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世界核心医学期刊文摘（胃肠病学分册） 2006年第10期2卷 15-16页

作者： McPher.on S. r.es C.J. ellis r. 张红凯 Depar.ment of Gastr.enter.logy South Tyneside District HospitalHarton LaneSouth ShieldsNE34 0PLUnited Kingdom

PUr.OSE: Clostr.dium difficile diar.hea is common in elder.y patients and leads to pr.longed hospitalization. Patients with sever. or.r.cur.ent Clostr.dium difficile diar.hea have poor.antitoxin antibody r.sponses. Intr.venous immunoglobulin has been advocated in these patients. This study was designed to assess the r.sponse of patients with r.fr.ctor., r.cur.ent, or.sever. Clostr.dium difficile diar.hea to intr.venous immunoglobulin. METHODS: r.tr.spective r.view (November.2003-Januar. 2005) of 14 patients with sever., r.fr.ctor., r.cur.ent Clostr.dium difficile diar.hea tr.ated with intr.venous immunoglobulin (Flebogamma, 150-400 mg/kg) fr.m 264 Clostr.dium difficile toxin-positive patients. r.SULTS: Median age was 79 (r.nge, 54-91) year.. Median length of symptoms befor. intr.venous immunoglobulin was 29 (r.nge, 3-90) days. Patients r.ceived a median of thr.e (r.nge, 1-5) cour.es of vancomycin or.metr.nidazole befor. intr.venous immunoglobulin. All had hypoalbuminemia (median, 22 g/l; r.nge, 18-33) and r.ised C-r.active pr.tein (median, 47 mg/l; r.nge, 25-255) at time of infusion. The median white cell count was 15.3×109/liter. (r.nge, 4-24). Eight patients had evidence of pancolitis on abdominal imaging, suggesting sever. Clostr.dium difficile diar.hea. All patients toler.ted intr.venous immunoglobulin without side effects. Nine (64 per.ent) r.sponded with bowels nor.alizing in a median of ten (r.nge, 2-26) days; one patient r.ceived two doses. One patient had a par.ial r.sponse fr.m two doses but died two months later.after.a r.cur.ence. The other.four.patients died of other.causes within thr.e weeks of infusion. CONCLUSIONS: Intr.venous immunoglobulin may be effective for.sever., r.fr.ctor., or.r.cur.ent Clostr.dium difficile diar.hea after.failed conventional tr.atment.

关键词：梭状芽胞杆菌免疫球蛋白感染型静脉滴注腹泻患者腹部影像学低蛋白血症抗毒梭菌白细胞计数

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Coar.e to Fine: The r.le of Sever. Plastic Defor.ation in Advancing Titanium-Based Medical Implants - A Compr.hensive r.view

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Jour.al of Wuhan Univer.ity of Technology(Mater.als Science) 2025年第1期40卷 295-306页

作者： Dr.gana r.Mihajlović Bojan I Međo Ivana Lj Cvijović-Alagić Veljko r.Djokić Faculty of Technology and Metallur.y University of BelgradeKarnegijeva 411120 BelgradeSerbia Vinča Institute of Nuclear.Sci-ences-National Institute of the r.public of Ser.ia University of Belgrade11001BeogradSerbia Innovation Centr. of the Faculty of Technology and Metallur.y Karnegijeva 411120 BelgradeSerbia

This paper.descr.bes sever. plastic defor.ation(SPD)pr.cedur.s,which ar. utilized to for. an ultr.fine-gr.ined str.ctur. in metallic *** the SPD pr.cess,a solid mater.al sample is subjected to ver. high loads without a significant change in sample *** the pr.sent wor.,the high-pr.ssur. tor.ion(HPT)pr.cess,as one of the SPD techniques,which achieves a high degr.e of defor.ation and ensur.s r.finement of the micr.str.ctur.,will be discussed in mor. *** that gr.in size contr.l is accepted as a method to obtain mater.als with desir.d char.cter.stics,an over.iew of the pr.per.ies of ultr.fine-gr.ined titanium-based biomater.als to be used in medicine is ***,par.icular.attention is dedicated to the influences of HPT pr.cess par.meter.,pr.mar.ly hydr.static pr.ssur.,and number.of r.volutions dur.ng tor.ion,on the gr.in size and physical and mechanical char.cter.stics(modulus of elasticity,micr.har.ness,and tensile pr.per.ies),cor.osion r.sistance,and biocompatibility of the titanium-based biomater.als.A r.view of the liter.tur. indicates that titanium-based mater.als obtained by the SPD pr.cess show impr.ved mechanical and physical pr.per.ies without losing biocompatibility and cor.osion r.sistance,which suggests that these methods of obtaining implants ar. something that should be fur.her.developed in the futur..

