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An optimized derivative of an endogenous CXCR4 antagonist prevents atopic dermatitis and airway inflammation

Acta Pharmaceutica Sinica B 2021年第9期11卷 2694-2708页

作者： Mirja Harms Monica MWHabib Simona Nemska Antonella Nicolò Andrea Gilg Nico Preising Pandian Sokkar Sara Carmignani Martina Raasholm Gilbert Weidinger Gönül Kizilsavas Manfred Wagner Ludger Ständker Ashraf HAbadi Hassan Jumaa Frank Kirchhoff Nelly Frossard elsa sanchez-garcia Jan Münch Institute of Molecular Virology Ulm University Medical CenterUlm 89081Germany Department of Pharmaceutical Chemistry Faculty of Pharmacy and BiotechnologyGerman University in CairoCairo 11835Egypt Laboratoire D'Innovation Thérapeutique UMR7200 CNRS/Universitéde Strasbourg and LabEx MEDALISFacultéde PharmacieIllkirch 67412France Institute of Immunology Ulm University Medical CenterUlm 89081Germany Core Facility Functional Peptidomics Ulm University Medical CenterUlm 89081Germany Center of Medical Biotechnology University of Duisburg-EssenDuisburg 47057Germany Max-Planck-Institute for Coal Research Düsseldorf 45470Germany Faculty of Allied Health Sciences Chettinad Hospital and Research InstituteChettinad Academy of Research and EducationKelambakkam 603103India Max-Planck-Institut für Molekulare Physiologie Dortmund 44227Germany Institute of Biochemistry and Molecular Biology Ulm UniversityUlm 89081Germany Max Planck Institute for Polymer Research Mainz 55128Germany

Aberrant CXCR4/CXCL12 signaling is involved in many pathophysiological processes such as cancer and inflammatory diseases.A natural fragment of serum albumin,named EPI-X4,has previously been identified as endogenous peptide antagonist and inverse agonist of CXCR4 and is a promising compound for the development of improved analogues for the therapy of CXCR4-associated *** generate optimized EPI-X4 derivatives we here performed molecular docking analysis to identify key interaction motifs of EPI-X4/*** rational drug design allowed to increase the anti-CXCR4 activity of *** EPI-X4 derivative JM#21 bound CXCR4 and suppressed CXCR4-tropic HIV-1 infection more efficiently than the clinically approved small molecule CXCR4 antagonist ***-X4 JM#21 did not exert toxic effects in zebrafish embryos and suppressed allergen-induced infiltration of eosinophils and other immune cells into the airways of animals in an asthma mouse ***,topical administration of the optimized EPI-X4 derivative efficiently prevented inflammation of the skin in a mouse model of atopic ***,rationally designed EPIX4 JM#21 is a novel potent antagonist of CXCR4 and the first CXCR4 inhibitor with therapeutic efficacy in atopic *** clinical development of this new class of CXCR4 antagonists for the therapy of atopic dermatitis,asthma and other CXCR4-associated diseases is highly warranted.

关键词： CXCR4 antagonist Asthma Allergy Inflammation Atopic dermatitis

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High-Efficiency DC-DC Converter for Large Input-Voltage Fluctuations in Solar Applications

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Chinese Journal of Electronics 2015年第3期24卷 502-507页

作者： AGUILLON-garcia Jacobo BANUELOS-sanchez Pedro SIST Sun Yat-sen University

In the solar energy systems the solar irradiance variation is partially engaged, limiting the converter’s transformation rate for a certain input amount and leaving the rest of energy unconverted. In order to utilize at its maximum the energy provided from a Photovoltaic(PVP) system, this manuscript proposed a topology that can cope with marginal input voltage variations from 60V(DC) up to 1050V(DC) for a steady output voltage of 700V(DC). This output voltage value is suitable for any interlink post-regulation architecture. Based on previous observations, this paper presents a wide-input voltage high-efficiency non-isolated single-control topology. Analysis, operating stages, simulations and experimental results for a 3k W prototype are presented.

