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超声内镜引导下细针穿刺针吸活检在胆囊肿瘤诊断中的应用

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世界核心医学期刊文摘（胃肠病学分册） 2005年第11期1卷 29-30页

作者： Varadarajulu S. eloubeidi m.a. 尹勇 Division of Gastroenterology-Hepatology University ofAlabama at Birmingham 1530 3rd Ave. South Birmingham AL 35294- 0007United StatesDr.

Background and study aims: There are very few data on endoscopic ultrasound guided fine-needle aspiration (EUS-FNA) of gallbladder masses. The aim of this study was to assess the utility and safety of EUS-FNA in the evaluation of patients with gallbladder masses. Patients and methods: Six patients who underwent EUS-FNA of gallbladder masses over a 2-year period between 2002 and 2004 were studied retrospectively. Reports of endoscopic ultrasound (EUS) procedures, EUS images, cytology results, and clinical records were reviewed. Abdominal computed tomography (CT) prior to EUS had revealed a definitive gallbladder mass in only one of the six patients and no gallbladder masses were identified in any of the patients who had undergone prior transabdominal ultrasound. Results: At EUS, all the patients were found to have an echo-poor mass arising from the gallbladder wall or within the lumen of the gallbladder. EUS-FNA of the gallbladder masses revealed adenocarcinoma in five patients and benign disease in one patient. After a m.a. follow-up period of 127 days (range 90 - 187 days), three patients had died, two were undergoing palliative chemoradiotherapy, and one had been confirmed as having chronic cholecystitis at surgery. No complications occurred. Conclusions: In patients with obstructive jaundice and equivocal ultrasound or CT findings, evaluation of the gallbladder for the presence of a primary malignancy by EUS is useful. In patients with gallbladder masses, EUS-FNA can be performed safely and can help to make a definitive diagnosis.

关键词：胆囊肿瘤穿刺针吸活检超声内镜胆囊壁胆囊腔细胞学结果原发恶性肿瘤腹部超声检查低回声团块阻塞性黄疸

EUS引导下FNA结合流式细胞分析术诊断可疑性或复发性胸内或腹膜后淋巴瘤

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世界核心医学期刊文摘（胃肠病学分册） 2006年第2期2卷 38-39页

作者： mehra m. Tam.a.e A. eloubeidi m.a. 王志宇 Endoscopic Ultrasound Program University of Alabama at Birmingham 1530 3rdAve. S.-ZRB636 BirminghamAL 35294- 0007United States Dr.

Background: Limited data exist on the combined use of EUS guided FNA (EUS-FNA) and flow cytometry (FC) in the diagnosis of lymphoma. The aim of this study was to evaluate the accuracy of EUS-FNA combined with FC in the diagnosis of primary or recurrent lymphoma. methods: This study was a retrospective analysis of a prospective collection of data over a 3-year period. Over 3 years, 29 patients with lesions (n = 31) suspicious for lymphoma underwent EUS-FNA and FC. Results: Of the 29 patients, 10 patients had lymphoma and 17 patients had nonlymphoma lesions; for two patients, final diagnosis was indeterminate because of insufficient material for FC. The lymphoma cases included non-Hodgkin’s lymphoma (n = 6, including 3 recurrences), mucosa-associated lymphoid tissue (mALT) lymphoma (n = 2), a non-GI lymphoma with mediastinal lymphadenopathy (n = 1), and an uncharacterized lymphoma (n = 1). Of the 31 lesions, 8 were true positive, 18 were true negative, and 3 were false negative; for two lesions, we could not determine the final diagnosis. No false-positive results were encountered. The sensitivity, the specificity, and the accuracy of EUS-FNA combined with FC for diagnosing lymphoma were 72.7% : 95% CI [43.3% , 90.3% ], 100% : 95% CI [82.4% , 100.0% ], and 89.7% : 95% CI [73.6% , 96.4% ], respectively. Limitations to this study include a short duration of follow-up and a lack of a surgical criterion standard. Conclusions: EUS-FNA in combination with FC allows the diagnosis of primary suspected or recurrent lymphoma. It also is an adjunct in staging mALT lymphoma and could direct clinicians toward further investigative procedures.

