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Journal of Life Sciences 2013年第12期7卷 1284-1287页

作者： Shadia Mohamed ahmed abdalla Mohamed Ibrahim Nabaa Kamal Alshafie Rabab Haroun Mohammed ahmed Ali Ismail Tamador Elkhansa Elnour Angara College of Veterinary Medicine University of Bahri Khartoum 11111 Sudan College of Veterinary Medicine Sudan University of Science and Technology (SUST) Khartoum 11111 Sudan College of Science and Technology of Animal Production Sudan University of Science and Technology (SUST) Khartoum 11111Sudan

A serological survey of Toxoplasma gondii was conducted using LAT （Latex Agglutination Test） on 205 sera collected from working horses and donkeys in Khartoum State, Sudan. The overall sero-prevalence of the investigated equines was 32.7%. Antibodies to T. gondii were found in 38% of 100 horses and 27.6% of 105 donkeys. The titers were 1：2 （4 heads）, 1：4 （11 heads）, 1：8 （13 heads）, 1：16 （17 heads）, 1：32 （5 heads）, 1：64 （10 donkeys） and 1：128 （7 donkeys）. Neither the area nor animal species showed significant differences between the investigated groups. However, age was reported to show significant （P 〈 0.05） effect on equine toxoplasmosis in the Sudan. This is the first report on equine toxoplasmosis in the Sudan.

关键词： Toxoplasma gondii equines sero-prevalence latex agglutination test Sudan.

ADAM10 silencing regulates critical metastatic pathways in adenocarcinoma cell lines in vitro.

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ADAM10 silencing regulates critical metastatic pathways in a...

The Expression of miRNAs in Sudanese Patients with Systemic Lupus Erythematosus in Khartoum State

第十一届全国高聚物分子与结构表征学术研讨会

作者： ahmed M.E.abdalla Miao Yu Chenxi Ouyang Guang Yang Department of Biomedical Engineering College of Life Science and TechnologyHuazhong University of Science and Technology Department of Vascular Surgery General Hospital of Ningxia Medical University Department of Vascular Surgery Fuwai Hospital National Center for Cardiovascular Disease Chinese Academy of Medical Sciences and Peking Union Medical College

＜正＞Adenocarcinoma is a highly aggressive malignancy characterized by rapid progression, invasiveness, and a high risk of metastasis. In this study, ADAM10 small interfering RNA （siRNA） was used to silence ADAM10 in lung adenocarcinoma cell lines A549. Then, the role of ADAM10 silencing in the progression of metastasis and angiogenesis was investigated in vitro by targeting specific cell surface proteins MUC1,

关键词： Adenocarcinoma cell lines cancer metastasis ADAM10

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Open Journal of Rheumatology and Autoimmune Diseases 2022年第4期12卷 128-136页

作者： Sarah Mohammed Dafalla ahmed Elhadi Elsadig Tarig A. M. Hamid Huda Mohamed Haroun Sana Eltahir abdalla Department of Haematology Medical Laboratory Sciences Program Alyarmouk College Khartoum Sudan Department of Haematology Faculty of Medical Laboratory Sciences Alzaiem Al Azhari University Khartoum Sudan Department of Haematology and Immunohematology Sharq El Nile College Khartoum North Sudan Department of Haematology Faculty of Medical Laboratory Sciences University of Gezira Madani Sudan Department of Pathology Faculty of Medicine Al Neelain University Khartoum Sudan

Background: MicroRNAs (miRs) are noncoding gene regulators that may have a role as diagnostic or prognostic biomarkers in systemic lupus erythematosus (SLE). Aim: To measure the blood levels of miR-146a, miR-126 and miR-30a in Sudanese SLE patients and to investigate their potential role in disease pathogenesis and utility as biomarkers for SLE. Material and Methods: A total of 48 SLE patients and 20 matched healthy individuals were enrolled in this study. SLE disease activity index (SLEDAI) was assessed. The blood levels of miR-146a, miR-126 and miR-30a were determined by Real-time polymerase chain reaction (PCR) in all participants. Γ-INF and IL-2 were analyzed by ELISA, and CD markers were used in flow cytometry. Results: The mean age of the patients was 31.5 ± 8.5 years with disease duration > 5 years. In SLE patients, the mean blood level fold changes of miR-146a (0.33 ± 0.277;P 0.305) compared to controls. Down regulation of miR-146a increase expression of γ-INF (P 0.05) as no differences between the SLE patients and healthy control. Conclusion: Circulating miR-146a and miR-126 could be a potential noninvasive biomarker in SLE. This study provides an overview of the current state of research on the role of miRNAs in the immune pathogenesis and regulation of SLE. Further studies are needed in miRNAs profiling expressions of SLE diseases.

