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Isolated intestinal neurofibromatous proliferations in the absence of associated systemic syndromes

World Journal of Gastroenterology 2008年第42期14卷 6569-6571页

作者： J elliot Carter Javier A Laurini Department of Pathology University of South Alabama Alabama 36617-2293 United StatesAuthor contributions: Carter JE and Laurini JA contributed equally to this work and Carter JE and Laurini JA wrote the paper.

Gastrointestinal tract involvement by neurofibromatous lesions is rare and occurs most frequently as one of the systemic manifestations of generalized neurofibromatosis type 1 （NF1）. In this setting, the lesions may manifest as focal scattered neurofibromas or as an extensive diffuse neural hyperplasia designated ganglioneuromatosis. Occasionally, such lesions may be the initial sign of NF1 in patients without any other clinical manifestations of the disease. Rarely, cases of isolated neurofibromatosis of the large bowel with no prior or subsequent evidence of generalized neurofibromatosis have been documented. We present the case of a 52 year-old female with abdominal pain and alternating bowel habits. Colonoscopic evaluation revealed multiple small polyps in the cecum and the presence of nodular mucosa in the colon and rectum. Pathologic evaluation of the biopsies from the cecum, descending colon, sigmoid colon, and rectum revealed tangled fascicles of spindle cells expanding the lamina propia leading to separation of the intestinal crypts. Immunohistochemical stains helped confirm the diagnosis of diffuse intestinal neurofibromatosis. A thorough clinical evaluation failed to reveal any stigmata of generalized neurofibromatosis. This case represents a rare presentation of isolated intestinal neurofibromatosis in a patient without classic systemic manifestations of generalized neurofibromatosis and highlights the need in such cases for close clinical follow-up to exclude neurofibromatosis type I or multiple endocrine neoplasia type Ⅱ.

关键词： Neurofibromatous Proliferations Isolated Intestinal

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The dual role of striatal interneurons:circuit modulation and trophic support for the basal ganglia

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Neural Regeneration Research 2024年第6期19卷 1277-1283页

作者： elliot Wegman Marlena Wosiski-Kuhn Yu Luo Department of Molecular and Cellular Biosciences University of CincinnatiCincinnatiOHUSA Department of Emergency Medicine at the School of Medicine University of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program University of CincinnatiCincinnatiOHUSA

Striatal interneurons play a key role in modulating striatal-dependent behaviors,including motor activity and reward and emotional *** not only provide modulation to the basal ganglia circuitry under homeostasis but are also involved in changes to plasticity and adaptation during disease conditions such as Parkinson's or Huntington's *** review aims to summarize recent findings regarding the role of striatal cholinergic and GABAergic interneurons in providing circuit modulation to the basal ganglia in both homeostatic and disease *** addition to direct circuit modulation,striatal interneurons have also been shown to provide trophic support to maintain neuron populations in *** discuss this interesting and novel role of striatal interneurons,with a focus on the maintenance of adult dopaminergic neurons from interneuronderived sonic-hedgehog.

关键词： cholinergic dopamine GABAergic interneuron levodopa-induced dyskinesia parvalbumin sonic hedgehog striatum trophic factor

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Media and the Interpretant: Between Facts and Feelings

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Language and Semiotic Studies 2019年第4期5卷 91-107页

作者： elliot Gaines Wright State University USA

Contemporary media are a dominant form of communication that empower messengers who influence audience perceptions of the *** the effects of the media and extreme divisions in contemporary social and political discourse in the US,understanding the differences between facts and opinions is of special *** an interview with the author,Richard Lanigan(2001)explained the concept of the interpretant and the semiotics of how people learn,and develop codes of *** previously unpublished interview provides comments that help clarify important issues in relation to the *** on established semiotic principles,this essay explores a basic understanding of recent neurological science that provocatively appears to be consistent with semiotics,and that can be applied to a better understanding of the effects of media.

