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Impact on dietary intake of a self-directed, gender-tailored diabetes prevention program in men

World journal of Diabetes 2017年第8期8卷 414-421页

作者： Megan E Rollo elroy j aguiar Kirrilly M Pursey Philip j Morgan Ronald C Plotnikoff Myles D Young Clare E Collins Robin Callister Priority Research Centre for Physical Activity and Nutrition School of Health Sciences Faculty of Health and Medicine University of Newcastle Callaghan Department of Kinesiology School of Public Health and Health Sciences University of Massachusetts Amherst Priority Research Centre for Physical Activity and Nutrition School of Education Faculty of Education and Arts University of Newcastle Priority Research Centre for Physical Activity and Nutrition School of Biomedical Sciences and Pharmacy Faculty of Health and Medicine University of Newcastle

AIMTo investigate changes in dietary intake following a 6-mo randomised controlled trial of the self-directed, gender-tailored type 2 diabetes mellitus (T2DM) Prevention Using LifeStyle Education (PULSE) program in men. METHODSMen aged 18-65 years, with a body mass index (BMI) 25-40 kg/m2, and at high risk for developing T2DM were recruited from the Hunter Region of New South Wales, Australia. Eligible participants were randomised into one of two groups: (1) waitlist control; or (2) PULSE intervention. Dietary intake was assessed at baseline and immediately post-program using the Australian Eating Survey food frequency questionnaire and diet quality measured using the Australian Recommended Food Score (ARFS). RESULTSOne hundred and one participants (n = 48, control; n = 53, intervention, mean age 52.3 ± 9.7 years, BMI of 32.6 ± 3.3 kg/m2) commenced the study. Following the active phase, differences between groups were observed for proportion of total energy consumed from healthful (core) foods (+7.6%EI, P < 0.001), energy-dense, nutrient-poor foods (-7.6%EI, P < 0.001), sodium (-369 mg, P = 0.047), and diet quality (ARFS) (+4.3, P = 0.004), including sub-scales for fruit (+1.1, P = 0.03), meat (+0.9, P = 0.004) and non-meat protein (+0.5, P = 0.03). CONCLUSIONThe PULSE prevention program’s nutrition messages led to significant improvements in dietary intake in men at risk of T2DM.

关键词： Dietary intake Diet quality Men Diabetes prevention program Self-directed

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Past,present and future of the Resonant-Mass gravitational wave detectors

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Research in Astronomy and Astrophysics 2011年第1期11卷 1-42页

作者： Odylio Denys aguiar Instituto Nacional de Pesquisas Espaciais Divisao de Astrofísica Av. dos Astronautas 1758 So José dos Campos 12227-010 SP Brazil

Resonant-mass gravitational wave detectors are reviewed from the concept of gravitational waves and its mathematical derivation, using Einstein＇s general relativity, to the present status of bars and spherical detectors, and their prospects for the future, which include dual detectors and spheres with non-resonant transducers. The review not only covers technical aspects of detectors and sciences that will be done, but also analyzes the subject in a historical perspective, covering the various detection efforts over four decades, starting from Weber＇s pioneering work.

关键词： gravitation -- gravitational waves -- instrumentation: detectors

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Saturated anisotropic hydraulic conductivity of a compacted lateritic soil

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journal of Rock Mechanics and Geotechnical Engineering 2018年第5期10卷 986-991页

作者： Roberto aguiar dos Santos Edmundo Rogerio Esquivel Varzea Grande Institute of Engineering Federal University of Mato Grosso Cuiaba Mato Grosso Brazil Sao Carlos School of Engineering University of Sao Paulo Sao Carlos Sao Paulo Brazil

This study focuses on the saturated anisotropic hydraulic conductivity of a compacted lateritic clayey sandy soil. The effects of the molding water content and the confining stress on the anisotropic hydraulic conductivity are investigated. The hydraulic conductivity is measured with a flexible-wall permeameter. Samples are dynamically compacted into the three compaction states of a standard Proctor compaction curve： the dry branch, optimum water content and wet branch. Depending on the molding water content and confining stress, the hydraulic conductivity may increase or decrease. In addition, the results indicate that, when the samples are compacted to the optimum water content, lower hydraulic conductivity is obtained, except at a confining stress equal to 50 kPa. The increase of the confining stress decreases the hydraulic conductivity for each of the evaluated compaction states. In the wet branch, horizontal hy- draulic conductivity is about 8 times higher than the vertical value. The anisotropic hydraulic conduc- tivities of the dry and wet branches decrease when the confining stress increases, and the opposite is observed in the optimum water content state.