关键词： Systemic Lupus Erythematosus (SLE) MicroRNAs

The Role of Kappa and Lambda in Subclassification of B Cell Lymphoblastic Leukemia in Sudanese Patients Using Flow Cytometry

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Open Journal of Blood Diseases 2016年第3期6卷 44-52页

作者： Hameeda Abd Eladeem abdalla Amira ahmed Khalid Humeida Eman Abbass Osama A. Altayeb Ghada M. Marghani Faculty of Medical Laboratory Sciences Al Neelain University Khartoum Sudan Faculty of Medicine Al Neelain University Khartoum Sudan Flow Cytometry Laboratory for Leukemia & Lymphoma Diagnosis Khartoum Sudan Medical Laboratory Flow Cytometry Laboratory for Leukemia & Lymphoma Diagnosis Khartoum Sudan

Background: B-cell Acute lymphoblastic leukemia (B-ALL) is a neoplasm of lymphoblasts which are of B-cell lineage typically composed of small to medium sized blast cells, moderately condensed to dispersed chromatin with scanty cytoplasm and inconspicuous nucleoli, involving the bone marrow and/or blood. Methods and materials: This is a prospective cross-sectional study in which 50 blood and/or bone marrow samples of newly diagnosed patients (B-ALL) were tested for immunophenotyping. All samples were prepared for surface and cytoplasmic markers including kappa and lambda human antibody for 10 minutes in dark place and then run by the Flow Cytometer. Results: 64% of the study populations were males and 36% were females. Cases were classified according to immunophenotype and the age into different subtypes and showed the following frequencies: Pro B-ALL (8%), early pre B-ALL (56%), common B-ALL (16%), Pre-B-ALL (14%) and Mature B-ALL (only 6%). Surface immunoglobulin was positive in 10% and negative in 90% of all patients, showing 100% positivity in mature B-ALL and totally negative in other subtypes. While cytoplasmic immunoglobulin was positive in 16% and negative in 84% of all patients and was positive in 100% of Pre-B-ALL and in 50% of mature B-ALL. Surface kappa was more expressed in mature B-ALL than lambda giving a ratio of 2:1, while cytoplasmic kappa:lambda was 6:1 in Pre-B-ALL. Conclusion: Kappa and lambda have important role in B-ALL classification which necessitates their presence in immunophenotyping of B-ALL.

关键词： B Cell Acute Lymphoblastic Leukemia Immunoglobulin Kappa Lambda Flow Cytometer

The Use of Bleaching Creams among Central Sudan Students, 2010

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Pharmacology & Pharmacy 2014年第5期5卷 532-539页

作者： Abubakr K. Yousif Aimun AE. ahmed abdalla E. Idris M. O. Elmustafa Elham H. S. ahmed Department of Pharmacology Faculty of Pharmacy Omdurman Islamic University Omdurman Sudan Department of Pharmacology Faculty of Pharmacy University of Gezira Wad Medani Sudan Drug Information Centre Ministry of Health Gezira State Wad Medani Sudan

The aim of this study was to examine the use of bleaching creams containing hydroquinone, corticosteroids and mercury for skin lightening among higher secondary school students in central Sudan. A cross-sectional epidemiological study was conducted at 19 different girls’ schools. A total of 1187 young students aged 16 - 19 years old were randomly selected and approached, using a well-structured questionnaire. The main outcome measure was a number of epidemiological factors per abusers. Results revealed that, 55.4% of the respondents misused this product, whilst 51.6% of girls used cosmetics to lighten their skin for 1 - 3 years with skin irritations prevalence of 3.3%, and the face was reported as main application site (35.4%). In conclusion, the lack of health awareness and ignorance was the main causative factor, whilst education, competent authorities awareness and prescriptions restrictions were highly recommended.

