-ALL发生和进展的机制并... 详细信息

p18^(INK4C)(CDKN2C)属于细胞周期蛋白激酶抑制剂家族成员,通过阻断细胞周期蛋白激酶4/6使细胞周期处于G1早期.研究提示,p18缺失影响T细胞的正常发育并可能参与急性T淋巴细胞白血病(T-ALL)的发生,但p18缺失导致T-ALL发生和进展的机制并不清楚.本文利用Notch-1胞内段(ICN-1)过表达诱导的T-ALL模型来研究p18影响T-ALL的发生和进展的可能机制.结果发现,p18-/-骨髓细胞过表达ICN-1可诱发T-ALL,白血病细胞表型为更加原始的CD4/CD8双阴性细胞,且这些细胞主要阻滞在DN3阶段;T-ALL细胞连续移植结果显示,p18缺失能够显著加速T-ALL的进展,且p18-/-T-ALL细胞更多地处于细胞周期的G0期,即静息状态;基因表达结果发现,与T-ALL发生直接相关的原癌基因Lmo2及共结合分子如Sfpi1,Nfe2及Ldb1等以及N-myc的表达水平在p18-/-组显著高于对照组.以上结果提示,p18缺失后可能通过激活Lmo2及N-myc等的表达从而加速T-ALL的进展.本研究对p18缺失如何加速T-ALL的发展进行了阐释,对临床伴随有p18缺失或者LMO2异常激活型突变T-ALL病人的预后提供了理论依据,具有一定的临床指导价值.

关键词：细胞周期蛋白激酶抑制剂 p18INK4C 急性T淋巴细胞白血病 LMO2

Could sport be part of pediatric obesity prevention and treatment? Expert conclusions from the 28th European Childhood Obesity Group Congress

在线全文

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2019年第4期8卷 350-352页

作者： Susanne Ring-Dimitriou Peter Krustrup Manuel J Coelho-E-Silva Jorge Mota Andera Seabra Carla Rego Artur Mazur Elpis Vlachopapadopoulou Margerita Caroli Marie-Laure Frelut Eva Erhardt Anders Forslund ema.Boyland Daniel Weghuber David Thivel Department of Sport Science and Kinesiology Paris Lo dron-UniversitySalzburg 5020Austria Paediatric Practice Albi 81000France Department of Paediatrics University of PecsPecs 7600Hungary Department of Women's and Children's Health Uppsala UniversityUppsala 74192Sweden Appetite&Obesity Research Group Department of Psychological SciencesUniversity of LiverpoolLiverpoolL69 7ZAUK Department of Pediatrics Obesity Research UnitParacelsus Medical UniversitySalzburg 5020Austria Laboratory of the Metabolic Adaptations to Exercise under Physiological and Pathological Conditions Auvergne Regional Center for Human NutritionClermont A uvergne UniversityClermont-Ferrand 63000France European Childhood Obesity Group(ECOG) Brussels 1000Belgium Department of Sports Science and Clinical Biomechanics SDU Sport and Health Sciences Cluster(SHSC)University of Southern DenmarkOdense 5000Denmark Faculty of Sport Sciences and Physical Education University of CoimbraCoimbra 3000Portugal Research Centre in Physical Activity Health and Leisure(CIAFEL)Faculty of SportUniversity of PortoPorto 4000Portugal Hospital Center for Research in Health Technologies and Information Systems(CINTESIS)Faculty of MedicineUniversity of PortoPorto 4000Portugal Pediatric Department Clinical Provincial Hospital No.2 in Rzesz6wFaculty of MedicineUniversity of RzeszowRzeszow 35-301Poland Department of Endocrinology Children's Hosp.P.&A.KyriakouAthens 10431Greece Paediatric Department Brindisi HospitalBrindisi 72100Italy

The prevalence of pediatric obesity continues to increase worldwide,bringing with it various metabolic,functional,social,and psychological complications.1 Both the prevention and treatment of childhood obesity must be based on multidisciplinary approaches combining nutrition,physical activity(PA),and psychological support.2 As an essential element of these multicomponent strategies,regular physical activity has been acknowledged as having beneficial effects on children's and adolescents,body composition,physical fitness,and metabolic profile,as well as on their health-related quality of life,social and psychological health,and academic achievement.3,4 Given that only a relatively small proportion of children and adolescents meet the public health recommendations for PA,5 and given that weight loss exercise-based interventions suffer from a high attrition rate,there is a clear need for appropriate PAs.

关键词： pediatric obesity prevention treatment 28th European Childhood Obesity Group Congress