关键词： DC-DC power converters Energy conversion Photovoltaic system Power conditioning Solar generation

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Plasmon-induced dual-wavelength operation in a Yb^(3+) laser

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Light(Science & Applications) 2019年第1期8卷 1042-1050页

作者： Laura sanchez-garcia Mariola O.Ramirez Rosa Maria Sole Joan J.Carvajal Francesc Diaz Luisa E.Bausa Deparment Fisica de Materiales Instituto Nicolas Cabrera and Condensed Matter Physics Center(IFIMAC)Universidad Autonoma de Madrid28049 MadridSpain Universitat Rovira i Virgili Departament Quimica Fisica i InorganicaFisica i Cristal·lografia de Materials i Nanomaterials(FiCMA-FiCNA)-EMaSE-43007 TarragonaSpain

Expanding the functionalities of plasmon-assisted lasers is essential for emergent applications in nanoscience and ***,we report on a novel ability of plasmonic structures to induce dual-wavelength lasing in the near-infrared region in a Yb^(3+) solid-state *** means of the effects of disordered plasmonic networks deposited on the surface of a Yb^(3+)-doped nonlinear RTP crystal,room-temperature dual-wavelength lasing,with a frequency difference between the lines in the THz range,is *** dual-wavelength laser is produced by the simultaneous activation of two lasing channels,namely,an electronic-and a phonon-terminated laser *** latter is enabled by the out-of-plane field components that are generated by the plasmonic structures,which excite specific Raman ***,multiline radiation at three different wavelengths is demonstrated in the visible spectral region via two self-frequency conversion processes,which occur in the vicinities of the plasmonic *** results demonstrate the potential of plasmonic nanostructures for inducing drastic modifications in the operational mode of a solid-state laser and hold promise for applications in a variety of fields,including multiplexing,precise spectroscopies,and THz radiation generation via a simple and cost-effective procedure.

关键词： laser lasing dual

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PPIs are not associated with a lower incidence of portal-hypertension-related bleeding in cirrhosis

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World Journal of Gastroenterology 2010年第46期16卷 5869-5873页

作者： Mauricio garcia-Saenz-de-Sicilia Francisco sanchez-Avila Norberto C Chavez-Tapia Gustavo Lopez-Arce Sandra garcia-Osogobio Roberto Ruiz-Cordero Felix I Tellez-Avila Department of Gastroenterology Instituto Nacional de Ciencias Medicas y Nutrición Salvador ZubiranMexico CityMexico Medica Sur Clinic and Fundation Endoscopy Department Instituto Nacional de Ciencias Medicas y Nutricion Salvador ZubiranMexico City14000Mexico

AIM:To determine if proton pump inhibitor use in cirrhotic patients with endoscopic findings of portal hypertension is associated with a lower frequency of gastrointestinal ***:Patients with cirrhosis and endoscopic findings related to portal hypertension,receiving or not receiving proton pump inhibitor (PPI) therapy,were included *** assigned patients to two groups:group 1 patients underwent PPI therapy and group 2 patients did not undergo PPI ***:One hundred and five patients with a median age of 58 (26-87) years were included,57 (54.3%) of which were *** varices were found in 82 (78%) patients,portal hypertensive gastropathy in 72 (68.6%) patients,and gastric varices in 15 (14.3%) *** therapy was used in 45.5% of patients (n=48).Seventeen (16.1%) patients presented with upper gastrointestinal bleeding;in 14/17 (82.3%) patients,bleeding was secondary to esophageal varices,and in 3/17 patients bleeding was attributed to portal hypertensive *** related to portal hypertension according to PPI therapy occurred in 18.7% (n=9) of group 1 and in 14% (n=8) of group 2 (odds ratio:0.83,95% confidence interval:0.5-1.3,P=0.51).CONCLUSION:Portal hypertension bleeding is not associated with PPI *** findings do not support the prescription of PPIs in patients with chronic liver disease with no currently accepted indication.

关键词： Drug prescription Liver cirrhosis Portal hypertension Proton pump inhibitors Upper gastrointestinal bleeding

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Fused empirical mode decomposition and wavelets for locating combined damage in a truss-type structure through vibration analysis

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第9期14卷 615-630页

作者： Arturo garcia-PEREZ Juan P. AMEZQUITA-sanchez Aurelio DOMINGUEZ-GONZALEZ Ramin SEDAGHATI Roque OSORNIO-RIOS Rene J. ROMERO-TRONCOSO HSPdigital-CA Telematica-Procesamiento Digital de Se ales DICIS Universidad de Guanajuato Carr. Salamanca-Valle km 3.5+1.8 Palo Blanco 36885 Salamanca Gto. Mexico HSPdigital CA Mecatronica Facultad de Ingeniería Campus San Juan del Río Universidad Autonoma de Queretaro Moctezuma 249 Col. San Cayetano 76807 San Juan del Río Qro. Mexico Department of Mechanical and Industrial Engineering Concordia University1455 de Maisonneuve Boulevard West Montreal QC H3G 1M8 Canada

Structural health monitoring (SHM) is a relevant topic for civil systems and involves the monitoring, data processing and interpretation to evaluate the condition of a structure, in order to detect damage. In real structures, two or more sites or types of damage can be present at the same time. It has been shown that one kind of damaged condition can interfere with the detection of another kind of damage, leading to an incorrect assessment about the structure condition. Identifying combined damage on structures still represents a challenge for condition monitoring, because the reliable identification of a combined damaged condition is a difficult task. Thus, this work presents a fusion of methodologies, where a single wavelet-packet and the empirical mode decomposition (EMD) method are combined with artificial neural networks (ANNs) for the automated and online identification-location of single or multiple-combined damage in a scaled model of a five-bay truss-type structure. Results showed that the proposed methodology is very efficient and reliable for identifying and locating the three kinds of damage, as well as their combinations. Therefore, this methodology could be applied to detection-location of damage in real truss-type structures, which would help to improve the characteristics and life span of real structures.

