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A fully inkjet-printed disposable glucose sensor on paper

npj Flexible Electronics 2018年第1期2卷 263-270页

作者： eloïse bihar Shofarul Wustoni Anna Maria Pappa Khaled N.Salama Derya Baran Sahika Inal Division of Biological and Environmental Science and Engineering King Abdullah University of Science and Technology(KAUST)Thuwal 23955Saudi Arabia Division of Physical Science and Engineering KAUST Solar CenterKAUSTThuwal 23955Saudi Arabia Department of Chemical Engineering and Biotechnology University of CambridgePhilippa Fawcett DriveCambridge CB30ASUK Division of Computer Electrical and Mathematical Sciences and EngineeringAdvanced Membranes and Porous Materials CenterKAUSTThuwal 23955Saudi Arabia

Inexpensive and easy-to-use diagnostic tools for fast health screening are imperative,especially in the developing world,where portability and affordability are a *** monitoring of metabolite levels can provide useful information regarding key metabolic activities of the body and detect the concomitant irregularities such as in the case of diabetes,a worldwide chronic ***,the majority of daily glucose monitoring tools rely on piercing the skin to draw *** pain and discomfort associated with finger pricking have created a global need to develop non-invasive,portable glucose *** this work,we develop a disposable analytical device which can measure physiologically relevant glucose concentrations in human saliva based on enzymatic electrochemical *** use inkjet-printing technology for the rapid and low-cost deposition of all the components of this glucose sensor,from the electronics to the biorecognition elements,on commercially available paper *** only electronic component of the sensor is the conducting polymer poly(3,4 ethylenedioxythiophene)doped with polystyrene sulfonate(PEDOT:PSS),while the biorecognition element comprises of the enzyme glucose oxidase coupled with an electron *** demonstrate that one month after its fabrication and storage in air-free environment,the sensor maintains its function with only minor performance *** fully printed,all-polymer biosensor with its ease of fabrication,accuracy,sensitivity and compatibility with easy-to-obtain biofluids such as saliva aids in the development of next generation low-cost,noninvasive,eco-friendly,and disposable diagnostic tools.

关键词： maintain sensor printing

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self-healable stretchable printed electronic cryogels for in-vivo plant monitoring

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npj Flexible Electronics 2023年第1期7卷 59-69页

作者： eloïse bihar Elliot J.Strand Catherine A.Crichton Megan N.Renny Ignacy Bonter Tai Tran Madhur Atreya Adrian Gestos Jim Haseloff Robert R.McLeod Gregory L.Whiting Paul M.Rady Department of Mechanical Engineering University of Colorado Boulder1111 Engineering DriveBoulderCO 80309USA Materials Science and Engineering University of Colorado Boulder4001 Discovery DriveBoulderCO 80303USA Department of Plant Sciences University of CambridgeDowning StreetCambridge CB23EAUK Materials Instrumentation and Multimodal Imaging Core Facility University of Colorado Boulder1111 Engineering Drive BoulderBoulderCO 80309USA Department of Electrical Computerand Energy EngineeringUniversity of Colorado Boulder1111 Engineering DriveBoulderCO 80309USA

A key challenge in bioelectronics is to establish and improve the interface between electronic devices and living tissues,enabling a direct assessment of biological *** integrated with plant tissue can provide valuable information about the plant itself as well as the surrounding environment,including air and soil *** obstacle in developing interfaces to plant tissue is mitigating the formation of fibrotic tissues,which can hinder continuous and accurate sensor operation over extended *** systems that utilize suitable biocompatible materials alongside appropriate fabrication techniques to establish plantelectronic interfaces could provide for enhanced environmental understanding and ecosystem management *** meet these demands,this study introduces an approach for integrating printed electronic materials with biocompatible cryogels,resulting in stable implantable hydrogel-based bioelectronic devices capable of long-term operation within plant *** inkjet-printed cryogels can be customized to provide various electronic functionalities,including electrodes and organic electrochemical transistors(OECTs),that exhibit high electrical conductivity for embedded conducting polymer traces(up to 350 S/cm),transconductance for OECTs in the mS range,a capacitance of up to 4.2mF g−1 in suitable structures,high stretchability(up to 330%strain),and selfhealing *** biocompatible functionalized cryogel-based electrodes and transistors were successfully implanted in plant tissue,and ionic activity in tomato plant stems was collected for over two months with minimal scar tissue formation,making these cryogel-based printed electronic devices excellent candidates for continuous,in-situ monitoring of plant and environmental status and health.

