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电信技术资料 1973年第2期 11-19页

作者： j.L.C.elliott

前言电话中继网路是英国邮政局电信网络的一个重要部分,它为本地电话交换局的所有电话业务服务(见图1)。这些话务的大部分是由直达线路或者经过中继转换交换进行传输的,其余的一

关键词：中继网中继阀乐用规划长远计划

Anaerobically Digested Dairy Fiber in Soilless Potting Media for Herbaceous Perennials

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American journal of Plant Sciences 2016年第2期7卷 288-295页

作者： john R. Lamont George C. elliott Department of Plant Science and Landscape Architecture University of Connecticut Storrs CT USA

Sphagnum peat moss has been a primary component of soilless potting media for decades;however, concerns over the sustainability of harvesting peat have fostered a search for renewable media components. Anaerobically digested dairy fiber (ADDF), a by-product of methane production, shows promise as an alternative to peat. Herbaceous nursery crops including “jack Frost” brunnera (Brunnera macrophylla I.M. johnst), “Moonbeam” coreopsis (Coreopsis verticillata L.), “Whoops-a-Daisy” Shasta daisy (Leucanthemum × superbum Bergmans ex j.W. Ingram), “Kobold Original” liatris (Liatris spicata (L.) Willd.) and “David” phlox (Phlox paniculata L.) were grown in media containing bark-peat-perlite or bark-ADDF-perlite in a 4:2:1 proportion. All leachate was collected from pots to evaluate cumulative nitrogen and phosphate leaching. Brunnera grew to a similar size and quality in both mixes, although brunnera in the bark-ADDF-perlite mix had slightly chlorotic leaf margins. Coreopsis grew to a similar size and quality in both mixes but was slightly etiolated and chlorotic in bark-ADDF-perlite. Shasta daisy grown in bark-ADDF-perlite were larger than those grown in bark-peat-perlite. Both mixes produced similar growth and quality liatris and phlox. More ammonium, nitrate and phosphate were recovered from leachate from bark-ADDF-perlite than from bark-ADDF-perlite.

关键词： Peat Substitution Substrate Nursery Crops Ornamentals Nutrient Leaching

Rapid metabolic fingerprinting with the aid of chemometric models to identify authenticity of natural medicines: Turmeric, Ocimum, and Withania somnifera study

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journal of Pharmaceutical Analysis 2023年第9期13卷 1041-1057页

作者： Samreen Khan Abhishek Kumar Rai Anjali Singh Saudan Singh Basant Kumar Dubey Raj Kishori Lal Arvind Singh Negi Nicholas Birse Prabodh Kumar Trivedi Christopher T.elliott Ratnasekhar Ch Metabolomics Lab Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India Department of Crop Production&Protection Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India Academy of Council of Scientific and Industrial Research(ACSIR) Ghaziabad201002India Department of Biotechnology Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India Genetics and Plant Breeding Department Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India Department of Phytochemistry Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India School of Biological Sciences Queen's UniversityBelfastBT95DLUK

Herbal medicines are popular natural medicines that have been used for *** use of alternative medicines continues to expand rapidly across the *** World Health Organization suggests that quality assessment of natural medicines is essential for any therapeutic or health care applications,as their therapeutic potential varies between different geographic origins,plant species,and *** of herbal medicines based on a limited number of secondary metabolites is not an ideal *** quality should be considered based on a complete metabolic profile,as their pharmacological activity is not due to a few specific secondary metabolites but rather a larger group of bioactive compounds.A holistic and integrative approach using rapid and nondestructive analytical strategies for the screening of herbal medicines is required for robust *** this study,a rapid and effective quality assessment system for geographical traceability,species,and variety-specific authenticity of the widely used natural medicines turmeric,Ocimum,and Withania somnifera was investigated using Fourier transform near-infrared(FT-NIR)spectroscopy-based metabolic *** different geographical origins of turmeric,five different Ocimum species,and three different varieties of roots and leaves of Withania somnifera were studied with the aid of machine learning *** good discrimination(R^(2)>0.98,Q^(2)>0.97,and accuracy=1.0)with sensitivity and specificity of 100%was achieved using this metabolic fingerprinting *** study demonstrated that FT-NIR-based rapid metabolic fingerprinting can be used as a robust analytical method to authenticate several important medicinal herbs.

关键词： Rapid metabolic fingerprinting Natural medicines FT-NIR Chemometric models

Helicity Amplitude Analysis of Z_c(3900)~± in e^+e^- →π^+π^-j/ψ

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Chinese Physics Letters 2016年第6期33卷 9-11页

作者：平荣刚 j.G.Messchendorp 苑长征 Institute of High Energy Physics Chinese Academy of Sciences KVI-CART University of Groningen

It is crucial to determine the spin and parity （jR） of Zc（3900）＋ for understanding its structure. We perform a helicity amplitude analysis on Zc（3900）＋ in the process e＋e- →π＋π-j/φ＊ with the hypotheses jP = 0-, 1＋, 1-, 2＋ and 2-. To estimate the significance of jP = 1＋ over other hypotheses, we perform a Monte Carlo simulation study, and we also discuss the prospect of measuring the spin parity in the future experiment with a large data sample.

