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Effect of Gastrointestinal Protease Digestion on Bioactivity of Marine Peptides

Journal of Agricultural Science and Technology(B) 2014年第1期4卷 74-84页

作者： Ida-Johanne Jensen Lisa Lystbek Andersen Carlo Gunnar Ossum Greta Jakobsen Cristian De Gobba Sabeena Farvin Koduvayur Habeebullah Inez Johansson else hoffmann Edel Oddny Elvevoll Flemming Jessen Henrik Hauch Nielsen Faculty of Bioscience Fisheries and Economics Norwegian College of FisheO Science UniversiO of Tromso Tromso 9037Norway Division ofIndustrial Food Research National Food Institute DTU-Food Technical University qf Denmark Lyngby DK-2800Denmark Department of Biology Cell and Developmental Biology Universitv of Copenhagen Copenhagen 2100 Denmark Marinova ApS Adelvej 11 Lem St. 6940 Denmark Department of Food Science University o[Copenhagen Frederiksberg C 1958 Denmark

Focus in nutritional science has turned towards components in, or added to, foods that may possess health beneficial activities beyond the classical nutritional value, namely functional food. Bioactive peptides are examples of such components. In vitro studies on bioactivities have mainly been executed without concerning subsequent digestion after intake and the aim of this work was hence to investigate how the in vitro antioxidative, antihypertensive and caspase activating activities of peptides are affected by digestion with gastrointestinal （GI） proteases. Five different fish protein hydrolysates were chosen to study the effect of in vitro digestion on bioactivity. The protein concentration decreased in all samples during digestion and the molecular weight distribution of the peptides shifted towards lower values. Thus, in vitro digestion with GI proteases resulted in a further degradation of the peptides obtained by hydrolysis. The antihypertensive effect increased in all samples after digestion with GI proteases whereas the antioxidative capacity decreased. The effect on the caspase activity depended on the proteases used in the preparation of hydrolysates. In conclusion, the caspase activity and antihypertensive activity are maintained during digestion with GI proteases, while the antioxidative capacity seems to be reduced.

关键词： Antioxidative ACE in vitro caspase bioactivity marine peptides.

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The Ca^(2+)-sensing receptor and the pocketome:comparing nature's complexity with human intervention in receptor modulation

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3153-3154页

作者： Edda S.F.Matthees Carsten hoffmann Institut fur Molekulare Zellbiologie CMB-Center for Molecular BiomedicineUniversitatsklinikum JenaHans-Knoll StraBe 2D-07745 JenaGermany Friedrich-Schiller-Universitat Jena Hans-KnollStraBe2D-07745 JenaGermany

In a recent paper published in Nature,the relatively understudied Ca^(2+)-sensing,receptor(CasR)within the Gprotein-coupled receptor(GPCR)family C,gained attention due to pioneering research led by Georgios Skiniotis ... 详细信息

关键词： Stanford gained Skin

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Navigating the Challenges of Emerging Contaminants to Protect Human and Ecological Health

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Engineering 2024年第6期37卷 1-2页

作者： Jiuhui Qu Michael R.hoffmann Gang Yu School of Environment Tsinghua UniversityBeijing 100084China Linde-Robinson Laboratories California Institute of TechnologyPasadenaCA 91125USA Advanced Interdisciplinary Institute of Environmental and Ecology Beijing Normal UniversityZhuhai 519000China

Emerging contaminants are defined as chemicals that are not currently(or have only recently been)regulated and about which there are concerns regarding their impact on human or ecological *** contaminants are widely detected in air,water,soil,sediment,and biotic *** is against this backdrop of urgency that we have curated this special issue titled“Emerging Contaminants Control:Science and Technology,”with the goal of uniting the latest scientific insights and pioneering strategies to address this global *** special issue embarks on a comprehensive examination of the emerging contaminants dilemma,covering aspects such as risk assessment,remediation technologies,environmental surveying,and the broader implications for *** a collection of articles,we probe deep into the core of this issue,showcasing studies that range from appraising environmental risks to forging new methods for treatment and scrutinizing the occurrence of contaminants across different environmental settings.

