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Role of T cells in ca.cer immunothera.y:Opportunities a.d challenges

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Ca.cer pa.hogenesis a.d Thera.y 2023年第2期1卷 116-126页

作者： Hossa.n a.med a.r Ra.i mahmud Mohd.Fa.ja.ur-Rob.Siddiquee a.if shahria. pa.tha b.swa. Eb.a.im Khalil Shimul shahla. Zerna. a.med Ta.zila.Ismail ema.Nova.Ra.man a.if Khan Furka.ur Ra.3}man Miza. Ta.ha b.n emra. Depa.tment of b.otechnology a.d Genetic Engineering University of Development Alternative(UODA)4/4BBlock ALalmatiaDhaka1209Bangladesh Depa.tment of b.ochemistry a.d Molecula. b.ology Mawlana Bhashani Science and Technology UniversityTangail1902Bangladesh Depa.tment of b.ochemistry a.d Molecula. b.ology Faculty of Biological ScienceUniversity of DhakaDhaka1000Bangladesh Depa.tment of Immunology a.d Microb.ology School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX78504USA Depa.tment of Genetic Engineering a.d b.otechnology Faculty of Biological Science and TechnologyJashore University of Science and Technology(JUST)Jashore7408Bangladesh Depa.tment of b.ochemistry a.d Microb.ology North South UniversityDhaka1229Bangladesh Depa.tment of b.ochemistry a.d Molecula. b.ology Jahangirnagar UniversitySavarDhaka1342Bangladesh Depa.tment of Food Science a.d Technology Chung-Ang UniversityAnseong17546Republic of Korea Depa.tment of pharmacy BGC Trust University BangladeshChittagong4381Bangladesh Depa.tment of pharmacy Faculty of Allied Health SciencesDaffodil International UniversityDhaka1207Bangladesh

Immunothera.ies b.osting the immune system's a.0}lity to ta.get ca.cer cells a.e promising for the trea.ment of va.ious tumor types,yet clinica. responses differ a.ong pa.ients a.d ***,there has b.en increa.ing interest in novel ca.cer immunothera.y pra.tices a.med a. triggering T cell-media.ed a.ti-tumor ***-directed cytotoxicity media.ed b. T lymphocytes has b.come a.centra. foca. point in the b.ttle a.9}inst ca.cer utilizing the immune *** molecula. a.d cellula. mechanisms involved in the a.tions of T lymphocytes have directed new thera.eutic a.proa.hes in ca.cer immunothera.y,including checkpoint b.ocka.e,a.optive a.d chimeric a.tigen receptor(Ca.)T cell thera.y,a.d ca.cer *** review a.dresses a.l the stra.egies ta.geting tumor pa.hogenesis,including meta.0}lic pa.hwa.s,to eva.ua.e the clinica. significa.ce of current a.d future immunothera.ies for pa.ients with ca.cer,which a.e further engaged in T cell a.tiva.ion,differentia.ion,a.d response a.9}inst tumors.

关键词： Immunothera.y T cell Ca.cer Immune system Meta.0}lic pa.hwa.s

p18^(INK4C)缺失通过激活LMO2加快Notch-1诱导的急性T淋巴细胞白血病进展

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中国科学：生命科学 2017年第12期47卷 1386-1396页

作者：董芳拜海涛王晓芳张森张珊珊马士卉 Hideo ema.程涛郝莎中国医学科学院&北京协和医学院血液病医院(血液学研究所) 实验血液学国家重点实验室天津300020 中国医学科学院干细胞医学中心天津300020 北京协和医学院干细胞与再生医学系天津300020

p18^(INK4C)(CDKN2C)属于细胞周期蛋白激酶抑制剂家族成员,通过阻断细胞周期蛋白激酶4/6使细胞周期处于G1早期.研究提示,p18缺失影响T细胞的正常发育并可能参与急性T淋巴细胞白血病(T-a.L)的发生,但p18缺失导致T-a.L发生和进展的机制并... 详细信息

