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CD8^(+)CD226^(high)T cells in liver metastases dictate the prognosis of colorectal cancer patients treated with chemotherapy and radical surgery

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Cellular & Molecular Immunology 2023年第4期20卷 365-378页

作者： Julien Viot Syrine Abdeljaoued Angélique Vienot Evan Seffar Laurie Spehner Adeline Bouard Kamal Asgarov Jean-RenéPallandre elodie Renaude elodie klajer ChloéMolimard Franck Monnien Frederic Bibeau Celia Turco Bruno Heyd Paul Peixoto Eric Hervouet Romain Loyon Alexandre Doussot Christophe Borg Marie Kroemer Department of Medical Oncology Biotechnology and Immuno-Oncology PlatformUniversity Hospital of BesançonBesançonFrance INSERM EFS BFCUMR1098RIGHTUniversity of Franche-ComtéInteractions Greffon-Hôte-Tumeur/Ingénierie Cellulaire et GéniqueBesançonFrance Department of Pathology University Hospital of BesançonBesançonFrance Department of Surgery University Hospital of BesançonBesançonFrance EPIGENEXP platform University of Bourgogne Franche-ComtéBesançonFrance Department of Pharmacy University Hospital of BesançonBesançonFrance

CD226 has been reported to participate in the rescue of CD8^(+)T cell *** this study,we aimed to assess the prognostic value of CD226 in tumor-inﬁltrating lymphocytes(TILs)derived from colorectal cancer(CRC)liver metastases treated with chemotherapy and radical *** from 43 metastases were isolated and analyzed ex vivo usingﬂow ***155 and CD3 levels in the tumor microenvironment were assessed by *** and validation of biological processes highlighted in this study were performed by bioinformatics analysis of bulk RNA-seq results for 28 CRC liver metastases pretreated with chemotherapy as well as public gene expression ***226 expression contributes to the deﬁnition of the immune context in CRC liver metastases and primary ***226 on CD8^(+)T cells was not speciﬁcally coexpressed with other immune checkpoints,such as PD1,TIGIT,and TIM3,in liver *** Cox regression analysis revealed CD226 expression on CD8^(+)T cells to be an independent prognostic factor(p=0.003),along with CD3 density at invasion margins(p=0.003)and TIGIT expression on CD4^(+)T cells(p=0.019).CD155 was not associated with the prognostic value of *** expression analysis in a validation dataset conﬁrmed the prognostic value of CD226 in CRC liver metastases but not in primary *** of CD226 on CD8^(+)TILs in the liver microenvironment was restored by IL15 ***,CD226 expression on liver metastasis-inﬁltrating CD8^(+)T cells selectively contributes to immune surveillance of CRC liver metastases and has prognostic value for patients undergoing radical surgery.

关键词： CD226 antigen Colorectal Neoplasms Liver metastasis Lymphocytes Tumor-Inﬁltrating

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FOLFOXIRI vs FOLFIRINOX as first-line chemotherapy in patients with advanced pancreatic cancer: A population-based cohort study

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World Journal of Gastrointestinal Oncology 2020年第3期12卷 332-346页

作者： Angélique Vienot Hortense Chevalier Clément Bolognini Elisabeta Gherga elodie klajer Aurélia Meurisse Marine Jary Stefano Kim Christelle d’Engremont Thierry Nguyen Fabien Calcagno Hamadi Almotlak Francine Fein Meher Nasri Syrine Abdeljaoued Anthony Turpin Christophe Borg Dewi Vernerey Department of Medical Oncology Besançon University HospitalBesançon F-25030France University Bourgogne Franche-Comté INSERMEFS BFCUMR1098Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et GéniqueBesançon F-25000France INSERM CIC-1431 Clinical Investigation Center in BiotherapyBesançon University HospitalBesançon F-25030France Department of Medical Oncology Lille University HospitalLille F-59000France Department of Medical Oncology Nord Franche-ComtéHospitalMontbéliard F-25020France Methodological and Quality of Life in Oncology Unit Besançon University HospitalBesançon F-25030France Department of Gastroenterology Besançon University HospitalBesançon F-25030France

