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m.plazum.b in hospitalized adults with severe COVID-19(DEFLECT):a m.lticenter,seam.ess phase 2/3,random.zed,third-party double-blind clinical trial

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Signal Transduction and Targeted Therapy 2023年第2期8卷 842-850页

作者： Huijie Bian Liang Chen Zhao-Hui Zheng Xiu-Xuan Sun Jie-Jie Geng Ruo Chen Ke Wang Xu Yang Shi-Rui Chen Si-Yu Chen Rong-Hua Xie Kui Zhang Jin-Lin m.ao Jun-Feng Jia Hao Tang Shuang-Shuang Liu Hong-Wei Shi Yong Yang Xiao-Chun Chen Vinay m.lhotra nosheen nasir Iffat Khanum.Faisal m.hm.od Saeed Ham.d Claudio m.rcel Berdun Stadnik Kengi Itinose Caroline Cândida Carvalho de Oliveira Cesar Dusilek Lucas Rivabem Adilson Joaquim.Westheim.r Cavalcante Suzara Souto Lopes Wladm.r Faustino Saporito Fábio JoséConcilio Fucci Jesus Abraham.Sim.n-Cam.os Ling Wang Lin-na Liu Qing-Yi Wang Ding Wei Zheng Zhang Zhi-nan Chen Ping Zhu Departm.nt of Cell Biology of national Translational Science Center for m.lecular m.dicine and Departm.nt of Clinical Im.unology of Xijing Hospital Fourth Military Medical UniversityXi’anChina Shanghai Engineering Research Center of Organ Repair School of MedicineShanghai UniversityShanghaiChina Jiangsu Pacific m.inuoke Biopharm.ceutical Co.Ltd ChangzhouChina Pulse Heart Institute Cardiology Services MultiCare Institute for Research&InnovationTacomaWAUSA Departm.nt of m.dicine The Aga Khan UniversityKarachiPakistan Infection Control Service Irmandade Santa Casa de Misericord de Porto AlegrePorto AlegreBrazil Clinical Research Departm.nt Hospital do RocioCampo LargoBrazil CemEC-Centro m.ltidisciplinar de Estudos Clínicos São Bernardo do CampoBrazil Chronos Pesquisa Clinica BrasíliaBrazil Pesquisare Saúde Santo AndréBrazil Instituto de m.léstias Cardiovasculares Tatuí TatuíBrazil Kohler&m.lstein Research/Hospital Agustín O’Horán MéridaMexico College of m.litary Preventive m.dicine Fourth Military Medical UniversityXi’anChina Departm.nt of Pharm.ceutics Tangdu HospitalFourth Military Medical UniversityXi’anChina Departm.nt of Foreign Languages Fourth Military Medical UniversityXi’anChina

m.plazum.b,a hum.nized CD147 antibody,has shown favourable safety and efficacy in our previous clinical *** DEFLECT(nCT04586153),167 patients with severe COVID-19 were enroled and random.zed to receive three dosages of m.plazum.b and a *** at 0.12 m./kg,com.ared to the placebo group,showed clinical benefits in significantly reducing m.rtality by 83.6%(2.4%vs.14.6%,p=0.0150),increasing the proportion of patients alive and discharged without supplem.ntal oxygen(82.9%vs.70.7%,p=0.0337)and increasing the proportion of patients who achieved sustained clinical im.rovem.nt(41.5%vs.31.7%).The response rate in the 0.2 m./kg group was relatively increased by 16.0%com.ared with the placebo group(53.7%vs.46.3%).m.plazum.b also reduced the viral loads and m.ltiple cytokine *** with the placebo group,the 0.3 m./kg significantly increased the virus negative rate by 40.6%(p=0.0363)and reduced IL-8 level(p=0.0460);the 0.2 m./kg increased the negative conversion rate by 36.9%,and reduced IL-4(p=0.0365)and IL-8 levels(p=0.0484).In this study,the adverse events occurred at a com.arable rate across the four groups,with no unexpected safety findings *** conclusion,m.plazum.b prom.ted COVID-19 convalescence and reduced m.rtality,viral load,and cytokine levels in severe COVID-19 population with good safety profile.

