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Biochemical analysis of the interactions of IQGAP1 C-terminal domain with CDC42

World journal of Biological Chemistry 2012年第3期3卷 53-60页

作者： Sarah F elliott George Allen David j Timson School of Bio- logical Sciences Queen's University BelfastMedical Biology CentreBelfastBT9 7BLUnited Kingdom

AIM:To understand the interaction of human IQGAP1 and CDC42,especially the effects of phosphorylation and a cancer-associated mutation. METHODS:Recombinant CDC42 and a novel C-termi- nal fragment of IQGAP1 were expressed in,and puri- fied from,Escherichia *** directed mutagenesis was used to create coding sequences for three phos- phomimicking variants(S1441E,S1443D and S1441E/ S1443D)and to recapitulate a cancer-associated mu- tation(M1231I).These variant proteins were also ex- pressed and ***-protein crosslinking using 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide was used to investigate interactions between the C-terminal fragment and *** interactions were quanti- fied using surface plasmon resonance *** modelling was employed to make predictions about changes to the structure and flexibility of the protein which occur in the cancer-associated variant. RESULTS:The novel,C-terminal region of human IQGAP1 (residues 877-1558)is soluble following expression and *** is also capable of binding to CDC42,as judged by crosslinking *** appears to be strongest in the presence of added *** three phosphomimicking mutants had different affini- ties for CDC42.S1441E had an approximately 200-fold reduction in affinity compared to wild *** was caused largely by a dramatic reduction in the associa- tion rate *** contrast,both S1443D and the double variant S1441E/S1443D had similar affinities to the wild *** cancer-associated variant,M1231I, also had a similar affinity to wild ***,in the case of this variant,both the association and dis- sociation rate constants were reduced approximately *** modelling of the M1231I variant, based on the published crystal structure of part of the C-terminal region,revealed no gross structural changes compared to wild type(root mean square deviation of 0.564over 5556 equivalent atoms).However,pre- dictions of the flexibility o

关键词： CDC42 Cytoskeleton Protein phosphorylation Cancer-associated mutation Protein-protein interaction

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New onset atrial fibrillation following sub-Tenon's anaesthesia

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International journal of Ophthalmology(English edition) 2013年第6期6卷 900-901页

作者： elliott Y.Ah-kee james F.Li Yim Department of Ophthalmology University Ayr Hospital

Dear Sir,We write to report a case of new onset atrial fibrillation following sub-Tenon’s *** surgery is nowadays mostly performed as a day case procedure with 95.5%of surgery performed under local *** can be done with sub-Tenon’s,retrobulbar,peribulbar,intracameral or topical anaesthesia[1].Sub-Tenon’s anaesthesia involves opening the conjunctiva and tenon’s

关键词： Figure New onset atrial fibrillation following sub-Tenon’s anaesthesia

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A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn j.W.So Konstantin Feinberg Marina Manoraj jenny Cheung jennifer Zhang Kaveh Mirmoeini jPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

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Veterans health administration hepatitis B testing and treatment with anti-CD20 antibody administration

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World journal of Gastroenterology 2016年第19期22卷 4732-4740页

作者： Christine M Hunt Lauren A Beste elliott Lowy Ayako Suzuki Cynthia A Moylan Hans L Tillmann George N Ioannou joseph K Lim Michael j Kelley Dawn Provenzale Department of Medicine Duke University School of Medicine Durham NC 27710 United States Department of Medicine Durham VA Medical Center Durham NC 27705 United States Department of Medicine Veterans Affairs Puget Sound Health Care System Seattle WA 98108 United States Health Services Research and Development Veterans Affairs Puget Sound Health Care System Seattle WA 98108 United States Department of Medicine University of Washington Seattle WA 98195 United States University of Washington School of Public Health Seattle WA 98195 United States Department of Medicine University of Arkansas for Medical Sciences Little Rock AR 72205 United States Division of Hepatology Central Arkansas Veterans Heathcare System Little Rock AR 72205 United States Department of Medicine Eastern Carolina University Greenville NC 27858 United States Yale Liver Center Section of Digestive Diseases Yale University School of Medicine New Haven CT 06520 United States Office of Patient Care Services Department of Veterans Affairs Washington DC 20420 United States Hematology-Oncology Service Durham Veterans Affairs Medical Center Durham NC 27705 United States Cooperative Studies Program Epidemiology Center-Durham Durham Veterans Affairs Medical Center Durham NC 27705 United States Center for Health Services Research in Primary Care Durham Veterans Affairs Medical Center Durham NC 27710 United States

