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Determination of Binding Parameters of miramistin to Serum Albumin by the Bioluminescent method

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Advances in Biological Chemistry 2014年第5期4卷 331-338页

作者： Nickolaj F. Starodub Andrey m. Katsev elvira R. Abduramanova Sergey L. Safronyuk marina V. Taran Department of General Chemistry Crimean State Medical University Named after S. I. Georgievsky Simpheropol Ukraine National University of Life and Environmental Sciences of Ukraine Kiev Ukraine

Bioassay based on the luminescent bacteria was used as a new method for the determination of the kinetic constants of ligand binding to the complexion agent. miramistin as the cationic surface-active antiseptic and serum blood albumin was taken as a model of interacting agent’s. It was concluded that this approach might have a wide range for applications, namely, in all cases where the ligand is an inhibitor of bacterial luminescence and its complex dose not effect the intensity of this process.

关键词： Bioluminescent Inhibition Test miramistin Albumin Association Constants Determination

Intimal sarcoma of the pulmonary artery with multiple lung metastases: Long-term survival case

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World Journal of Clinical Oncology 2017年第4期8卷 366-370页

作者： Sonia García-Cabezas macarena Centeno-Haro Simona Espejo-Pérez elvira Carmona-Asenjo Alberto L moreno-Vega Rosa Ortega-Salas Amalia Palacios-Eito Department of Radiation Oncology Reina Sofia University Hospital Department of Pathological Anatomy Reina Sofia University Hospital Department of Radiology Reina Sofia University Hospital Department of Nuclear medicine Reina Sofia University Hospital Department of medical Oncology Reina Sofia University Hospital

Pulmonary artery intimal sarcoma(PAIS) is a rare tumor with a very poor prognosis. Clinical and radiological findings usually mimic thromboembolic disease, leading to diagnostic delays. The treatment of choice is surgery, and adjuvant chemotherapy and radiotherapy have limited results. We report the case of a 48-year-old male patient, initially suspected with pulmonary thromboembolism. The angio-CT revealed a filling defect in the pulmonary artery trunk. The patient underwent surgery, resulting in with complete resection of the mass with a diagnosis of PAIS. The tumor progressed rapidly in the lung, requiring surgery of multiple lung metastases. The patient was treated with stereotactic body radiation therapy(SBRT) on two occasions for new pulmonary lesions. In the last follow-up(4 years after initial diagnosis), the patient was disease-free. In conclusion, SBRT proved to be an alternative treatment to metastasectomy, allowing palliative chemotherapy to be delayed or omitted, which may result in improved quality of life.

关键词： Intimal sarcoma of the pulmonary artery Lung metastases metastasectomy Stereotactic body radiation therapy Treatment

Strengthening the Security of Supervised Networks by Automating Hardening mechanisms

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Journal of Computer and Communications 2023年第5期11卷 108-136页

作者： Patrick Dany Bavoua Kenfack Alphonse Binele Abana Emmanuel Tonye Genevieve elvira Ndjana Leka Department of Electrical and Telecommunications Engineering National Advanced School of Engineering of Yaounde University of Yaounde I Yaounde Cameroon

In recent years, the place occupied by the various manifestations of cyber-crime in companies has been considerable. Indeed, due to the rapid evolution of telecommunications technologies, companies, regardless of their size or sector of activity, are now the target of advanced persistent threats. The Work 2035 study also revealed that cyber crimes (such as critical infrastructure hacks) and massive data breaches are major sources of concern. Thus, it is important for organizations to guarantee a minimum level of security to avoid potential attacks that can cause paralysis of systems, loss of sensitive data, exposure to blackmail, damage to reputation or even a commercial harm. To do this, among other means, hardening is used, the main objective of which is to reduce the attack surface within a company. The execution of the hardening configurations as well as the verification of these are carried out on the servers and network equipment with the aim of reducing the number of openings present by keeping only those which are necessary for proper operation. However, nowadays, in many companies, these tasks are done manually. As a result, the execution and verification of hardening configurations are very often subject to potential errors but also highly consuming human and financial resources. The problem is that it is essential for operators to maintain an optimal level of security while minimizing costs, hence the interest in automating hardening processes and verifying the hardening of servers and network equipment. It is in this logic that we propose within the framework of this work the reinforcement of the security of the information systems (IS) by the automation of the mechanisms of hardening. In our work, we have, on the one hand, set up a hardening procedure in accordance with international security standards for servers, routers and switches and, on the other hand, designed and produced a functional application which makes it possible to: 1) Realise the confi

关键词： Hardening Supervised Network Cyber Security Information System

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跟宿便分手还肠胃一个清爽

医学美学美容（美颜志） 2010年第2期 62-63页

作者： elvira

最近有一本“便便书”很流行，教大家每天观察自己大便的形状，从而判断自己的健康状态——理想的粪便应该是香蕉形状，介于黄色和黄褐色，能漂浮在水面上。其实，人体75％的毒素集中在粪便（其余为尿液、汗液等），囤积宿便，等于把毒... 详细信息

最近有一本“便便书”很流行，教大家每天观察自己大便的形状，从而判断自己的健康状态——理想的粪便应该是香蕉形状，介于黄色和黄褐色，能漂浮在水面上。其实，人体75％的毒素集中在粪便（其余为尿液、汗液等），囤积宿便，等于把毒素囤在体内，过多的坏菌会随着血液跑到各个器官，造成器官“内伤”，短时间可能难以看出，但是疲倦、黯沉、长痘痘。很快就会反映出来，可说是美容杀手!