关键词： Hydraulic conductivity Anisotropic behavior Lateritic soil Tropical soil Compacted soil

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Supercritical fluid technology as a sustainable alternative method for textile dyeing:An approach on waste,energy,and CO_(2)emission reduction

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journal of Environmental Sciences 2024年第6期140卷 123-145页

作者： Carlos Rafael Silva de Oliveira Patrícia Viera de Oliveira Leandro Pellenz Catia Rosana Lange de aguiar Afonso Henrique da Silva júnior Federal University of Santa Catarina Textile Engineering Department2514 João Pessoa St.BlumenauSC89036-004Brazil Federal University of Santa Catarina Chemical Engineering DepartmentS/n Biotério Central St.FlorianópolisSC88040-900Brazil

The clothing industry is considered one of the most polluting industries on the planet due to the high consumption of water,energy,chemicals/dyes,and high generation of solid waste and *** with environmental concerns,the textile ennoblement sector is the most critical of the textile production chain,especially the traditional dyeing *** an alternative to current problems,dyeing with supercritical CO_(2)(scCO_(2))has been presented as a clean and efficient process for a sustainable textile *** fluid dyeing(SFD)has shown a growing interest due to its significant impact on environmental preservation and social,economic,and financial *** main SFD benefits include economy and reuse of non-adsorbed dyes;reduction of process time and energy expenditure;capture of atmospheric CO_(2)(greenhouse gas);use and recycling of CO_(2)in SFD;generation of carbon credits;water-free process;effluent-free process;reduction of CO_(2)emission and auxiliary *** being still a non-scalable and evolving technology,SFD is the future of *** review presented a comprehensive overview of the environmental impacts caused by traditional processes and confronted the advantages of *** SFD technique was introduced,along with its latest advances and future *** and environmental gains were also discussed.

关键词： Textile industry Supercritical dyeing Sustainable processes Water free dyeing Energy saving Cleaner production

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RNAi mechanisms in Huntington’s disease therapy:siRNA versus shRNA

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Translational Neurodegeneration 2017年第1期6卷 300-309页

作者： Sebastian aguiar Bram van der Gaag Francesco Albert Bosco Cortese Molecular Neuroscience Laboratory Swammerdam Institute for Life Sciences(SILS-CNS)University of AmsterdamAmsterdamNetherlands Fulbright Program US Department of State(IIE)New York CityNYUSA Department of Neurobiology Care Sciences and SocietyKarolinska InstituteStockholmSweden Biogerontology Research Foundation(BGRF) OxfordUK Department of Biomedical and Molecular Sciences Queen’s University School of MedicineQueen’s UniversityKingstonCanada

Huntington’s Disease(HD)is a genetically dominant trinucleotide repeat disorder resulting from CAG repeats within the Huntingtin(HTT)gene exceeding a normal range(>36 CAGs).Symptoms of the disease manifest in middle age and include chorea,dystonia,and cognitive *** latency from diagnosis to death is 20 *** are currently no disease-modifying therapies available to HD *** is a potentially curative therapy for HD.A popular line of research employs siRNA or antisense oligonucleotides(ASO)to knock down mutant Huntingtin mRNA(mHTT).Unfortunately,this modality requires repeated dosing,commonly exhibit off target effects(OTEs),and exert renal and hepatic *** contrast,a single AAV-mediated short-hairpin RNA(shRNA)dose can last years with low *** addition,we highlight research indicating that shRNA elicits fewer OTEs than siRNA when tested *** this promise,shRNA therapy has been held back by difficulties controlling expression(oversaturating cells with toxic levels of RNA construct).In this review,we compare RNAi modalities for HD and propose novel methods of optimizing shRNA expression and on-target fidelity.

关键词： RNAi shRNA siRNA Huntington’s disease Off-target effects Huntingtin Silencing

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A Review of Recent Advances in Hybrid Natural Fiber Reinforced Polymer Composites

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journal of Renewable Materials 2022年第3期10卷 561-589页

作者： jorge Neto Henrique Queiroz Ricardo aguiar Rosemere Lima Daniel Cavalcanti Mariana Doina Banea Federal Centre of Technological Education in Rio de janeiro(CEFET/Rj) Rio de JaneiroBrazil