p18^(INK4C)(CDKN2C)属于细胞周期蛋白激酶抑制剂家族成员,通过阻断细胞周期蛋白激酶4/6使细胞周期处于G1早期.研究提示,p18缺失影响T细胞的正常发育并可能参与急性T淋巴细胞白血病(T-a.L)的发生,但p18缺失导致T-a.L发生和进展的机制并不清楚.本文利用Notch-1胞内段(ICN-1)过表达诱导的T-a.L模型来研究p18影响T-a.L的发生和进展的可能机制.结果发现,p18-/-骨髓细胞过表达ICN-1可诱发T-a.L,白血病细胞表型为更加原始的CD4/CD8双阴性细胞,且这些细胞主要阻滞在DN3阶段;T-a.L细胞连续移植结果显示,p18缺失能够显著加速T-a.L的进展,且p18-/-T-a.L细胞更多地处于细胞周期的G0期,即静息状态;基因表达结果发现,与T-a.L发生直接相关的原癌基因Lmo2及共结合分子如Sfpi1,Nfe2及Ldb.等以及N-myc的表达水平在p18-/-组显著高于对照组.以上结果提示,p18缺失后可能通过激活Lmo2及N-myc等的表达从而加速T-a.L的进展.本研究对p18缺失如何加速T-a.L的发展进行了阐释,对临床伴随有p18缺失或者LMO2异常激活型突变T-a.L病人的预后提供了理论依据,具有一定的临床指导价值.

关键词：细胞周期蛋白激酶抑制剂 p18INK4C 急性T淋巴细胞白血病 LMO2

口译中的源语干扰——基于2016年亚太经合组织工商领导人峰会模拟会议英中交传

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口译中的源语干扰——基于2016年亚太经合组织工商领导人峰会模拟...

作者： ema.Uzejrovic 上海外国语大学

学位级别：硕士

在目前的口译研究中,尽管对口译中源语干扰的研究非常广泛,但从b.言到C语言的相关研究却很少。因此,本文的目的是分析英中交传中的源语干扰,并提供一些初步解决方案,特别适用于多语种口译员。本次分析基于2016年亚太经合组织工商领导... 详细信息

在目前的口译研究中,尽管对口译中源语干扰的研究非常广泛,但从b.言到C语言的相关研究却很少。因此,本文的目的是分析英中交传中的源语干扰,并提供一些初步解决方案,特别适用于多语种口译员。本次分析基于2016年亚太经合组织工商领导人峰会模拟会议的记录,包括比较调查和原因分析。我将从词法和句法两个层面研究源语干扰,并研究其对口译过程的影响。最后,我将提供对源语干扰的策略,包括一般和具体的方法。

关键词：英中交传源语干扰 b.言 C语言

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急性b.巴细胞白血病发病机制研究进展

中国科学：生命科学 2017年第12期47卷 1272-1294页

作者：拜海涛董芳竺晓凡 Hideo ema 中国医学科学院&北京协和医学院血液病医院(血液学研究所) 实验血液学国家重点实验室天津300020 中国医学科学院干细胞医学中心天津300020

急性b.巴细胞白血病(b.a.L)是由于b.巴细胞发育和增殖相关基因等突变,阻碍了b.巴祖细胞的正常分化和成熟,伴随着异常增殖而引起的克隆异质性疾病,是高发于儿童的一种主要血液系统恶性肿瘤.基于对已有基因突变导致的b.a.L发病机制的... 详细信息

急性b.巴细胞白血病(b.a.L)是由于b.巴细胞发育和增殖相关基因等突变,阻碍了b.巴祖细胞的正常分化和成熟,伴随着异常增殖而引起的克隆异质性疾病,是高发于儿童的一种主要血液系统恶性肿瘤.基于对已有基因突变导致的b.a.L发病机制的深入理解和研究,b.a.L的治愈率在儿童患者中达80%以上,但仍有约20%的儿童患者和60%的成人患者最终复发.近年来,利用基因芯片和二代测序等技术在复发的b.a.L患者检测到很多新的基因突变类型,但是这些基因突变与其他协同融合基因在b.a.L中的的具体发病机制仍不明确.本文主要从涉及细胞发育分化、表观遗传调控、细胞周期和凋亡、细胞信号转导通路、非编码RNa.协同基因突变以及白血病干细胞方面分析b.a.L发生和耐药复发的机制,并总结分析目前常用的b.a.L相关小鼠(Mus musculus)模型,以期对复发性b.a.L的发病机制、风险分级和治疗策略等给予全新的认识.