BACKGROUND FOLFIRINOX regimen is the first-line reference chemotherapy(L1)in advanced pancreatic ductal adenocarcinoma(aPDAC).FOLFOXIRI,a schedule with a lower dose of irinotecan and no bolus 5-fluorouracil,has demonstrated efficacy and feasibility in colorectal *** To investigate the potential clinical value of FOLFOXIRI in patients with aPDAC in routine clinical *** Analyses were derived from all consecutive aPDAC patients treated in L1 between January 2011 and December 2017 in two French institutions,with either FOLFOXIRI(n=165)or FOLFIRINOX(n=124)*** consisted of irinotecan(165 mg/m2),oxaliplatin(85 mg/m2),leucovorin(200 mg/m2)and 5-fluorouracil(3200 mg/m2 as a 48-h continuous infusion)every 2 ***-six pairs of patients were selected through propensity score matching,and clinical outcomes of the two treatment regimens were *** Median overall survival was 11.1 mo in the FOLFOXIRI and 11.6 mo in the FOLFIRINOX cohorts,*** propensity score matching,survival rates remained similar between the two regimens in terms of overall survival(hazard ratio=1.22;P=0.219)and progression-free survival(hazard ratio=1.27;P=0.120).The objective response rate was 37.1%in the FOLFOXIRI group vs 47.8%in the FOLFIRINOX group(P=0.187).Grade 3/4 toxicities occurred in 28.7%of patients in the FOLFOXIRI cohort vs 19.5%in the FOLFIRINOX cohort(P=0.079).FOLFOXIRI was associated with a higher incidence of grade 3/4 digestive adverse *** growth factors were used after each chemotherapy cycle and the low hematological toxicity rates were below 5%with both *** FOLFOXIRI is feasible in L1 in patients with aPDAC but does not confer any therapeutic benefit as compared with *** low hematological toxicity rates strengthened the relevance of primary prophylaxis with hematopoietic growth factors.

关键词： Advanced pancreatic cancer First-line chemotherapy FOLFOXIRI FOLFIRINOX Propensity score Cohort study

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Commutators of maximal functions on spaces of homogeneous type and their weighted,local versions

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Frontiers of Mathematics in China 2022年第4期17卷 625-652页

作者： Zunwei FU elodie POZZI Qingyan WU School of Mathematics and Statistics Linyi UniversityLinyi276005China School of Mathematical Sciences Qufu Normal UniversityQufu273100China Department of Mathematics and Statistics Saint Louis UniversitySt.LouisMO63103USA

We obtain the characterizations of commutators of several versions of maximal functions on spaces of homogeneous *** addition,with the aid of interpolation theory,we provide weighted version of the commutator theorems by establishing new characterizations of the weighted BMO ***,a concrete example shows that the local version of commutators also has an independent interest.

关键词： Maximal function space of homogeneous type BMO space weight commutator

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Palynostratigraphy of the Zorritas Formation, Antofagasta region, Chile： Insights on the Devonian]Carboniferous boundary in western Gondwana

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Geoscience Frontiers 2017年第3期8卷 493-506页

作者： Claudia V. Rubinstein elodie Petus Hans Niemeyer IANIGLA CCT-CONICET Mendoza Av. Ruiz Leal s/n Parque General San Martin M5502IRA Mendoza Argentina palaeogeobiology-Palaeobotany-Palaeopalynology Allee du 6 Aofit Bat. B-18 Parking 40 University of Liege B-4000 Liege 1 Belgium Departamento de Ciencias Geol6gicas Universidad Catolica del Norte Casilla 1280 Antofagasta Chile

The Middle Member of the Zorritas Formation in the Antofagasta region of northern Chile, yielded terrestrial and marine palynomorph assemblages which span the Devonian/Carboniferous boundary. The assemblages show a clear predominance of terrestrial palynomorphs with 70 miospore species, 18 marine phytoplankton species, two non-marine algae and one chitinozoan species, all coming from 15 productive levels. Palynomorphs are poorly preserved and most of them are reworked. Three palyno- logical associations are recognized based on miospores. These are assigned to the Tournaisian-Visean, Tournaisian and probable latest Famennian. Age assignments are discussed in the frame of the spore zonal schemes established for Euramerica and western Gondwana. The stratigraphical distribution of spores allows the identification of the probable position of the Devonian/Carboniferous boundary within the Zorritas Formation. This system boundary is proposed for the first time in Palaeozoic sedimentary rocks of northern Chile. The presence of Gondwanan typical miospore species indicates affinities with this palaeocontinent even though the Tournaisian and Tournaisian-Viseao miospore associations sup- port the cosmopolitanism already suggested for the early Carboniferous flora. The significant number of reworked palynomorphs together with the sedimentological analysis of the studied sections, suggest that these deposits were severely impacted by the climatic change and major sea level fluctuations. Similar conditions were recorded in coeval western Gondwana basins.

