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Chemsex and its risk factors associated with human immunodeficiency virus among men who have sex with men in Hong Kong

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World Journal of Virology 2022年第4期11卷 208-211页

作者： Alex Siu Wing Chan Patrick Ming Kuen Tang elsie yan Department of Applied Social Sciences The Hong Kong Polytechnic UniversityHong Kong 999077China Department of Anatomical and Cellular Pathology The Chinese University of Hong KongHong Kong 999077China

We were intrigued by Hanum et al,who published a study on the prevalence of human immunodeficiency virus(HIV)in homosexual,bisexual,and other men who have sex with men at sexual health clinics in England and the relationship between baseline variables and future HIV ***-enhanced sexual experience(chemsex)is becoming a global *** are increasing medical and academic concerns about chemsex,where substances are used to boost sexual satisfaction,which is prevalent in groups,especially among ***,gays,bisexuals,transgenders,and queers have become increasingly visible,valued,and committed ***,chemsex requires urgent attention.

关键词： Men who have sex with men Methamphetamine Application of novel psychoactive substances Drug abuse Lesbians,gays,bisexuals,transgenders Chemsex

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Cetuximab plus irinotecan in pretreated metastatic colorectal cancer patients:The elsie study

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World Journal of Gastroenterology 2011年第14期17卷 1879-1888页

作者： Robert Lim yan Sun Seock-Ah Im Ruey-Kuen Hsieh Tsz Kok Yau Anthony Bonaventura Arkom Cheirsilpa Regina Esser Matthias Mueser Suresh Advani Department of Hematology-Oncology National University Hospital 119074 Singapore Singapore Department of Medical Oncology Cancer Hospital and Institute Chinese Academy of Medical Science Beijing 100021 China Division of Hematology-Oncology Department of Internal Medicine Seoul National University Hospital Seoul 110-744 South Korea Department of Oncology-Hematology Mackay Memorial Hospital Taipei 104 Taiwan China Department of Clinical Oncology Pamela Youde Nethersole Eastern Hospital Hong Kong China Department of Medical Oncology Calvary Mater Newcastle Hospital Waratah New South Wales 2298. Australia National Cancer Institute Bangkok 10400 Thailand Global Clinical Development Unit Oncology Merck KGaA Darmstadt 64293 Germany Medical Affairs Oncology Asia Pacific Merck Serono 609927 Singapore Singapore Jaslok Hospital and Research Centre Mumbai 400026 India

AIM:To evaluate the efficacy and safety of cetuxim-ab plus irinotecan in irinotecan-refractory metastatic colorectal cancer (mCRC) patients from South-East Asia and Australia. METHODS:In this open-label,phase Ⅱ study,the main eligibility criteria were epidermal growth factor receptor-positive mCRC with progressive disease within 3 mo of an irinotecan-based regimen as the most recent chemotherapy. Patients received cetuximab 400 mg/m2 initially,then 250 mg/m2 every week,with the same regimen of irinotecan on which the patients had progressed (4 pre-defined regim-ens allowed). The prim-ary objective was evaluation of progression-free survival (PFS) at 12 wk. Secondary objectives included a further investigation of PFS,and an assessment of the overall response rate (ORR),duration of response,time to treatment failure (TTF),overall survival and the safety profile. RESULTS:One hundred and twenty nine patients were enrolled from-25 centers in the Asia-Pacific region and of these 123 received cetuximab plus irinotecan. The most common recent irinotecan regimen used was 180 mg/m2 every 2 wk which had been used in 93 patients (75.6%). The PFS rate at 12 wk was 50% (95% confidence interval (CI,41-59) and m-edian PFS tim-e was 12.1 wk (95% CI:9.7-17.7). The ORR was 13.8% (95% CI:8.3-21.2) and disease control rate was 49.6% (95% CI:40.5-58.8). Median duration of response was 31.1 wk (95% CI:18.0-42.6) and median overall survival was 9.5 mo (95% CI,7.5-11.7). The median TTF was 11.7 wk (95% CI:9.1-17.4). Treatment was generally well tolerated. The most common grade 3/4 adverse events were diarrhea (13.8%),neutropenia (8.9%),rash (5.7%) and vomiting (5.7%).CONCLUSION:In patients from Asia and Australia,this study confirm-s the activity and safety of cetuxim-ab plus irinotecan observed in previous studies in Europe and South America.

关键词： Epidermal growth factor receptor Cetuximab Irinotecan Metastatic colorectal cancer Asia

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干旱胁迫下20个茶花品种的抗旱能力比较

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湖北林业科技 2023年第4期52卷 11-21,38页

作者：魏鸣祁雄辉赵帅晏召贵李清源陈宝林傅劭王祥许林武汉市农业科学院武汉430065 湖北生态工程职业技术学院武汉430200 华中农业大学园艺林学学院武汉430070 荆门市十里牌林场荆门448000

为选育出湖北省兼具观赏性和抗旱性的茶花品种,以适宜华中地区栽植且观赏性较强的20个茶花品种2 a生扦插苗为研究对象,在塑料大棚室温15~25℃下,通过盆栽控水法进行干旱胁迫试验,对表形、叶片气体交换参数及相关生理指标变化进行跟踪分... 详细信息

为选育出湖北省兼具观赏性和抗旱性的茶花品种,以适宜华中地区栽植且观赏性较强的20个茶花品种2 a生扦插苗为研究对象,在塑料大棚室温15~25℃下,通过盆栽控水法进行干旱胁迫试验,对表形、叶片气体交换参数及相关生理指标变化进行跟踪分析,研究茶花的抗旱性能、干旱条件下理化特性变化,进行品种间抗旱能力比较排序。试验结果表明:不同茶花品种对于干旱环境下的耐受度有显著差异,严重干旱对各项生理指标、光合指标产生影响,抑制植株生长。在20个茶花品种中,‘十八学士’和‘黑骑士’抗旱能力最强,‘情人节’和‘休斯富豪’最弱。

关键词：茶花干旱胁迫抗旱性表型生理指标气体交换参数

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