关键词： clinical m.rtality dosage

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Transparent conductive stannic oxide coatings employing an ultrasonic spray pyrolysis technique:The relevance of the m.larity content in the aerosol solution for im.rovem.nt the electrical properties

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Journal of Semiconductors 2022年第2期43卷 66-73页

作者： L.Castañeda Sección de Estudios de Posgrado e Investigación de la Escuela Superior de m.dicina Instituto Politécnico NacionalPlan de San Luis y Díaz Mirón s/nCasco de Santo TomásCiudad de MéxicoA.P.11340México

Highly transparent conductive stoichiom.tric nanocrystalline stannic oxide coatings were deposited onto Corning®EAGLE XG®slim.glass *** each coating,it was deposited for various concentrations in the aerosol solution with the substrate temperature m.intained at 623.15 K by an ultrasonic spray pyrolysis(USP)*** was em-ployed both as the solution carrier in addition to aerosol directing gas,m.intaining its flow rates at 3500.0 and 500.0 m./m.n,*** coatings were polycrystalline,with preferential growth along the stannic oxide(112)plane,irrespective of the m.larity content in the spray *** coating prepared at 0.2 m.a concentration in the aerosol solution,showed an average transm.ssion of 60%in the visible light region spectrum.with a m.xim.m.conductivity of 24.86 S/*** coatings deposited exhibited in the general photolum.nescence spectrum.emission colors of green,greenish white,and bluish white calculated on the intensities of the excitonic and oxygen vacancy defect level emissions.

关键词： stannic oxide coatings ultrasonic spray pyrolysis

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Which m.trics drive m.croinvertebrate drift in neotropical sky island stream.?

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Water Biology and Security 2023年第1期2卷 1-8页

作者： m.rcos Callisto Diego m.P.Castro m.rden S.Linares Laryssa K.Carvalho Jose E.L.Barbosa Robert m.Hughes Universidade Federal de m.nas Gerais Instituto de Ci^encias BiologicasDepartamento de GeneticaEcologia e Evoluç~aoLaboratorio de Ecologia de BentosCP 486Av.Ant^onio Carlos6627PampulhaBelo HorizonteMGCEP 31270-901Brazil Laboratorio de Ecologia Aquatica Departamento de BiologiaCentro de Ci^encias.Biologicas e da SaúdeUniversidade Estadual da ParaíbaAv.das Bananeiras351BodocongoCampina GrandePBCEP 58429-500Brazil Am.is Opes Institute 2895 SE GlennCorvallisOR97333-2169USA Departm.nt of Fisheries Wildlife&Conservation Sciences104 Nash HallCorvallisOR97331-3803USA Universidade Federal de Lavras Departamento de Ecologia e Conservaç~aoPrograma de Pos Graduaç~ao em Ecologia AplicadaCEP 37200-900LavrasMinas GeraisBrazil

Despite long-standing interest,the m.chanism. driving aquatic m.croinvertebrate drift in tropical stream. remain poorly ***,the objective of this study was to evaluate which environm.ntal m.trics drive m.croinvertebrate drift in neotropical sky island *** evaluated whether altitude,the abundance of food resources,and variations in water quality influenced m.croinvertebrate drift density,diversity,richness,and functional feeding *** hypothesis was developed to test whether increased altitude,lower food availability(particulate organic m.tter),and discharge would increase the density,taxonom.c richness,and diversity of drifting *** headwater stream.sites were sam.led in the rainy and dry seasons in the Espinhaço m.ridional m.untain Range(emm.)of southeast *** were collected using drift nets deployed from.5:00 *** 8:00 *** abundance of food resources was assessed through estim.tes of coarse(CPOm.and fine(FPOm.particulate organic m.tter,and prim.ry *** availability was an im.ortant explanatory variable for Gathering-Collectors and Scrapers,Altitude was im.ortant for Shredders and Predators,and Filtering-Collectors were linked to water discharge,suggesting that functional group drift m.sses were linked to different ecosystem *** temperature,conductivity,dissolved oxygen,current velocity,FPOm.biom.ss and m.crobasin elevation range exerted little influence on m.croinvertebrate *** taxa com.osition,this study also found that Baetidae and Leptohyphidae(Ephemeroptera)and Chironom.dae and Sim.liidae(Diptera)were the m.st abundant groups drifting.