关键词： of on is Helicity Amplitude Analysis of Z_c in e for that

从欧洲视角探究食物中天然毒素对健康的潜在长期风险

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粮油食品科技 2024年第4期32卷 1-15页

作者： Rudolf KRSKA Christoph BUESCHL Mari ESKOLA Chris elliott 李冰杰(译) 维也纳自然资源与生命科学大学生物分析与农业代谢组学研究所农业生物技术系奥地利图尔恩3430 贝尔法斯特女王大学生物科学学院全球食品安全研究所英国北爱尔兰贝尔法斯特BT95DL Medifiles临床实验有限公司芬兰万塔01640 国家粮食和物资储备局科学研究院粮油质量安全研究所

食品中完全无毒素的理念往往更接近于一种理想化的幻想而非现实。为辨别并优先处理长期摄入食品累积的有害物质,特别是天然毒素带来的健康风险,我们开展了一项针对性研究。通过审查100多项主要由欧洲食品安全局(EFSA)开展的欧洲层面的... 详细信息

食品中完全无毒素的理念往往更接近于一种理想化的幻想而非现实。为辨别并优先处理长期摄入食品累积的有害物质,特别是天然毒素带来的健康风险,我们开展了一项针对性研究。通过审查100多项主要由欧洲食品安全局(EFSA)开展的欧洲层面的风险评估研究来评估食品供应的安全性。深入探讨了欧洲消费者长期接触的食品中潜在天然毒素对健康的影响,以及关于特定毒素的研究发现。此外,尝试对长期接触与公众健康有关的食品化学污染物所构成的风险进行排名。黄曲霉毒素被列为食品中第三大重要的化学污染物,因其具有很强的致癌能力,会导致人类患肝癌,加之欧洲谷物类食品消费量高,导致了高风险。虽然吡啶碱类物质具有基因毒性和致癌性,但由于人类接触这类植物毒素的来源有限——例如通过茶、蜂蜜或草药,它们在榜单中仅排第五。

关键词：欧洲视角天然毒素食品供应安全性风险评估

Comprehensive profiling of EBV gene expression in nasopharyn- geal carcinoma through paired-end transcriptome sequencing

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Frontiers of Medicine 2016年第1期10卷 61-75页

作者： Lijuan Hu Zhirui Lin YanhengWu juqin Dong Bo Zhao Yanbing Cheng Peiyu Huang Lihua Xu Tianliang Xia Dan Xiong Hongbo Wang Manzhi Li Ling Guo elliott Kieff YixinZeng State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine and Department of Experimental Research Sun Yat-sen University Cancer Center Guangzhou 510060 China First Affiliated Hospital of jinan University Guangzhou 510630 China Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer Center Guangzhou 510060 China Division of Infectious Disease Brigham and Women 's Hospital and Department of Microbiology and Immunobiology Harvard Medical School Boston MA 02115 USA Beijing Genomics Institute Co. Ltd. Shenzhen 518083 China Department of Medical Oncology Affiliated Tumor Hospital of Guangzhou Medical University Guangzhou 510095 China Department of Oncology and Hematology The First Affiliated Hospital of Guangzhou Medical University Guangzhou 510120 China

The latent expression pattern of Epstein-Barr Virus （EBV）igenes in nasopharyngeal carcinoma （NPC） has been extensively investigated, and the expression of several lytic genes in NPC has been reported. However, comprehensive information through EBV transcriptome analysis in NPC is limited. We performed paired-end RNA-seq to systematically and comprehensively characterize the expression of EBV genes in NPC tissue and C666-1 NPC cell line, which consistently carries EBV. In addition to the transcripts restricted to type II latency infection, the type Ⅲ latency EBNA3s genes and a substantial number of lytic genes, such as BZLF1, BRLF1, and BMRF1, were detected through RNA-seq and were further verified in C666-1 cells and NPC tissue through real- time PCR. We also performed clustering analysis to classify NPC patient groups in terms of EBV gene expression, which presented two subtypes of NPC samples. Results revealed interesting patterns of EBV gene expression in NPC patients. This clustering was correlated with many signaling pathways, such as those related to heterotrimeric G-protein signaling, inflammation mediated by chemokine and cytokine signaling, ribosomes, protein metabolism, influenza infection, and ECM-receptor interaction. Our combined findings suggested that the expression of EBV genes in NPC is restricted not only to type II latency genes but also to type Ⅲ latency and lyric genes. This study provided further insights into the potential role of EBV in the development of NPC.

