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Agreement of angle closure assessments between gonioscopy, anterior segment optical coherence tomography and spectral domain optical coherence tomography

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International Journal of Ophthalmology(English edition) 2015年第2期8卷 342-346页

作者： elton lik tong tay Vernon Khet Yau Yong Boon Ang Lim Stelson Sia Elizabeth Poh Ying Wong Leonard Wei Leon Yip Department of Ophthalmology Tan Tock Seng Hospital Republic of Singapore Air Force Aeromedical Centre Cardinal Santos Medical Center

AIM: To determine angle closure agreements between gonioscopy and anterior segment optical coherence tomography(AS-OCT), as well as gonioscopy and spectral domain OCT(SD-OCT). A secondary objective was to quantify inter-observer agreements of AS-OCT and SD-OCT ***: Seventeen consecutive subjects(33 eyes)were recruited from the study hospital’s Glaucoma *** was performed by a glaucomatologist masked to OCT results. OCT images were read independently by 2 other glaucomatologists masked to gonioscopy findings as well as each other’s analyses of OCT ***: Totally 84.8% and 45.5% of scleral spurs were visualized in AS-OCT and SD-OCT images respectively(P <0.01). The agreement for angle closure between AS-OCT and gonioscopy was fair at k =0.31(95% confidence interval, CI: 0.03-0.59) and k =0.35(95%CI: 0.07-0.63) for reader 1 and 2 respectively. The agreement for angle closure between SD-OCT and gonioscopy was fair at k =0.21(95% CI: 0.07-0.49) and slight at k =0.17(95% CI: 0.08-0.42) for reader 1 and 2 respectively. The inter-reader agreement for angle closure in AS-OCT images was moderate at 0.51(95% CI: 0.13-0.88). The inter-reader agreement for angle closure in SD-OCT images was slight at 0.18(95% CI: 0.08-0.45).CONCLUSION: Significant proportion of scleral spurs were not visualised with SD-OCT imaging resulting in weaker inter-reader agreements. Identifying other angle landmarks in SD-OCT images will allow more consistent angle closure assessments. Gonioscopy and OCT imaging do not always agree in angle closure assessments but have their own advantages, and should be used together and not exclusively.

关键词： anterior segment imaging spectral domain imaging angle closure assessment

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大型复材储罐罐顶新型加固技术及稳定性分析

工业建筑 2024年第1期54卷 140-146页

作者：梁旭王云浩谭力豪胡黎俐冯鹏上海交通大学船舶海洋与建筑工程学院上海200240 北京航空航天大学交通科学与工程学院北京100191 清华大学土木工程系北京100084

大型储罐罐顶的罐壁薄、跨度大,在外压作用下容易出现失稳问题。以某大型2万t复材储罐典型工程为例,针对其罐顶稳定性提升的需求,提出复材拱加固、复材拱–工字钢–槽钢组合加固、工字钢-槽钢组合加固、三角钢桁架加固罐顶等四种加固方... 详细信息

大型储罐罐顶的罐壁薄、跨度大,在外压作用下容易出现失稳问题。以某大型2万t复材储罐典型工程为例,针对其罐顶稳定性提升的需求,提出复材拱加固、复材拱–工字钢–槽钢组合加固、工字钢-槽钢组合加固、三角钢桁架加固罐顶等四种加固方案,并建立有限元模型对加固前后的储罐进行特征值屈曲分析。结果表明,加固前罐顶稳定系数为1.29,远小于GB150—1998《钢制压力容器》的要求(稳定系数为15)。除复材拱加固外,其余应用钢结构与复材进行组合的加固方案均有较好的效果,加固后罐顶稳定系数均满足GB150—1998的要求。在此基础上,综合分析了各加固方案的造价及施工工艺,结果表明小截面三角钢桁架加固复材罐顶为最优方案,为大型复材储罐罐顶的加固和优化设计提供技术参考。

关键词：复材大型储罐加固钢桁架稳定系数

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Mechano-responsive hydrogel for direct stem cell manufacturing to therapy

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Bioactive Materials 2023年第6期24卷 387-400页

作者： Yufeng Shou Ling Liu Qimin Liu Zhicheng Le Khang Leng Lee Hua Li Xianlei Li Dion Zhanyun Koh Yuwen Wang tong Ming Liu Zheng Yang Chwee Teck Lim Christine Cheung Andy tay Department of Biomedical Engineering National University of Singapore117583Singapore Institute for Health Innovation&Technology National University of Singapore117599Singapore School of Civil Engineering and Architecture Wuhan University of Technology430070WuhanChina NUS Tissue Engineering Program National University of Singapore117510Singapore Lee Kong Chian School of Medicine Nanyang Technological University636921Singapore School of Mechanical and Aerospace Engineering Nanyang Technological University639798Singapore Institute of Molecular and Cell Biology Agency for ScienceTechnology and Research(A*STAR)138648Singapore Department of Orthopaedic Surgery Yong Loo Lin School of MedicineNational University of Singapore119288Singapore Mechanobiology Institute National University of Singapore117411Singapore