Natural fiber reinforced polymer composites(NFRCs)have demonstrated great potential for many different applications in various industries due to their advantages compared to synthetic fiber-reinforced composites,such as low environmental impact and low ***,one of the drawbacks is that the NFRCs present relatively low mechanical properties and the absorption of humidity due to the hydrophilic characteristic of the natural *** method to increase their performance is ***,understanding the properties and potential of using multiple reinforcement’s materials to develop hybrid composites is of great *** paper provides an overview of the recent advances in hybrid natural fiber reinforced polymer ***,the main factors that affect the performance of hybrid fiber-reinforced composites were briefly *** effect of hybridization on the mechanical and thermal properties of hybrid composites reinforced with several types of natural fibers(i.e.,sisal,jute,curauá,ramie,banana,etc.)or natural fibers combined with synthetic fibers is ***,the water absorption behaviour of hybrid fiber-reinforced composites is also *** was con-cluded that the main challenges that need to be addressed in order to increase the use of natural-natural or natural-synthetic hybrid composites in industry are the poor adhesion between natural fibers and matrix,thermal stability and moisture absorption of natural *** of these challenges were addressed by recent develop-ment in fibers treatment and modification,and product innovation(hybridization).

关键词： Natural fiber composites(NFC) hybrid composites mechanical properties thermal properties water absorption

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Dipeptidyl peptidase 4(DPP4),adipose inflammation,and insulin resistance:is it time to look to the hepatocyte?

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Hepatobiliary Surgery and Nutrition 2018年第6期7卷 499-500页

作者： Wellington S.Silva júnior Maria das Gracas C.Souza Luiz Guilherme Kraemer-aguiar Endocrinology Discipline Faculty of MedicineCenter of NaturalHumanHealthand Technology SciencesFederal University of Maranhao(UFMA)PinheiroMABrazil Laboratory for Clinical and Experimental Research on Vascular Biology(BioVasc) Biomedical CenterState University of Rio de Janeiro(UERJ)Rio de JaneiroRJBrazil Postgraduate Program in Clinical and Experimental Physiopathology(FISCLINEX) Faculty of Medical SciencesUERJRio de JaneiroRJBrazil Endocrinology Department of Internal MedicineFaculty of Medical SciencesUERJRio de JaneiroRJBrazil

Dipeptidyl peptidase 4(DPP4),also known as adenosine deaminase binding protein or cluster of differentiation 26(CD26),is a serine exopeptidase able to inactivate peptides composed of proline,hydroxyproline,or alanine as the penultimate *** has a strong capacity to act in various peptides and is also widely expressed in many specialized cell types,such as endothelial cells,macrophages,and *** its physiological aspects,DPP4 inactivates the glucagon-like peptide-1(GLP-1),an incretin secreted by the gastrointestinal tract(1).Based on the antidiabetic actions of this incretin,several DPP4 inhibitors(named as gliptins)were launched in the market and are being in use for the treatment of type 2 diabetes(1).It is noteworthy that DPP4 also inactivate some cytokines,chemokines,and neuropeptides involved in inflammation,immunity,and vascular function(2).

关键词： inflammation immunity peptidase

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Ion dynamics into different pore size distributions in supercapacitors under compression

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journal of Energy Chemistry 2023年第5期80卷 110-119,I0004页

作者： joão Pedro aguiar dos Santos Cesar j.B.Pagan Rafael Vicentini Reinaldo F.Teófilo Renato Beraldo Leonardo M.Da Silva Hudson Zanin Brazilian Renewable Energies Center for Innovation on New EnergiesSchool of Electrical and Computer EngineeringUniversity of CampinasAv.Albert Einstein 40CampinasSP13083-852Brazil School of Electrical and Computer Engineering University of CampinasSP 13083-852Brazil Multivariate Chemical Data Analysis Laboratory Department of ChemistryUniversidade Federal de Viçosa36570-900 ViçosaMGBrazil Department of Chemistry Laboratory of Fundamental and Applied ElectrochemistryFederal University of Jequitinhonha and Mucuri's ValleyRodovia MGT 367km 5835000 Alto da Jacuba39100-000DiamantinaMGBrazil

Compressing supercapacitor(SCs)electrode is essential for improving the energy storage characteristics and minimizing ions’distance travel,faradaic reactions,and overall ohmic *** comprising the ion dynamics in SC electrodes under compression are still ***,the ionic dynamics of five aqueous electrolytes in electrodes under compression were studied in this work for tracking electrochemical and structural changes under mechanical stress.A superionic state is formed when the electrode is compressed until the micropores match the dimensions with the electrolyte’s hydrated ion sizes,which increases the *** excessive compression is applied,the accessible pore regions decrease,and the capacitance ***,as the studied hydrated ions have different dimensions,the match between ion/pore sizes *** the LiOH and NaClO4electrolytes,increasing the pressure from 60 to 120 and 100 PSI raised the capacitance from 13.5 to 35.2 F g^(-1)and 30.9 to 39.0 F g^(-1),***,the KOH electrolyte with the lowest and LiCl with the biggest combination of hydrated ion size have their point of maximum capacitance(39.5 and 36.7F g^(-1))achieved at 140 and 80 PSI,*** LiCl and KCl electrolytes,overcompression causes a drop in capacitance higher than 23%.