关键词： electronic utilize integrating

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Therapeutic potential of exercise-hormone irisin in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1555-1564页

作者： Eunhee Kim Rudolph ETanzi se Hoon Choi Genetics and Aging Research Unit MassGeneral Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMAUSA McCance Center for Brain Health Massachusetts General HospitalBostonMAUSA

Irisin is a myokine that is generated by cleavage of the membrane protein fibronectin type Ⅲ domain-containing protein 5(FNDC5) in response to physical exercise. Studies reveal that irisin/FNDC5 has neuroprotective functions against Alzheimer's disease, the most common form of dementia in the elderly, by improving cognitive function and reducing amyloid-β and tau pathologies as well as neuroinflammation in cell culture or animal models of Alzheimer's disease. Although current and ongoing studies on irisin/FNDC5 show promising results, further mechanistic studies are required to clarify its potential as a meaningful therapeutic target for alleviating Alzheimer's disease. We recently found that irisin treatment reduces amyloid-β pathology by increasing the activity/levels of amyloid-β-degrading enzyme neprilysin secreted from astrocytes. Herein, we present an overview of irisin/FNDC5's protective roles and mechanisms against Alzheimer's disease.

关键词： Alzheimer's disease exercise fibronectin typeⅢdomain-containing protein 5(FNDC5) irisin

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Dental pulp stem cells as a promising model to study imprinting diseases

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International Journal of Oral Science 2022年第2期14卷 174-181页

作者： eloïse Giabicani Aurélie Pham Céline Sélénou Marie-Laure Sobrier Caroline Andrique Julie Lesieur Agnès Linglart Anne Poliard Catherine Chaussain Irène Netchine Universitéde Paris URP2496Laboratoire Pathologiesimagerie et biothérapies oro-facialesMontrougeFrance INseRM UMRS_938 Centre de Recherche Saint AntoineParisFrance APHP Hôpital de BicêtreEndocrinologie et Diabétologie de l’EnfantCentre de Référence des Maladies Rares du Métabolisme du Calcium et du PhosphateLe Kremlin-BicêtreFrance APHP Hôpital BretonneauCentre de Référence des Maladies Rares du Métabolisme du Calcium et du Phosphate et FHU DDS-netParisFrance Sorbonne Université INSERMUMRS_938APHPHôpital Armand TrousseauExplorations Fonctionnelles EndocriniennesParisFrance

Parental imprinting is an epigenetic process leading to monoallelic expression of certain genes depending on their parental *** diseases are characterized by growth and metabolic issues starting from birth to *** are mainly due to methylation defects in imprinting control region that drive the abnormal expression of imprinted *** currently lack relevant animal or cellular models to unravel the pathophysiology of growth failure in these *** aimed to characterize the methylation of imprinting regions in dental pulp stem cells and during their differentiation in osteogenic cells(involved in growth regulation)to assess the interest of this cells in modeling imprinting *** collected dental pulp stem cells from five controls and four patients(three with Silver-Russell syndrome and one with Beckwith-Wiedemann syndrome).Methylation analysis of imprinting control regions involved in these syndromes showed a normal profile in controls and the imprinting defect in *** results were maintained in dental pulp stem cells cultured under osteogenic ***,we confirmed the same pattern in six other loci involved in imprinting diseases in *** also confirmed monoallelic expression of H19(an imprinted gene)in controls and its biallelic expression in one *** imprinting control regions methylation analysis shows the strong potential of dental pulp stem cells in modeling imprinting diseases,in which imprinting regions are preserved in culture and during osteogenic *** will allow to perform in vitro functional and therapeutic tests in cells derived from dental pulp stem cells and generate other cell-types.

关键词： pulp maintained fir

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Effect of Short-Term Exposure to Mercuric Chloride on the Air-Breathing Catfish,Heteropneustes fossilis──Ⅰ.Light Microscopic Study of the Gill

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Biomedical and Environmental Sciences 1994年第4期7卷 327-336页

作者： MAYA S. PRASAD (Department of Zoology, bihar University, Muzaffarpur 842001, India) Department of Zoology Bihar University Muzaffarpur India.

Histopathological effects of sublethal (0.1, 0.2, 0.3 ppm) and lethal (0.5, 1.0 ppm)solutions of mercuric chloride (HgCl2) have been studied on the gills of the air breathing catfish, Heteropneustes fossilis at the intervals ranging from 6h to 15 days. Thickening of the epithelium, swelling and hyperplasia of the mucous cells, fusion of secondary lamellae, formation of interlamellar bridge and deposition of mucous over the entire surface are some noteworthy features of mercury poisoning in sublethal concentrations. Acute pathological manifestations are formation of subepithelial space, sloughing of the epithelial layer, hemorrhage and hypertrophy of the mucous cells. Causes and impact of these cellular alterations affecting survival of the fish have been discussed

关键词： Light Microscopic Study of the Gill Effect of Short-Term Exposure to Mercuric Chloride on the Air-Breathing Catfish,Heteropneustes fossilis

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Dual Zariski Spaces of Modules

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Algebra Colloquium 2023年第4期30卷 569-584页

作者： seçilÇeken Department of Mathematics Trakya UniversityEdirneTurkey

Let R be a commutative ring with identity,M be an R-module,L(M)denote the set of all submodules of M and g■(M)\{OM}.For any submodule N of M,we set gV^(d)(N)={K∈g:K■N}and gζ^(d)(M)=(GV^(d)(N):N■L(M)).Consider χ■L(R)\{R},where L(R)is the set of all ideals of *** set χV(I)=(J∈x:I■J)and χζ(R)={xV(I):I■L(R)}for any ideal I of *** this paper,we investigate when,for arbitrary χ and g as above,χζ(R)and gζ^(d)(M)form a topology and a semimodule,*** investigate the structure of gζ^(d)(M)in the case that it is a semimodule.