Bone marrow-derived mesenchymal stem cell(MSC)is one of the most actively studied cell types due to its regenerative potential and immunomodulatory *** cell expansion methods using 2D tissue culture plates and 2.5D microcarriers in bioreactors can generate large cell numbers,but they compromise stem cell potency and lack mechanical preconditioning to prepare MSC for physiological loading expected in *** overcome these challenges,in this work,we describe a 3D dynamic hydrogel using magneto-stimulation for direct MSC manufacturing to *** our technology,we found that dynamic mechanical stimulation(DMS)enhanced matrix-integrinβ1 interactions which induced MSCs spreading and *** addition,DMS could modulate MSC biofunctions including directing MSC differentiation into specific lineages and boosting paracrine activities(e.g.,growth factor secretion)through YAP nuclear localization and FAK-ERK *** our magnetic hydrogel,complex procedures from MSC manufacturing to final clinical use,can be integrated into one single platform,and we believe this‘all-in-one’technology could offer a paradigm shift to existing standards in MSC therapy.

关键词： Mesenchymal stem cell Dynamic mechanical stimulation Magnetic hydrogel Stem cell manufacturing Cell therapy

Versatile and scalable chemical vapor deposition of vertically aligned MoTe2 on reusable Mo foils

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Nano Research 2020年第9期13卷 2371-2377页

作者： Jinjun Lin Hong Wang Roland Yingjie tay Hongling Li Maziar Shakerzadeh Siu Hon Tsang Zheng Liu Edwin Hang tong Teo School of Electrical and Electronic Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore Temasek Laboratories@NTU 50 Nanyang AvenueSingapore 639798Singapore School of Materials Science and Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore

Layered MoTe2 has shown great promises for optoelectronics and energy-storage applications due to its exceptional optical and electrochemical *** date,considerable efforts have been devoted to fabricating layered MoTe2 with lateral orientation by means of mechanical/chemical exfoliation and chemical vapor deposition(CVD)*** compared to its horizontal counterparts,vertically aligned MoTe2 with higher density of active edge sites is expected to possess unique optoelectronic and electrochemical properties,while which has not been reported *** this work,we report a versatile and scalable CVD growth of vertically aligned MoTe2 with length of up to〜7.5 fjm on Mo ***,the dominant phase of the vertically aligned MoTe2 can be tuned from 2H to 1T’by increasing the growth temperature from 630 to *** to the weak interaction between the as-grown MoTe2 and Mo foil,the as-grown MoTe2 can be easily detached from the Mo *** in turn enabled economic reuse of the Mo foil for multiple ***,the vertical growth of the MoTe2 is proposed to be caused by the internal strain generated during tellurization of Mo ***,the as-grown MoTe2 can also be directly dispersed in solvent to produce high-quality MoTe2 *** versatility of this growth strategy was further demonstrated by fabricating other vertically aligned transition metal chalcogenides(TMDs)such as TaTe2 and ***,this work paves the path towards achieving unique TMDs structures to enable high-performance optoelectronic and electrochemical devices.

关键词： molybdenum dltelluride chemical vapor deposition vertical growth reusable substrate

道家思想中的权能经验及思想——以“道”和“德”为参考初步观察

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深圳大学学报（人文社会科学版） 2012年第4期29卷 5-12,79页

作者：唐力权美国美田大学

道德是权能的重要表现,是构成及维持人类社会功能的权能模式,道德的权能可以说是文明秩序的骨干,"道"无处不在,无穷无尽,具有整体自反的特性,使自己不断重造再生而为万物生生不息的创化之元或泉源,"道"有超越性及内在性的特质,其内在性... 详细信息

道德是权能的重要表现,是构成及维持人类社会功能的权能模式,道德的权能可以说是文明秩序的骨干,"道"无处不在,无穷无尽,具有整体自反的特性,使自己不断重造再生而为万物生生不息的创化之元或泉源,"道"有超越性及内在性的特质,其内在性特质又称"德","道"与"德"在权能基础上本质是相同的,"道"是"德","德"是"道";原创字"道"字的原本语义内容是道的人的图腾物体,"德"字的古意也隐含于"道"字的形符,以直立的姿态行走的权能及能力为重点;"德"是持久正直的活动或行动的善德或超卓,人类虽有能力达成,但要实现正当或真实的人性,仍须靠努力;从广阔的角度考虑,中国哲学传统或是我们开展研究事业的最佳位置,要寻找问题的答案,我们必须先正确认识太古时期的语义学中的古代逻辑及文法。

关键词：中国哲学道家思想 “道” “德” 权能

Students’ Perceptions of MyMathLab:An Online Learning Management System

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Students’ Perceptions of MyMathLab:An Online Learning Manag...

