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Sodium alendronate loaded poly(L-lactideco-glycolide)microparticles immobilized on ceramic scaffolds for local treatment of bone defects

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Regenerative Biomaterials 2020年第3期7卷 293-302页

作者： Lucja Rumian Cornelia Wolf-Brandstetter Sina Roβler Katarzyna Reczynska Hanna Tiainen Havard J.Haugen Dieter Scharnweber elzbieta pamula Faculty of Materials Science and Ceramics Department of Biomaterials and CompositesAGH University of Science and TechnologyAl.A.Mickiewicza 30Krakow 30-059Poland Technische Universitat Dresden Institute of Materials ScienceMax Bergmann Center of BiomaterialsBudapester Str.27Dresden 01-069Germany Department of Biomaterials Institute for Clinical DentistryUniversity of OsloGeitmyrsveien 71BlindernP.O.Box 1109Oslo NO-0317Norway

Bone tissue regeneration in critical-size defects is possible after implantation of a 3D scaffold and can be additionally enhanced once the scaffold is enriched with drugs or other factors supporting bone remodelling and *** alendronate(Aln),a widely used anti-osteoporosis drug,exhibits strong inhibitory effect on bone resorption performed by ***,we propose a new approach for the treatment of bone defects in craniofacial region combining biocompatible titanium dioxide scaffolds and poly(L-lactide-co-glycolide)microparticles(MPs)loaded with *** MPs were effectively attached to the surface of the scaffolds’pore walls by human recombinant *** release from the scaffolds was characterized by initial burst(2466% of the drug released within first 24 h)followed by a sustained release phase(on average 5 mg of Aln released per day from Day 3 to Day 18).In vitro tests evidenced that Aln at concentrations of 5 and 2.5 mg/ml was not cytotoxic for MG-63 osteoblast-like cells(viability between 8166% and 9863% of control),but it prevented RANKL-induced formation of osteoclast-like cells from macrophages derived from peripheral blood mononuclear cells,as shown by reduced fusion capability and decreased tartrateresistant acid phosphatase 5b activity(5665% reduction in comparison to control after 8 days of culture).Results show that it is feasible to design the scaffolds providing required doses of Aln inhibiting osteoclastogenesis,reducing osteoclast activity,but not affecting osteoblast functions,which may be beneficial in the treatment of critical-size bone tissue defects.

关键词： ceramic scaffolds sodium alendronate osteoblasts osteoclastogenesis collagen critical-size defect poly(L-lactideco-glycolide) microparticles

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