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Immunoregulatory and Anti-cancer Activities of Combination Treatment of Novel Four-Herb Formula and Doxorubicin in 4T1-Breast Cancer Bearing Mice

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Chinese Journal of Integrative Medicine 2024年第4期30卷 311-321页

作者： Lea Ling-Yu Kan Ben Chung-Lap Chan Grace Gar-Lee Yue LI Pei-ting Sharon sze-Man Hon HUANG Dan-qi Miranda Sin-Man Tsang Clara Bik-San lau Ping-Chung Leung Chun-Kwok Wong Institute of Chinese Medicine The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants The Chinese University of Hong KongHong KongChina Department of Chemical Pathology The Chinese University of Hong KongHong Kong SARChina China-Australia International Research Centre for Chinese Medicine School of Health and Biomedical SciencesSTEM CollegeRMIT UniversityBundooraVictoriaAustralia Li Dak Sum Yip Yio Chin R&D Centre for Chinese Medicine The Chinese University of Hong Kong SARHong KongChina

Objective To investigate the in vivo immunomodulatory and anti-tumor mechanisms of the combined treatment of novel Four-Herb formula(4HF)and doxorubicin in triple-negative breast cancer(TNBC).Methods Murine-derived triple-negative mammary carcinoma cell line,4T1 cells,was cultured and inoculated into mouse mammary ***-six mice were randomly assigned into 6 groups(n=11 in ench):naive,control,LD 4HF(low dose 4HF),HD 4HF(high dose 4HF),LD 4HF+D(low dose and doxorubicin),and D(doxorubicin).Apart from the naive group,each mouse received subcutaneous inoculation with 5×10^(5)4T1 cells resuspended in 100µL of normal saline in the mammary fat *** from the day of tumor cell inoculation,tumors were grown for 6 *** LD and HD groups received daily oral gavage of 658 and 2,630 mg/kg 4HF,*** LD 4HF+D group received daily oral gavage of 658 mg/kg 4HF and weekly intraperitoneal injection of doxorubicin(5 mg/kg).The D group received weekly intraperitoneal injections of doxorubicin(5 mg/kg).The treatment naive mice received daily oral gavage of 0.2 mL double distilled water and 0.1 mL normal saline via intraperitoneal injection once a *** control group received daily oral gavage of 0.2 mL double-distilled *** treatment period was 30 *** the end of treatment,mice organs were harvested to analyze immunological activities via immunophenotyping,gene and multiplex analysis,histological staining,and gut microbiota *** Mice treated with the combination of 4HF and doxorubicin resulted in significantly reduced tumor and spleen burdens(P<0.05),altered the hypoxia and overall immune lymphocyte landscape,and manipulated gut microbiota to favor the anti-tumor immunological ***,immunosuppressive genes,cytokines,and chemokines such as C-C motif chemokine 2 and interleukin-10 of tumors were significantly downregulated(P<0.05).4HF-doxorubicin combination treatment demonstrated synergetic activities and was most effective

关键词： adjunctivetherapy breast cancer cytokines Chinese medicine tumor microenvironment

The Pioneering Works of Professor Duzheng YE on Atmospheric Dispersion,Tibetan Plateau Meteorology,and Air–Sea Interaction

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Advances in Atmospheric Sciences 2017年第10期34卷 1137-1149页

作者： ngar-Cheung lau Institute of Environment Energy and Sustainabilityand Department of Geography and Resource ManagementThe Chinese University of Hong KongShatinN.T.Hong Kong