AIM: To evaluate pretreatment hepatitis B virus (HBV) testing, vaccination, and antiviral treatment rates in Veterans Affairs patients receiving anti-CD20 Ab for quality ***: We performed a retrospective cohort study using a national repository of Veterans Health Administration (VHA) electronic health record data. We identified all patients receiving anti-CD20 Ab treatment (2002-2014). We ascertained patient demographics, laboratory results, HBV vaccination status (from vaccination records), pharmacy data, and vital status. The high risk period for HBV reactivation is during anti-CD20 Ab treatment and 12 mo follow up. Therefore, we analyzed those who were followed to death or for at least 12 mo after completing anti-CD20 Ab. Pretreatment serologic tests were used to categorize chronic HBV (hepatitis B surface antigen positive or HBsAg+), past HBV (HBsAg-, hepatitis B core antibody positive or HBcAb+), resolved HBV (HBsAg-, HBcAb+, hepatitis B surface antibody positive or HBsAb+), likely prior vaccination (isolated HBsAb+), HBV negative (HBsAg-, HBcAb-), or unknown. Acute hepatitis B was defined by the appearance of HBsAg+ in the high risk period in patients who were pretreatment HBV negative. We assessed HBV antiviral treatment and the incidence of hepatitis, liver failure, and death during the high risk period. Cumulative hepatitis, liver failure, and death after anti-CD20 Ab initiation were compared by HBV disease categories and differences compared using the χ2 test. Mean time to hepatitis peak alanine aminotransferase, liver failure, and death relative to anti-CD20 Ab administration and follow-up were also compared by HBV disease ***: Among 19304 VHA patients who received anti-CD20 Ab, 10224 (53%) had pretreatment HBsAg testing during the study period, with 49% and 43% tested for HBsAg and HBcAb, respectively within 6 mo pretreatment in 2014. Of those tested, 2% (167/10224) had chronic HBV, 4% (326/7903) past HBV, 5%

关键词： Hepatitis B Hepatitis B reactivation Anti-CD20 antibody Rituximab Lymphoma Chemotherapy Hepatitis B antivirals Vaccination Veteran

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Thermodynamics of the Reduction Roasting of Nickeliferous Laterite Ores

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journal of Minerals and Materials Characterization and Engineering 2016年第6期4卷 320-346页

作者： R. elliott C. A. Pickles j. Forster Robert M. Buchan Department of Mining Queen’s University Kingston Canada

The global nickel sulphide resources are becoming more difficult to mine and, as a result, there is increasing interest in the current and future development of the oxidic nickel laterite deposits. In comparison to the sulphide ores, the nickel laterites cannot be readily upgraded by conventional means and growing attention is being focused on the development of new methods for processing these ores. In this paper, firstly, brief overviews of laterite ore mineralogy and the conventional techniques used to extract the nickel from both the limonitic and the saprolitic nickeliferous laterites are provided. Secondly, previous research on the thermodynamic modelling of the reduction of the laterites is discussed. Thirdly, an improved thermodynamic model is used to predict the equilibrium products arising from the solid state reduction of both the limonitic and the saprolitic ores. Based on these thermodynamic predictions, the reduction behaviors of the two ore types are compared in terms of nickel recovery and grade in the ferronickel product. The effects of reduction temperature, ore composition and carbon additions were studied. Finally, the results from the simulations are compared to the experimental data available in the literature.

关键词： Limonite Saprolite Nickel Thermodynamics Reduction

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Common eye drops and their implications for p H measurements in the management of chemical eye injuries

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International journal of Ophthalmology(English edition) 2014年第6期7卷 1067-1068页

作者： Lik Thai Lim elliott Y.Ah-kee Cian E.Collins Tennent Institute of Ophthalmology Gartnavel General Hospital University of Glasgow University Avenue Altnagelvin Area Hospital

Dear Sir,Eye drops(single use)commonly used in clinics do have varying pH *** use of such drops in the initial management of chemical eye injury may influence the accuracy of pH measurement of the eye,and subsequently influence its *** eye injury is an ophthalmic emergency,which may be caused by exposure to an acidic(pH10)solution to the *** the eye decreases the concentration of these solutions on ocular *** initial management would be copious irrigation with clean or sterile water or Ringer’s solution(pH 7.3-7.4)or its equivalent,of a

关键词： pH Common eye drops and their implications for p H measurements in the management of chemical eye injuries

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The effectiveness of mI SMART:A nurse practitioner led technology intervention for multiple chronic conditions in primary care

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International journal of Nursing Sciences 2018年第2期5卷 131-137页

作者： jennifer A.Mallow Laurie A.Theeke elliott Theeke Brian K.Mallow West Virginia University School of NursingUnited States of America Sovern Run LLCUnited States of America

Aims:Used as integrated tools,technology may improve access and outcomes of care.A new intervention that integrates multiple technologies called mI SMART has been developed,implemented,and evaluated by Nurse *** aim of this paper is to present the initial effectiveness of a webbased,structure of sensors and mobile devices designed to overcome the known health determinant of access to care for rural,chronically ill patients by using ***:The study was conducted at a community primary-care clinic that provides free healthcare to impoverished *** with at least one chronic condition,a minimum of 3rd grade reading level,and without dementia/psychosis were *** were given a Nexus7 tablet and Bluetooth self-monitoring *** intervention lasted for 12 *** glucose,blood pressure,and weight were collected using the provided Bluetooth devices and means were evaluated with paired-samples ttests before and after the ***:Thirty participants were majority female,white,married,high-school educated or less,earning less than$20,000 per annum,and had multiple chronic ***-intervention glucose,systolic blood pressure,diastolic blood pressure,weight and Body Mass Index were all reduced after the 12-week ***:The mI SMART intervention is efficacious for use in improvised adults living in rural areas with multiple chronic *** previously reported,the intervention was also shown to be feasible and acceptable to *** next step is a larger randomized controlled trial.