关键词： Miospores Phytoplankton Devonian/Carboniferous boundary Western Gondwana Chile

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Pressureless sintering behavior and properties of Ag-SnO_2

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Rare Metals 2019年第1期38卷 35-41页

作者： Henri Desplats elodie Brisson Philippe Rogeon Patrick Carré Alexandre Bonhomme Department of Materials Engineering IRDL FRE CNRS 3744University of South Brittany Schneider Electric-Electropole 31 rue Pierre Mendes France

In this study, the results of measurements on pressureless sintering behavior of Ag-SnO_2(88%wt Ag,12%wt SnO_2) pellets were reported. Dilatometric measurements, relative densities, hardness values, rupture transverse strength and electrical conductivities function of sintering temperatures were presented. A constant thermal expansion coefficient was determined, and a threshold temperature of densification(T_d) was exhibited. Sintering kinetics were reported for different temperatures. Hardness values were measured, and no increase in hardness is found under Td. Three-points bending tests were used to determine the transverse rupture strength whose evolution appears importantly well under Td. In the same manner, the increase in initial electrical conductivities begins well under Td. Under the threshold temperature, the relative increase in electrical conductivity is found to be independent of initial density of green compact pellets. This work highlights different evolutions in function of sintering temperature for the electrical conductivity and transverse rupture strength on the one hand, and for the densification and hardness on the other hand.

关键词： Ag-SnO2 Pressureless sintering Dilatometry Mechanical properties Electrical conductivity

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Perceptual lateralization of vocal stimuli in goats

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Current Zoology 2019年第1期65卷 67-74页

作者： Luigi Baciadonna Christian Nawroth elodie F. Briefer Alan G. McELLiGOTT Biological and Experimental Psychology School of Biological and Chemical Sciences Queen Mary University of London Mile End Road London E1 4NS UK Institute of Behavioural Physiology Leibniz Institute for Farm Animal Biology Dummerstorf Germany Institute of Agricultural Sciences ETH Zurich Universitatstrasse 2 8092 Zurich Switzerland Department of Life Sciences University of Roehampton London SW15 4JD UK

Functional asymmetries, for example, the preferential involvement of 1 brain hemisphere to process stimuli, may increase brain efficiency and the capacity to carry out tasks simultaneously. We investigated which hemisphere was primarily invoIved in processing acoustic stimuli in goats using a headorienting paradigm. Three playbacks using goat vocalizations recorded in different contexts: food anticipation (positive), isolation (negative), food frustration (negative), as well as 1 playback involving dog barks (negative) were presented on the left and right sides of the test subjects simultaneously. The head-orienting response (left or right) and latency to resume feeding were recorded. The direction of the head-orienting response did not differ between the various playbacks. However, when the head-orienting response was tested against chanee level, goats showed a right bias regardless of the stimuli presented. Goats responded more to dog barks than to food frustration calls, whereas responses to food anticipation and isolation calls were intermediate. In addition, the latency to resume feeding, an indicator of fear reaction, was not affected by the kind of vocalization presented. These results provide evidence for asymmetries in goat vocal perceptio n of emotional-li nked con specific and heterospecific calls. They also suggest involvement of the left brain hemisphere for processing acoustic stimuli, which might have been perceived as familiar and non -threate ning.

关键词： auditory processing brain asymmetry emotions lateralization social cognition vocal communication

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Influence of Particle Size Distribution of Bimodal Reactive Alumina on Properties of LCC Refractory Castables

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China's Refractories 2015年第1期24卷 63-68页

作者： Jerome KIENNEMANN elodie CHABAS Carol ULRICH ALTEO

The effect of particle size distribution of alumina has been investigated for silica-free tabular alumina low cement castables（ LCC）. Three different combinations of alumina have been included in the matrix formulation of the castables. All the three combinations are composed of a bimodal reactive alumina and a fine ground monomodal reactive alumina. The first A1 and second A2 combinations are respectively composed of bimodal and monomodal aluminas from Alteo,with a different fine /coarse particles ratio for the bimodal alumina. The two Alteo combinations have been compared with a third combination C composed of a bimodal commercially available grade and a monomodal commercially available grade. Optimization of particle size packing has been performed for the three different formulations using the Dinger and Funk model. With this optimization,the two formulations based on Alteo material（ PFR,PBR and PFR40） achieve the same level of performance in applicative tests（ flowability,cold physical properties,mechanical resistance,crystalline phases,thermal shocks and corrosion） as reference solutions on the market.

