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From the epididymis to the egg： participation of CRISP proteins in mammalian fertilization

Asian Journal of Andrology 2015年第5期17卷 711-715,I0005页

作者： Vanina G Da Ros Mariana Weigel Munoz Maria A Battistone Nicolas G Brukman Guillermo Carvajal Ludmila Curci Matlas D Gomez-elias Debora J Cohen Patricia S Cuasnicu Instituto de Biologi y Medicina Experimental (IByME-CONICET) Buenos Aires C1428ADN Argentina

Mammalian fertilization is a complex process that involves different steps of interaction between the male and female gametes. In spite of its relevance, the molecular mechanisms underlying this process still remain to be elucidated. The present review describes the contribution of our laboratory to the understanding of mammalian fertilization using Cysteine-Rlch Secretory Proteins （CRISP） as model molecules. Substantial evidence obtained from in vitro assays and knockout models shows that epididymal CRISP1 associates with the sperm surface with two different affinities during maturation, and participates in the regulation of signaling pathways during capacitation as well as in both sperm-zona pellucida interaction and gamete fusion. These observations can be extended to humans as judged by our findings showing that the human homolog of the rodent protein （hCRISP1） is also involved in both stages of fertilization. Evidence supports that other members of the CRISP family secreted in the testis （CRISP2）, epididymis （CRISP3-4） or during ejaculation （CRISP3） are also involved in sperm-egg interaction, supporting the existence of a functional redundancy and cooperation between homolog proteins ensuring the success of fertilization. Together, our observations indicate that CRISP proteins accompany spermatozoa along their transit through both the male and female reproductive tracts. We believe these results not only contribute to a better mechanistic understanding of fertilization but also support CRISP proteins as excellent candidates for future research on infertility and contraception.

关键词： Cysteine-Rlch Secretory Proteins epididymal proteins fertilization sperm

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Splenic Arteriogastric Fistula Resulting from Adrenocortical Carcinoma: A Rare Cause of Massive Upper Gastrointestinal Hemorrhage

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Open Journal of Radiology 2013年第4期3卷 165-168页

作者： elias J. Dayoub Kyung J. Cho Department of Radiology Division of Vascular & Interventional Radiology University of Michigan Health System Ann Arbor USA University of Michigan Medical School Ann Arbor USA John F. Kennedy School of Government Harvard University Cambridge USA

Splenic arteriogastric fistula is a rare cause of upper gastrointestinal (GI) hemorrhage, only reported a handful of times in the literature. Herein, we present a case of a 49-year-old woman with metastatic adrenocortical carcincoma who developed a fistula between the splenic artery and gastric lumen as a result of local invasion of her primary tumor. This fistula led to several episodes of massive upper GI bleeding. Selective splenic artery embolization was successful in ceasing the GI bleed;however, the intervention was not timely enough for the patient to survive the hemorrhage. We outline several clinical and imaging findings to assist physicians with earlier detection of splenic arteriogastric fistulas, and advocate prophylactic selective splenic artery embolization when this rare but highly fatal entity is discovered.

关键词： Splenic Artery Fistula Pseudoaneurysm Adrenocortical Carcinoma Embolization

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Safety Evaluation of Stop-Sign Mounted Beacons—A Cross-Sectional Study

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Journal of Transportation Technologies 2019年第1期9卷 95-108页

作者： Amrita Goswamy Shauna Hallmark Guillermo Basulto-elias Michael Pawlovich Department of Civil Construction and Environmental Engineering Iowa State University Ames USA Center for Statistics and Applications in Forensic Evidence Iowa State University Ames USA Jerome J. Lohr College of Engineering South Dakota State University Brookings USA