关键词： Mechanic compression Pore size distribution lon dynamics Activated carbon Supercapacitors

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Impact of train speed on the mechanical behaviours of track-bed materials

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journal of Rock Mechanics and Geotechnical Engineering 2017年第5期9卷 818-829页

作者： Francisco Lamas-Lopez Yu-jun Cui Nicolas Calon Sofia Costa D’aguiar Tongwei Zhang Laboratoire Navier/CERMES Ecole des Ponts ParisTech Marne-la-Vallée 77455 France Département Ligne Voie et Environnement SNCF-Engineering La Plaine St. Denis 93574 France Division Auscultation Modélisation & Mesures SNCF-Research & Development Paris 75012 France

For the 30,000 km long French conventional railway lines(94% of the whole network),the train speed is currently limited to 220 km/h,whilst the speed is 320 km/h for the 1800 km long high-speed ***,there is a growing need to improve the services by increasing the speed limit for the conventional *** paper aims at studying the influence of train speed on the mechanical behaviours of track-bed materials based on field monitoring *** is put on the behaviours of interlayer and subgrade *** selected experimental site is located in Vierzon,*** sensors including accelerometers and soil pressure gauges were installed at different *** vertical strains of different layers can be obtained by integrating the records of accelerometers installed at different trackbed *** experimentation was carried out using an intercity test train running at different speeds from 60 km/h to 200 km/*** test train was composed of a locomotive(22.5 Mg/axle) and 7 'Corail'coaches(10.5 Mg/axle).It was observed that when the train speed was raised,the loadings transmitted to the track-bed ***,the response of the track-bed materials was amplified by the speed rise at different depths:the vertical dynamic stress was increased by about 10% when the train speed was raised from 60 km/h to 200 km/h for the locomotive loading,and the vertical strains doubled their quasistatic values in the shallow ***,the stressestrain paths were estimated using the vertical stress and strain for each train *** loading paths allowed the resilient modulus Mrto be *** was found that the resilient modulus(M_r) was decreased by about 10% when the train speed was increased from 100 km/h to 200 km/***,the damping ratio(D_r) kept stable in the range of speeds explored.

关键词： Field experimentation Conventional track-bed materials Train speed upgrade Mechanical behaviours Reversible modulus Damping ratio

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Alternative Method to Evaluate Performance Improvement Rate in Athletics Middle Distance Events

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journal of Science in Sport and Exercise 2022年第2期4卷 128-134页

作者： Lucas Pinheiro Barbosa Patrick aguiar Santos Samuel Silva aguiar Herbert Gustavo Simões Pantelis Theodoros Nikolaidis Beat Knechtle Caio Victor Sousa Graduate Program in Physical Education Catholic University of BrasíliaBrasíliaDFBrazil Exercise Physiology Laboratory NikaiaGreece School of Health and Care Sciences University of West AtticaAthensGreece Medbase St.Gallen Am Vadianplatz Vadianstrasse 269001 St.GallenSwitzerland Institute of Primary Care University of ZurichZurichSwitzerland Bouve College of Health Sciences Northeastern UniversityBostonMAUSA

Purpose The aims of this study were to propose an alternative method to assess an optimal performance improvement rate(PIR)that would be used as a tool for coaches and elite athletes willing to reach their personal best,mainly those seeking for national,continental or even world record(WR)in middle-distance *** further compared the improvement rate of women *** of the top-10 ranked athletes in the IAAF running these middle-distance events Method The top 10 athletes in the IAAF ranking of 800 m,1500 m,and 3000 m events for each sex were assessed for their history of race times before achieving their personal record(PR).The difference between PR(‘actual’season)and the best race time in the last season was defined as the 1st season improvement rate(1-SIR),whereas the average improvement rate in the last and preceding seasons was the multi-season improvement rate(M-SIR).1-SIR and M-SIR were calculated for each *** There were sex differences in the 1500 m with a large effect size(d=−0.746)in 1-SIR(P=0.001)and very large(d=−2.249)in M-SIR(P=0.001).Women improved more than men before the PR/WR achievements in the 800 m and 1500 m events(P=0.001)and had similar improvement rates before performing PR/WR in 3000 m events(P=0.533).Conclusion Women improve more before PR/WR achievement in 800 m and 1500 m ***,in the 3000 m men and women have similar improvement rates in previous seasons before the PR/WR achievement.

关键词： Performance Running Track-and-field Middle-distance Athletics

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