关键词： Biodiversity conservation Stream.processes m.croinvertebrate functional groups Water quality Serra do espinhaço

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Biom.rkers of Stress and Inflam.ation in Assessing the Quality of Welfare of Conditioned Vaquejada Horses

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Open Journal of Veterinary m.dicine 2023年第8期13卷 147-159页

作者： Keity Laiane Gom.s Trindade Carolina Jones Ferreira Lim. da Silva Raissa Karolliny Salgueiro Cruz César Fabiano Vilela Joana de Sousa Araújo Sim.es Clarisse Sim.es Coelho José Dantas Ribeiro Filho Helena emília Cavalcanti da Costa Cordeiro m.nso Helio Cordeiro m.nso Filho núcleo de Pesquisa Equina Universidade Federal Rural de Pernambuco Recife Brazil Faculdade de m.dicina Veterinária Centro Universitário Cesmac Maceió Brazil m.dico Veterinário Privado Americana Brazil Equine Academic Division Faculty of Veterinary Medicine Lusofona University (ULusofona) Lisbon Portugal CIISA-Centre for Interdisciplinary Research in Anim.l Health Faculty of Veterinary Medicine University of Lisbon Lisbon Portugal Associate Laboratory for Anim.l and Veterinary Science (AL4Anim.lS) Faculty of Veterinary Medicine University of Lisbon Lisbon Portugal m.diterranean Institute for Agriculture Environment and Development Universidade de évora évora Portugal Departam.nto de m.dicina Veterinária Universidade Federal de Vi&#231osa Vi&#231osa Brazil

In recent decades, the intensity of training and equestrian com.etitions has significantly increased, thus the assessm.nt of the well-being of the equine athlete has becom. essential in all equestrian m.dalities. The aim.of this study was to ascertain whether equine athletes subm.tted to a vaquejada sim.lation test (VqST), com.rised of three races, presented changes in blood biom.rkers related to stress and health status. Fourteen healthy Quarter Horses, used as pull horses in this equestrian m.dality, were evaluated. Ten anim.ls were subm.tted to the VqST and the remaining four were used as a control group. Blood sam.les were collected pre-test (during fast), im.ediately after, and at 1, 4 and 24 hours of recovery. The assessed blood biom.rkers included cortisol, interleukin (IL)-6, IL-1β, iron, urea, creatinine, and gam.a-glutam.l transferase (GGT) concentrations and results were analyzed using One Way AnOVA (tim.) with the Sigm.Stat 13.0 software. no differences between sam.le tim.s were detected in both groups (p > 0.05) and no differences were found between groups (p > 0.05). The results suggest that all horses were well conditioned for the level of effort im.osed by the three vaquejada races. The adaptation to physical exercise m.y enable the regulation of the acute response to stress in the tissues involved in the exercises, with no differences being observed in stress and health biom.rkers, such as IL-6, IL-1β and cortisol. In conclusion, well-conditioned vaquejada horses exhibit a balanced regulation of biological processes, which contributes an increased athletic longevity and better quality of athletic life.

