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Hydro-Ethanol Extract of Persea americana Fruit Pulp Ameliorates Dyslipidaemia and Cardiotoxicity Exerted by Alloxan-Induced Diabetes Mellitus

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Journal of Biosciences and Medicines 2022年第12期10卷 201-216页

作者： Bernard Omokheshi Adele Chidi Okonkwo Anthony Olusoji Odetola Idara Emmanuel Emediong Abayomi Oluwatosin Ige elsie Olufunke Adewoye Applied and Environmental Physiology Unit Department of Physiology University of Ibadan Ibadan Nigeria Department of Physiology College of Health Sciences Nnamdi Azikiwe University Awka Nigeria

Diabetes-induced dyslipidaemia has been associated with an increased risk of atherosclerosis and coronary heart diseases. Persea americana fruit has been reported to possess anti-diabetic properties. Therefore, this study assessed the lipid profile and likely cardio-protective effects of hydroethanolic extracts of P. americana fruits in alloxan-induced diabetic Wistar rats. Thirty-five male rats (150 ± 30 g) were divided into 5 groups (n = 7) and treated orally as follows;groups I-II were normal animals treated with distilled water (0.3 ml/day) and P. americana (300 mg/kg) only respectively. Animals in groups III-V were made diabetic using alloxan monohydrate (100 mg/kg i.p.) and treated orally with distilled water (0.3 ml/day), P. americana (300 mg/kg) and glibenclamide (5 mg/kg) respectively for 21 days. Fasting blood glucose level was monitored prior to, after induction of diabetes mellitus, and on day 21 post-treatment, respectively. Thereafter, retro-orbital blood samples were collected after anaesthesia and analysed for insulin, total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL) levels, apolipoproteins A1 and B, superoxide dismutase (SOD) and catalase activities, reduced glutathione (GSH), Vitamin C and malondialdehyde levels, respectively. VLDL, atherogenic index (AI) and ApoB/A1 ratio were estimated mathematically. Pancreatic and cardiac structures were also investigated using Haematoxylin and Eosin stains. Treatment with P. ameriacana extracts reduced (p P. americana treated diabetic group. The hydro-ethanol fruit extract of Persea americana attenuates diabetes induced dyslipidaemia and reduces the susceptibility to cardiac impairment in experimental diabetes mellitus.

关键词： Persea americana Diabetes Mellitus Dyslipidaemia and Alloxan

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瑶族知多少

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英语角 2023年第30期 8-9页

作者： elsie 欣巴达不详

节日是展现民族特色与艺术的舞台,也是文化传承的重要途径。同学们,看了瑶族盘王节的习俗,是不是对瑶族也充满了好奇呢?快快往下读吧!

关键词：瑶族盘王节文化传承民族特色习俗

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Genistein Mitigates the Gastro-Toxic Effects of Bisphenol A in Male Wistar Rats

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Journal of Biosciences and Medicines 2022年第9期10卷 60-78页

作者： Abayomi Oluwatosin Ige Olayinka Oyinkansola Adebayo Bernard Omokheshi Adele Anthony Olusoji Odetola Idara Emmanuel Emediong elsie Olufunke Adewoye Applied and Environmental Physiology Unit Department of Physiology University of Ibadan Ibadan Nigeria Department of Physiology College of Health Sciences Nnamdi Azikwe University Akwa Nigeria

Exposure to Bisphenol A (BPA) worldwide is on the increase. Its toxicities in various tissues expressing estrogen receptors have been reported. However, limited information exists on its effects on the gastric tissue. This study therefore investigated the gastric effects of BPA exposure and the likely ameliorative potential of genistein, a phytoestrogen antioxidant, known to interact with estrogen receptors. Eighty-four male Wistar rats were randomly divided into 6 groups (n = 14) and orally treated for 28 days. Group I-IV received distilled water (0.2 ml), corn oil (3 ml/kg), BPA (50 mg/kg) and genistein (50 mg/kg) respectively. Group V was pre-treated daily with BPA one hour prior to genistein administration while Group VI was pre-treated daily with genistein one hour prior to BPA treatment. Thereafter, blood was collected into heparinized bottles for hematological analysis. Gastric juice was collected for pH and electrolytes determination. Gastric tissue was excised and analyzed for superoxide dismutase (SOD), reduced glutathione (GSH), malondialdehyde, nitric oxide (NO), mucin, parietal and mucous cell counts, and histology. The BPA only treatment group exhibited significant increases (p < 0.05) in white blood cell count, neutrophil-lymphocyte ratio, mucin concentration, NO, and malondialdehyde while gastric juice pH, bicarbonate, SOD, and GSH levels were reduced compared to control. The gastric mucosa also showed pathologies consistent with inflammation. Genistein pre-and post-treatment in BPA exposed rats significantly (p < 0.05) ameliorated these effects of BPA. However, some signs of gastric inflammation were still evident in the mucosal samples. Bisphenol A induces gastro-toxicity by increasing gastric acidity, reducing gastric juice bicarbonate level and disrupting prooxidant/antioxidant balance. Genistein pre- and post-treatment ameliorated these gastro-toxic effects of Bisphenol A via gastroprotective, antioxidant and anti-inflammatory mechanisms.