关键词： Health disparities mHealth Multiple chronic conditions Nursing informatics Rural

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壳模型的综述

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核物理动态 1991年第4期8卷 17-21,13页

作者： j.P.elliott 赵玉民

本文首先对壳模型历史上几个重要进展做一简单回顾,随后讨论发展的目标,对诸如有效相互作用的选择以及入侵态的存在予以更详细的讨论。最后展望一下将来简化大规模壳模型计算的可能途径。

关键词：壳模型核结构

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Role of amygdala in mediating sexual and emotional behavior via coupled nitric oxide release

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Acta Pharmacologica Sinica 2005年第4期26卷 389-395页

作者： elliott SALAMON Tobias ESCH George B STEFANO Neuroscience Research Institute State University of New York College at Old Westbury Old Westbury New York 11568 USA Neuroscience Research Institute State University of New York College at Old Westbury Old Westbury New York 11568 USA Charit University Medicine Berlin Institute for General Practice and Family Medicine Schumannstrasse 10117 Berlin Germany Neuroscience Research Institute State University of New York College at Old Westbury Old Westbury New York 11568 USA

Although the anatomical configuration of the amygdala has been studied a greatdeal,very little research has been conducted on understanding the precise mecha-nism by which this emotional regulatory center exerts its control on emotional andsexual *** applying research methodology from the Neuroscience Re-search Institute,State University of New York,College at Old Westbury,we in-tended to demonstrate that much of the mediated effects of the amygdala,specifi-cally the regulation of the male and female sexual response cycles,as well asrelated emotional considerations,exert their effects coupled to nitric oxide (NO)***,by using current anatomical and histological data,wedemonstrated that amygdalar tissue rich in endocannabinoid and opiate,as wellas catecholamine,receptors could exert its neurochemical effects within an NO-mediated *** paradigm,together with the existence of estrogen andandrogen signaling within the amygdala,further lends credence to our *** begin with a brief anatomical and functional review of amygdalarfunction,and then proceed to demonstrate its relationship with NO.

关键词： amygdala sex nitric oxide morphine emotion

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亚洲高山流域千年尺度地表剥蚀的制约因素

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中国科学:地球科学 2025年第1期 75-94页

作者：杨业 Steven A.BINNIE 徐胜刘丛强 Tibor j.DUNAI 天津大学地球系统科学学院表层地球系统科学研究院 Institute of Geology and Mineralogy University of Cologne

本研究利用前人1233个亚洲高山流域沉积物宇宙成因核素10Be数据统一计算了地表剥蚀速率,以约束构造、气候和地形如何影响和控制地表剥蚀过程.基于高程数据逐个像元的核素产率,使用蒙特卡洛模拟方法重新计算了10Be流域剥蚀速率.剥蚀速率... 详细信息

本研究利用前人1233个亚洲高山流域沉积物宇宙成因核素10Be数据统一计算了地表剥蚀速率,以约束构造、气候和地形如何影响和控制地表剥蚀过程.基于高程数据逐个像元的核素产率,使用蒙特卡洛模拟方法重新计算了10Be流域剥蚀速率.剥蚀速率变化范围从（7.4±0.7）mm ka-1（1σ;青藏高原内部）到（9,646744+777）mm ka-1（1σ;青藏高原南部）跨四个数量级,中位数为186mm ka-1.逐个像元计算的核素产率与传统模型使用质心坐标和平均高程计算的核素产率相比,后者96.6%核素产率被低估,其中高程差越大越被低估.两种方法计算的产率偏差可达40%,究其原因可能是流域高程分布不均和核素产率随海拔和纬度呈非线性变化.通过量化地表剥蚀速率与构造、气候、地形和岩性之间的相关性将有助于推演未知流域的剥蚀速率.从局部小尺度分析,亚热带台湾岛地区剥蚀速率可能主要受降水和新构造驱动的山体滑坡影响,而降水变化范围较窄的青藏高原东部的剥蚀速率主要受控于地形;冰川覆盖的高原地区剥蚀速率受冰川作用影响,如帕米尔、青藏高原内部和南部地区;青藏高原内部剥蚀速率较低是因为较低的降水和较高的侵蚀基准面,从而限制了河流的下切和地表起伏度演化.与局部小尺度强调单一主控因素不同,本研究对亚洲高山流域宏观大尺度进行量化分析发现:（1）地形指标（包括坡度、地形起伏度和河道陡峭指数）与剥蚀速率在千年尺度呈现一致的幂函数关系,而非简单线性;（2）剥蚀速率与气候（包括与海拔相关的降水、温度和植被覆盖度）和新构造活动（地震核密度分布）呈近似幂函数关系,为次要控制因素;（3）岩性与剥蚀速率没有明显的相关性,可能受限于流域复杂的岩性混合和低分辨率的可侵蚀指数数据.

关键词： 10Be剥蚀速率气候变化构造抬升地形梯度亚洲高山流域

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