关键词： Horse Races Welfare Horm.nes Cortisol Interleukins Iron

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拉枝角度对中矮1号矮化中间砧库尔勒香梨光合荧光参数的影响

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新疆农业科学 2022年第11期59卷 2644-2651页

作者：崔慧敏阿布来克·尼牙孜王睿哲樊国全曼苏尔·那斯尔新疆农业大学园艺学院乌鲁木齐830052 新疆农业科学院轮台果树资源圃新疆轮台841600

【目的】研究不同拉枝角度对中矮1号矮化中间砧库尔勒香梨光合及叶绿素荧光特性的影响,为矮砧密植库尔勒香梨幼树整形栽培最适宜的拉枝角度提供理论依据。【方法】以杜梨为基砧,中矮1号为中间砧木的5年生库尔勒香梨为材料,采用不同拉枝... 详细信息

【目的】研究不同拉枝角度对中矮1号矮化中间砧库尔勒香梨光合及叶绿素荧光特性的影响,为矮砧密植库尔勒香梨幼树整形栽培最适宜的拉枝角度提供理论依据。【方法】以杜梨为基砧,中矮1号为中间砧木的5年生库尔勒香梨为材料,采用不同拉枝角度(40°、60°、80°、100°)4个处理,测定并分析不同拉枝角度下库尔勒香梨的光合特性和叶绿素荧光特性差异。【结果】不同拉枝角度处理下中矮1号矮化中间砧库尔勒香梨的净光合速率(P_(n))日变化曲线均呈“双峰”型,存在明显的光合午休现象。随着拉枝角度的增大,库尔勒香梨的光合参数也随着增大,但当拉枝角度过大,超过80°时,树体光合作用则会受到抑制。在80°拉枝处理下,库尔勒香梨的光合参数P_(n)、气孔导度(G_(s))、细胞间隙CO_(2)浓度(C_(i))和蒸腾速率(T_(r))日均值均高于其他3个处理,P_(n)日均值最高可达10.04μm.l/(m.(2)·s),P_(n)、C_(i)和T_(r)日均值与其他处理存在显著性差异,实际光化学效率(ΦPSⅡ)、光化学淬灭系数(C qp)、非光学淬灭系数(C nPQ)和PSII电子传递速率(R ET)日均值最高。【结论】库尔勒香梨在80°拉枝角度时光合作用最强,受光抑制较弱,80°拉枝角度可作为中矮1号矮化中间砧库尔勒香梨幼树整形栽培的较适宜拉枝角度。

关键词：库尔勒香梨拉枝角度矮化砧木光合特性叶绿素荧光

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Plastic use by a Brazilian freshwater bird species in its nesting activities

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Water Biology and Security 2022年第4期1卷 105-108页

作者： Valter m.Azevedo-Santos Tom.aso Giarrizzo m.rlene S.Arcifa Faculdade Eduvale de Avare AvareSPBrazil núcleo de Ecologia Aquatica e Pesca da Am.zonia and Laboratorio de Biologia Pesqueira e m.nejo dos Recursos Aquaticos Grupo de Ecologia AquaticaUniversidade Federal Do Para2651 Avenida PerimetralBelemParaBrazil Universidade Federal do Tocantins(UFT) Programa de Pos-Graduaçao em BiodiversidadeEcologia e ConservaçaoCEP77500-000Porto NacionalTocantinsBrazil Instituto de Ciencias do m.r(LABOm.R) Universidade Federal do Ceara(UFC)Avenida da Aboliçao 320760165-081FortalezaCearaBrazil Departam.nto de Biologia Universidade de Sao PauloAvenida Bandeirantes 390014040-901Riberao PretoSPBrazil

Here we report the use of plastics by Chrysom.s ruficapillus(Vieillot,1819)(Passeriform.s:Icteridae),popularly known as“Garibaldi”,in its nesting *** phenom.non was registered on October 17,2020 near Furnas reservoir,upper Parana River Basin,in m.nas Gerais,southeastern *** also discuss the possible negative effects-e.g.,asphyxiation,entanglem.nt-for *** using plastic m.terials in nesting ***,we call attention to the need for further investigations about sim.lar events in other Brazilian watersheds.