关键词：流式细胞分析术 EUS FNA 淋巴瘤病非霍奇金淋巴瘤可疑病灶淋巴瘤诊断纵隔淋巴结细针抽吸

超声内镜引导细针抽吸对慢性胰腺炎和无慢性胰腺炎患者胰腺肿块的诊断率对比

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世界核心医学期刊文摘（胃肠病学分册） 2006年第3期2卷 42-43页

作者： Varadarajulu S. Tam.a.e A. eloubeidi m.a. 郝筱倩 Division of Gastroenterology-Hepatology University of Alabama at Birmingham 410 Lyons Harrison Research Bldg. 1530 3rd Ave South Birmingham AL 35294-0007 United StatesDr

Background: Evaluation of a focal pancreatic mass in the setting of chronic pancreatitis (CP) is a diagnostic challenge. The objectives of the study were to com.a.e the diagnostic yield and accuracy of EUS-guided FNA (EUS-FNA) in the evaluation of pancreatic-mass lesions in the presence or the absence of CP and to identify predictors of CP before EUS-FNA of pancreatic-mass lesions. methods: The study design was analysis of data collected prospectively on all patients with solid pancreatic-mass lesions who underwent EUS-FNA at a tertiary referral center. A total of 282 consecutive patients underwent 300 EUS-FNA procedures of pancreatic-mass lesions over a 3 year period. The diagnostic yield and the accuracy of EUS-FNA was com.a.ed between patients with and without CP. CP was defined by the presence of more than 4 EUS criteria. Results: Final diagnosis was adenocarcinoma in 210 (70%), benign disease in 64 (21%), other pathology in 19 (6%), and indeterminate in 4 (2%); 3 patients (1%) were lost to follow-up. CP was noted in 75/300 (25%) patients. A lower sensitivity for EUS-FNA was observed in patients with CP than in those without CP (73.9%vs. 91.3%; p = 0.02). While patients with CP had a higher negative predictive value (88.9%vs. 45.5%; p more EUS-FNA passes to establish a diagnosis vs. those without CP (median, 5 vs. 2; p multivariable analysis, age male gender (p m.a.t of EUS-FNA on long-term clinical management was not analyzed. The im.a.t of individual EUS features of CP on sensitivity of EUS-FNA wa

关键词：慢性胰腺炎胰腺肿块超声内镜诊断率超声诊断标准良性肿块多内假阴性结果阴性预测值黑色人

超声内镜引导下细针穿刺抽吸胰腺肿块的主要并发症发生率:一项前瞻性研究

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世界核心医学期刊文摘（胃肠病学分册） 2006年第9期2卷 34-35页

作者： eloubeidi m.a. Tam.a.e A. Varadarajulu S. Wilcox C.m. 程妍 Endoscopic Ultrasound Program University of Alabama at BirminghamS-ZRB 6361530 3rd AveBirminghamAL 35294-0007United States Dr.

Background:EUS-guided FNA is effective for establishing tissue diagnosis in suspected pancreatic ***,data on the frequency of major complications following EUS-FNA are ***:To evaluate the frequency of major complications after EUS-FNA of solid pancreatic ***:Prospective cohort ***:Tertiary University based referral center for pancreatico-biliary ***:Consecutive patients who underwent EUS-FNA of a solid pancreatic over a 42-month *** immediate complications were recorded by the *** complications were assessed at 72 hours and at 30-days after the *** Outcomes m.a.urements:major complications were defined as acute pancreatitis,bleeding,infection,perforation,use of reversal medication,hospitalization or ***:A total of 355 consecutive patients with a solid pancreatic mass underwent *** complications were encountered in 9 patients(2.54%,95%CI 1.17-4.76).Acute pancreatitis occurred in 3 of 355(0.85 %,95%CI 0.17-2.45);2 patients were hospitalized,and 1 patient recovered with outpatient *** patients were admitted for severe pain after the procedure;all were treated with analgesics and subsequently discharged with no *** patients(0.56%,95%CI 0.07-2.02)developed fever and were admitted for intravenous antibiotics;1 patient recovered with intravenous antibiotics and the other required surgical debridement for *** patient required the use of reversal ***,1.97%(95%CI 0.80-4.02)of the patients were hospitalized for complications(range 1-16 days).None of the patients experienced clinically significant hemorrhage,perforation,or *** clear predisposing risk factors were ***:Lack of surgical gold standard and referral to a tertiary ***:EUS-FNA of solid pancreatic masses infrequently leads to major *** results can be used by endosonographers to counsel patients before EUS-FNA of

关键词：并发症发生率超声内镜引导胰腺肿块细针穿刺抽吸前瞻性研究前瞻性队列研究急性胰腺炎住院治疗

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超声内镜对胰胆管疾病患儿评估的影响

世界核心医学期刊文摘（胃肠病学分册） 2005年第11期1卷 43-44页

作者： Varadarajulu S. Wilcox C.m. eloubeidi m.a. 陈云茹 Division of Gastroenterology-Hep-atology University of Alabama at Birmingham 410 Lyons Harrison Research Bldg. 1530 3rd Ave SouthBirminghamAL 35294- 0007United StatesDr.