This paper provides an overview of the impacts of the original works of Professor Duzheng YE on a selected set of observational and model studies with which the present author has been associated over the past several decades. The main themes of these works include atmospheric energy dispersion, air–land interactions over the Tibetan Plateau, and El Ni n？orelated air–sea coupling over East *** dispersive behavior of observed atmospheric fluctuations accompanying cold surge events in East Asia is demonstrated. Cold air outbreaks over Korea and southern China are coincident with the successive downstream development of troughs and ridges, with the group velocity of such wave packets being notably faster than the phase propagation speed of individual troughs and ridges. In a more general context, dispersive features are also discernible from lagged teleconnection charts and cross-spectra of observed and model-simulated geopotential height variations on 10–30-day time *** the output from a high-resolution general circulation model, the relative contributions of condensational, sensible, and radiative heating to the atmospheric energy budget over the Tibetan Plateau are documented. The rapid changes of the upper tropospheric Tibetan anticyclone and East Asian mei-yu（＂plum rain＂） precipitation band associated with the development of the Asian monsoon system are *** principal anomalies in sea level pressure, surface wind, precipitation and sea surface temperature over southeastern China and the Philippine Sea region during El Nio events are presented. The contributions of remote El Nio-related forcing and local air–sea interaction to the occurrence of these anomalies are assessed.

关键词： atmospheric dispersion Tibetan Plateau meteorology El Nio

Martin boundary and exit space on the Sierpinski gasket

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Science China Mathematics 2012年第3期55卷 475-494页

作者： lau Ka-Sing NGAI sze-Man Department of Mathematics The Chinese University of Hong Kong Department of Mathematical Sciences Georgia Southern University

We define a new Markov chain on the symbolic space representing the Sierpinski gasket (SG),and show that the corresponding Martin boundary is homeomorphic to the SG while the minimal Martin boundary is the three vertices of the *** addition,the harmonic structure induced by the Markov chain coincides with the canonical one on the *** suggests another approach to consider the existence of Laplacians on those self-similar sets for which the problem is still not settled.

关键词： Martin boundary Markov chain Green function harmonic function fractal Sierpinski gasket

Reproductive Outcome of Transcervical Uterine Incision in Unicornuate Uterus

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Chinese Medical Journal 2017年第3期130卷 256-261页

作者： En-Lan Xia Tin-Chiu Li sze-ngar Sylvia Choi Qiao-Yun Zhou Hysteroscopic Center Fu Xing Hospital Capital Medical University Beijing 100038 China Department of Obstetrics and Gynaecology Prince of Wales Hospital Hong Kong 999077 China Department of Obstetrics and Gynaecology United Christian Hospital Hong Kong 999077 China

Background： The pregnancy outcome of the unicornuate uterus is associated with an increased risk of miscarriage, cervical incompetence, and a number of obstetric complications. However, at present, there is no accepted treatment method for women with unicornuate uterus, other than expectant measures. The aim of this study was to evaluate the reproductive outcome of transcervical uterine incision （TCUI） in patients with unicornuate uterus. Methods： Thirty-three patients with unicoruuate uterus presented to our tertiary center tbr infertility or miscarriage. All 33 patients underwent TCUI and were followed up for 10-52 months. The pregnancy outcomes （first-trimester miscarriage, second-trimester miscarriage, preterm, term, intrauterine death, ongoing pregnancy, and live birth） before and after TCUI were compared by t-test. Results： Among 31 patients who attempted to conceive alter TCUI, twenty conceived including one terufination of pregnancy, one second-trimester miscarriage, one ectopic pregnancy, five preterm deliveries, 11 term delivery, and one ongoing pregnancy. There were 16 live births in total. There was significant reduction in the first-trimester miscarriage rate （t = 4.890; P 〈 0.001 ）, increase in term delivery （t = -3.288; P =0.002）, and live birth rates （t = -4.073; P 〈 0.001 ） after TCUI. Conclusion： TCUI appeared to improve the pregnancy outcome in women with unicoruuate uterus presenting with infertility or miscarriage.