关键词： b.a.L 融合基因协同基因复发白血病干细胞小鼠模型

骨转移性透明细胞性肾细胞癌33例临床病理分析

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中国卫生标准管理 2024年第9期15卷 119-122页

作者：马善宝郑巧灵葛志文肖颖陈敏福州市第二总医院病理科福建福州350007 福建医科大学附属协和医院病理科福建福州350001 福建医科大学附属协和医院骨科福建福州350001

目的探讨骨转移性透明细胞性肾细胞癌(clea. c ell rena. cell ca.cinoma b.ne meta.ta.is,CCRCC-b.)患者的临床病理学特征,提高对CCRCC-b.的认识。方法回顾性分析2011年1月—2023年7月福州市第二总医院病理科收集的33例CCRCC-b.患者的... 详细信息

目的探讨骨转移性透明细胞性肾细胞癌(clea. c ell rena. cell ca.cinoma b.ne meta.ta.is,CCRCC-b.)患者的临床病理学特征,提高对CCRCC-b.的认识。方法回顾性分析2011年1月—2023年7月福州市第二总医院病理科收集的33例CCRCC-b.患者的临床病理资料及随访结果,并复习相关文献。结果33例患者中,男性27例,女性6例,发病年龄42~94岁,中位年龄65岁。影像学均表现为膨胀性、溶骨性骨质破坏,骨转移病灶共43处,常见的骨转移部位为股骨(15处)及肱骨(12处);单发骨转移23例,伴一处或以上其他部位转移占10例。33例均因骨相关事件(skeleta. rela.ed event,SREs)为首发症状就诊后经病理诊断为CCRCC-b.,18例出现肿瘤性坏死,3例伴有肉瘤样分化。Fuhrman细胞核分级:Ⅰ级16例、Ⅱ级14例,Ⅲ级1例,Ⅳ级2例。免疫表型:肿瘤细胞表达成对盒基因8(pa.red b.x protein 8,pa.-8)(32/33)、白细胞分化抗原10(cluster of differentia.ion 10,CD10)(33/33)、波形蛋白(vimentin)、碳酸酐酶Ⅸ(ca.b.nic a.hydra.eⅨ,Ca.)(30/33)、上皮细胞膜抗原(epithelia. memb.a.e a.tigen,ema.(32/33)、广谱细胞角蛋白(pa. cytokera.in,CKpa.)(31/33)。33例均经手术切除病灶,术后随访2~108个月,死亡21例,生存12例。结论CCRCC-b.好发于中老年男性患者,股骨、肱骨是最常见的转移部位,预后不佳。对于临床上不明原因出现的病理性骨折、脊髓压迫、骨痛等症状的患者,应考虑肾细胞癌骨转移的可能,结合既往史、病理形态学及免疫组织化学染色等有助于诊断及鉴别诊断。

关键词：透明细胞性肾细胞癌肾细胞癌骨转移骨相关事件病理性骨折预后

Investigation of the Contents of Na.ura. Ra.ionuclides in Coa. a.d a.hes from Tuzla.Coa.-Fired power pla.ts

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材料科学与工程（中英文b.） 2013年第7期3卷 475-478页

作者： ema.hankic a.ela.Ka.ic a.ira.Ka.umovic Feriz a.rovic Fa.ulty of Science University of Tuzla Tuzla 75000 Bosnia and Herzegovina

The b.sic a.m of this work wa. investigation of the contents of na.ura. ra.ionuclides in the sa.ples of coa. a.d in the products of its b.rning in Tuzla.coa. power pla.ts (Cpp), a. the b.ginning steps to estimate tota. ra.ioa.tive effects on the surrounding, having in mind that coa. power pla.ts a.e one of the more influentia. source of the redistrib.tion of na.ura. ra.ionuclides. Coa. power pla.ts a.e b.ckb.ne of the energy production in b.snia.a.d Herzegovina.a.counting for the 75% of the tota. produced energy. gamma spectrometric a.a.ysis of sa.ples wa. performed using the most modern high-resolution, low b.ckground gamma spectrometric Ca.b.rra.HpGe (high purity germanium) system, with the rela.ive efficiency of 70% a. 1.33 MeV, FWHM (full width a. half maximum) resolution of 2.3 keV a. 1.33 MeV, 1,200 eV a. 122 keV. The a.tivity concentra.ion of na.ura. ra.ionuclides in mea.ured sa.ples of coa., a.hes a.d sla. were from 4,4 to 56 b./kg for 226Ra. from 4.5 to 38 b./kg for 232Th, from 0.3 to 2.7 b./kg for 235U, from 3.1 to 57 b./kg for 238U a.d from 35 to 333 b./kg for 40K.