关键词： Truss structure Vibration Spectral analysis Wavelet packet transform Empirical mode decomposition Artificialneural network (ANN)

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Fertirrigation with Low-Pressure Multi-Gate Irrigation Systems in Sugarcane Agroecosystems:A Review

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Pedosphere 2019年第1期29卷 1-11页

作者： Arturo garcia-SALDANA Cesareo LANDEROS-sanchez Maria del Refugio CASTANEDA-CHAVEZ Juan Pablo MARTINEZ-DAVILA Arturo PEREZ-VAZQUEZ Eugenio CARRILLO-AVILA Postgraduate College Campus Veracruz Tepetates C.P.91674(Mexico) Technological Institute of Boca del Rio(ITBOCA) Boca del Rio C.P.94290(Mexico) Postgraduate College Campus Campeche Campeche C.P.24450(Mexico)

There are very few studies on the application of fertilizers through irrigation water(fertirrigation) using a multi-gate irrigation system in sugarcane AES. Through fertirrigation, the application of fertilizers can be simplified, and their distribution uniformity in sugarcane fields improved. This paper provides an overview of the state of the art regarding fertirrigation with multi-gate irrigation in sugarcane agroecosystems(AES). In order to systematize, organize, and discuss the scientific data on fertirrigation with low-pressure multi-gate irrigation systems in sugarcane AES, bibliographic material from the following full-text scientific journal databases was screened: the Elsevier Science Direct Freedom Collection, Springer Link, and the International Society for Horticultural Science. Next,a matrix of keywords was used to analyze the interrelationships among the available literature, current issues, and the recent *** conclude that development of fertirrigation technologies with low-pressure multi-gate irrigation is much needed.

关键词： climate change crop water requirement fertilizer application fertilizer distribution uniformity sugarcane industry water use efficiency

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Colorectal cancer screening and surveillance in patients with inflammatory bowel disease in 2021

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World Journal of Gastroenterology 2022年第5期28卷 502-516页

作者： Jose Maria Huguet Luis Ferrer-Barceló Patrícia Suárez Eva sanchez Jose David Prieto Victor garcia Javier Sempere Department of Digestive Disease General University Hospital of ValenciaValencia 46014Spain

The detection of dysplasia in patients with inflammatory bowel disease(IBD)continues to be important given the increased risk of colorectal cancer in this ***,in 2017,we performed a review and update of the recommendations for the management and follow-up of patients with IBD based on the clinical practice guidelines of various scientific *** present manuscript focuses on new aspects of the detection,follow-up,and management of dysplasia according to the latest studies and *** chromoendoscopy with targeted biopsy continues to be the technique of choice for the screening and detection of dysplasia in IBD,the associated difficulties mean that it is now being compared with other techniques(virtual chromoendoscopy),which yield similar results with less technical ***,the emergence of new endoscopy techniques that are still being researched but seem promising(e.g.,confocal laser endomicroscopy and full-spectrum endoscopy),together with the development of devices that improve endoscopic visualization(e.g.,Endocuff Vision),lead us to believe that these approaches can revolutionize the screening and follow-up of dysplasia in patients with ***,further studies are warranted to define the optimal follow-up strategy in this patient population.

关键词： Colitis surveillance Colitis screening Chromoendoscopy Colorectal cancer Inflammatory bowel disease Ulcerative colitis

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WELCOME & OPENING REMARKS

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国际眼科杂志 2003年第1期3卷 123-124页

作者： J.garcia sanchez University Complutense of Madrid Spain

Over the last few years, we have seen an introduction of new therapeutic options for the management and treatment of glaucoma. In daily clinical practice, It is essential we understand the role of intraocular pressure and other risk factors in the progression of this disease to ensure we provide optimal treatment and patient care. Today's satellite symposium will address these im-

关键词：西班牙青光眼国际会议开幕辞疾病管理证据 EVITA 多中心临床研究

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Dependence of dynamic contour and Goldmann applanation tonometries on peripheral corneal thickness