关键词： Bisphenol A Genistein Stomach Gastro-Protection Gastric Impairment

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形成倒装芯片焊点的铜接线柱焊凸(SBC)法

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电子工业专用设备 2006年第5期35卷 36-40页

作者： Consuelo Tangpuz elsie A.Cabahug 飞兆半导体公司MEZ Lapu-Lapu CityCebu

在倒装芯片应用中生长晶圆焊凸的工艺中对于间距较小(即小于150μm)、具有数个尺寸为150μm的焊凸,倒装前的焊锡涂敷好坏对产品的良率和可靠性起着重要作用。因为,如果涂敷的焊锡体积不均匀,就经不起涂敷过程中为确保涂敷在引线框上焊... 详细信息

在倒装芯片应用中生长晶圆焊凸的工艺中对于间距较小(即小于150μm)、具有数个尺寸为150μm的焊凸,倒装前的焊锡涂敷好坏对产品的良率和可靠性起着重要作用。因为,如果涂敷的焊锡体积不均匀,就经不起涂敷过程中为确保涂敷在引线框上焊锡的完整和体积一致性而引入的强制视像系统检查,从而降低产出率。这就是一些组装工艺正设法减少或取消这些限制的原因。另一方面,采用直接熔化焊凸的方法来形成焊点是一种速度较快的工艺,但在保证回流处理后的离板高度方面有缺点,导致在温度和功率循环测试中的表现较差。介绍的采用铜接线柱焊凸(SolderBumponCopperStud;SBC)法解决了这些问题;对于那些需要倒装的组装工艺而言,这是可保障其制造性较佳的解决方案。介绍采用铜接线柱焊凸(SBC)工艺在附着在倒装芯片上的金属基片和焊凸之间形成焊点的新方法,利用铜接线柱焊凸技术再配合晶圆级的焊锡丝印工艺在半导体上预先形成焊凸。这是替代电镀焊凸工艺一种别具成本效益的方法。

关键词：倒装芯片铜接线柱焊凸(SBC)

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溶液论

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1948年

作者： elsie M.Smith R.N. 吴建庵译

来源：汇雅图书（南通市图书馆... 评论

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Prevalence of Post-Traumatic Stress Disorder (PTSD) among Healthcare Workers Following COVID-19 Pandemic in Jazan Region, KSA

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Journal of Biosciences and Medicines 2023年第2期11卷 186-193页

作者： Mazharul Hoque Mohamed Moukhyer Mohtashim Lohani Bahja Siddig elsie L. Miguen Shane Alam Hassan Ghazwani Aziza Mukhayer Emergency Medical Services Faculty of Applied Medical Sciences Jazan University Jazan Saudi Arabia Medical Laboratory Technology Department Jazan University Jazan Saudi Arabia Faculty of Medicine Ahfad University for Women Omdurman Sudan Department of Health Promotion University of Maastricht Maastricht The Netherland

Background: COVID-19 was declared a worldwide pandemic by the World Health Organization in 2020. Many pieces of research have been published on the virus’s pattern and transmission routes, and a few studies have been published on its psychological repercussions for the general public and health care workers in particular. We aimed in this study to figure out the impact of COVID-19 pandemic on the mental health of health care workers in the Jazan region and compare it to non-health care workers. Results: There were 221 participants in this study conducted in the Jazan region KSA, during the first part of 2022. 117 participants were non-HCWs (Health Care Workers) and 104 participants were HCWs. 31.7% of HCWs had high score of PTSD symptoms which may suppress their immunity, PTSD was a clinical concern in 12.5%, 6.7% had probable PTSD, and 49% had no PTSD. The average PTSD score in HCWs was 26.14. In contrast, the great majority of non-HCWs (69.2%) had no PTSD;PTSD was a clinical concern in 16.2%, 11.1% had a score indicating PTSD had the potential for immunosuppression, and 3.4% had probable PTSD. Conclusion: The COVID-19 pandemic did not affect just those who were infected with the virus, nor was it restricted to the mental health of those afflicted;rather, the influence expanded until it reached the general public and, in particular, those who had contact with patients, such as health care workers. As a result, mental health investigation, follow-up, and therapy are required to preserve the mental health of health care workers as well as the general population.