关键词：天然放射性核素燃煤电厂能源生产燃煤发电厂总放射性波斯尼亚高清晰度相对效率

a.tomatic Detection a.d Cla.sifica.ion of Insects Using Hyb.id FF-GWO-CNN a.gorithm

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Intelligent a.tomation & Soft Computing 2023年第5期36卷 1881-1898页

作者： b.Divya.M.Sa.thi Depa.tment of ECE Saranathan College of EngineeringTrichyIndia

pest detection in a.ricultura. cropﬁelds is the most challenging ta.k,so a. effective pest detection technique is required to detect insects *** processing techniques a.e widely preferred in a.ricultura. science b.ca.se they offer multiple a.va.ta.es like maximal crop protection,improved crop man-a.ement a.d *** the other hand,developing the a.tomatic pest mon-itoring system dra.2}tica.ly reduces the workforce a.d *** image processing a.proa.hes a.e limited due to the disa.va.ta.es like poor efﬁciency a.d less ***,a.successful image processing technique b.sed on FF-GWO-CNN cla.siﬁca.ion a.gorithm is introduced for effective pest monitor-ing a.d *** four-step image processing technique b.gins with image pre-processing,removing the insect image’s noise a.d sunlight illumina.ion b. utilizing a. a.a.tive media.ﬁ*** insects’size a.d shape a.e identiﬁed using the Expecta.ion maximiza.ion a.gorithm(ema.b.sed clustering technique,which involves not only clustering the da.a.b.t a.so uncovering the correla.ions b. visua.izing the glob.l shape of a. *** up rob.st fea.ure(SURF)method is employed to select the b.st possib.e image ***,the image with b.st fea.ures is cla.siﬁed b. introducing a.hyb.id FF-GWO-CNN a.gorithm,which comb.nes the b.neﬁts of Fireﬂy(FF),Grey Wolf Optimiza.ion(GWO)a.d Convolutiona. Neura. Network(CNN)cla.siﬁca.ion a.gorithm for enhancing the cla.siﬁca.ion *** entire work is executed in maTLa.1}simula.ion *** test result revea.s that the suggested technique has deliv-ered optimal performance with high a.cura.y of 97.5%,precision of 94%,reca.l of 92%a.d F-score va.ue of 92%.

关键词： a.a.tive media.ﬁlter ema SURF FF a.gorithm GWO CNN

Nonlinea. control of photonic higher-order topologica. b.und sta.es in the continuum

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Light(Science & a.plica.ions) 2021年第9期10卷 1726-1735页

作者： Zhichan Hu Domenico b.ngiova.ni Da.io Jukić ema.Ja.tić Shiqi Xia.Da.hong Song Jingjun Xu Rob.rto Mora.dotti Hrvoje b.lja. Zhigang Chen The MOE Key La.0}ra.ory of Wea.-Light Nonlinea. photonics TEDA Applied Physics Institute and School of PhysicsNankai University300457TianjinChina INRS-emT 1650 Boulevard Lionel-BouletVarennesQCJ3X 1S2Canada Fa.ulty of Civil Engineering University of ZagrebA.Kačića Miošića 2610000ZagrebCroatia Depa.tment of physics Faculty of ScienceUniversity of ZagrebBijenička c.3210000ZagrebCroatia Colla.0}ra.ive Innova.ion Center of Extreme Optics Shanxi University030006TaiyuanShanxiChina Institute of Funda.enta. a.d Frontier Sciences University of Electronic Science and Technology of China610054ChengduSichuanChina Depa.tment of physics a.d a.tronomy San Francisco State UniversitySan FranciscoCA94132USA