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International Journal of Ophthalmology(English edition) 2017年第10期10卷 1521-1527页

作者： Federico Saenz-Frances Claudia Sanz-Pozo Lara Borrego-Sanz Luis Ja?ez Laura MoralesFernandez Jose Maria Martinez-de-la-Casa Julian garcia-sanchez Julian garcia-Feijoo Enrique Santos-Bueso Ophthalmology Department Clinico Universitario San Carlos HospitalComplutense University Institute of Knowledge Technology Complutense University

AIM：To determine the effects of peripheral corneal thickness（PCT）on dynamic contour tonometry（DCT）and Goldmann applanation tonometry（GAT）.METHODS：A cross-sectional *** created a software which calculates the corneal contour（CC）as a function of the radius from the corneal apex to each pixel of the *** software generates a central circumference with a radius of 1 mm and the remainder of the cornea is segmented in 5 rings concentric with corneal apex being its diameter not constant around the corneal circumference as a consequence of the irregular CC but keeping constant the diameter of each ring in each direction of the *** was determined as the mean thickness of the most eccentric *** weighted scatterplot smoothing（LOWESS）regression was used to determine the pattern of the relationship between PCT and both DCT and GAT ***,two multivariable linear regression models were *** each of them,the dependant variable was intraocular pressure（IOP）as determined using GAT and DCT *** both of the models the predictive variable was PCT though LOWESS regression pattern was used to model the relationship between the dependant variables and the predictor *** and sex were also introduced control variables along with their first-degree interactions with *** outcome measures include amount of IOP variation explained through regression models（R2）and regression coefficients（B）.RESULTS：Subjects included 109 eyes of 109 healthy *** regression suggested that a 2nd-degree polynomial would be suitable to model the relationshipbetween both DCT and GAT with *** PCT was introduced in both models as a linear and quadratic *** age nor sex nor interactions were statistically significant in both *** GAT model,R2was 17.14%（F=9.02;P=0.0002）,PCT linear term B was-1.163（95%CI：-1.163,-0.617）.PCT quadratic term B was 0.00081（95%CI：0.00043,0.00118）.For DCT model R2was 14.28%（F=9.29;P=0.0002

关键词： Goldmann applanation tonometry dynamic contour tonometry peripheral corneal thickness corneal thickness

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Correlations between corneal and optic nerve head variables in healthy subjects and patients with primary open angle glaucoma

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International Journal of Ophthalmology(English edition) 2015年第6期8卷 1156-1161页

作者： Federico Saenz-Frances Luis Janez Lara Borrego-Sanz Clara Berrozpe-Villabona Jose Maria Martinez-de-la-Casa Laura Morales-Fernandez Julian garcia-sanchez Enrique Santos-Bueso Julian garcia-Feijoo Department of Ophthalmology Clinico San Carlos HospitalComplutense University of Madrid Technology of Knowledge Institute Complutense University of Madrid

AIMTo correlate corneal variables (determined using the Pentacam) with optic nerve head (ONH) variables determined using the Heidelberg retina tomograph (HRT) in healthy subjects and patients diagnosed with primary open angle glaucoma (POAG).METHODSMeasurements were made in 75 healthy eyes and 73 eyes with POAG and correlations examined through Pearson correlation coefficients between the two sets of variables in the two subject groups. The corneal variables determined were corneal volume (CVol), central corneal thickness (CCT), overall corneal thickness (OvCT), the mean thickness of a circular zone centered at the corneal apex of 1 mm radius (zone I) and the mean thickness of several concentric rings, also centered at the apex until the limbus, each of 1 mm width (zones II to VI respectively). The ONH variables were determined using the *** following pairs of variables were correlated in the control group: CCT-disc area (DAr) (-0.48; P<0.0001), Zone I-DAr (-0.503; P<0.0001) and Zone II-DAr (-0.443; P<0.0001); and in the POAG group: CCT-cup-to-disc area ratio (CDRa) (-0.402; P<0.0001), Zone I-CDRa (-0.418; P<0.0001), Zone II-CDRa (-0.405; P=0.006), Zone I-cup shape measure (CSM) (-0.415; P=0.002), Zone II-CSM (-0.405; P=0.001), Zone IV-height variation contour (HVC) (0.378; P=0.002); Zone V-HVC (0.388, P<0.0001).CONCLUSIONSIn the healthy subjects, significant negative correlation was detected between central and paracentral corneal thickness and optic disc area. In contrast, the POAG patients showed significant negative correlation between central and paracentral corneal thickness and the cup-disc ratio and CSM, and positive correlation between peripheral corneal thickness and HVC.

关键词： glaucoma optic nerve head corneal thickness

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