Background: While the role of EUS in the evaluation of pancreaticobiliary (PB) disorders in adults is well established, its utility in children remains unproven. This pros-pective study evaluates the feasibility, the safety, and the im.a.t of EUS in the evaluation of PB disorders in children. methods: All children (main outcome m.a.ure was to evaluate the im.a.t of EUS in the evaluation of PB disorders in children. EUS was considered to have a significant im.a.t if a new diagnosis was established or if the findings altered subsequent management. Results: Fourteen patients (m.a. age 13 years; range 5- 17 years) underwent 15 EUS procedures over a 3-year period. main indications were the following: acute or recurrent pancreatitis (6 patients), suspected biliary obstruction (5), and abdominal pain suggestive of PB origin (3). EUS diagnosed chronic pancreatitis (3 patients), idiopathic fibrosing pancreatitis (2), carcinoid tumor (1), pancreatic pse-udocyst (1), pancreas divisum (1), choledocholithiasis (1), duodenal duplication cyst (1), and normal (4). Dia-gnosis of idiopathic fibrosing pancreatitis and carcinoid tumor was established by EUS-guided FNA. The procedure was successful in all patients, and no complications were encountered. EUS had an im.a.t on patient management in 93% of cases: established new diagnosis (10), precluded need for ERCP (9), and provided additional information that facilitated focused endotherapy (4). A limitation was the small number of enrolled patients and absence of long-term clinical follow-up. Conclusions: EUS and EUS-guided FNA are feasible, safe, and have significant im.a.t that alters subsequent management in the majority of children with PB disorders. Further studies and dissemination of information is required to facilitate its increased application in children.

关键词：疾病患儿超声内镜胰胆管类癌瘤胆总管结石病主要适应证胰腺假囊肿镜下治疗胰腺分裂症细针穿刺

超声内镜引导胰腺实质性病变的细针穿刺:300例操作经验

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世界核心医学期刊文摘（胃肠病学分册） 2005年第9期1卷 32-32页

作者： eloubeidi m.a. Tam.a.e A. 徐瑞 Endoscopic Ultrasound Program University of Alabama at Birmingham ZRB 636 1530 3rd Ave. S. Birmingham AL 35294-0007United States Dr.

Background: The objective of our study was to assess a single operator’s learning curve with regard to the number of passes, the diagnostic accuracy, and the complications associated with EUS-guided FNA (EUS-FNA) of solid pancreatic masses. methods: The number of passes, the diagnostic accuracy, and the complication rate were prospectively evaluated in 300 consecutive EUS-FNA of solid pancreatic masses performed by a single endosonographer over a 3-year period. The procedures were placed into 3 groups,which contained 100 procedures each. The endosonographer had undergone a third-tier EUS fellowship and had performed 45 supervised pancreatic EUS-FNA during his training. Results: Of the 300 EUS-FNA performed (median age 63 years, 64%men), no statistically significant differences among the 3 groups with regard to age, gender, race, location, or size of the mass were found. Diagnostic accuracy of the EUS-FNA procedure was similar over time (Group 1, 92%; Group 2, 92%; Group 3, 95%). median number of passes showed a decreasing trend over the 3-year study period, despite an increasing trend of the number of procedures performed (r = -0.14, p = 0.42). The median number of passes was lower for Group 2 (median, 3; p = 0.02) and Group 3 (median, 3; p = 0.003) com.a.ed with Group 1 (median, 4). Group 3 (7/100, 7%) was less likely to encounter complications com.a.ed with Group 1 (13/100, 13%; p = 0.24) and Group 2 (18/100, 18%; p = 0.03). Frequency of serious complications was similar across the 3 groups (1%-3%). Conclusions: With adequate third-tier training, a newly developed EUS program can achieve safe and accurate results of EUS-FNA of the pancreas. The learning curve, however, needs to continue after the fellowship, because more procedures are needed for one to gain proficiency and efficiency with EUS-FNA.

关键词：实质性病变超声内镜细针穿刺穿刺次数培训阶段精确率检查程序

Preliminary results of lithological and palynological study of Svobodny,ancient man’s parking relic in Amur region,Russia

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Global Geology 2024年第3期27卷 121-131页

作者： Kovalenko S.V. Kezina T.V. Kryuchko E.I. mironov m.a. Center for the Preservation of Historical and Cultural Heritage of the Amur Region Blagoveshchensk 675000Russia Amur State University Blagoveshchensk 675027Russia

A single-layer monument Svobodny,ancient man's parking lot-1,discovered in 2021 as part of archaeological work to study the zone of economic development of the Amur region was investigated lithologically and *** on the results of geomorphological analysis of the territory,the study of artifacts,palynological data,as well as analogy with previously identified and sufficiently studied relics in the region,the existence of the Osinoozersk late Neolithic culture in this territory is *** time of its expansion in the Amur region is determined within the framework of the second half of theⅣmillennium BC to the first half of theⅡmillennium *** preliminary results of palynological analysis suggest the existence of a temperate climate here,was close to the modern one,which does not contradict the reconstructed paleoclimate and environments of the region during the Holocene period.