Agencies in Iowa have utilized both overhead flashing beacons and stop-sign mounted beacons. Although several studies have shown that overhead flashing beacons are effective, some concerns have been raised about driver confusion. The main concern is that a driver may interpret a multiface flashing beacon with a red indication for their approach as an all-way stop control. As a result, the Iowa DOT has been advocating use of stop-sign mounted beacons rather than overhead flashing beacons. Since little information is available about this countermeasure, data for intersections with (treatment) and without (control) stop-sign mounted beacons were identified and a cross-sectional analysis conducted (due to few confirmable installation dates). Rural stop-controlled intersections with stop-sign mounted beacons in Iowa (USA) were identified (40 in total). Intersection characteristics such as number of approaches, intersection angle etc. were extracted. Additionally, characteristics of individual approaches such as roadway surface (gravel/paved), advanced stop-sign rumble strips, and advance signing were recorded. One or more control locations were manually selected for each treatment intersection based on matching roadway configuration, presence of lighting, advance stop line rumble strips, number of approaches, channelization, traffic volume, and proximity. Propensity scores were estimated to match 40 control locations for comparison. Negative binomial models for different injury combinations at nighttime and daytime were developed with an indicator variable for presence and absence of stop-sign mounted beacons. Presence of stop-sign mounted beacons was associated with a 5% - 54% reduction in nighttime crashes. Injury nighttime crashes decreased by 54% and total nighttime crashes reduced by 18%.

关键词： Stop-Sign Mounted Beacons Safety Analysis Nighttime Crashes Crash Modification Functions

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Simultaneous multiple time scale imaging for kHz-MHz high-speed accelerometry

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Photonics Research 2022年第7期10卷 1712-1722页

作者： VASSILY KORNIENKO DAVID ANDERSSON MEHDI STITI JONAS RAVELID SIMON EK ANDREAS EHN EDOUARD BERROCAL elias KRISTENSSON Division of Combustion Physics Department of PhysicsLund UniversityLundSweden

Fast transient events,such as the disintegration of liquid bodies or chemical reactions between radical species,involve various processes that may occur at different time ***,there are two alternatives for monitoring such events:burst-or high-speed *** imaging at ultrahigh speeds(~100 MHz to THz)allows for the capture of nature's fastest processes but only for a narrowly confined period of time and at a repetition rate of~10 *** long lasting,rapidly evolving transient events requires a significantly higher repetition rate,which is met by existing~kHz to 1 MHz high-speed imaging ***,the use of such systems eliminates the possibility to observe dynamics occurring on the sub-microsecond time *** this paper,we present a solution to this technological gap by combining multiplexed imaging with high-speed sensor technology,resulting in temporally resolved,high-spatial-resolution image series at two simultaneous time *** further demonstrate how the collection of such data opens up the tracking of rapidly evolving structures up to MHz burst rates over long durations,allowing,for the first time,to our knowledge,the extraction of acceleration fields acting upon the liquid bodies of an atomizing spray in two dimensions at k Hz frame rates.

关键词： repetition high transient

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Revisiting endovascular treatment in below-the-knee disease. Are drug-eluting stents the best option？

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World Journal of Cardiology 2018年第11期10卷 196-200页

作者： Stavros Spiliopoulos Panagiotis M Kitrou elias N Brountzos 2nd Radiology Department Interventional Radiology Unit University of Athens Attikon University General Hospital Athens 12461 Greece Department of Interventional Radiology Patras University Hospital Patras 26500 Greece

Patients with below-the-knee arterial disease are primarily individuals suffering from critical limb ischemia(CLI), while a large percentage of these patients are also suffering from diabetes or chronic renal failure or both. Available data from randomized controlled trials and their meta-analysis demonstrated that the use of infrapopliteal drug-eluting stents(DES), in short-to medium-length lesions, obtains significantly better results compared to plain balloon angioplasty and bare metal stenting with regards to vascular restenosis, target lesion revascularization, wound healing and amputations. Nonetheless, the use of this technology in every-day clinical practice remains limited mainly due to concerns regarding the deployment of a permanent metallic scaffold and the possibility of valid future therapeutic perspectives. However, in the majority of the cases, these concerns are not scientifically justified. Large-scale, multicenter randomized controlled trials, investigating a significantly larger number of patients than those already published, would provide more solid evidence and consolidate the use of infrapopliteal DES in CLI patients. Moreover, there is still little evidence on whether this technology can be as effective for longer below-the-knee lesions, where a considerable number of DES is required. The development and investigation of new, longer balloon-expanding or perhaps selfexpanding DES could be the answer to this problem.