关键词： particle size distribution bimodal reactive alumina LCC castables

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Proteomic composition of the acrostyle＂ Novel approaches to identify cuticular proteins involved in virus-insect interactions

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Insect Science 2017年第6期24卷 990-1002页

作者： Craig Graham Webster Maelle Thillier elodie Pirolles Bastien Cayrol Stephane Blanc Marilyne Uzest INRA UMR 0385 BGPI CIRAD-INRA-Montpellier SupAgro Campus International de Baillarguet Montpellier Cedex France

The acrostyle is a distinct anatomical region present on the cuticle at the inner face of the common food/salivary canal at the tip of aphid maxillary stylets. This conserved structure is of particular interest as it harbors the protein receptors of at least l plant virus, Cauliflower mosaic virus＇, and presumably has other roles in plant-insect interactions. Previously we reported immunolabeling of a highly conserved motif of cuticular proteins from the CPR family （named for the presence of a Rebers and Riddiford consensus） within the acrostyle. Here we report the development of novel tools to further study the proteomic composition of this region and to identify proteins involved in insect- virus interactions. Using a series of antibodies against cuticular proteins from the RR-2 subfamily, we identified additional peptides present within the acrostyle. Our results demonstrated that the acrostyle is a complex structure containing multiple domains of cuticular proteins accessible for interaction. In addition, an array of overlapping peptides,which covers the diversity of the majority of the RR-2 subfamily, was ~tevelopect as a generic tool to characterize cuticular protein/pathogen interactions. Upon probing this array with Cucumber mosaic virus particles, consensus peptide sequences from hybridizing peptides were identified. Use of these novel tools has extended our knowledge of the proteomic composition of insect maxillary stylets and identified sequences that could be involved in virus binding, thus contributing to further elucidation of the various properties and functions of the acrostyle.

关键词： acrostyle aphid cuticular protein immunolabeling peptide array stylet

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Gemcitabine-induced peripheral vascular disease and prolonged response in a patient with metastatic pancreatic adenocarcinoma:A case report

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World Journal of Clinical Cases 2023年第6期11卷 1372-1378页

作者： Moinard-Butot Fabien Poprawa elodie Schohn Anna Pietro Addeo Benabdelghani Meher Department of Medical Oncology Institut de Cancérologie Strasbourg EuropeStrasbourg 67200France Department of Supportive Care Institut de cancérologie Strasbourg EuropeStrasbourg 67200France Hepato-Pancreato-Biliary Surgery and Liver Transplantation Hôpitaux Universitaires de StrasbourgStrasbourg 67200France

BACKGROUND Gemcitabine is an antimetabolite used in the treatment of pancreatic *** of the side effects of gemcitabine is vascular ***,we report the case of a patient treated with gemcitabine who had peripheral vascular disease concomi-tant with a prolonged antitumor *** SUMMARY A 75-year-old man was diagnosed with locally recurrent pancreatic *** response was achieved after 9 mo of *** the same time,the patient reported peripheral vascular disease without *** was suspended,and after one month the Positron Emission Tomography(PET)scan showed locoregional tumor *** was resumed and partial response was obtained,but peripheral vascular disease *** Our results suggest that the appearance of peripheral vascular disease may be related to a prolonged response to gemcitabine.

关键词： Gemcitabine Pancreatic cancer Peripheral vascular disease Prolonged tumor response Case report

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Systemic chemotherapy for hepatocellular carcinoma in non-cirrhotic liver:A retrospective study

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World Journal of Gastroenterology 2009年第6期15卷 713-716页

作者： Julien Edeline Jean-Luc Raoul elodie Vauleon Anne Guillygomac'h Karim Boud jema Eveline Boucher Department of Medical Oncology Centre Eugène Marquis CS 4422935042 Rennes cedexFrance European University in Brittany 35042 Rennes cedexFrance Department of Liver Disease Pontchaillou University Hospital35033 Rennes cedexFrance Department of Liver Surgery and Transplantation Pontchaillou University Hospital35033 Rennes cedexFrance

AIM:To investigate the efficacy and toxicity of systemic chemotherapy in a retrospective study of patients with hepatocellular carcinoma(HCC)occurring in normal or fibrotic liver without cirrhosis. METHODS:Twenty-four patients with metastatic or locally advanced HCC in a normal or a fibrotic liver were given systemic chemotherapy(epirubicin,cis- platin and 5-fluorouracil or epirubicin,cisplatin and capecitabine regimens).Tumor response,time to pro- gression,survival,and toxicity were evaluated. RESULTS:There were 7 women and 17 men,mean age 54±10 years;18 patients had a normal liver and 6 had a fibrotic liver(F1/F2 on biopsy).Mean tumor size was 14 cm,5 patients had portal vein thrombosis and 7 had *** received a median of 4 chemotherapy *** tolerance was good. There were 5 partial responses(objective response rate =22%),and tumor control rate was 52%.Second line surgical resection was possible in two *** survival was 11 mo,and 1-and 2-year overall survival rates were 50%±10%and 32%±11%,respectively. CONCLUSION:In patients with HCC in a non-cirrhotic liver,chemotherapy was well tolerated and associated with an objective response rate of 22%,including two patients who underwent secondary surgical resection.

关键词： Antineoplastic protocols Chemotherapy Hepatocellular carcinoma

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