关键词： Ecological surveying environmental

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The 5C Model of Linguistic Creativity:Construction Grammar as a Cognitive Theory of Verbal Creativity

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Journal of Foreign Languages and Cultures 2024年第1期8卷 139-154页

作者： Thomas hoffmann Catholic University Eichstatt-Ingolstadt

Creativity is a design feature of human *** paper presents a cognitive model of verbal creativity that draws on insights from the psychological research into creativity-particularly Glaveanu's 5A model that distinguishes five crucial perspectives on a creative act(actors,audience,artefacts,actions and affordances).The paper will outline a linguistic version of this model that adopts Construction Grammar as its theoretical *** resulting"5C model of constructional creativity"argues that the central elements of linguistic creativity are constructors,co-constructors,constructs,constructional blending and the constructional network.

关键词： creativity construction grammar cognitive linguistics blending 5C model of constructional creativity cognition constructional networks

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Egg-associated secretions from the brown planthopper(Nilaparvata lugens)activate rice immune responses

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Insect Science 2024年第4期31卷 1135-1149页

作者： Jing Li Shuai Li Jing Li Xinyang Tan Zhichang Zhao Lei Jiang Ary A.hoffmann Jichao Fang Rui Ji Institute of Plant Protection Jiangsu Academy of Agricultural SciencesJiangsu Key Laboratory for Food and Safety-State Key Laboratory Cultivation Base of Ministry of Science and TechnologyNanjingChina College of Plant Protection Nanjing Agricultural UniversityNanjingChina School of Plant Protection Anhui Agricultural UniversityHefeiChina School of BioSciences Bio21 InstituteUniversity of MelbourneParkvilleVICAustralia Jiangsu Collaborative Innovation Center of Regional Modern Agriculture&Environmental Protection Huaiyin Normal UniversityHuaianJiangsu ProvinceChina

The brown planthopper(BPH,Nilaparvata lugens)is a notorious sap-sucking insect pest that damages rice(Oryza sativa)plants throughout *** BPH feeding,saliva enters rice plant tissues,whereas during oviposition egg-associated secretions(EAS)are deposited in damaged plant *** changes in rice to planthopper salivary effectors have been widely ***,the effects of EAS from planthopper on rice immunity remains largely *** this study,we found that both infestation of rice by gravid BPH female adults and treatment with the EAS elicited a strong and rapid accumulation of jasmonic acid(JA),JA-isoleucine,and hydrogen peroxide in *** enhanced plant defenses not only in rice but also in tobacco,and these impaired the performance of BPH on rice,as well as the performance of aphids and whiteflies on ***-throughput proteome sequencing of EAS led to 110 proteins being identified and 53 proteins with 2 or more unique peptides being *** proteins from BPH EAS were also found in the salivary proteome from herbivores,suggesting potential evolutionary conservation of effector functions across feeding and oviposition;however,others were only identified in EAS,and these are likely specifically related to *** findings point to novel proteins affecting interactions between planthoppers and rice during oviposition,providing an additional source of information for effector studies.

关键词： egg-associated secretion Nilaparvata lugens oviposition plant immunity proteome

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Attitudes,beliefs,behaviours and perspectives on barriers and enablers of Australian general practitioners towards non-drug interventions:a national survey

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Family Medicine and Community Health 2024年第1期12卷 1-8页

作者： Loai Albarqouni Hannah Greenwood Caroline Dowsett Tammy hoffmann Rae Thomas Paul Glasziou Institute for Evidence-based Healthcare Faculty of Health Sciences&MedicineBond UniversityRobinaQueenslandAustralia Tropical Australian Academic Health Centre TownsvilleQueenslandAustralia