关键词： Critical limb ischemia Infrapopliteal arterial disease Drug-eluting stents Peripheral arterial disease Balloon angioplasty

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Risk Evaluation in Blood Donation Using Failure Mode and Effective Analysis

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Journal of Biomedical Science and Engineering 2021年第4期14卷 177-184页

作者： Razaz M. Salih Eltahir M. Husein elias Hassan Department of Biomedical Engineering Sudan University of Science and Technology Khartoum Sudan

The recognition and management of risk in donation process and blood product is critical to ensure donor and patient safety. To achieve this goal, the failure mode and effects analysis (FMEA) is a convenient method;moreover it was used to prevent the occurrence of adverse events and look at what could go strong at each step. This study aimed to utilize FMEA in central blood bank in Khartoum to evaluate the potential risk and adverse event that may occur during the donation process. According to the severity, occurrence and the detection of each failure mode, the risk priority number (RPN) was calculated to determine which of the failures should take priority to find a solution and applying corrective action to reduce the failure risk. The statistical package for social sciences (SPSS) version 11 was used as descriptive and analytical statistics tool. The FMEA technique provides a systematic method for finding vulnerabilities in a process before they result in an error, and in this study a satisfactory outcome was reached.

关键词： Donation Blood Product Donor Failure Mode and Effective Analysis Adverse Event Risk Priority Number

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Cholesteryl ester storage disease of clinical and genetic characterisation: A case report and review of literature

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World Journal of Clinical Cases 2020年第9期8卷 1642-1650页

作者： elias Badal Rashu Anders Ellekær Junker Karen Vagner Danielsen Emilie Dahl Ole Hamberg Line Borgwardt Vibeke Brix Christensen Nicolai J Wewer Albrechtsen Lise L Gluud Gastrounit Copenhagen University Hospital HvidovreHvidovre 2650Denmark Department of Hepatology RigshospitaletCopenhagen UniversityCopenhagen 2100Denmark Centre of Genomic Medicine RigshospitaletCopenhagen UniversityCopenhagen 2100Denmark Department of Paediatrics and Adolescent Medicine RigshospitaletCopenhagen UniversityCopenhagen 2100Denmark Novo Nordisk Foundation Center for Protein Research Faculty of Health and Medical SciencesUniversity of CopenhagenCopenhagen 2200Denmark Department for Clinical Biochemistry RigshospitaletUniversity of CopenhagenCopenhagen 2200Denmark

BACKGROUND Cholesteryl ester storage disease(CESD)is a rare genetic *** symptoms and severity are highly *** is a systemic disease that can lead to the accumulation of fat and inflammation in the liver,as well as gastrointestinal and cardiovascular *** majority of patients require liver transplantation due to decompensated *** replacement therapy has been approved based on a randomized *** study aims to clinically and genetically evaluate two siblings with CESD who underwent liver transplantation,as well as their first-degree family *** SUMMARY The siblings were compound heterozygous for the missense variant in LIPA exon 8,c.894G>A,(***298Gln)and a single base pair deletion,c.482del(***161Ilefs*19).Analyses of single nucleotide polymorphisms showed variants with an increased risk of fatty liver disease and fibrosis for both ***,both patients show signs of recurrence of CESD in the liver after transplantation and additional gastrointestinal and cardiovascular signs of *** family members who were LIPA heterozygous had a lysosomal acid lipase activity below the reference *** of these carriers,a seven-year-old boy,was found to have severe dyslipidemia and was subsequently treated with *** Our study underlines that CESD is a multi-organ disease,the progression of which may occur post-liver *** findings underline the need for monitoring of complications and assessment of possible further treatment.

关键词： Lysosomal acid lipase deficiency Lysosomal storage disease Non-alcoholicfatty liver disease Liver transplantation Sebelipase alfa Case report

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皮肤表面pH值及其临床意义

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中国皮肤性病学杂志 2007年第8期21卷 503-505页

作者：蔄茂强辛淑君 Peter M elias 辽宁省大连市皮肤病医院辽宁大连116021 美国加利福尼亚大学旧金山分校医学院

皮肤表面pH值是皮肤的生理指标之一,它随机体的不同生长发育时期和皮肤的生物状态的不同而不同。老年人及新生儿皮肤表面pH值较高;某些皮肤病可导致皮肤表面pH值升高。皮肤表面pH值升高可直接或间接影响角质形成细胞的代谢,从而引起角... 详细信息