关键词： Richard Lanigan media semiotics interpretant neurological science

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Miscellaneous Remarks on the Lineage of Byang La-Stod

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中国藏学 1992年第S1期 272-277页

作者： elliot Sperling

In 1974 Tibetan savant Rtsis--dpon Zhwa -- sgab -- pa Dbang--phyug bde--ldan published acollection of historical works selected from his private holding. One of the texts made available as aresult is a short account of the Byang La--stod area in Central Tibet, the Sde--pa G. yas--ro Byang--pa’ i rgyag--rabs rin -- po -- che bstar ba(hereafter Byang -- pa’ i rgyal -- rabs; it is comprised oftwenty--two folia of which six [ff. 16v -- 21v; the colophon is on ff. 21v--22r] deal with the ab-

关键词：刀脚山甲组刀声明产次脚口切口

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Development of gradient boosting-assisted machine learning data-driven model for free chlorine residual prediction

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Frontiers of Environmental Science & Engineering 2024年第2期18卷 35-46页

作者： Wiley Helm Shifa Zhong elliot Reid Thomas Igou Yongsheng Chen School of Civil and Environmental Engineering Georgia Institute of TechnologyAtlantaGA 30332USA School of Ecological and Environmental Sciences East China Normal UniversityShanghai 200241China

Chlorine-based disinfection is ubiquitous in conventional drinking water treatment (DWT) and serves to mitigate threats of acute microbial disease caused by pathogens that may be present in source water. An important index of disinfection efficiency is the free chlorine residual (FCR), a regulated disinfection parameter in the US that indirectly measures disinfectant power for prevention of microbial recontamination during DWT and distribution. This work demonstrates how machine learning (ML) can be implemented to improve FCR forecasting when supplied with water quality data from a real, full-scale chlorine disinfection system in Georgia, USA. More precisely, a gradient-boosting ML method (CatBoost) was developed from a full year of DWT plant-generated chlorine disinfection data, including water quality parameters (e.g., temperature, turbidity, pH) and operational process data (e.g., flowrates), to predict FCR. Four gradient-boosting models were implemented, with the highest performance achieving a coefficient of determination, R2, of 0.937. Values that provide explanations using Shapley’s additive method were used to interpret the model’s results, uncovering that standard DWT operating parameters, although non-intuitive and theoretically non-causal, vastly improved prediction performance. These results provide a base case for data-driven DWT disinfection supervision and suggest process monitoring methods to provide better information to plant operators for implementation of safe chlorine dosing to maintain optimum FCR.

关键词： Machine learning Data-driven modeling Drinking water treatment Disinfection Chlorination

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The efficacy and safety profile of albumin administration for patients with cirrhosis at high risk of hepatorenal syndrome is dose dependent

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Gastroenterology Report 2015年第3期3卷 216-221页

作者： Yuliya Afinogenova elliot B.Tapper Harvard Medical School BostonMAUSA Division of Gastroenterology and Hepatology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA

Background:Albumin is a critical component in the standard therapeutic approach to acute renal failure(ARF)and spontaneous bacterial peritonitis(SBP)in the setting of ***,data regarding the safety and minimumeffective dose are ***:We conducted a retrospective review of patients with decompensated cirrhosis who received albumin within the first 48 hours of hospitalization at Beth Israel Deaconess Medical Center between 2010 and *** included 90-day risk of death or transplantation(primary)and(secondary)complications of albumin infusion(length of stay(LOS)and need for critical care),all adjusted for comorbidity and severity of ***:We included 169 patients with ARF and 88 patients with *** optimal doses of albumin for a survival benefit were found to be 87.5 g and 100 g in the ARF and SBP cohorts,*** odds ratio(OR)for the 90-day risk of death or liver transplantation associated with the optimal loading dose was 0.36(95%CI:0.17-0.76,P=0.008)and 0.28(95%CI:0.07-0.97,P=0.04)for the ARF and SBP cohorts,*** effect persisted for patients with ARF who had neither hepatorenal syndrome(HRS)nor SBP(OR:0.13,95%CI:0.007-0.79,P=0.02).LOS(beta coefficient per log albumin dose:1.69;95%CI:0.14-3.24,P=0.03)and risk of critical care(OR/g albumin:1.03;95%CI:1.01-1.05,P=0.01)were also dose ***:Albumin has a dose-dependent effect on both survival and complications in patients with cirrhosis with ARF(HRS and otherwise)and/or SBP.

关键词： albumin cirrhosis ascites hepatorenal syndrome acute renal failure spontaneous bacterial peritonitis

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Probability and statistical inference 6th ed.