关键词： Hysteroscopy Pregnancy Outcome Surgery Transcervical Incision of Uterus Unicornuate Uterus Uterine Anomalies

Phoenix Rising ——The Early Censorship of William Tyndale＇s New Testament and Its Influence on The King James Bible

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Journal of Literature and Art Studies 2017年第8期7卷 945-957页

作者： sze M Suze Ceaminia lau Wycliffe Associates Orlando Florida USA

The early censorship of the English Bible was imposed during the sixteenth century. One example is William Tyndale＇s pocket-size New Testament translation, which underwem destruction including the burning of its manuscript, the published translation texts, and even the printers and possessors of these materials. This article reviews the legal history and the religious significance of the censorship, which further influences the appearance of the Authorized Version （1611 ）. Related facts are parliamentary policies concerning imports of foreign priming, book licensing and the use of the Bible. The latter part of this paper reviews evems organized by Wolsey, Tunstall and Warham, and the launch of scholarly based Bible-translation. This paper concludes by re-emphasizing the significance of these parties in sustaining the divine preservation and development of Biblical literature-readers, translators, printers, traders, clergy and legislators. They made the Phoenix rise from the heap of ashes to heaven, and inspired the work of the King James Bible.

关键词： William Tydale Bible Translation censorship New Testament Henry VIII monopoly King James

Motifs of Revulsion in George Eliot＇s Middlemarch and Induction of Moral Conflicts

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Journal of Literature and Art Studies 2017年第9期7卷 1091-1102页

作者： sze M Suze Ceaminia lau Wycliffe Associates OrlandoFloridaUSA

This paper selects revulsion and its networking emotion： resentment and disgust as a generic form of novel studies and the subject of moral investigation. Motifs of revulsion create complex bedding texture of the plot, which introduces personality and inner visions of characters in the novel. It unifies the binding power of narrative history and informs readers various aspects of morality in the Victorian era, in addition, to present a lyrical tone of social ethics. The following analysis takes Eliot＇s Middlemarch as the base text. I shall explain the lexical meaning and textual discussion of revulsion, resentment and disgust spirally within its context, then illustrate with paranthetical examples and different idioms. Later arguments turn to what Eliot defines as faction of human duty in life, which is the nuanced requirement of a subject stands against himself or herself through the disposition of conscience as verdict. This disposition provides unlimited parallels for instinctive presence of internal feelings and thresholds that are constantly affecting moral understandings.

关键词： motifs revulsion Middlemarch moral conflicts texts and emotions

A new osteogenic protein isolated from Dioscorea opposita Thunb accelerates bone defect healing through the mTOR signaling axis

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Bioactive Materials 2023年第9期27卷 429-446页

作者： John Akrofi Kubi Augustine Suurinobah Brah Kenneth Man Chee Cheung Yin lau Lee Kai-Fai Lee Stephen Cho Wing sze Wei Qiao Kelvin Wai-Kwok Yeung Department of Orthopaedics and Traumatology Li Ka Shing Faculty of MedicineThe University of Hong Kong(HKU)Hong Kong S.A.R.PR China Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma HKU-Shenzhen HospitalShenzhen518053PR China Department of Obstetrics and Gynaecology Li Ka Shing Faculty of MedicineHKU21 Sassoon RoadHong Kong S.A.RPR China Shenzhen Key Laboratory of Fertility Regulation Reproductive Medicine CenterHKU-Shenzhen HospitalShenzhenPR China Department of Biology Faculty of ScienceHong Kong Baptist UniversityKowloon TongHong Kong S.A.RPR China Golden Meditech Center for NeuroRegeneration Sciences Hong Kong Baptist UniversityKowloon TongHong Kong S.A.RPR China Applied Oral Sciences and Community Dental Care Faculty of DentistryHong Kong S.A.RPR China

Delayed bone defect repairs lead to severe health and socioeconomic impacts on patients. Hence, there are increasing demands for medical interventions to promote bone defect healing. Recombinant proteins such as BMP-2 have been recognized as one of the powerful osteogenic substances that promote mesenchymal stem cells (MSCs) to osteoblast differentiation and are widely applied clinically for bone defect repairs. However, recent reports show that BMP-2 treatment has been associated with clinical adverse side effects such as ectopic bone formation, osteolysis and stimulation of inflammation. Here, we have identified one new osteogenic protein, named ‘HKUOT-S2’ protein, from Dioscorea opposita Thunb. Using the bone defect model, we have shown that the HKUOT-S2 protein can accelerate bone defect repair by activating the mTOR signaling axis of MSCs-derived osteoblasts and increasing osteoblastic biomineralization. The HKUOT-S2 protein can also modulate the transcriptomic changes of macrophages, stem cells, and osteoblasts, thereby enhancing the crosstalk between the polarized macrophages and MSCs-osteoblast differentiation to facilitate osteogenesis. Furthermore, this protein had no toxic effects in vivo. We have also identified HKUOT-S2 peptide sequence TKSSLPGQTK as a functional osteogenic unit that can promote osteoblast differentiation in vitro. The HKUOT-S2 protein with robust osteogenic activity could be a potential alternative osteoanabolic agent for promoting osteogenesis and bone defect repairs. We believe that the HKUOT-S2 protein may potentially be applied clinically as a new class of osteogenic agent for bone defect healing.