Background Many guidelines recommend non-drug interventions(NDIs)for managing common conditions in primary ***,compared with drug interventions,NDIs are less widely known,promoted and *** aim to(1)examine general practitioners’(GPs’)knowledge,attitudes and practices for NDIs,including their use of the Royal Australian College of General Practitioners(RACGP)Handbook of Non-Drug Interventions(HANDI),and(2)identify factors influencing their use of NDIs and *** We conducted a web-based cross-sectional survey of practicing GP members in Australia during October-November *** survey contained five sections:characteristics of GP;knowledge and use of NDIs;attitudes towards NDIs;barriers and enablers to using HANDI;and suggestions of NDIs and ideas to improve the uptake of NDIs in primary *** Of the 366 GPs who completed the survey,242(66%)were female,and 248(74%)were≥45 years *** in three GPs reported that they regularly(‘always’)recommend NDIs to their patients when appropriate(34%),whereas one-third of GPs were unaware of HANDI(39%).GPs identified several factors that improve the uptake of HANDI,including‘access and integration of HANDI in clinical practice’,‘content and support to use in practice’and‘awareness and training’.Conclusions While many GPs are aware of the effectiveness of NDIs and often endorse their use,obstacles still prevent widespread adoption in primary *** results of this survey can serve as a foundation for developing implementation strategies to improve the uptake of effective evidence-based NDIs in primary care.

关键词： enable survey sectional

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应对新污染物挑战，保护人类和生态健康（英文）

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Engineering 2024年第6期 1-2页

作者：曲久辉 Michael R.hoffmann 余刚 School of Environment Tsinghua University Linde-Robinson Laboratories California Institute of Technology Advanced Interdisciplinary Institute of Environmental and Ecology Beijing Normal University

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涂料助剂:用量小,作用大

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中国涂料 2024年第2期39卷 75-76页

作者： Bettina hoffmann 不详

自2020年以来,涂料市场经历了一段动荡、艰难的时期,至今仍未完全稳定下来,不过,助剂的好日子也即将又一次到来。即使增长潜力既不可靠,规模也不大,但再也不会存在挥之不去的不确定性迹象。近年来,助剂制造商面临着各种挑战。与所有原... 详细信息

自2020年以来,涂料市场经历了一段动荡、艰难的时期,至今仍未完全稳定下来,不过,助剂的好日子也即将又一次到来。即使增长潜力既不可靠,规模也不大,但再也不会存在挥之不去的不确定性迹象。近年来,助剂制造商面临着各种挑战。与所有原材料供应商一样,大多数的全球性问题引起了很多连锁反应:新冠肺炎疫情、通货膨胀和价格波动引起的材料短缺、供应链延误、需求波动。然而,全球涂料助剂市场的发展令人备受鼓舞:市场研究机构Frost&Sullivan认为,2022年的销售额约为98亿欧元。这相当于估计250万~300万t的销售量(见图1)。

关键词：涂料助剂市场研究机构涂料市场原材料供应商全球性问题连锁反应需求波动增长潜力

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Prehospital transdermal glyceryl trinitrate for ultra- acute ischaemic stroke: data from the RIGHT- 2 randomised sham- controlled ambulance trial

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Stroke & Vascular Neurology 2024年第1期9卷 38-49,I0035-I0046页

作者： Jason Philip Appleton Lisa J Woodhouse Craig S Anderson Sandeep Ankolekar Lesley Cala Mark Dixon Timothy J England Kailash Krishnan Grant Mair Keith W Muir John Potter Christopher I Price Marc Randall Thompson G Robinson Christine Roffe else C Sandset Jeffrey L Saver Angela Shone Aloysius Niroshan Siriwardena Joanna M Wardlaw Nikola Sprigg Philip M Bath Stroke University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Applied HealthResearch University of Birmingham College of Medical and Dental SciencesBirminghamUK Stroke Trials Unit Mental Health and Clinical NeurosciencesUniversity of NottinghamNottinghamUK Faculty of Medicine The George Institute for Global HealthSydneyNew South WalesAustralia The George Institute China at Peking University Health Science Center BeijingChina Neurology Royal Prince Alfred HospitalSydney Health PartnersSydneyNew South WalesAustralia Department of Neurology King's College Hospital NHS Foundation TrustLondonUK Faculty of Health and Medical Sciences University of Western AustraliaCrawleyWestern AustraliaAustralia East Midlands Ambulance Service NHS Trust NottinghamUK Stroke Queen's Medical CentreNottingham University Hospitals NHS TrustNottinghamUK Centre for Clinical Brain Sciences Dementia Research InstituteUniveristy of EdinburghEdinburghUK Institute of Neurology and Psychology University of GlasgowGlasgowUK Bob Champion Research and Education Building University of East AngliaNorwichUK Institute of Neuroscience Newcastle UniversityNewcastle upon TyneUK Department of Neurology Leeds Teaching Hospitals NHS TrustLeedsUK Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre University of LeicesterLeicesterUK Stroke Research in Stoke Institute for Science and Technology in MedicineKeele UniversityStoke-on TrentUK Department of Neurology Oslo University HospitalOsloNorway Research and Development Norwegian Air Ambulance FoundationOsloNorway Department of Neurology and Comprehensive Stroke Center David Geffen School of MedicineUCLALos AngelesCaliforniaUSA Research and Graduate Services University of NottinghamNottinghamUK Community and Health Research Unit University of LincolnLincolnUK