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2001年

作者： Robert V. Hogg, elliot A. Tanis.

来源：畅想之星图书光盘版（南... 评论

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Mobile health interventions for improving maternal and child health outcomes in South Africa:a systematic review

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Global Health Journal 2024年第3期8卷 103-112页

作者： elliot Mbunge Maureen Nokuthula Sibiya Division of Research Innovation and EngagementMangosuthu University of TechnologyUmlaziDurban 4031South Africa Mangosuthu University of Technology UmlaziDurban 4031South Africa

Background:Maternal and child health(MCH)remains a significant public health concern globally despite previous efforts made to improve MCH *** such as antenatal care,postnatal care services exclusive breastfeeding,child vaccination and supplements have been rolled out to improve MCH ***,inadequate maternal healthcare,socioeconomic factors,obstetric haemorrhaging,complications of hypertension during pregnancy,lack of maternal information,poor universal health coverage and uptake of MCH services exacerbate maternal mortality and child mortality rates,especially in resource-constrained areas in many sub-Saharan African countries including South ***:This study aimed to review mobile health(mHealth)interventions deployed to improve maternal and child health ***:The study adopted the Preferred Reporting Items for Systematic Reviews and Meta-Analyses model to search and retrieve relevant literature from reputable,prominent electronic databases(Google Scholar,Scopus,PubMed,Embase,CINAHL,Web of Science,etc.).A total of 26 papers were selected and ***:The findings revealed several mHealth interventions such as MomConnect,Mobile Alliance for Maternal Action,NurseConnect,ChildConnect,CommCare,Road to Health Application and Philani Mobile Video Intervention for Exclusive Breastfeeding have been utilized by healthcare workers and women to improve access to MCH ***,inadequate digital infrastructure,digital divide,resistance to change,inadequate funding,language barriers,short message service and data costs,lack of digital skills and support,compatibility,scalability and interoperability issues,legislative and policy compliance,lack of mHealth awareness,data security and privacy concerns hinder uptake and utilisation of mHealth *** is a need to scale up and sustain mHealth interventions and update existing regulatory framework,policies and ***:mHealth interventions of

关键词： Mobile health(mHealth) Child health Maternal health Digital health technologies South Africa

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Interventions to improve physical function and prevent adverse events in cirrhosis

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Gastroenterology Report 2018年第1期6卷 13-20,I0001页

作者： Hirsh D.Trivedi elliot B.Tapper Liver Center Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Department of Hepatology University of MichiganAnn ArborMIUSA

Cirrhosis is associated with debilitating complications that significantly impact on a patient’s physical function and reduce quality of *** to highly prevalent sarcopenia,malnutrition and hepatic encephalopathy,functional impairment or frailty is a common complication of *** in turn increases the patient’s risk of hospitalization,accidental falls and fractures,and *** management of frailty and its associated adverse effects is imperative in improving the overall prognosis of patients with advanced liver *** cornerstone of therapy revolves around optimizing physical function with appropriate nutrition and *** therapy with protein supplementation has shown significant benefit,while studies on exercise have been ***,newly emerging studies trend towards a beneficial effect of physical exercise with improvement in quality of *** implementation of technology in liver disease management shows future *** and other wearable devices can be used to help monitor a patient’s personal progress in physical exercise and nutritional ***,the progressive development of new smartphone applications to help aid in the diagnosis and monitoring of complications of cirrhosis provides a sophisticated avenue for improving care of patients with cirrhosis.

关键词： Hepatic encephalopathy frailty sarcopenia malnutrition liver disease

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Acute optic neuritis: a clinical paradigm for evaluation of neuroprotective and restorative strategies?

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Neural Regeneration Research 2015年第10期10卷 1599-1601页

作者： Sara S.Qureshi elliot M.Frohman Department of Neurology University of Texas Southwestern School of Medicine Department of Ophthalmology University of Texas Southwestern School of Medicine

What makes the acute optic neuritis model unique in an era of trials for neuroprotective and myelin repair agents？Acute optic neuritis（AON）is a common,and often the earliest manifestation of central nervous system... 详细信息

关键词： RNFL a clinical paradigm for evaluation of neuroprotective and restorative strategies VEP

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