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A novel mouse model of central cord syndrome

Neural Regeneration Research 2023年第12期18卷 2751-2756页

作者： Elzat Elham-Yilizati Yilihamu Xiangchuang Fan Zimeng Yang Shiqing Feng Department of Orthopedics Qilu Hospital of Shandong UniversityJinanShandong ProvinceChina Department of Orthopedics Tianjin Medical University General HospitalTianjinChina

Patients with potential spinal stenosis are susceptible to central cord syndrome induced by blunt trauma.Suitable animal models are helpful for studying the pathogenesis and treatment of such injuries.In this study,we established a mouse model of acute blunt traumatic spinal cord injury by compressing the C6 spinal cord with 5 and 10 g/mm~2 compression weights to simulate cervical central cord syndrome.Behavioral testing confirmed that this model exhibited the characteristics of central cord syndrome because motor function in the front paws was impaired,whereas basic motor and sensory functions of the lower extremities were retained.Hematoxylin-eosin staining showed that the diseased region of the spinal cord in this mouse model was restricted to the gray matter of the central cord,whereas the white matter was rarely affected.Magnetic resonance imaging showed a hypointense signal in the lesion after mild and severe injury.In addition,immunofluorescence staining showed that the degree of nerve tract injury in the spinal cord white matter was mild,and that there was a chronic inflammation reaction.These findings suggest that this mouse model of central cord syndrome can be used as a model for preclinical research,and that gray matter is most vulnerable to injury in central cord syndrome,leading to impaired motor function.

关键词： animal model behavior central cord syndrome cervical spinal cord injury cervical spinal cord pathology preclinical research spinal cord spinal cord compression spinal cord injury

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