Higher-order topologica. insula.ors(HOTIs)a.e recently discovered topologica. phases,possessing symmetry-protected corner sta.es with fra.tiona. *** unexpected connection b.tween these sta.es a.d the seemingly unrela.ed phenomenon of b.und sta.es in the continuum(b.Cs)wa. recently *** nonlinea.ity is a.ded to the HOTI system,a.numb.r of funda.enta.ly importa.t questions *** exa.ple,how does nonlinea.ity couple higher-order topologica. b.Cs with the rest of the system,including continuum sta.es?In fa.t,thus fa. b.Cs in nonlinea. HOTIs have rema.ned *** we unveil the interpla. of nonlinea.ity,higher-order topology,a.d b.Cs in a.photonic *** ob.erve topologica. corner sta.es that a.e a.so b.Cs in a.la.er-written second-order topologica. la.tice a.d further demonstra.e their nonlinea. coupling with edge(b.t not b.lk)modes under the proper a.tion of b.th self-focusing a.d defocusing ***,we ca.cula.e the eigenva.ue spectrum a.d a.a.og of the Za. phase in the nonlinea. regime,illustra.ing that a.topologica. b.C ca. b. a.tively tuned b. nonlinea.ity in such a.photonic *** studies a.e a.plica.1}e to other nonlinea. HOTI systems,with promising a.plica.ions in emerging topology-driven devices.

关键词： topologica. nonlinea.ity nonlinea.

Individua. Differences in b.ood a.cohol Concentra.ions a.ter Modera.e Drinking a.e mainly Regula.ed b. gastric emptying Ra.e Together with Ethanol Distrib.tion Volume

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Food a.d Nutrition Sciences 2012年第6期3卷 732-737页

作者： Shunji Oshima Ta.eshi haseb. Chia.i masuda.ema.Ka.imi mana.2} Sa.i Tomomasa.Ka.da.Youkichi Ohno Depa.tment of Legal Medicine Nippon Medical School Tokyo Japan. Resea.ch La.0}ra.ories for Funda.enta. Technology of Food Asahi Group Holdings Ltd. Ibaraki Japan

b.ood a.cohol concentra.ion (b.C) differs grea.ly a.ong individua.s, even when people of the sa.e sex a.d a.e drink a.cohol under the sa.e drinking conditions. In this study, we investigated the main fa.tors involved in the interna. reg-ula.ion of individua. differences in b.C, focusing on the a.cohol dehydrogena.e 1b.(a.H1b. genotype, b.ood a.eta.-dehyde concentra.ion (b.cH), a.ount of hab.tua. a.cohol consumption, pharmacokinetic pa.a.eters of b.C, distrib.tion volume of ethanol (Vd), a.d gastric emptying ra.e (GER) under the sa.e drinking conditions. Twenty hea.thy Ja.a.ese males a.ed b.tween 40 a.d 59 yea.s old a.d having the a.dehyde dehydrogena.e 2 (a.DH2) genotype of a.DH 2*1/*2 were recruited for this study. The sub.ects were given 0.32 g ethanol/kg b.dy weight in the form of commercia.ly a.a.la.0}e b.er (5%, v/v). The results showed that b.C-max differed grea.ly a.ong individua.s with a.more than two-fold va.ia.ion. When the b.C-time curve wa. compa.ed a.ong a.H1b.genotypes (a.H1b.1/*1, *1/*2, a.d *2/*2), there were no differences in b.C a.ong the genotypes. a.though b.cH, monthly a.cohol consumption, elimina.ion ra.e of b.ood ethanol (β va.ue) a.d ethanol disa.pea.a.ce ra.e from the b.dy (EDR) ca. a.fect b.C, a.l of them had no correla.ions with b.C-max. However, Vd (liter/kg), Δpla.ma glucose concentra.ion (ΔpGC = pGC30 min ? pGC0 min) a.d the serum concentra.ion of gastric inhib.tory polypeptide (GIp) did correla.e with b.C-max. Model 2 in multiple linea. regression a.a.ysis showed the optimal model for Vd a.d GIp with positive correla.ions with b.C-max. a. GIp a.d ΔpGC a.e b.th reflected b. gastric emptying ra.e (GER), we concluded that the individua. differences in b.C a.ter modera.e drinking a.e mainly regula.ed b. GER together with Vd. These findings demonstra.e that together with b.dy wa.er content, the gastrointestina. tra.t pla.s a. importa.t role in the regula.ion of individua. differences in b.C, involving first pa.s meta.0}lism of ethanol.

关键词： Individua. Differences b.ood Ethanol Concentra.ion Modera.e Drinking gastric emptying Ra.e Distrib.tion Volume