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Targeting autophagy by polyphenols to prevent glycative stress-toxicity in the brain

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Neural regeneration research 2024年第5期19卷 941-942页

作者： Alejandro Ponce-Mora eloy Bejarano Department of Biomedical Sciences School of Health Sciences and Veterinary SchoolUniversidad Cardenal Herrera-CEUCEU UniversitiesValenciaSpain

Glycative stress-a pathological hub in brain dysfunction:The nervous system is an intricate network that requires precise and complex *** recent years,growing evidence highlights the detrimental impact of glycative stress on brain homeostasis,which disables a network of vital processes,necessary for optimal function(Gómez et al.,2021).

关键词： homeostasis stress

Microstructure evolution in low carbon boron steels

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Baosteel Technical research 2010年第S1期4卷 48-页

作者： eloy martinez r J Gerardo CABAAS M SvMet Engineering S.A. Puebla Mexico Instituto Politecnico Nacional CNMN Mexico D.F.

Low carbon steels for long products either for automotive applications and others have been added with *** addition of boron has improved the mechanical properties such lower hardness,lower yield strength and higher *** added steels varied both in residual elements and most importantly in nitrogen content. The microstructure of B-added steels reveals very fine *** optimum cooling of B-added steels is related to the thermodynamics of boron reaction with nitrogen and other elements such as *** understanding of these reactions is key to control the final mechanical properties.

关键词： boron boron nitride thermodynamics of boron temperature

PDGFr in PDGF-BB/PDGFr Signaling Pathway Does Orchestrates Osteogenesis ina Temporal Manner

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research 2024年第1期2023卷 33-48页

作者： Fangqian Wang Yuxiao Ye Zengjie Zhang Wangsiyuan Teng Hangxiang Sun Xupeng Chai Xingzhi Zhou Jiayu Chen Haochen Mou Yinwang eloy Xiaoqiang Jin Liang Chen Zhenxuan Shao Yan Wu Yue Shen An Liu Peng Lin Jianwei Wang Xiaohua Yu Zhaoming Ye Department of Orthopedic Surgery the Second Affiliated HospitalZhejang University School of MedicineHangzhou CityZhejiang ProvincePR China Orthopedics research Institute of Zhejang University Hangzhou CityZhejiang ProvincePR China Key Laboratory of Motor System Disease research and Precision Therapy of Zhejiang Province Hangzhou CityZhejiang ProvincePR China School of Material Science and Engineering University of New South WalesSydney 2052Australia

Platelet-derived growth factor-BB(PDGF-BB)/platelet-derived growth factor receptor-β(PDGFr-β)pathway is conventionally considered as an important pathway to promote osteogenesis;however,recent study suggested its role during osteogenesis to be *** the differential functions of this pathway during 3 stages of bone healing,we hypothesized that temporal inhibition of PDGF-BB/PDGFr-βpathway could shift the proliferation/differentiation balance of skeletal stem and progenitor cells,toward osteogenic lineage,which leads to improved bone *** first validated that inhibition of PDGFr-βat late stage of osteogenic induction effectively enhanced differentiation toward *** effect was also replicated invivo by showing accelerated bone formation when block PDGFr-βpathway at late stage of critical bone defect healing mediated using ***,we found that such PDGFr-βinhibitor-initiated bone healing was also effective in the absence of scaffold implantation when administrated ***,timely inhibition of PDGFr-βblocked extracellular regulated protein kinase 1/2 pathway,which shift proliferation/differentiation balance of skeletal stem and progenitor cell to osteogenic lineage by upregulating osteogenesis-related products of Smad to induce *** study offered updated understanding of the use of PDGFr-βpathway and provides new insight routes of action and novel therapeutic methods in the field of bone repair.

