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Effects of yeast fermented soursop and umbu-caja pulps on the colonic microbiota of middle-aged hypertensive adults

Food Bioscience 2023年第1期51卷 1067-1075页

作者： elvira de lourdes chaves macedo Tatiana Colombo Pimentel Janne Santos de Morais Dirceu de Sousa Melo Angelica Cristina de Souza Marcos dos Santos Lima Karoliny Brito Sampaio Noadia Priscila Araújo Rodrigues Disney Ribeiro DiasEvandro Leite de Souza Rosane Freitas Schwan Marciane Magnani Laboratory of Microbial Processes in Foods Federal University of Paraiba58051-900Joao PessoaPBBrazil Federal Institute of Parana 87703-536ParanavaíPRBrazil Federal University of Lavras 37200-900LavrasMGBrazil Institute Federal of Sertao Pernambucano 56314-520PetrolinaPEBrazil Laboratory of Food Microbiology Federal University of Paraiba58058-600Joao PessoaPBBrazil

The effects of umbu-caja and soursop pulps fermented by the yeast Issatchenkia terricola 129 on the colonic microbiota of middle-aged hypertensive adults were evaluated in vitro fermentation during 48 *** relative abundance of distinct bacterial groups,pH values,and contents of organic acids,sugars,and phenolic compounds were determined at 0,24,and 48 h of *** boulardii CNCM I-745,a recognized probiotic yeast,was used for comparison *** colonic fermentation,maltose,glucose,and fructose were metabolized,resulting in reduced pH values and decreased relative abundance of Bacteroides spp./Prevotella *** soursop pulp with *** 129 improved the colonic microbiota by increasing the relative abundance of Bifidobacterium *** Lactobacillus *** reducing the relative abundance of Eubacterium rectale/Clostridium coccoides and Clostridium histolyticum,resulting in the highest prebiotic *** the same time,the consumption of rhamnose and gallic acid and higher contents of propionic and acetic acids and procyanidin B2 were *** effects on colonic microbiota were less pronounced for *** followed by umbu-caja pulp with *** *** results indicate that fermented soursop pulp with *** 129 may modulate the colonic microbiota of middle-aged hypertensive adults.

关键词： Colonic fermentation Microbiota Metabolism Spondias spp. Annona muricata L

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Efficacy and long-term evaluation of intramyocardial injection of autologous CD34-enriched PBMSC in old myocardial infarction

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World Journal of Cardiovascular Diseases 2012年第4期2卷 283-290页

作者： Jose Luis Aceves Abel Archundia Araceli Paez Rafael Vilchis elvira Varela Emma Rodriguez Guillermo Diaz lourdes Flores-Luna Martha Alvarado Manuel Lopez Hernandez Luis Felipe Montano Felipe Masso department of Cardiovascular Surgery National Medic Center 20 de Noviembre ISSSTEMexico CityMexico department of Cellular Physiology National Institute of Cardiology“Ignacio Chavez”Mexico CityMexico Center of Population Health Research National Institute of Public HealthMexico CityMexico department of Hematology National Medic Center 20 de Noviembre ISSSTEMexico CityMexico Immunobiology Laboratory Department of Cell and Tissue BiologySchool of Medicine UNAMMexico CityMexico

Aims: We have shown that autologous transplant of CD34+-enriched peripheral-blood mononuclear cells (PBMSC) could restore depressed myocardial function, and sustain adequate myocardial function 12 months after surgery in patients with old (>one year-old) myocardial infarction. Our aim is to report the long-term morbidity and mortality efficacy of this procedure. Methods and results: Seventy patients with an old anteroseptal myocardial infarction were followed for 2 to 7 years, 35 had a revascularization procedure and received an intra-myocardial injection of autologous CD34+-enriched PBMSC (8 × 108 mononuclear cells/ml including 3 × 107 CD34+ cells/ml)(Group A). Group B patients only had the revascularization. Abnormal pre-surgical values of LVEF (33.2% ± 4.8%), LVDV (178 ± 13.7 ml), LVSV (120 ± 16 m), LVDD (58.9 ± 3.84 mm), E and A waves without contractility in infarction area in group A patients improved to approximate normal values (50% ± 3% for LVEF;90 ± 9.3 ml for LVDV;80 ± 9.9 ml for LVSV;55.3 ± 3 mm for LVDD;5.2 ± 0.5 cm/s for E wave and 4.18 ± 0.3 cm/s for A wave) 1 year after the procedure and have remained unaltered for all the follow-up period. All the patients remain alive. Only seven patients have been readmitted to the hospital for non-myocardial related events. Group B only 11 patients continued alive to 5 years after surgery and LEVF never increased more than 6%, all of them with many hospitalizations (n ≥ 10) by heart failure events. Conclusion: Intramyocardial injection of CD34+ highly enriched PBSC represent an encouraging alternative for patients with severely scarred and dysfunctional myocardium.

关键词： Stem Cells Myocardial Infarction CD34+ Cells Revascularization Heart Failure Ventricular Function

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