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世界核心医学期刊文摘（胃肠病学分册） 2005年第8期1卷 12-13页

作者： elsurer r Tatar G Simsek H 徐小杰 Department of Internal M edicine Hacettepe Univ. Med. Fac.Hospital K. Mah. Galdiran Sok. Pk. Apt. 11/1 Ankara 06420 Turkey.Dr

Celiac disease (CD) is characterized by malabsorption of nutrients in the smal l intestine. The availability of highly specific and sensitive serologic tests h as facilitated its diagnosis, increasing the disease prevalence. The aim of this study was to determine the clinical, laboratory, and histopathological features of CD in Turkish adults. Between 1968 and 2002, CD patients presenting to the G astroenterology Unit were evaluated retrospectively. From 2002, newly diagnosed patients were prospectively followed up. Sixty patients (39 female, 21 male)-we re included in the study. Mean body mass index was 22.2 ±5.4 kg/m2. The most co mmon symptoms were diarrhea, weight loss, and flatulence. Most common comorbidit ies were anemia,osteoporosis, type 1 diabetes mellitus, and steatohepatitis. Six (10.0%) patients had a family history of diabetes mellitus; one (1.7%) patient had a family history of CD. Plasma glucose and serum γ-glutamyltransferase levels were significantly hig her in females than males. Most common histopathological findings were increased lymphocytes in the lamina propria (76.2%) and villus epithelium (59.5%). Over the years, the cumulative frequency of CD increased more in females than males. This is thefirst study in the literature showing the characteristics of CD in T urkish adults. In our previous recent study, the prevalence of tissue transgluta minase antibody positivity in Turkish healthy blood donors was 1.3%, indicating a high prevalence of CD in our population. In this study, the cumulative freque ncy of CD increased more in females than males. With the better understanding an d increased suspicion of the disease, more patients are being diagnosed in our p opulation.

关键词：乳糜泻发病特征黏膜固有层肠胃胀气糖尿病家族史吸收障碍骨质疏松肠营养平均体重指数确诊患者

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通过检测健康献血者组织谷氨酰胺转移酶抗体筛查土耳其人群的乳糜泻

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世界核心医学期刊文摘（胃肠病学分册） 2005年第2期1卷 8-8页

作者： Tatar G. elsurer r. Simsek H. 郝筱倩

Celiac disease (CD) is a disease having the characteristic pathology of the mu cosa of the small intestine. The prevalence of CD in the Turkish population has not been investigated previously. The present study was designed to determine th e prevalence of CD in healthy blood donors. Serum samples of 2000 healthy blood donors presenting to Hacettepe University Faculty of Medicine Hospital Blood Ban k were tested for tissue transglutaminase (tTG) IgA and IgG antibodies with enzy me-linked immunosorbent assay (ELISA; Euroimmune, Germany). The histopathologic al findings for the cases with positive serology were evaluated. The distributio n of sex was 95.7%male, and 4.3%female. The mean age was 33±9. Among 2000 don ors, 23 (1.15%) were positive for tTG IgA antibody and 3 (0.15%) were positive for tTG IgG antibody. None of the samples was positive for both antibodies. Ser um total IgA was measured in two cases with only tTG IgG positivity and was foun d to be low in one case. Twelve subjects positive for tTG agreed to endoscopy an d biopsy. Histopathological examination revealed changes classified as Marsh III -II in one,Marsh II in two, Marsh I in seven, and Marsh 0 in two donors. This w as the first study conducted to determine the prevalence of tTG positivity in th e Turkish population. The tTG antibody positivity prevalence in healthy blood do nors was as high as 1.3%. This study shows that the prevalence of CD in the Tur kish population is relatively high in comparison to that in the Western world.

关键词：乳糜泻健康献血者谷氨酰胺转移酶抗体筛查组织病理学改变土耳其人抗体阳性者 IgG 内镜检查小肠黏膜

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