关键词： healing sized implantation

Association between Helicobacter pylori infection,mismatch repair,HEr2 and tumor-infiltrating lymphocytes in gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2487-2503页

作者： Carlos A Castaneda Miluska Castillo Luis A Bernabe Joselyn Sanchez Matteo Fassan Katherine Tello Ignacio Ivan Wistuba Ivan Chavez Passiuri eloy ruiz Juvenal Sanchez Fernando Barreda Daniel Valdivia Yaqueline Bazan Milagros Abad-Licham Claudio Mengoa Hugo Fuentes Paola Montenegro Ebert Poquioma raul Alatrista Claudio J Flores Luis Taxa Faculty of Health Sciences Universidad Cientifica del SurLima 15038Peru GECO PErU Grupo de Estudios Clinicos Oncologicos del PeruLima 15038Peru Department of research Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Faculty of Human Medicine Universidad Ricardo PalmaLima 15039Peru Department of Medicine Surgical Pathology&Cytopathology UnitUniversity of PaduaPadua 35121Italy Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Abdominal Surgery Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Pathology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Medical Specialties Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Pathology Instituto Regional de Enfermedades Neoplasicas del NorteTrujillo 13001Peru Faculty of Human Medicine Universidad Privada Antenor OrregoTrujillo 13008Peru Department of Surgery Instituto Regional de Enfermedades Neoplasicas del SurArequipa 04002Peru Department of Medical Oncology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Epidemiology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Unidad de Investigación Básica y Traslacional Oncosalud-AUNALima 15038Peru Faculty of Medicine Universidad San Martin de PorresLima 15008Peru

BACKGrOUND The influence of Helicobacter-pylori(***)infection and the characteristics of gastric cancer(GC)on tumor-infiltrating lymphocyte(TIL)levels has not been extensively *** of infiltrating-immune-cell subtypes as well as survival is necessary to obtain comprehensive *** To determine the rates of deficient mismatch-repair(dMMr),HEr2-status and *** infection and their association with TIL levels in *** Samples from 503 resected GC tumors were included and TIL levels were evaluated following the international-TILs-working-group recommendations with assessment of the intratumoral(IT),stromal(ST)and invasive-border(IB)*** density of CD3,CD8 and CD163 immune cells,and dMMr and HEr2-status were determined by immunohistochemistry(IHC).*** infection was evaluated by routine histology and quantitative PCr(qPCr)in a subset of *** dMMr was found in 34.4%,HEr2+in 5%and ***-positive in 55.7%of *** IT-TIL was associated with grade-3(P=0.038),while ST-TIL with grade-1(Precurrence(P=0.003).dMMr was associated with high TIL levels in the ST(P=0.019)and IB(P=0.01)compartments,and STCD3(P=0.049)and ST-CD8(P=0.05)***2-was associated with high IT-CD8(P=0.009).*** was associated with high IT-TIL levels(P=0.009)when assessed by routine-histology,and with high TIL levels in the 3 compartments(P=0.002-0.047)and CD8 density in the IT and ST compartments(P=0.001)when assessed by qPCr.A longer overall survival was associated with low IT-CD163(P=0.003)and CD8/CD3(P=0.001 in IT and P=0.002 in ST)and high IT-CD3(P=0.021),ST-CD3(P=0.003)and CD3/CD163(P=0.002).CONCLUSION TIL levels were related to dMMr and *** CD8/CD3 and high CD163/CD3 were associated with lower recurrence and longer survival.

关键词： Lymphocytes Macrophages Gastric cancer Helicobacter pylori HEr2 Mismatch repair

Feeding Calcium Salts of Linseed Oil on Metabolic Status and reproductive Traits in Grazing Dairy Cows

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Open Journal of Animal Sciences 2024年第3期14卷 219-233页

作者： Jesica Daniela Iorio Yaliska Moreno González Maria Florencia Olmeda Dino Curletto Daniel Edgardo Scandolo Martin Guillermo Maciel rafael Alejandro Palladino Mauricio Javier Giuliodori eloy Eduardo Salado School of Agriculture of the University of Buenos Aires (FAUBA) Buenos Aires Argentina Faculty of Agricultural Sciences National University of Lomas de Zamora (UNLZ) Lomas de Zamora Argentina rafaela Agricultural Experiment Station National Institute of Agricultural Technology (INTA) Rafaela Argentina Faculty of Veterinary Science La Plata National University (FCV) La Plata Argentina