基于生物可给性的某冶炼厂土壤重金属健康风险评价

2012 3rd International Conference on e-Education,e-Business,e-Management and e-Learning（IC4E 2012）

作者： Check-Yee Law lik-Neo Ng Wei-Wei Goh Cheng-Lan tay Yong-Wee Sek Centre for Foundation Studies&Extension Education Multimedia University Faculty of Information and Communication Technology Universiti Teknikal Malaysia Melaka

With the evolution of web-based technologies,technology-based instructions have been partially or fully incorporated into teaching and learning *** study analyzes students’perceptions of the use of MyMathLab（MML）as a supplement in a mathematics ***,students were satisfied with the use of MML in their *** students only rated the system marginally positive,it had provided them with their first hand experience in using online learning and assessment tools.

关键词： online learning perception MyMathlab mathematics pre-university

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中国环境科学 2021年第1期41卷 442-450页

作者：冯康宏范缙 lik Ung Stanley Hii 罗启仕曹心德续晓云上海交通大学环境科学与工程学院上海200240 永清环保股份有限公司上海200051

为科学评价重金属污染场地的人体健康风险,以某冶炼厂土壤为研究对象,采用PBET(Physiologically-Based Extraction Test)和IVG(In-Vitro gastrointestinal)两种方法测定了As、Cd、Cu、Pb、Zn的生物可给性,并对比了只考虑重金属总量与基... 详细信息

为科学评价重金属污染场地的人体健康风险,以某冶炼厂土壤为研究对象,采用PBET(Physiologically-Based Extraction Test)和IVG(In-Vitro gastrointestinal)两种方法测定了As、Cd、Cu、Pb、Zn的生物可给性,并对比了只考虑重金属总量与基于生物可给性的人体健康风险.结果表明,场地土壤As、Cd、Pb的平均含量分别高达7063,691,3811mg/kg,严重超过国家环境质量标准.在PBET和IVG测试中,5种重金属的平均生物可给性介于1.81%~44.8%与1.78%~30.1%之间.As是PBET中生物可给性最高的重金属元素,而在IVG中Cd的生物可给性最高;含磷矿物的存在使Pb的生物可给性最低.提取液pH值及组成组分与重金属元素间的化学行为是造成两种方法结果差异的主要原因.在模型假设的条件下,土壤原有重金属的总危险商与总致癌系数为27.2与2.95×10^-3.考虑生物可给性使二者降低了59.9%~84.4%与55.6%~79.4%,且两个系数大小均呈现PBET胃液>PBET胃肠液>IVG胃液>IVG胃肠液的规律.调整后可以认为Pb不再具有健康风险,Cd仅具有致癌风险,只有As同时具有非致癌风险与致癌风险.尽管考虑重金属生物可给性后场地仍具有不可忽视的人体健康风险,但经过调整后能更准确地识别重金属的危害程度,避免场地的过度修复.

关键词：重金属生物可给性土壤风险评价

^(68)Gallium-labelled PSMA-PET/CT as a diagnostic and clinical decision-making tool in Asian prostate cancer patients following prostatectomy

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Cancer Biology & Medicine 2019年第1期16卷 157-165页

作者： Janice S.H.Tan Charles X.Y.Goh Yen Sin Koh Youquan Li Jeffrey K.L.Tuan Eu Tiong Chua Terence W.K.Tan Michael L.C.Wang Lui Shiong Lee Kae Jack tay Ravindran Kanesvaran Chee Keong Toh Aaron K.T.tong Winnie W.C.Lam Melvin L.K.Chua Division of Radiation Oncology National Cancer Centre Singapore Department of Nuclear Medicine and Molecular Imaging Singapore General Hospital Radiological Sciences Academic Clinical Programme Duke-NUS Medical School Oncology Academic Clinical Programme Duke-NUS Medical School Department of Urology Singapore General Hospital Department of Surgery Sengkang General Hospital Division of Medical Oncology National Cancer Centre Singapore Division of Medical Sciences National Cancer Centre Singapore

