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Prediction modelling in the early detection of neonatal sepsis

World Journal of Pediatrics 2022年第3期18卷 160-175页

作者： Puspita Sahu elstin anbu raj stanly Leslie Edward Simon Lewis Krishnananda Prabhu Mahadev Rao Vijayanarayana Kunhikatta Department of Pharmacy Practice Manipal College of Pharmaceutical SciencesManipal Academy of Higher Education(MAHE)Manipal 576104KarnatakaIndia Department of Paediatrics Kasturba Medical CollegeManipal Academy of Higher Education(MAHE)ManipalKarnatakaIndia 576104 Department of Biochemistry Kasturba Medical CollegeManipal Academy of Higher Education(MAHE)ManipalKarnatakaIndia 576104

Background Prediction modelling can greatly assist the health-care professionals in the management of diseases,thus sparking interest in neonatal sepsis *** main objective of the study was to provide a complete picture of performance of prediction models for early detection of neonatal *** PubMed,Scopus,CINAHL databases were searched and articles which used various prediction modelling measures for the early detection of neonatal sepsis were *** extraction was carried out based on Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modelling Studies *** data consisted of objective,study design,patient characteristics,type of statistical model,predictors,outcome,sample size and *** model Risk of Bias Assessment Tool was applied to gauge the risk of bias of the *** An aggregate of ten studies were included in the review among which eight studies had applied logistic regression to build a prediction model,while the remaining two had applied artificial *** predictors like neonatal fever,birth weight,foetal morbidity and gender,cervicovaginitis and maternal age were identified for the early detection of neonatal ***,birth weight,endotracheal intubation,thyroid hypofunction and umbilical venous catheter were promising factors for predicting late-onset sepsis;while gestational age,intrapartum temperature and antibiotics treatment were utilised as budding prognosticators for early-onset sepsis *** Prediction modelling approaches were able to recognise promising maternal,neonatal and laboratory predictors in the rapid detection of early and late neonatal sepsis and thus,can be considered as a novel way for clinician decisionmaking towards the disease diagnosis if not used alone,in the years to come.

关键词： Neonatal sepsis Predictors Prediction modelling Systematic review Validation

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