This experiment aimed to evaluate the effect of calcium salts of linseed oil (rich in alpha-linolenic acid (ALA, C18:3n-3) on metabolic and reproductive traits in high-producing dairy cows under grazing. Thirty-six Holstein dairy cows were randomly assigned, in a complete block design, to receive ALA supplementation (0.85 kg∙day−1 of calcium salts of linseed oil) or to remain as untreated control (CON). The concentrate was formulated to offer the same amount of energy across treatments (CON cows received an extra kg of corn to compensate for the higher energy density of ALA treatment). A PMr + Alfalfa pasture was offered to all cows at the same time. A fixed time artiﬁcial insemination (FTAI) at 80 DIM, preceded by a Presynch plus Ovsynch protocol was implemented for the first service and later, on return to estrus, heat detection and artiﬁcial insemination (AI) were performed. Pregnancy diagnosis was checked at 30, 42, 60, and 90 d after AI. Blood and milk samples were taken biweekly. Treatment affected plasma cholesterol concentration (160.36 vs. 186.70 mg∙dl−1, p = 0.03, for ALA and CON, respectively) and on size of corpus luteum (CL, 17.6 vs. 13.7 mm, p = 0.02, for ALA and CON, respectively). Supplementation tended (p = 0.136) to increase conception rate by 200 DIM (81.69% vs. 55.43% in ALA and CON cows, respectively). However, treatment had no effect (p > 0.05) on body weight (BW), body condition score (BCS), and circulating levels of beta-hydroxybutyrate (BHBA), glucose, insulin, growth hormone (GH) and insulin-like growth factor (IGF-I). Our results suggest that supplementation with calcium salts of linseed oil could enhance ovarian function without affecting energy metabolism in early lactation dairy cows.

关键词： α-Linolenic Acid Supplementation reproduction Grazing Dairy Cows

Boosting proteolytic pathways as a treatment against glycation-derived damage in the brain?

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Neural regeneration research 2022年第2期17卷 320-322页

作者： Allen Taylor eloy Bejarano Laboratory for Nutrition and Vision research USDA Human Nutrition Research Center on AgingTufts UniversityBostonMAUSA Departments of Chemical and Molecular Biology and Ophthalmology Tufts University School of MedicineBostonMAUSA Friedman School of Nutrition and Science Policy Tufts UniversityBostonMAUSA School of Health Sciences and Veterinary School Universidad Cardenal Herrera-CEUCEU UniversitiesMoncadaValenciaSpain

The worldwide adaptation of a Western lifestyle is associated with the increased consumption of high glycemia diets and an increased prevalence of obesity, metabolic syndrome, and diabetes.

关键词： damage obesity prevalence

Using fireball networks to track more frequent reentries:Falcon 9 upperstage orbit determination from video recordings

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Astrodynamics 2021年第4期5卷 347-358页

作者： eloy Pena-Asensio Josep M.Trigo-rodriguez Marco Langbroek Albert rimola Antonio J.robles Departament de Química Universitat Autònoma de Barcelona(UAB)BellaterraCatalonia 08193Spain Institute of Space Sciences(CSIC) Cerdanyola del VallèsBarcelonaCatalonia 08193Spain Institut d’Estudis Espacials de Catalunya(IEEC) Ed.NexusBarcelonaCatalonia 08034Spain Leiden Observatory Faculty of ScienceLeiden University95002300 RA Leidenthe Netherlands Belgian Working Group Satellites(BWGS) Belgium Spanish Meteor Network(SPMN)Team Spain

On February 16,2021,an artificial object moving slowly over the Mediterranean was recorded by the Spanish Meteor Network(SPMN).Based on astrometric measurements,we identified this event as the reentry engine burn of a SpaceX Falcon 9 launch vehicle’s upper *** study this event in detail,we adapted the plane intersection method for near-straight meteoroid trajectories to analyze the slow and curved orbits associated with artificial *** corroborate our results,we approximated the orbital elements of the upper stage using four pieces of“debris”cataloged by the ***’s Combined Space Operations *** on these calculations,we also estimated the possible deorbit hazard zone using the MSISE90 model *** provide guidance regarding the interference that these artificial bolides may generate in fireball ***,because artificial bolides will likely become more frequent in the future,we point out the new role that ground-based detection networks can play in the monitoring of potentially hazardous artificial objects in near-Earth space and in determining the strewn fields of artificial space debris.