Objective: Prostate cancers(PCa) in Asian individuals are molecularly distinct from those found in their Caucasian *** is no risk stratification tool for Asian men with rapid biochemical recurrence(BCR) following radical prostatectomy(Rad P). This study aims to assess the detection rate of ^(68)Ga-prostate-specific membrane antigen-positron emission tomography/computed tomography(PSMA-PET/CT) for diagnosis of clinical recurrence and as a treatment decision making tool in Asian patients with BCR post-Rad ***: ^(68)Ga PSMA-PET and CT body with/without bone scan [conventional workup(CWU)] were performed in 55 Asian patients with BCR within 36 months post-Rad P. Two blinded reviewers assessed the images. Detection rates of ^(68)Ga PSMAPET/CT were evaluated, and impact on management was reviewed by comparison with ***: Median time to BCR post-Rad P was 8.1 months. Detection rate for ^(68)Ga PSMA-PET/CT was 80%(44/55). A positive scan was significantly associated with increasing prostate-specific antigen(PSA) level [odds ratio(OR) = 1.13(95% CI 1.05–1.30), P =0.017], but not with higher Gleason grade or shorter PSA doubling time. Compared to CWU, ^(68)Ga PSMA-PET/CT detected an additional 106 lesions in 33/44 patients with a positive scan, resulting in a change in management in 25/44(56.8%) patients: 10 to hormonal therapy(HT) and whole pelvis radiotherapy(RT) in addition to bed RT, and 15 to palliative HT ***: In the present report, we demonstrated the diagnostic and treatment decision utility of ^(68)Ga PSMA-PET/CT in Asian men with rapid BCR. Detection of small volume nodal and systemic recurrences at low PSA levels(< 1.0 ng/mL) highlights the role of the tool in assigning patients to treatment intensification with HT-RT or palliative HT in polymetastatic disease.

关键词： ^68Ga PSMA PET/CT prostate cancer Asian diagnostic recurrence prostatectomy salvage radiotherapy

Phylogeny and taxonomy of Rhytisma‑like species worldwide

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Fungal Diversity 2023年第3期120卷 77-119页

作者： Qiu‑tong Wang Mei‑Jun Guo Tu Lv Hao Zhou Shuang Wang Shi‑Juan Wang Ying‑Ren Lin Sarah Gronefeld Roland Kirschner Meike Piepenbring Tina A.Hofmann Paul F.Cannon Cheng‑Lin Hou College of Life Science Capital Normal UniversityXisanhuanbeilu 105Haidian 100048BeijingChina Beijing Key Laboratory of Plant Gene Resources and Biotechnology for Carbon Reduction and Environmental Improvement Capital Normal UniversityXisanhuanbeilu 105Haidian 100048BeijingChina Anhui Provincial Key Laboratory for Microbial Control&School of Forestry&Landscape Architecture Anhui Agricultural UniversityWest Changjiang Road 130Hefei 230036AnhuiChina School of Forestry&Resource Conservation National Taiwan UniversityDaan DistrictRoosevelt Rd.Sec.4 No.1Taipei City 10617China Department of Mycology BiologicumMax‑Von‑Laue‑Str.1360438 Frankfurt am MainGermany Centro de Investigaciones Micológicas Herbario UCHUniversidad Autónoma de Chiriquí0427 DavidPanama Royal Botanic Gardens Kew TW93ABSurreyUK

Rhytisma *** the type genus of Rhytismataceae(Rhytismatales,Leotiomycetes,Ascomycota).Rhytisma-like species include members of Cryptomyces,Rhytisma and *** are parasites on leaves of broadleaf trees and cause tar spot *** this study,a phylogeny based on the large subunit of the ribosomal rRNA gene(nrLSU)and the mitochondrial small subunit(mtSSU)is presented,including sequences of 39 newly collected specimens from East Asia,Europe,and temperate as well as tropical *** on analyses of morphology,phylogeny as well as host-specificity and diversification time estimates,the family Rhytismataceae sensu stricto is proposed,and eight genera are accepted in this narrow family,including four novel genera(Densorhytisma,Fanglania,Johnstoniella and Shiqia),the type genus Rhytisma,and the reinstated genera Lophodermina,Placuntium and *** clusters within the main Rhytisma clade in our analyses,but is divergent in morphological terms,not having large compound *** species are recognized,including seven novel species(Fanglania hubeiensis,***,Johnstoniella yunnanensis,Rhytisma japonicum,***,Xyloma globosum,and ***),fifteen new combinations(Densorhytisma anhuiense,***,***,***,***-integrae,***-latifoliae,***-pedunculosae,***,***,Shiqia menziesii,***,***,***,***,and ***),one new name(***),seven known species(Lophodermina melaleuca,Placuntium andromedae,Rhytisma acerinum,***,***,***,and ***).In addition,seven immature specimens were studied but not assigned to existing species,herein referred to as Fanglania sp.1,Johnstoniella sp.1,Johnstoniella sp.2,Placuntium sp.1,Placuntium sp.2,Rhytisma sp.1,and Xyloma *** systematic positions of Cryptomyces maximus,*** and Vladracula annuliformis are re-assigned based on phylogenetic *** Rhytisma-lik

关键词： 29 New taxa Host-specificity Phylogeny Rhytisma Taxonomy