Background The effect of transdermal glyceryl trinitrate(GTN,a nitrovasodilator)on clinical outcome when administered before hospital admission in suspected stroke patients is ***,we assess the safety and efficacy of GTN in the prespecified subgroup of patients who had an ischaemic stroke within the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2(RIGHT-2).Methods RIGHT-2 was an ambulance-based multicentre sham-controlled blinded-endpoint study with patients randomised within 4hours of *** primary outcome was a shift in scores on the modified Rankin scale(mRS)at day *** outcomes included death;a global analysis(Wei-Lachin test)containing Barthel Index,EuroQol-5D,mRS,telephone interview for cognitive status-modified and Zung depression scale;and neuroimaging-determined‘brain frailty’*** were reported as n(%),mean(SD),median[IQR],adjusted common OR(acOR),mean difference or Mann-Whitney difference(MWD)with 95%*** 597 of 1149(52%)patients had a final diagnosis of ischaemic stroke;age 75(12)years,premorbid mRS>2107(18%),Glasgow Coma Scale 14(2)and time from onset to randomisation 67[45,108]***‘brain frailty’was common:median score 2[2,3](range 0–3).At day 90,GTN did not influence the primary outcome(acOR for increased disability 1.15,95%CI 0.85 to 1.54),death or global analysis(MWD 0.00,95%CI-0.10 to 0.09).In subgroup analyses,there were non-significant interactions suggesting GTN may be associated with more death and dependency in participants randomised within 1hour of symptom onset and in those with more severe *** In patients who had an ischaemic stroke,ultra-acute administration of transdermal GTN in the ambulance did not improve clinical outcomes in a population with more clinical and radiological frailty than seen in previous in-hospital *** IS ALREADY KNOWN ON THIS TOPIC⇒Transdermal glyceryl trinitrate(GTN)was associat-ed with less death and dependency in those w

关键词： Glasgow nitrate random

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The Merits of Passive Compliant Joints in Legged Locomotion： Fast Learning, Superior Energy Efficiency and Versatile Sensing in a Quadruped Robot

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Journal of Bionic Engineering 2017年第1期14卷 1-14页

作者： Matej hoffmann Jakub Simanek iCub Facility Istituto Italiano di Tecnologia Genova 16123 Italy Artificial Intelligence Laboratory Department of lnformatics University of Zurich Zurich 8050 Switzerland Department of Measurement Faculty of Electrical Engineering Czech Technical University in Prague Prague 166 27 Czech Republic

A quadruped robot with four actuated hip joints and four passive highly compliant knee joints is used to demonstrate the potential of underactuation from two standpoints： learning locomotion and perception. First, we show that：（i） forward locomotion on flat ground can be learned rapidly （minutes of optimization time）; （ii） a simulation study reveals that a passive knee configuration leads to faster, more stable, and more efficient locomotion than a variant of the robot with active knees; （iii） the robot is capable of learning turning gaits as well. The merits of underactuation （reduced controller complexity, weight, and energy consumption） are thus preserved without compromising the versatility of behavior. Direct optimization on the reduced space of active joints leads to effective learning of model-free controllers. Second, we find passive compliant joints with po- tentiometers to effectively complement inertial sensors in a velocity estimation task and to outperform inertial and pressure sensors in a terrain detection task. Encoders on passive compliant joints thus constitute a cheap and compact but powerful sensing device that gauges joint position and force/torque, and -- if mounted more distally than the last actuated joints in a legged robot -- it delivers valuable information about the interaction of the robot with the ground.

关键词： legged robots underactuated robots compliant joints learning locomotion force and tactile sensing haptic terrain classification

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