关键词： Dioscorea spp protein Mesenchymal stem cells(MSCs) Osteoblast differentiation Bone mineral density(BMD) Bone defect repair mTOR signaling pathway

Cytogenetic and molecular genetic alterations in hepatocellular carcinoma

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Acta Pharmacologica Sinica 2005年第6期26卷 659-665页

作者： sze-hang lau, Xin-yuan GUAN~1 Department of Clinical Oncology, Faculty of Medicine, The University of Hong Kong, Hong Kong, China Department of Clinical Oncology Faculty of Medicine The University of Hong Kong Hong Kong China

Specific chromosome aberrations are frequently detected during the development of hepatocellular carcinoma. Molecular cytogenetic approaches such as comparative genomic hybridization and loss of heterozygosity analyses have provided fruitful information on changes in HCC cases at the genomic level. Mapping of chromosome gains and losses have frequently resulted in the identification of oncogenes and tumor suppressors, respectively. In this review, we summarize some frequently detected chromosomal aberrations reported for hepatocellular carcinoma cases using comparative genomic hybridization and loss of heterozygosity studies. Focus will be on gains of lq, 8q, and 20q, and losses of 4q, 8p, 13q, 16q, and 17p. We then examine the candidate oncogenes and tumor suppressors located within these regions, and explore their possible functions in hepatocarcinogenesis. Finally, the impact of microarray-based screening platforms will be discussed.

关键词： hepatocellular carcinoma chromosome aberrations oncogenes tumor suppressor genes

Evaluation of a Rapid Immunochromatographic Middle East Respiratory Syndrome Coronavirus Antigen Detection Assay

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Infectious Microbes & Diseases 2022年第4期4卷 175-177页

作者： Susanna Kar-Pui lau Kenneth sze-Ming Li Jade Lee-Lee Teng Sunitha Joseph Hayes Kam-Hei Luk Joshua Fung Ulrich Wernery Patrick Chiu-Yat Woo Department of Microbiology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong KongChina Central Veterinary Research Laboratory DubaiUnited Arab Emirates PhD Program in Translational Medicine and Department of Life Sciences National Chung Hsing UniversityTaichungTaiwan The iEGG and Animal Biotechnology Research Center National Chung Hsing UniversityTaichungTaiwan

Middle East respiratory syndrome coronavirus(MERS-CoV)infection in humans has a high mortality of>30%.Dromedaries are the reservoir of MERS-CoV and the main source of human ***,MERS-CoV infections in dromedaries are usually *** diagnosis of MERS-CoV infection in these animals is important in preventing camel-to-human transmission of the *** possible cross-reactivity of a previously reported rapid nucleocapsid protein-based antigen detection assay for MERS-CoV was examined with different CoVs,including Tylonycteris bat CoV HKU4,dromedary camel CoV UAE-HKU23,human CoV-229E,human CoV-OC43,severe acute respiratory syndrome CoV-2 and rabbit CoV HKU14,where none of them showed false-positive *** assay was further validated using quantitative real-time reverse transcription-polymerase chain reaction-confirmed MERS-CoV-positive and MERS-CoV-negative dromedary nasal samples collected in Dubai,the United Arab Emirates,which showed that the rapid antigen detection assay has a specificity of 100%and sensitivity of 91.7%.

关键词： MERS-CoV rapid antigen detection assay dromedary camels