关键词： dual Zariski semimodule χ-Zariski semiring ·-coprime submodule subtractive subspace

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Theoretical insights of the pharmaceutical compound fluoxetine in water:Role in direct photolysis and indirect photolysis by free radicals

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Journal of Environmental Sciences 2024年第8期142卷 269-278页

作者： Ying Lu se Wang Yifan Shen School of Environmental Science and Engineering Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologyJiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution ControlNanjing University of Information Science and TechnologyNanjing 210044China

The frequent detection of pharmaceutical compounds in the environment has led to a growing awareness,which may pose a major threat to the aquatic *** this study,photodegradation(direct and indirect photolysis)of two different dissociation states of fluoxetine(FLU)was investigated in water,mainly including the determination of photolytic transition states and products,and the mechanisms of indirect photodegradation with·OH,CO_(3)^(*-)and NO_(3)^(*).The main direct photolysis pathways are defluorination and C–C bond *** addition,the indirect photodegradation of FLU in water is mainly through the reactions with·OH and NO_(3)^(*),and the photodegradation reaction with CO_(3)^(*-)is relatively difficult to occur in the water *** results provide a theoretical basis for understanding the phototransformation process of FLU in the water environment and assessing its potential risk.

关键词： Fluoxetine Photochemical mechanism Direct photolysis Free radical reaction DFT

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Sympathetic nervous system activation and heart failure:Current state of evidence and the pathophysiology in the light of novel biomarkers

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World Journal of Cardiology 2020年第8期12卷 373-408页

作者： Josip Anđelo Borovac Domenico D'Amario Josko Bozic Duska Glavas Department of Pathophysiology University of Split School of MedicineSplit 21000Croatia Working Group on Heart Failure of Croatian Cardiac Society Zagreb 10000Croatia Department of Cardiovascular and Thoracic Sciences IRCCS Fondazione Policlinico A.GemelliUniversita Cattolica Sacro CuoreRome 00168Italy Clinic for Cardiovascular Diseases University Hospital of SplitSplit 21000Croatia

Heart failure(HF)is a complex clinical syndrome characterized by the activation of at least several neurohumoral pathways that have a common role in maintaining cardiac output and adequate perfusion pressure of target organs and *** sympathetic nervous system(SNS)is upregulated in HF as evident in dysfunctional baroreceptor and chemoreceptor reflexes,circulating and neuronal catecholamine spillover,attenuated parasympathetic response,and augmented sympathetic outflow to the heart,kidneys and skeletal *** these sympathoexcitatory effects on the cardiovascular system are sustained chronically they initiate the vicious circle of HF progression and become associated with cardiomyocyte apoptosis,maladaptive ventricular and vascular remodeling,arrhythmogenesis,and poor prognosis in patients with *** detrimental effects of SNS activity on outcomes in HF warrant adequate diagnostic and treatment ***,this review summarizes basic physiological concepts about the interaction of SNS with the cardiovascular system and highlights key pathophysiological mechanisms of SNS derangement in ***,special emphasis in this review is placed on the integrative and up-to-date overview of diagnostic modalities such as SNS imaging methods and novel laboratory biomarkers that could aid in the assessment of the degree of SNS activation and provide reliable prognostic information among patients with HF.

关键词： Autonomic nervous system Biomarkers Catecholamines Catestatin Chromaffin system Epinephrine Heart failure Myocardial failure Norepinephrine Sympathetic nervous system

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A Noteon Fuzzy Groups

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模糊系统与数学 1998年第1期 50-53页

作者： $$$$ Manorajan Kumar Singh (Department of Mathematics, Gram Bharti college, Ramgarh (Kaimur), HBABUA (bihar))

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Re-visiting supersymmetric Janus solutions: a perturbative construction

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Chinese Physics C 2020年第7期44卷 43-54页

作者： Nakwoo Kim se-Jin Kim Department of Physics and Research Institute of Basic Science Kyung Hee UniversitySeoul 02447Republic of Korea

We construct holographic Janus solutions,which describe a conformal interface in the theory of M2-branes,in four-dimensional gauged supergravities using a perturbative *** particular,we study three Einsteinscalar systems and their BPS equations,which are derived by Bobev,Pilch,and Warner(2014).The actions of our interest are all consistent truncations of D=11 supergravity,chosen to be invariant under SO(4)×SO(4),SU(3)×U(1)×U(1),and G2 symmetry subgroups of SO(8).The utility of our semi-analytic result is illustrated by the calculation of minimal area surface and the associated holographic entanglement entropy.

关键词： holography Janus solutions supergravity entanglement entropy

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