关键词： Osinoozersk culture palynological spectra Zeya River paleoclimate

Dysprosium oxide,alumina,and graphene oxide reinforced polycaprolactone thin films:Thermal stability,morphology,and cell viability

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Journal of Rare Earths 2024年第7期42卷 1337-1343,I0005页

作者： mohamed Tharwat Elabbasy mohamed R.Atteya mai A.Samak mousa Abdelrahman Tahani Almahmoud m.a.El-morsy A.A.menazea m.F.H.Abd El-Kader Department of Public Health College of Public Health and Health InformaticsUniversity of Ha'ilHa'il2440Saudi Arabia Food Control Department Faculty of Veterinary MedicineZagazig UniversityZagazig44519Egypt Department of Physical Therapy College of Applied Medical SciencesUniversity of Ha'ilHa'ilSaudi Arabia Department of Histology and Cell Biology Faculty of MedicineZagazig UniversityZagazig44519Egypt College of Nursing University of Ha'ilHa'ilSaudi Arabia College of Science and Humanities in Al-Kharj Physics DepartmentPlasma Technology and Material Science UnitPrince Sattam Bin Abdulaziz UniversityAl-kharj11942Saudi Arabia Physics Department Faculty of ScienceUniversity of DamiettaNew Damietta34517Egypt Spectroscopy Department Physics Research InstituteNational Research CentreDokki12622GizaEgypt Biophysics Department Faculty of ScienceCairo UniversityGizaEgypt

Developing a biomaterial for wound healing applications is still a ***,dysprosium oxide(Dy_(2)O_(3)),aluminum oxide(Al_(2)O_(3)),and graphene oxide(GO)were embedded in cast films based on polycaprolactone(PCL)to be examined for wound dressing *** techniques were used to characterize the fabricated films including X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR),Raman,and scanning electron microscopy(SEm),besides their biological *** thermogravimetric analysis(TGA)exhibits high thermal stability as the scaffold weight decreases slightly to 98.6%after raising the temperature from room temperature to 280℃.The cell viability was investigated and it is shown that the viable cells grow up to approximately 93%at 75μg/***,the cell attachment shows excellent behavior as the cells attach on most of the surface of the modified PCL which shows high biocom.a.ibility.

关键词： Wound healing Polycaprolactone Dy_(2)O_(3) Al_(2)O_(3) Biocom.a.ible Rare earths

CT引导穿刺活检或支气管镜检阴性时应用超声内镜引导下的针吸活检术检查邻近或毗连食管的肺部肿块

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世界核心医学期刊文摘（胃肠病学分册） 2005年第1期1卷 38-38页

作者： Varadarajulu S. Hoffman B.J. Hawes R.H. eloubeidi m.a. 杨雪娟 University of Alabama at Birmingham BirminghamAlabama Med. Univ. of S. CarolinaCharleston SC United States

Background The accuracy, the safety, and the cost-effectiveness of EUS-guided FNA for screening patients with lung cancer for mediastinal metastasis are well established, but the utility of EUS-guided FNA in evaluating lung mass per se has not been investigated. This study retrospectively evaluated experience with EUS-guided FNA of lung mass lesions after unsuccessful attempts by CT-guided or bronchoscopic tissue sampling to establish a tissue diagnosis. methods A database was searched for all patients who had EUS-guided FNA of lung mass lesions over a 3-year period. The diagnostic yield and safety of EUS guided FNA were evaluated. Observations Eighteen patients(11 men, 7 women) underwent EUS-guided FNA of lung mass lesions adjacent to or abutting the esophagus. The indication for EUS-guided FNA was evaluation of the mediastinum of patients with lung mass of unclear etiology. EUS-guided FNA yielded tissue for diagnosis in 100% of patients: 15 non-small-cell lung cancer, one small-cell lung cancer, two metastatic lung disease. Ten patients had unresectable disease; in 8, the mass was confined to the lung parenchyma. The m.a. number of needle passes required to establish a diagnosis was two (range 1-6). No complication was encountered (m.a. follow-up 141 days; range 72-396 days). Five patients underwent curative surgery, and 13 had palliative chemoradiation. Conclusions In this study, EUS-guided FNA of lung mass was safe, and it established a diagnosis in all patients with accessible *** these preliminary data, a prospective evaluation of this new indication for EUS-guided FNA is justified.

关键词：肺部肿块 CT 超声内镜支气管镜检穿刺活检针吸非小细胞肺癌成本-效益病变诊断气管镜