关键词： COVID-19 PTSD Health Care Workers

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乳与初生动物

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中国畜牧兽医 1985年第4期 19-23页

作者：谭景和 elsie M.Widdowson

一、初次喂乳对消化道发育的影响动物出生前,肠道已行使一定的机能,即从吞入的羊膜液中吸收水和溶解于其中的物质。这点小的机能对肠道的发育来说也可能是很有意义的。然而,初乳和常乳却与羊膜液大不相同,因为含有羊膜液中不曾有的乳蛋... 详细信息

一、初次喂乳对消化道发育的影响动物出生前,肠道已行使一定的机能,即从吞入的羊膜液中吸收水和溶解于其中的物质。这点小的机能对肠道的发育来说也可能是很有意义的。然而,初乳和常乳却与羊膜液大不相同,因为含有羊膜液中不曾有的乳蛋白、脂肪和乳糖,这些成分都要比水难消化得多。

关键词：肠粘膜肠道 IgG 动物人初乳仔猪幼犬

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深腔焊膏印刷

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中国印刷与包装研究 2009年第2期1卷 59-61页

作者： elsie A.Cabahug Marlon D.Bartolo 李翔 Fairchild Semiconductor Lapulapu City

过去,在金属介质上进行倒装芯片组装时,如何在有凹槽空间的介质上实现焊膏印刷成为一大挑战。主要瓶颈是限流器有限区域内的模腔(深度小于2.0mm)。一种做法是印刷焊膏时使用多孔焊膏喷嘴,其带来的问题在于喷嘴堵塞会造成焊膏量不一致。... 详细信息

过去,在金属介质上进行倒装芯片组装时,如何在有凹槽空间的介质上实现焊膏印刷成为一大挑战。主要瓶颈是限流器有限区域内的模腔(深度小于2.0mm)。一种做法是印刷焊膏时使用多孔焊膏喷嘴,其带来的问题在于喷嘴堵塞会造成焊膏量不一致。而喷嘴口的多重设计和焊膏尺寸的一致性对于提高焊膏性能至关重要。焊膏印刷技术已经使用多年。然而,传统的二维模版技术主要适用于平面介质。最近,相关模版制造商研发了一种新的模版技术,能够在小于100μm的凹槽上印刷。最新的研发成果是使用3D模版,配合一个专门设计的刮刀,以实现在受力变形的有限空间上良好的印刷效果。本文研究的是采用3D模版在凹槽深300μm、小于2.0mm区域上实现焊膏印刷的技术,该技术可在有限空间内实现一致的焊膏印刷效果;此外,本文还研究了在间隔400μm、凹槽深150μm的区域上实现焊膏印刷的技术。3D模版可帮助焊膏印刷在凹槽空间内更好地控制焊膏质量。以下几个因素会影响焊膏印刷质量:焊料类型、模版布局、刮刀类型、凹槽形态及深度,此外还包含印刷参数。上述因素的相互作用使得在凹槽上进行连续的焊膏印刷成为可能。

关键词：印刷技术印刷质量芯片组装研发成果相互作用介质区域内有限

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Therapeutic efficacy and effects of artemisinin-based combination treatments on uncomplicated Plasmodium falciparum malaria-associated anaemia in Nigerian children during seven years of adoption as first-line treatments

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Infectious Diseases of Poverty 2017年第1期6卷 315-334页