关键词： fireball reentry deorbit artificial meteor multistation

Effect of the Mediterranean Diet on BMI in Middle-Aged Hispanic Women with Pre-Obesity and Obesity Central Washington State

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International Journal of Clinical Medicine 2019年第6期10卷 363-378页

作者： eloy Espinoza School of Public Health Benedictine University Lisle IL USA

Background: Conclusive evidence has yet to emerge regarding the effectiveness and applicability of the Mediterranean diet on middle-aged Hispanic women, the largest female minority group in the United States who is at-risk of metabolic disorders. Objective: The aim of this study is to evaluate the effect of the Mediterranean diet (MED) on the BMI in middle-aged Hispanic women with pre-obesity and obesity in Central Washington State. Design: A prospective study was performed to determine the effect of Mediterranean diet on the BMI of 67 Hispanic women with pre-obesity and obesity between 45 to 65 years of age in Central Washington State. The study was carried out for eight weeks. Dietary adherence was monitored to ensure consistent results. results: The proportion of Hispanic women who reported a reduction in BMI was 94%, with a decrease in mean BMI after eight weeks of 2.8 (95% CI: 2.5 to 3.0) and P = 0.02, with an odds ratio of 2.6. Multiple linear regression analysis was used to adjust for age, education, physical activity, and smoking. Conclusion: The reduction in BMI demonstrates that the Mediterranean diet can be a promising, culturally appropriate therapy to address the obesity epidemic that is prevalent among Hispanic women.

关键词： Obesity Hispanics Public Health Mediterranean Diet Chronic Disease Metabolic Disorders Diabetes Type 2 Coronary Heart Disease Primary Prevention

Bridge plating in the setting of radiocarpal instability:Does distal fixation to the second or third metacarpal matter?A cadaveric study

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World Journal of Orthopedics 2023年第4期14卷 207-217页

作者： eloy Tabeayo James M Saucedo ramesh C Srinivasan Amita r Shah Efstathios Karamanos Jason rockwood E Carlos rodriguez-Merchan Department of Orthopedic Surgery Albert Einstein College of MedicineMontefiore Medical CenterNew YorkNY 10461United States Houston Methodist Institute for Academic Medicine Houston Methodist Orthopedics and Sports MedicineHoustonTX 77479United States Hand Center of San Antonio and the Department of Orthopedic Surgery University of Texas Health Science CenterThe Hand Center of San AntonioSan AntonioTX 78240United States University of Texas Health Science Center at San Antonio University of North Carolina at Chapel HillSan AntonioTX 78229United States Surgeon in the Division of Acute Care Surgery in the Department of Surgery at Henry Ford Hospital in Detroit UT Health San AntonioSan AntonioTX 78229United States Naval Hospital Yokosuka Yokosuka96350-1600Japan Department of Orthopedic Surgery La Paz University Hospital-IdiPazMadrid 28046Spain

BACKGrOUND radiocarpal dislocations are rare but potentially devastating *** outcomes are associated with inadequate or lost reduction,such as ulnar translocation,but no consensus exists on the ideal fixation *** bridge plate fixation has been described for various settings in the treatment of complex distal radius fractures and can be fixed distally to the second or third metacarpal,but its application for radiocarpal dislocations has not been *** To determine whether distal fixation to the second or third metacarpal *** Using a cadaveric radiocarpal dislocation model,the effect of distal fixation was studied in two stages:(1)A pilot study that investigated the effect of distal fixation alone;and(2)a more refined study that investigated the effect of described techniques for distal and proximal *** were measured in various parameters to determine the quality of the reduction *** The pilot study found that focusing on distal fixation alone without changing proximal fixation results in ulnar translocation and volar subluxation when fixing distally to the second metacarpal compared with the *** second iteration demonstrated that anatomic alignment in coronal and sagittal planes could be achieved with each *** In a cadaveric radiocarpal dislocation model,anatomic alignment can be maintained with bridge plate fixation to the second metacarpal or the third metacarpal if the described technique is *** considering dorsal bridge plate fixation for radiocarpal dislocations,the surgeon is encouraged to understand the nuances of different fixation techniques and how implant design features may influence proximal placement.

关键词： Wrist Instability Bridge plate Dorsal spanning plate radiocarpal dislocation model Cadaveric study