关键词： high-pr.ssur. tor.ion pr.cess ultr.fine-gr.ined titanium-based mater.als electr.chemical anodization physical pr.per.ies mechanical pr.per.ies

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Emer.ing potential of pr.gr.nulin-dependent Sor.S2 signaling in healthy and diseased ner.ous systems

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Neur.l r.gener.tion r.sear.h 2025年第9期20卷 2591-2593页

作者： Alena Salasova Ander. Nykjær Danish r.sear.h Institute of Tr.nslational Neur.science DANDr.TE-Nor.ic EMBL Par.ner.hip for.Molecular.Medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The for.ation of the mammalian ner.ous system and its matur.tion into sensor.,motor.cognitive,and behavior.l cir.uits is a complex pr.cess that begins dur.ng ear.y embr.ogenesis and lasts until young *** neur.developm... 详细信息

关键词： pr.gr jointly CS2

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Secur.ty Str.tegy of Digital Medical Contents Based on Blockchain in Gener.tive AI Model

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Computer., Mater.als & Continua 2025年第1期82卷 259-278页

作者： Hoon Ko Mar.k r.Ogiela Division of Computer.Science and Engineer.ng Sunmoon UniversityAsan31460Republic of Korea AGH Univer.ity of Kr.kow Cryptography and Cognitive Informatics LaboratoryKrakow30-059Poland

This study pr.sents an innovative appr.ach to enhancing the secur.ty of visual medical data in the gener.tive AI envir.nment thr.ugh the integr.tion of blockchain *** combining the str.ngths of blockchain and gener.tive AI,the r.sear.h team aimed to addr.ss the timely challenge of safeguar.ing visual medical *** par.icipating r.sear.her. conducted a compr.hensive analysis,examining the vulner.bilities of medical AI ser.ices,per.onal infor.ation pr.tection issues,and over.ll secur.ty *** multi faceted explor.tion led to an indepth evaluation of the model’s per.or.ance and ***,the cor.elation between accur.cy,detection r.te,and er.or.r.te was *** analysis r.vealed insights into the model’s str.ngths and limitations,while the consider.tion of standar. deviation shed light on the model’s stability and per.or.ance *** study pr.posed pr.ctical impr.vements,emphasizing the r.duction of false negatives to enhance detection r.te and lever.ging blockchain technology to ensur. visual data integr.ty in medical *** blockchain to gener.tive AI-cr.ated medical content addr.sses key per.onal infor.ation pr.tection *** utilizing the distr.buted ledger.system of blockchain,the r.sear.h team aimed to pr.tect the pr.vacy and integr.ty of medical data especially medical *** appr.ach not only enhances secur.ty but also enables tr.nspar.nt and tamper.r.of ***,the use of gener.tive AI models ensur.s the cr.ation of novel medical content without compr.mising per.onal infor.ation,fur.her.safeguar.ing patient *** conclusion,this study showcases the potential of blockchain-based solutions in the medical field,par.icular.y in secur.ng sensitive medical data and pr.tecting patient *** pr.posed appr.ach,combining blockchain and gener.tive AI,offer. a pr.mising dir.ction towar. mor. r.bust and secur. medical content *** r.sear.h and advancements

关键词： Digitalmedical content medical diagnostic visualization secur.ty analysis gener.tiveAI blockchain vulner.bility patter. r.cognition

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Antisense oligonucleotides pr.vide optimism to the ther.peutic landscape for.tauopathies