关键词： Bleaching Creams Cosmetics Hydroquinone Mercury Corticosteroids Sudan

Nutritional Status of Mothers and Its Determinants in Alemtidad Area, Khartoum

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Food and Nutrition Sciences 2014年第22期5卷 2203-2208页

作者： Waled Amen Mohammed ahmed Eiman abdalla ahmed Khalid Ahmad Omar Arafa Ehab Ibrahim Salih El-Amin Ziad M. Alostaz Khalid Eltahir Khalid Nursing Department Faculty of Applied Medical Sciences Albaha University Al Bahah Saudi Arabia Altaiseer Medical Complex Khartoum Sudan Faculty of Applied Medical Sciences Albaha University Al Bahah Saudi Arabia Basic Sciences Department Faculty of Applied Medical Sciences Albaha University Al Bahah Saudi Arabia Faculty of Applied Medical Sciences Albaha University Al Bahah Saudi Arabia

Background: Nutritional status of mothers is considered one of the major problems facing mothers in the world. The nutrition plays a major role in mothers and child health. Objective: This study aims to assess mothers’ nutritional status and its determinants in Alemtidad area, Khartoum. Methods: A descriptive community based survey was conducted in the Alemtidad area of Khartoum between November 2012 and December 2012. One hundred and eighty mothers were selected by simple randomization. Data were collected by using structured designed questionnaire which was then analyzed by (SPSS) program version 20. Results: The study conducted among mothers in Alemtidad area;their age ranged between 19 and 86 years with the mean age 38 ± 12 years. From those mothers about half were unemployed, and having mainly primary and secondary educational level. 81.1% of mothers were not able to select the proper food according to age and nutrients and about 71.1% of mothers took two meals per day and 23.3% one meals per day, and only 5.6 take three meals per day. The Body Mass Index (BMI) was calculated to measure the nutrition status of mothers;this study shows that mothers in Alemtidad are mainly overweight and obese, 45.6% and 18% respectively and only 35% within normal range of Body Mass Index (BMI). Conclusion: The study concludes that mothers are either overweight or obese (45.6%, 17.7% respectively). Compared to national and international statistics the findings of this study reflect high Body Mass Index (BMI) of mothers in Alemtidad.

关键词： Nutritional Status Determinant of Nutritional Status Food Consumption Mothers

Fibrinogen Levels in Hypertensive and Normotensive: A Cross-Sectional Study from El-Obied City, Sudan

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Journal of Biosciences and Medicines 2016年第2期4卷 28-32页

作者： ahmed abdalla Agab Eldour Tarig Osman Khalafallah Hassan Mohammed Noja Eltayib Siddig Mohammed Saad Mohieldin Elsayid Asaad Mohammed ahmed Abd Allah Babker Faculty of Medicine and Health Science Medical Laboratory Science Program University of Kordofan El-Obied Sudan Future Lab Medical Laboratories Co. Ltd. Al Kharj KSA Departments of Clinical Laboratory Sciences College of Applied Medical Sciences King Saud Bin Abdulaziz University for Health Sciences Riyadh KSA Department of Medical Laboratory Science Al-Ghad International College for Health Sciences Al-Madinah Al-Monawarah KSA

Hypertension (HTN) has been defined as a blood pressure level at which an otherwise healthy person would have an increased risk of cardiovascular disease that could be mitigated through blood pressure-lowering treatment. Worldwide, hypertension is one of the most common causes of death. The prevalence of hypertension and cardiovascular disease increases with age, and has been found to be higher in those of South Asian and African ancestry, and in Aboriginal populations. Hypertension is not only one of the most important risk factors for cardiovascular disease, but also the number one modifiable risk factor for stroke. Alterations in blood coagulation system have been reported in patients of hypertension. Fibrinogen has been identified as a major independent risk factor for cardiovascular diseases. This was a descriptive cross-sectional study, conducted in Elobied teaching hospital during period from March to June 2014. The aim of this study is to determine the level of fibrinogen among hypertensive patients. Seventy percent of the patients (about 35 patients) had high fibrinogen level above 400 mg/dl compared with the control and about 30% (15 patients) were within the normal range of 200 mg - 400 mg/dl. This study has concluded that there was a significant increase in fibrinogen level in hypertensive patients compared to control, while the gender has no effect on the level of fibrinogen.