作者： Akintunde Sowunmi Kazeem Akano Godwin Ntadom Adejumoke I.Ayede Folasade O.Ibironke Temitope Aderoyeje elsie O.Adewoye Bayo Fatunmbi Stephen Oguche Henrietta U.Okafor Ismaila Watila Martin Meremikwu Philip Agomo William Ogala Chimere Agomo Onikepe A.Folarin Grace O.Gbotosho Christian T.Happi Department of Pharmacology and Therapeutics University of IbadanIbadanNigeria Institute for Medical Research and Training College of MedicineUniversity of IbadanIbadanNigeria National Malaria Elimination Programme Federal Ministry of HealthAbujaNigeria Department of Paediatrics University of IbadanIbadanNigeria Department of Clinical Pharmacology University College HospitalIbadanNigeria Department of Physiology University of IbadanIbadanNigeria World Health Organization Regional Office for the Western PacificKhan Daun PenhPhnom PenhCambodia Department of Paediatrics University of JosJosNigeria Department of Paediatrics Institute of Child HealthUniversity of Nigeria Teaching HospitalEnuguNigeria Department of Paediatrics Specialist HospitalMaiduguriBorno SateNigeria Department of Paediatrics University of CalabarCalabarCross Rivers StateNigeria Nigeria Institute of Medical Research YabaLagosNigeria Department of Paediatrics Ahmadu Bello UniversityZariaNigeria Department of Biological Sciences Redeemer’s UniversityEdeOsun StateNigeria

Background:Artemisinin-based combination treatments(ACTs)are the first-line treatments of uncomplicated Plasmodium falciparum malaria in many endemic areas but there are few evaluation of their efficacy in anaemic malarious ***:Therapeutic efficacy of 3-day regimens of artesunate-amodiaquine and artemether-lumefantrine was evaluated in 437 anaemic and 909 non-anaemic malarious children following treatment during a seven-year period(2008-2014).Patterns of temporal changes in haematocrit were classified based on haematocrit values<30%and≥30%.Kinetics of the disposition of the deficit in haematocrit from 30%following treatment were evaluated using a non-compartment ***:PCR-corrected parasitological efficacy 28 days after start of treatment was significantly higher in artesunateamodiaquine-compared to artemether-lumefantrine-treated children[97%(95%CI:92.8-100)versus 96.4%(95%CI:91.3-99.4),P=0.02],but it was similar in non-anaemic and anaemic *** in haematocrit/1000 asexual parasites cleared from peripheral blood was significantly greater at lower compared to higher parasitaemias(P<0.0001),and in non-anaemic compared to anaemic children(P=0.007).In anaemic children at presentation,mean anaemia recovery time(AnRT)was 15.4 days(95%CI:13.3-17.4)and it did not change over the *** in haematocrit deficits from 30%were monoexponential with mean estimated half-time of 1.4 days(95%CI:1.2-1.6).Anaemia half-time(t_(1/2anaemia))correlated positively with AnRT in the same patients(r=0.69,P<0.0001).Bland-Altman analysis of 10 multiples of t_(1/2anaemia) and AnRT showed narrow limit of agreement with insignificant bias(P=0.07)suggesting both can be used interchangeably in the same ***:Artesunate-amodiaquine and artemether-lumefantrine remain efficacious treatments of uncomplicated *** infections in non-anaemic and anaemic Nigerian children in the last 7 years of adoption as first-line *** ACTs may also

关键词： Malaria-associated anaemia “Haematocrit conservation” Artemisinin-based combination treatments Children Nigeria

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拓扑DNA在壳聚糖纳米粒子中的固定化负载

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浙江科技学院学报 2020年第1期32卷 1-6页

作者： Annang elsie Odua 张亚青 Chiteme Tafadzwa Evangelista 柳永刘士旺浙江科技学院生物与化学工程学院杭州310023 浙江省农产品化学与生物加工技术重点实验室杭州310023 浙江省农业生物资源生化制造协同创新中心杭州310023

为了体外固定化不稳定单链拓扑DNA,采用阴阳离子共聚法制备壳聚糖/拓扑DNA复合纳米粒子,并进行傅立叶变换红外光谱、粒径/zeta电位和透射电子显微镜等分析表征。结果显示,纳米粒子中DNA上磷酸基团振动峰显著减弱,高温制备样品中双链DNA... 详细信息

为了体外固定化不稳定单链拓扑DNA,采用阴阳离子共聚法制备壳聚糖/拓扑DNA复合纳米粒子,并进行傅立叶变换红外光谱、粒径/zeta电位和透射电子显微镜等分析表征。结果显示,纳米粒子中DNA上磷酸基团振动峰显著减弱,高温制备样品中双链DNA含量少于低温样品,表明DNA的不稳定单链结构获得了体外固定化;同时,伴随DNA单链比例升高,复合纳米粒子的平均水合粒径由573.9 nm降到205 nm,zeta电位由19.53 mV降到9.75 mV,复合纳米粒子结构由核壳结构转变为实心胶束结构。几种差异结构壳聚糖/DNA纳米粒子的成功制备,可为后续生物活性或载药研究提供良好的技术支持。

关键词： DNA 壳聚糖拓扑结构固定化纳米粒子

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