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Neur.l r.gener.tion r.sear.h 2025年第3期20卷 803-804页

作者： Glenn A.Har.is Laur.n r.Hir.chfeld r.inwater.Char.table Foundation Fort WorthTXUSA

Tauopathies ar. a gr.up of neur.degener.tive diseases char.cter.zed by abnor.al metabolism of the misfolded tau pr.tein. Tau is encoded by the micr.tubule-associated pr.tein tau gene(MAPT) and can be classified as either.3-r.peat(3r. or.4-r.peat(4r. based on the number.of r.peat domains fr.m alter.ative splicing of exon 10 of the MAPT gene.

关键词： tau metabolism diseases

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Machine Lear.ing Techniques in Pr.dicting Hot Defor.ation Behavior.of Metallic Mater.als

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Computer.Modeling in Engineer.ng & Sciences 2025年第1期142卷 713-732页

作者： Petr.Opela Josef Walek Jar.mír.Kopecek Depar.ment of Metallur.ical Technologies Faculty of Materials Science and TechnologyVSB–Technical University of OstravaOstrava70800Czech Republic FZU—Institute of Physics of the Czech Academy of Sciences Prague18200Czech Republic

In engineer.ng pr.ctice,it is often necessar. to deter.ine functional r.lationships between dependent and independent *** r.lationships can be highly nonlinear.and classical r.gr.ssion appr.aches cannot always pr.vide sufficiently r.liable ***,Machine Lear.ing(ML)techniques,which offer.advanced r.gr.ssion tools to addr.ss complicated engineer.ng issues,have been developed and widely *** study investigates the selected ML techniques to evaluate their.suitability for.application in the hot defor.ation behavior.of metallic *** ML-based r.gr.ssion methods of Ar.ificial Neur.l Networ.s(ANNs),Suppor. Vector.Machine(SVM),Decision Tr.e r.gr.ssion(DTr.,and Gaussian Pr.cess r.gr.ssion(GPr.ar. applied to mathematically descr.be hot flow str.ss cur.e datasets acquir.d exper.mentally for.a medium-car.on *** the GPr.method has not been used for.such a r.gr.ssion task befor.,the r.sults showed that its per.or.ance is the most favor.ble and pr.ctically unr.valed;neither.the ANN method nor.the other.studied ML techniques pr.vide such pr.cise r.sults of the solved r.gr.ssion analysis.

关键词： Machine lear.ing Gaussian pr.cess r.gr.ssion ar.ificial neur.l networ.s suppor. vector.machine hot defor.ation behavior

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Heter.geneity of matur. oligodendr.cytes in the centr.l ner.ous system

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Neur.l r.gener.tion r.sear.h 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam M.r.Gr.h Moein Yaqubi Qiao-Ling Cui Jo Anne Str.tton G.r.Wayne Moor. Jack P.Antel Neur.immunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Depar.ment of Neur.logy Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Matur. oligodendr.cytes for. myelin sheaths that ar. cr.cial for.the insulation of axons and efficient signal tr.nsmission in the centr.l ner.ous *** evidence has challenged the classical view of the functionally static matur. oligodendr.cyte and r.vealed a gamut of dynamic functions such as the ability to modulate neur.nal cir.uitr. and pr.vide metabolic suppor. to *** the r.cognition of potential heter.geneity in matur. oligodendr.cyte function,a compr.hensive summar. of matur. oligodendr.cyte diver.ity is *** delve into ear.y 20th-centur. studies by r.ber.son and r.o-Hor.ega that laid the foundation for.the moder. identification of r.gional and mor.hological heter.geneity in matur. ***,r.cent mor.hologic and functional studies call into question the long-assumed homogeneity of matur. oligodendr.cyte function thr.ugh the identification of distinct subtypes with var.ing myelination ***,moder. molecular.investigations,employing techniques such as single cell/nucleus r.A sequencing,consistently unveil at least six matur. oligodendr.cyte subpopulations in the human centr.l ner.ous system that ar. highly tr.nscr.ptomically diver.e and var. with centr.l ner.ous system *** and disease r.lated matur. oligodendr.cyte var.ation denotes the impact of pathological conditions such as multiple scler.sis,Alzheimer.s disease,and psychiatr.c ***,caution is war.anted when subclassifying matur. oligodendr.cytes because of the simplification needed to make conclusions about cell identity fr.m tempor.lly confined *** studies lever.ging advanced techniques like spatial tr.nscr.ptomics and single-cell pr.teomics pr.mise a mor. nuanced under.tanding of matur. oligodendr.cyte *** r.sear.h avenues that pr.cisely evaluate matur. oligodendr.cyte heter.geneity with car. to under.tand the mitigating influence of species,sex,centr.l ner.ous system r.gion,age,and disease,