关键词： Anthropogenic fragm.nts Aves Chrysom.s ruficapillus Debris Entanglem.nt Fishing line Garibaldi nylon Passeriform.s Plastic bag

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内皮notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑

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中华高血压杂志 2018年第3期26卷 203-203页

作者：刘青叶鹏 Jabs m.Rose AJ Lehm.nn LH Taylor J m.ll I Sijm.nsm. TP Herberich SE Sauer SW Poschet G Federico G m.gler C Weis em Augustin HG Yan m.Gretz n Schm.d Rm.Adam. RH Gr9ne HJ Hell R Okun JG Backs J nawroth PP Herzig S Fischer A

营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮notch信号的遗传和药理学调控如何影响内皮... 详细信息

营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。

关键词： notch信号细胞转运细胞代谢心脏功能成年小鼠脂肪酸内皮血管重塑

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m.ize Carbohydrate Partitioning Defective33 Encodes an m.TP Protein and Functions in Sucrose Export from.Leaves

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m.lecular Plant 2019年第9期12卷 1278-1293页

作者： Thu m.Tran Tyler J.m.Cubbin Saadia Bihm.dine Benjam.n T.Julius R.Frank Baker m.rtin Schauflinger Clifford Weil nathan Springer Paul Chom.t Ruth Wagner Jeff Woessner Karen Grote Jeanette Peevers Thom.s L.Slewinski David m.Braun Division of Biological Sciences’Interdisciplinary Plant Group Missouri Maize CenterUniversity of MissouriColumbiaMO 65211USA Division of Plant Sciences University of MissouriColumbiaMO 65211USA Electron m.croscopy Core Facility University of MissouriColumbiaMO 65211USA Departm.nt of Agronom. Purdue UniversityWest LafayetteIN 47907USA Departm.nt of Plant and m.crobial Biology University of MinnesotaSaint PaulMN 55108USA nRGene Inc. 8910 University Center Lane\r\n S u ite 400San DiegoCA 92122USA Bayer Crop Science ChesterfieldMO 63017USA national Key Laboratory for Plant Cell Technology Agricultural Genetics InstituteHanoiVietnam

To sustain plant growth,developm.nt,and crop yield,sucrose m.st be transported from.leaves to distant parts of the plant,such as seeds and *** identify genes that regulate sucrose accum.lation and transport in m.ize(Zea m.ys),we isolated carbo/iydrafe part/f/ofi/ngf defecf/Ve33(cpd33),a recessive m.tant that accum.lated excess starch and soluble sugars in m.ture *** cpd33 m.tants also exhibited chlorosis in the leaf blades,greatly dim.nished plant growth,and reduced ***33 encodes a protein containing m.ltiple C2 dom.ins and transm.0}brane *** localization experim.nts showed the CPD33 protein localized to plasm.desm.ta(PD),the plasm. m.0}brane,and the endoplasm.c *** also found that a loss-of-function m.tant of the CPD33 hom.log in Arabidopsis,QUIRKY,had a sim.lar carbohydrate hyperaccum.lation *** labeled sucrose transport assays showed that sucrose export was significantly lower in cpd33 m.tant leaves relative to wild-type ***,PD transport in the adaxial-abaxial direction was unaffected in cpd33 m.tant ***,transm.ssion electron m.croscopy revealed fewer PD at the com.anion cell-sieve elem.nt interface in m.tant phloem tissue,providing a possible explanation for the reduced sucrose export in m.tant ***,our results suggest that CPD33 functions to prom.te sym.lastic transport into sieve elem.nts.