关键词： Hypertensive Normotensive Fibrinogen Level El-Obied City Sudan

Diagnostic Performance of glmM Gene and Histological Stains for Detection of Helicobacter pylori in Gastric Biopsy from Patients Admitted to Wad Madani Teaching Hospital, Sudan

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Natural Science 2022年第8期14卷 343-352页

作者： Karima Ali Hamid Albadawi Abdelbagi Talha Abdalraheem Ali Babiker Mohammed Ibrahim Malik Adam Dawoud Abakar Omer Mustafa Elsidig A Saeed Mohmed Bushra ahmed Elhadi abdalla ahmed Department of Histopathology and Cytology Faculty of Medical Laboratory Sciences University of Gezira Wad Medani Sudan Department of Clinical Laboratory Sciences College of Applied Medical Sciences Jouf University Al Jouf Kingdom of Saudi Arabia Department of Medicine Faculty of Medicine University of Gezira Wad Medani Sudan Department of Medical Microbiology Faculty of Medical Laboratory Sciences University of Gezira Wad Medani Sudan

Helicobacter pylori is the microbial agent most responsible for gastro-duodenal ulcer and chronic gastritis, which can develop into carcinoma of the stomach. This study was performed in Wad Medani Teaching Hospital, Sudan to detect Helicobacter pylori in stomach samples, and evaluate the performance of the tests used, which were histological stains and PCR. Gastric biopsies were obtained from 105 referred patients during endoscopy, and fixed specimens examined by haematoxylin-eosin and Warthin-Starry silver stains, while DNA was extracted for glmM gene amplification. Epigastric pain was the most common symptom at 78% (82/105) and chronic gastritis recorded with 71% (68/105) of endoscopy results. Warthin-Starry silver stain gave 31% (33/105) as positive for Helicobacter pylori followed by glmM gene 27% (28/105) and haematoxylin-eosin 24% (25/105). The study indicated good performance of histological staining and high specificity of glmM gene in detection of Helicobacter pylori from gastric biopsies.

关键词： Helicobacter pylori Histological Stains glmM Gene Gastric Biopsy Sudan

Genetic Diversity Analysis of Elite Doubled Haploid Rice Genotypes for Yield Attributing Traits in White Nile State, Sudan

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Agricultural Sciences 2022年第3期13卷 330-344页

作者： Khalid A. Osman Sara M. abdalla Kyung-Ho Kang Lee Sang-Bok ahmed E. Mohamed Yassir M. ahmed Amir I. Ismial Agricultural Research Corporation (ARC) Rice Breeding Program White Nile Research Station Kosti Sudan National Institute of Crop Science Rural Development Administration (RDA) South Korea & AfricaRice Saint-Louis Senegal

The development of new rice varieties is highly dependent on genetic diversity in desirable agronomic traits. Therefore, this study aimed to identify potential genotypes having the characters of Korean varieties (Tongil-type) and japonica developed through doubled haploid (DH) technology to apply in our breeding materials. 35 elite DH lines derived from another culture of Korean and African rice along with two local checks were planted in a randomized complete block design with three replications during the two seasons of 2019 and 2020. All evaluated genotypes exhibited a wide and significant variation in the ten measured traits. The highest heritability related to high genetic advance was recorded for the number of tiller/plant, grain yield t/ha, number of filled grain per panicle, and thousand grain weights (g). Genotypic coefficient of variation and genetic advance were recorded for number of tiller/plant, number of filled grain per panicle, 1000 grain weight and grain yield t/ha in both seasons. Moreover, there was a highly significant and positive correlation of grain yield with number of filled grain per panicle (0.65), number of tiller/plant (0.64) and number of panicle per m2 (0.54). Cluster analysis based on grain yield components trait grouped the 37 rice genotypes into four clusters. Cluster B was the largest and consisted of 13 genotypes. Finally, it could be concluded that, based on number of productive tillers, number of filled grain/panicle, number of panicle per m2, and grain yield, the lines KF170506, KF170509, KF170542, KF170530, KF170543, KF170500 and KF170510 were high potential for further selection for new type of irrigated rice. In addition, hybridization of these 7 high-yielding could be used to achieve higher heterosis among the genotypes. Furthermore, this evaluation could be useful in developing reliable selection indices for improving rice breeding programs.

关键词： Doubled Haploid Anther Culture Yield Components Heritability and Correlation