关键词： aging centr.l ner.ous system diseases electr.n micr.scopy heter.geneity immunohistochemistr. myelin sheath natur.l histor. neur.glia oligodendr.glia single-cell gene expr.ssion analysis

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Spastin and alsin pr.tein inter.ctome analyses begin to r.veal key canonical pathways and suggest novel dr.ggable tar.ets

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Neur.l r.gener.tion r.sear.h 2025年第3期20卷 725-739页

作者： Benjamin r.Helmold Angela Ahr.ns Zachar. Fitzger.ld P.Hande Ozdinler Depar.ment of Neur.logy Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Center.for.Molecular.Innovation and Dr.g Discover. Center for Developmental TherapeuticsChemistry of Life Processes InstituteNorthwestern UniversityEvanstonILUSA Mesulam Center.for.Cognitive Neur.logy and Alzheimer.s Disease Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Feinber. School of Medicine Les Turner ALS Center at Northwestern UniversityChicagoILUSA

Developing effective and long-ter. tr.atment str.tegies for.r.r. and complex neur.degener.tive diseases is challenging. One of the major.r.adblocks is the extensive heter.geneity among patients. This hinder. under.tanding the under.ying disease-causing mechanisms and building solutions that have implications for.a br.ad spectr.m of patients. One potential solution is to develop per.onalized medicine appr.aches based on str.tegies that tar.et the most pr.valent cellular.events that ar. per.ur.ed in patients. Especially in patients with a known genetic mutation, it may be possible to under.tand how these mutations contr.bute to pr.blems that lead to neur.degener.tion. Pr.tein–pr.tein inter.ction analyses offer.gr.at advantages for.r.vealing how pr.teins inter.ct, which cellular.events ar. pr.mar.ly involved in these inter.ctions, and how they become affected when key genes ar. mutated in patients. This line of investigation also suggests novel dr.ggable tar.ets for.patients with differ.nt mutations. Her., we focus on alsin and spastin, two pr.teins that ar. identified as “causative” for.amyotr.phic later.l scler.sis and her.ditar. spastic par.plegia, r.spectively, when mutated. Our.r.view analyzes the pr.tein inter.ctome for.alsin and spastin, the canonical pathways that ar. pr.mar.ly impor.ant for.each pr.tein domain, as well as compounds that ar. either.Food and Dr.g Administr.tion–appr.ved or.ar. in active clinical tr.als concer.ing the affected cellular.pathways. This line of r.sear.h begins to pave the way for.per.onalized medicine appr.aches that ar. desper.tely needed for.r.r. neur.degener.tive diseases that ar. complex and heter.geneous.

关键词： ALS2 alsin amyotr.phic later.l scler.sis her.ditar. spastic par.plegia neur.degener.tive diseases per.onalized medicine pr.cision medicine pr.tein inter.ctome pr.tein-pr.tein inter.ctions SPAST spastin

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r.al-time in situ detection and quantification of bacter.a in the Ar.tic envir.nment

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Jour.al of Innovative Optical Health Sciences 2014年第2期7卷 35-45页

作者： Linda Power. Walther.r.ellis Jr. Chr.stopher.r.Lloyd Depar.ment of Electr.cal and Computer.Engineer.ng Depar.ment of Biomedical Engineer.ng Univer.ity of Ar.zona Tuc sonAZ 85721 Depar.ment of Biomedical Enginer.ng University of ArizonaTucsonAz 85721 Micr.BioSystems of Ar.zona 1665.E 18th St.Suite 204TucsonAZ 85719