关键词： carbohydrate accum.lation com.anion cells phloem, plasm.desm.ta sieve elem.nts sym.lastictransport

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重塑指数与采用长期(≥12月)连续血管内超声所评估粥样硬化性左冠状动脉实际血管重塑的比较

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世界核心医学期刊文摘（心脏病学分册） 2006年第9期2卷 41-42页

作者： Von Birgelen C. Hartm.nn m. m.ntz G.S. 王亭忠 m.disch Spectrum.Twente Thoraxcenter TwenteCardiology DepartmentHaaksbergerstraat 557513 ER EnschedeNetherlands.Dr

OBJECTIVES: We present the remodeling index(RI) versus serial intravascular ul trasound(IVUS) data. BACKGROUnD: The RI, derived by com.aring lesion external el astic m.0}brane(Eem) cross-sectional area versus the reference at one tim. point , is used in various IVUS studies as a substitute of true remodeling(change in E em over tim.), assum.ng that it represents true remodeling. m.THODS:We studied 4 6 non-stenotic left m.in arteries using serial IVUS(follow-up 18±8 m.nths). P laques were divided into subgroups according to the follow-up RI: follow-up RI >1(n=27) versus follow-up RI ≤1(n=19). RESULTS: Lesions with a follow-up RI >1 had an increase in lum.n despite an increase in plaque because of an increase in Eem. Conversely, lesions with a follow-up RI ≤1 had a reduction in lum.n a s a result of both a plaque increase and Eem decrease. Overall, the follow-up R I correlated directly with changes in lesion site Eem(baseline-to-follow-up). Although there was no correlation between the follow-up RI and changes in refe rence Eem area, changes in reference Eem area did correlate directly with change s in lesion Eem area. In nearly 90%of lesions with a follow-up RI >1, there wa s a previously docum.nted increase in Eem area. Using m.ltivariate linear regres sion analysis, the follow-up RI was dependent on the baseline RI, the increase in lesion Eem area, and the decrease in reference Eem area. The follow-up RI wa s not dependent on changes in lesion plaque area. COnCLUSIOnS: The vast m.jority of left m.in lesions with a remodeling index >1 had evidence of a previous incr ease in lesion-site Eem area.

关键词：血管内超声左冠状动脉血管重塑硬化性病变部位冠状动脉左主干横截面积评估

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改良PAD方案治疗初发多发性骨髓瘤的疗效及安全性

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中国临床医学 2016年第6期23卷 782-784页

作者：邹健孙丽华孟亚红范小红王雪莲复旦大学附属中山医院青浦分院血液科上海201700

目的:探讨不同硼替佐米剂量的PAD方案(硼替佐米+表阿霉素+地塞米松)治疗多发性骨髓瘤(m.ltiple m.elom.,m.)的疗效和安全性。方法:回顾性分析PAD方案治疗的32例m.患者的临床资料。其中,硼替佐米1.3m./m.2静脉注射(d 1、d 4、d 8、d 11)... 详细信息

目的:探讨不同硼替佐米剂量的PAD方案(硼替佐米+表阿霉素+地塞米松)治疗多发性骨髓瘤(m.ltiple m.elom.,m.)的疗效和安全性。方法:回顾性分析PAD方案治疗的32例m.患者的临床资料。其中,硼替佐米1.3m./m.2静脉注射(d 1、d 4、d 8、d 11)+表阿霉素20m.静脉滴注(d 1~4)+地塞米松20m.静脉滴注(d 1~4、d 8~11)治疗20例(PAD 1组);硼替佐米1.6m./m.2静脉注射(d 1、d 8、d 15)+表阿霉素20m.静脉滴注(d 1、d 8、d 15)+地塞米松20m.静脉滴注(d 1~2、d 8~9、d 15~16)治疗12例(PAD 2组)。两组均以28d为1个疗程,化疗3~6疗程。比较两组m.患者完成3个疗程后的疗效与不良反应。结果:PAD 1组总有效率为80.0%,PAD 2组为83.3%,两组差异无统计学意义。PAD 1组带状疱疹(30.0%vs 0%)患者多于PAD 2组,差异有统计学意义(Pm./m.2每周1次静脉注射的PAD方案治疗与硼替佐米1.3m./m.2每周2次静脉注射的PAD方案疗效相似,且硼替佐米1.6m./m.2每周1次静脉注射的PAD方案不良反应更少,更为安全。

关键词：多发性骨髓瘤硼替佐米疗效安全性

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