关键词： Epstein-Barr virus paired-end transcriptome sequencing latency genes lytic genes nasopharyngeal carcinoma

羊鲍(Haliotis ovina)和耳鲍(***)MtDNA COⅠ和COⅡ基因片段序列的比较研究

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海洋与湖沼 2008年第2期39卷 168-173页

作者：黎中宝 Appleyard Sharon A. elliott Nicholas G. 集美大学水产学院厦门361021 集美大学水产生物技术研究所厦门361021 CSIRO Marine and Atmospheric Research GPO Box 1538HobartTasmania 7001Australia

采用基因测序的方法,对我国海南产的羊鲍和耳鲍两个自然种群的COⅠ和COⅡ基因片段进行了PCR扩增和测序。结果表明,羊鲍和耳鲍COⅠ基因片段的核苷酸序列均为193bp,4种碱基组成非常相似,且其A+T的含量也非常相似,分别为45.08%和45.60%。... 详细信息

采用基因测序的方法,对我国海南产的羊鲍和耳鲍两个自然种群的COⅠ和COⅡ基因片段进行了PCR扩增和测序。结果表明,羊鲍和耳鲍COⅠ基因片段的核苷酸序列均为193bp,4种碱基组成非常相似,且其A+T的含量也非常相似,分别为45.08%和45.60%。羊鲍和耳鲍COⅠ基因片段的核苷酸序列之间有29bp的差异,其中有8处发生碱基颠换,21处发生碱基转换,差异为15.03%,同源性为84.97%;羊鲍和耳鲍COⅡ基因片段的核苷酸序列均为157bp,羊鲍和耳鲍4种碱基组成差异较大,且其A+T的含量也不同,分别为59.24%和55.41%。羊鲍和耳鲍COⅡ基因片段的核苷酸序列之间有19bp的差异,其中3处发生碱基颠换,16处发生碱基转换,达到12.10%的差异,同源性为87.90%。分子变异分析表明羊鲍和耳鲍物种间的变异组成为0.50,变异百分数为100.00,羊鲍和耳鲍物种间的遗传分化显著(FST=1,P<0.001)。

关键词：羊鲍耳鲍 MtCOⅠ基因 MtCOⅡ基因序列 Touch Down PCR

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi juan Pablo de Rivero Vaccari jennifer C.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang j.Adrian Tyndall Binu Tharakan Firas Kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

The supernova remnant CTB 37B and its associated magnetar CXOU j171405.7-381031:evidence for a magnetar-driven remnant

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Research in Astronomy and Astrophysics 2011年第6期11卷 625-630页

作者： j.E.Horvath M.P.Allen Instituto de Astronomia Geofísica e Ciências Atmosféricas-Universidade de So PauloRua do Mato122605508-900 Cidade Universitria So Paulo SPBrazil CEFET So Paulo Rua Pedro Vicente 62501109-010Caninde'So Paulo SPBrazil

We discuss the association between the candidate magnetar CXOU j171405.7-381031 and the supernova remnant CTB *** recent detection of the period derivative of the object allowed an estimation of a young characteristic age of only ～ *** value is too small to be compatible even with the minimum radius of the remnant being ≥ 10 pc,the value corresponding to the lower limit of the estimated distance of 10.2 ± 3.5 kpc,unless the true distance happens to be even smaller than the lower *** argue that a consistent scenario for the remnant＇s origin,in which the latter is powered by the energy injected by a young magnetar,is indeed more accurate to explain the young age,and demonstrates its non-standard（***-driven） nature.

关键词： stars:supernova — stars:neutron

Safe mining practices under wide spans in underground non-caving mines——Case studies

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International journal of Mining Science and Technology 2019年第4期29卷 535-540页

作者： j.j.Ran Kinross Gold Corporation

Mining under wide span is of concern as it increases the probability of back caving causing personnel injury and equipment damage in underground mines in open stoping and underhand drift-and-fill *** restricting personnel access to well supported lateral development is commonly practiced,it is not always possible to implement this requirement due to various factors such as ore loss control,drilling equipment limitations,availability of remote operating capacity and consideration of *** with rules implemented to limit personnel entry into openings with wide spans,the hazards of equipment damage and back caving still *** the years,different practices have been reported and adopted to minimize risks associated with exposure to large spans in various underground *** from these practices are beneficial to current and future mines with challenges of safe extraction of thick deposits in a non-caving *** paper briefly summarizes practices in mining wide orebodies using the open stoping method without personnel access and underhand mining using the drift-andfill method with personnel exposure in the industry and presents cases from Kinross mines where the hanging pillar design was tested,and stope backs were naturally and artificially supported for extraction under wide spans using the open stoping method.

关键词： Mine safety Wide span Back stability Underhand mining Hanging pillar