At pr.sent,ther. ar. no methods that deter.ine the total micr. ial load on an abiotic substr. tein r.al *** utility of such a capability r.nges fr.m ster.lization and medical diagnostics tothe sear.h for.new micr.or.anisms in the envir.nment and study of their.ecological *** the development of a hand held,fluor.scence detection device and demonstr.te its applicability to the field detection of Ar.tic bacter.a,This technology is based on the ear.y pioneer.ng wor. of Br.tton Chance which elucidated the intr.nsic fiuor.scence of a number.ofmetabolites and pr.tein cofactor. in cels,including r.duced pyr.dine nucleotides,cytochr.mesand flavins.A PDA contr.ls the device(fluor.scence excitation and data collection)and pr.cessesthe multiwavelength signals to yield bacter.al cell counts,including cstimates of ive cells,deadcells and *** existing methods for.cell counting,this method r.quir.s no samplecontact or.addition of *** use of this technology is demonstr.ted with in situmea sur.ments of two sub-glacial micr.bial communities at sites in Palander.and colonized sur.acer.cks in the Bockijor. Volcanic Complex dur.ng AMASE 2008(Ar.tic Mar. Analog Svalbar. Expedition),The total bacter.al load on the inter.ogated sample sur.aces r.nged fr.m1o9 cells/cm^(2).

关键词： Intr.nsic fuor.scence micr.bial sensor optical detection amplitude modulation Svalbar. Ar.hipelago.

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Scalable Ir.Doped NiFe_(2)O_(4)/TiO_(2)Heter.junction Anode for.Decentr.lized Saline Wastewater.Tr.atment and H_(2)Pr.duction

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Nano-Micr. Letter. 2025年第3期17卷 1-18页

作者： Sukhwa Hong Jiseon Kim Jaebeom Par. Sunmi Im Michael r.Hoffmann Kangwoo Cho Division of Envir.nmental Science and Engineer.ng Pohang University of Science and Technology(POSTECH)Pohang 790−784Korea Linde Labor.tor. California Institute of TechnologyPasadenaCA 91125USA Institute for.Conver.ence r.sear.h and Education in Advanced Technology(I‑Cr.ATE) Yonsei University International CampusIncheon 21983Republic of Korea

Wastewater.electr.lysis cells(WECs)for.decentr.lized wastewater.tr.atment/r.use coupled with H_(2)pr.duction can r.duce the car.on footpr.nt associated with tr.nspor.ation of water.waste,and ener.y *** study r.por.s Ir.doped NiFe_(2)O_(4)(NFI,~5 at%Ir.spinel layer.with TiO_(2)over.ayer.NFI/TiO_(2)),as a scalable heter.junction anode for.dir.ct electr.lysis of wastewater.with cir.umneutr.l pH in a single-compar.ment *** dilute(0.1 M)NaCl solutions,the NFI/TiO_(2)mar.s super.or.activity and selectivity for.chlor.ne evolution r.action,outper.or.ing the benchmar. Ir._(2).r.bust oper.tion in near.neutr.l pH was *** including oper.ndo X-r.y absor.tion spectr.scopy unveiled cr.cial r.les of TiO_(2) which ser.es both as the pr.mar. site for.Cl−chemisor.tion and a pr.tective layer.for.NFI as an ohmic *** electr.lysis of NH4+-laden synthetic wastewater.demonstr.ted that NFI/TiO_(2)not only achieves quasi-stoichiometr.c NH_(4)^(+)-to-N_(2)conver.ion,but also enhances H_(2)gener.tion efficiency with minimal competing r.actions such as r.duction of dissolved oxygen and r.active *** scaled-up WEC with NFI/TiO_(2)was demonstr.ted for.electr.lysis of toilet wastewater.

关键词： Wastewater.electr.lysis cell Ir.doped NiFe_(2)O_(4) r.active chlor.ne species Decentr.lized H_(2)pr.duction On-site wastewater.tr.atment

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