关键词：宿便肠胃健康状态形状粪便毒素器官

Cerebral metabolism in major depressive disorder:a voxel-based meta-analysis of Positron Emission Tomography studies

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Cerebral metabolism in major depressive disorder:a voxel-bas...

中华医学会第十次全国精神医学学术会议

作者：苏亮蔡亦蕴施慎逊 Anirban Dutt elvira Bramon-Bosch 复旦大学附属华山医院 Institute of Psychiatry King's College LondonDe Crespigny ParkSE5 8AFLondonUK Shanghai mental Health Center Shanghai Jiao Tong University School of Medicine

Background:major depressive disorder(mDD) is a common mental illness with high lifetime prevalence.A large number of researches had been performed to investigate brain regions involved in the pathophysiology of *** the results are different from these studies using different neuroimaging methods. Objective To evaluate current evidence from Positron Emission Tomography(PET) studies,we conducted a voxel-based meta-analysis of brain cerebral metabolism in mDD. methods Data were collected from the following databases:Pubmed,China Biological medicine Database,China National Knowledge Infrastructure, Cochrane Library and Web of Science,with the last report up to April ***-based meta-analyses were performed using the revised activation likelihood estimation(ALE) software(GingerALE 2.0).The resulting ALE map was threshold at p multiple comparisons by false discovery rate),and a minimum cluster size of supra threshold voxels exceeding 100 mm was imposed. Results Ten whole-brain-based FDG-PET studies in mDD were included in the meta-analysis included 188 mDD patients and 169 healthy *** analyses showed the brain metabolism in bilateral insula,left lentiform nucleus putamen and extra-nuclear,right caudate and cingulate gyrus were ***,the brain activity in right thalamus pulvinar and declive of posterior lobe,left culmen of vermis in anterior lobe were increased in mDD *** results show that volumes the brain regions of decreased are more than that of increased regions. Conclusion Our meta-analysis suggested mDD patients showed a dysfunctional circuit including insula,limbic system,basal ganglia,thalamus,and cerebellum that has been discussed in the pathphysiology of *** decreased insula activity might play the key roles in the neuropathology of *** patients suffer from mDD compensated by an increased metabolism in thalamus and cerebellum.

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来源： cnki会议评论

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设计如此动人心

影像视觉 2007年第2期8卷 40-43页

作者： elvira 1-DNA异智品牌传播乐家卫浴

乐家欧洲时尚卫浴,不仅以其出色的产品设计著称,而且其市场营销也做得有声有色,从平面、电视广告到设计师讲座和体验中心的设立,但最后的目标无不是为了让设计更深入人心。下面我们将刊登乐家的几张平面作品,与读者共享。

关键词：电视广告重设计平面广告设计师设计理念品牌传播西班牙体验讲座概念

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中国元素的现代演绎

影像视觉 2007年第3期8卷 46-47页

作者： elvira

第一期CCP视觉大擂台,迎来了众多创意及制作高手的亮相。当然,最瞩目的就是冠军了,它就是广州奥美的雪堡冰啤广告。趁热打铁,我们请来创意主角之一Forest Young来谈谈创意与执行。

关键词：中国元素创意广告市场定位现代艺术冰啤啤酒制作珠江被子

Follistatin, a Novel Biomarker for malignant Gliomas

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Neuroscience & medicine 2015年第3期6卷 121-129页

作者： elvira Lekka Nicolas Tsesmetzis Katherine m. Ashton Peter Abel Charles Davies Gregory Hall Timothy Dawson Robert W. Lea Department of Neurosurgery Lancashire Teaching Hospitals NHS Trust Royal Preston Hospital Preston UK Faculty of Life Sciences University of Manchester Manchester UK Department of Pathology Lancashire Teaching Hospitals NHS Trust Royal Preston Hospital Preston UK School of Pharmacy and Biomedical Sciences University of Central Lancashire Preston UK

molecular biomarkers are commonly used for the management of several types of malignant tumours in routine clinical practice. However, this is not the case for malignant gliomas. Cytokines and Angiogenesis factors are potential candidates due to their intrinsic role in tumourigenesis. Pre- and post-operative serum from 36 malignant glioma patients and 36 controls was analysed using the Bio-Plex Pro Angiogenesis and Cytokines Assay (Bio-Rad, USA). Amongst the molecules tested, the serum concentration of follistatin was significantly higher in patients than in controls. moreover, the serum concentration of follistatin of the patients postoperatively was significantly reduced compared to that preoperatively. Factors such as age and gender did not affect the concentrations of follistatin measured in the serum of patients pre- and post-operatively as well as healthy controls. This is the first report of follistatin as potential biomarker for the detection of malignant gliomas.

关键词： Serum malignant Gliomas Follistatin Biomarker Cancer

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大广告,大制作

影像视觉 2007年第1期8卷 38-41页

作者： elvira 北京奥美广告公司

　　北京奥美一直以来是mOTO手机的广告代理.他们的广告向来以投入大、创意非凡以及制作团队大牌而闻名,本次mOTO Rokr E6手机的广告也不例外.下面我们请本广告的创意总监邹浩扬Wilson Chow结合本广告案例,来谈谈他们对广告摄影的一些想... 详细信息

　　北京奥美一直以来是mOTO手机的广告代理.他们的广告向来以投入大、创意非凡以及制作团队大牌而闻名,本次mOTO Rokr E6手机的广告也不例外.下面我们请本广告的创意总监邹浩扬Wilson Chow结合本广告案例,来谈谈他们对广告摄影的一些想法.……

关键词：摄影师 Wilson 周杰伦