皮肤表面pH值是皮肤的生理指标之一,它随机体的不同生长发育时期和皮肤的生物状态的不同而不同。老年人及新生儿皮肤表面pH值较高;某些皮肤病可导致皮肤表面pH值升高。皮肤表面pH值升高可直接或间接影响角质形成细胞的代谢,从而引起角质形成细胞增生、分化的异常,皮肤屏障功能改变,角质层致密性降低等。因此,测量皮肤表面pH值对判断表皮乃至整个机体的生物状态具有重要参考价值;皮肤表面pH值维持在最佳生理水平对延缓皮肤老化、防止和治疗某些皮肤病具有一定的指导意义。

关键词：表皮角质层皮肤pH

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New Approaches to the Prognosis and Diagnosis of Breast Cancer Using Fuzzy Expert Systems

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Journal of Computer and Communications 2024年第5期12卷 151-169页

作者： elias Ayinbila Apasiya Abdul-Mumin Salifu Peter Awon-Natemi Agbedemnab Department of Computer Science School of Computing and Information Sciences C. K. Tedam University of Technology and Applied Sciences Navrongo Ghana

Breast cancer remains a significant global health challenge, necessitating effective early detection and prognosis to enhance patient outcomes. Current diagnostic methods, including mammography and MRI, suffer from limitations such as uncertainty and imprecise data, leading to late-stage diagnoses. To address this, various expert systems have been developed, but many rely on type-1 fuzzy logic and lack mobile-based applications for data collection and feedback to healthcare practitioners. This research investigates the development of an Enhanced Mobile-based Fuzzy Expert system (EMFES) for breast cancer pre-growth prognosis. The study explores the use of type-2 fuzzy logic to enhance accuracy and model uncertainty effectively. Additionally, it evaluates the advantages of employing the python programming language over java for implementation and considers specific risk factors for data collection. The research aims to dynamically generate fuzzy rules, adapting to evolving breast cancer research and patient data. Key research questions focus on the comparative effectiveness of type-2 fuzzy logic, the handling of uncertainty and imprecise data, the integration of mobile-based features, the choice of programming language, and the creation of dynamic fuzzy rules. Furthermore, the study examines the differences between the Mamdani Inference System and the Sugeno Fuzzy Inference method and explores challenges and opportunities in deploying the EMFES on mobile devices. The research identifies a critical gap in existing breast cancer diagnostic systems, emphasizing the need for a comprehensive, mobile-enabled, and adaptable solution by developing an EMFES that leverages Type-2 fuzzy logic, the Sugeno Inference Algorithm, Python Programming, and dynamic fuzzy rule generation. This study seeks to enhance early breast cancer detection and ultimately reduce breast cancer-related mortality.

关键词： EMFES Breast Cancer Type-2 Fl Soft Computing Membership Functions Fuzzy Set Fuzzy Rules Risk Factors.

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Mycotoxin’s Infections and Prevention Methods: State of the Art

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Agricultural Sciences 2021年第11期12卷 1269-1285页

作者： Ishimwe Viviane Emmanuel Masabo Habiyaremye Joseph Mitsindo Rene elias Bizuru African Center of Excellence in Internet of Things University of Rwanda Kigali Rwanda African Center of Excellence in Data Science University of Rwanda Kigali Rwanda

Fungi that attack field crops and contaminate agricultural commodities produce mycotoxins when conditions are favorable. These are specialized metabolites made of poisonous chemical compounds created by bacteria, fungi, or plants that aren’t involved in the organism’s usual growth, development, or reproduction. They have an adversarial hold on humans, wildlife, and the agricultural sector, resulting in mysterious ailments and economic disruptions. Mycotoxins-tainted food and fodder can be found all over the world, posing a global concern. Consumption of contaminated food and fodder is a typical cause of epidemic outbreaks. Other mycotoxins have been associated with esophageal cancer and neural tube defects (NTDs);the immunotoxin deoxynivalenol (DON) causes diarrhea when combined with trichothecenes, and ochratoxin A (OTA) has been linked to kidney failure. The direct market costs associated with missed trade or lower revenues owing to tainted food or feed could be viewed as the economic repercussions of mycotoxins on human society. This review describes frequent groups of mycotoxins in detail, their impact on global health, their impact on the socio-economy;the methods of detection and prevention of these mycotoxins.

关键词： Mycotoxins Global Health Impact Socio-Economy Impact Mycotoxin’s Detection Prevention Methods

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